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1 suggest the phosphodonor is instead the EspA histidine kinase.
2 for analysing ligand regulation of a sensor histidine kinase.
3 are sometimes fused into a so-called hybrid histidine kinase.
4 eraction between transmembrane receptors and histidine kinase.
5 n) is phosphorylated by the WalK(Spn) (VicK) histidine kinase.
6 Trimers activate and control the histidine kinase.
7 nced the autophosphorylation activity of the histidine kinase.
8 um between the inactive and active states of histidine kinases.
9 r specificity in vitro relative to canonical histidine kinases.
10 with a two-state model for ligand control of histidine kinases.
11 0.10 min(-1)] and typical of those of other histidine kinases.
12 le is known about the signals sensed by WalK histidine kinases.
13 lation via a phosphorelay involving multiple histidine kinases.
14 been identified that directly interact with histidine kinases.
15 ryl donor but not with two other recombinant histidine kinases.
16 ce with the GHKL domain of bacterial sensory histidine kinases.
17 different from those observed in prokaryotic histidine kinases.
18 ing methyl-accepting chemotaxis proteins and histidine kinases.
19 lar architecture of KinB is similar to other histidine kinases.
21 modular proteins consisting of rhodopsin, a histidine kinase, a response regulator, and in some case
22 orelay based on genetic analysis of receptor histidine kinase activity and mutants involving the type
24 alyses of gene expression support a role for histidine kinase activity in eliciting the ethylene resp
26 reversal frequencies, an in vivo measure of histidine kinase activity in the phototaxis system, indi
27 yte phytochromes also retain light-regulated histidine kinase activity lost in the streptophyte phyto
29 1) and ETHYLENE RESPONSE SENSOR1 (ERS1) have histidine kinase activity, unlike the subfamily 2 member
32 a transmembrane region; a cytoplasmic HAMP (histidine kinase, adenylyl cyclases, methyl-accepting ch
33 ely 55 amino acid motifs first identified in histidine kinases, adenylyl cyclases, methyl-accepting c
34 MP domains mediate input-output signaling in histidine kinases, adenylyl cyclases, methyl-accepting c
35 model for PAS (Per-Arnt-Sim) and poly-HAMP (histidine kinase-adenylyl cyclase-methyl-accepting chemo
37 he histidine phosphotransferase AHP2 and the histidine kinases AHK2 and AHK3, previously reported to
38 the extracellular domain of the Arabidopsis histidine kinase (AHKs) receptors induces autophosphoryl
40 requires the CYTOKININ INDEPENDENT 1 (CKI1) histidine kinase, an activator of the cytokinin signalin
41 cally composed of a membrane-spanning sensor histidine kinase and a cytoplasmic response regulator.
42 signal transduction pathways consisting of a histidine kinase and a response regulator are used by pr
43 idization probes were designed to target the histidine kinase and glyceraldehyde-3-phosphate dehydrog
45 ine kinase that is predicted to contain both histidine kinase and response regulator domains, but it
46 scribed with scnK and scnR, which encode the histidine kinase and response regulator, respectively, o
47 cifically designed to predict pairing of the histidine kinase and response-regulator proteins forming
50 g network that involves integration from two histidine kinases and branching to three response regula
55 wo-component systems (TCS) comprising sensor histidine kinases and response regulator proteins are am
56 first assess the algorithm's performance on histidine kinases and response regulators from bacterial
59 TCS both modulate phosphorelays comprised of histidine kinases and response regulators, some of which
60 nal transduction systems consist of pairs of histidine kinases and response regulators, which mediate
63 , high-quality domain models for identifying histidine kinases and response regulators; neighboring t
66 ound a core phosphotransfer reaction between histidine kinases and their output response regulator pr
67 of the algZ [fimS] gene, encoding a putative histidine kinase), and PAO1 DeltaalgR for swarming motil
69 axis, transmembrane chemoreceptors, the CheA histidine kinase, and the CheW coupling protein assemble
71 ncoding the NarL response regulator and NarS histidine kinase are hypothesized to constitute a two-co
72 phosphotransfer activities of a conventional histidine kinase are split onto two distinct proteins th
73 osphorelay in which phosphoryl groups from a histidine kinase are successively transferred via relay
75 avin-binding LOV (light, oxygen, or voltage) histidine kinases are competent to perceive cytoplasmic
80 l transduction system, comprised of a sensor histidine kinase (ArsS) and a response regulator (ArsR),
81 a to favorable environments by controlling a histidine kinase as a function of chemoreceptor ligand o
82 xygen and regulates the activity of the FixL histidine kinase as part of a two-component signaling sy
83 n addition, we identified His390 of the LytS histidine kinase as the site of autophosphorylation and
84 ically thought to be mediated exclusively by histidine kinases as part of two-component signaling sys
85 e TipN polar marker, and indirectly the PleC histidine kinase, at the cell pole, but it is not requir
86 redicted to be a hybrid sensor kinase with a histidine kinase/ATPase (HATPase) domain, a receiver (Re
88 receipt of a stimulus, a homodimeric sensor histidine kinase autophosphorylates and then transfers i
93 lubolar C-terminal structure, and the sensor histidine kinase BovK contains eight transmembrane segme
94 ls binding to sensor domains activate sensor histidine kinases by causing localized strain and unwind
97 lts emphasize how the bifunctional nature of histidine kinases can help switch cells between mutually
100 Two phosphorelays, each initiating with the histidine kinase CckA, promote CtrA activation by drivin
106 rs form ternary signaling complexes with the histidine kinase CheA through the coupling protein CheW.
107 ciate with the coupling protein CheW and the histidine kinase CheA to form an ultrasensitive, ultrast
108 ay, involving the receptor signaling domain, histidine kinase CheA, and adaptor protein CheW, as well
110 heW that interact with the large multidomain histidine kinase CheA, as well as with the transmembrane
111 n CheW, which bridges the chemoreceptors and histidine kinase CheA, is essential for chemotaxis.
114 its are composed of transmembrane receptors, histidine-kinase CheA, and coupling protein CheW, but it
115 nt of the component transmembrane receptors, histidine kinases (CheA) and CheW coupling proteins.
116 e chemoreceptors associated with a dedicated histidine kinase, CheA, and a linker protein, CheW, that
118 tners of TlpD, which included the chemotaxis histidine kinase CheAY2, the central metabolic enzyme ac
120 he Chp chemosensory system, which includes a histidine kinase, ChpA, and two CheY-like response regul
123 y this phosphodiesterase is dependent on the histidine kinase component of the chemotaxis machinery,
124 ea-nodulating endosymbiont, encodes a sensor histidine kinase containing a LOV domain at the N-termin
125 of two-component systems, in which multiple histidine kinases converge to PhyR, the phosphorylation
127 nce, we have examined cross-talk between the histidine kinase CpxA and non-cognate response regulator
128 se system is comprised of the inner membrane histidine kinase CpxA, the cytosolic response regulator
129 erminus of signaling proteins such as sensor histidine kinases, cyclic-di-GMP synthases/hydrolases, a
130 hosphorylation of the receiver domain of the histidine kinase CYTOKININ-INDEPENDENT 1 (CKI1RD) from A
131 ansduction proteins such as bacterial sensor histidine kinases, designed to transition between multip
132 rylation is conserved in orthologous sets of histidine kinases despite highly dissimilar loop sequenc
134 have multiple Per/Arnt/Sim (PAS) domains, a histidine kinase domain and a C-terminal receiver (REC)
135 irected mutagenesis, we demonstrate that the histidine kinase domain of ChpA and the phosphoacceptor
136 d extent of structural change orientates the histidine kinase domain to elicit the desired light-acti
137 he light-oxygen-voltage sensor domain to the histidine kinase domain via a 40 degrees -60 degrees rot
138 st transmembrane helix, whereas those in the histidine kinase domain were mostly clustered to a regio
139 ophytochrome structure, including its output histidine kinase domain, suggests how local structural c
144 that the coiled coil linker and the attached histidine kinase domains undergo a left handed rotation
146 nditions, its induction is controlled by two histidine kinases, DosS and DosT, and recent experimenta
148 ays for Spo0A activation, one dependent on a histidine kinase encoded by cac0323, the other on both h
150 erization specificity, focusing on the model histidine kinase EnvZ and RstB, its closest paralog in E
152 specific sensing of ethanolamine by a sensor histidine kinase (EutW), resulting in autophosphorylatio
155 l biosynthesis operon, a bacteriophytochrome-histidine kinase gene and the fnr-type regulatory gene,
157 p phosphorelay system, was phosphorylated by histidine kinase GHK4, which was essential for flagellar
158 ever, the detailed mechanism(s) by which the histidine kinase, GraS, senses specific HD-CAPs is not w
161 alyses reveal that up 1.7% of all identified histidine kinases have the potential to be split and bif
163 ity of downstream signaling proteins such as histidine kinases (HisKa) in a NO-dependent manner.
165 in two-component response pathway, including histidine kinases, histidine phosphotransfer proteins an
167 gnaling pathways composed of two proteins: a histidine kinase (HK) and a response regulator (RR).
168 nal transduction system (TCST) consists of a histidine kinase (HK) and a response regulator (RR).
170 ble this reconstitution, coding sequences of histidine kinase (HK) and response regulator (RR) compon
171 we aimed to target the TCS signal transducer histidine kinase (HK) by focusing on their highly conser
172 pically used very high concentrations of the histidine kinase (HK) compared to the RR approximately P
174 gnal-induced autophosphorylation of a sensor histidine kinase (HK) followed by phosphoryl transfer to
179 flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex
184 mbined NMR and crystallographic study on the histidine kinase HK853 and its response regulator RR468
185 arly through phosphotransfer between cognate histidine kinases (HKs) and response regulators (RRs) to
186 e paralogous signaling systems, comprised of histidine kinases (HKs) and their cognate response regul
189 Most of these signals are sensed through histidine kinases (HKs), which comprise the main sensory
194 the HisKA and HATPase-ATP-binding domains of histidine kinases identified amino acid interactions for
196 o identify the downstream target of the DifE histidine kinase in the regulation of exopolysaccharide
197 tivity of the largest family of bifunctional histidine kinases in response to the change of environme
198 y simple orthologous relationships among the histidine kinases in rice and Arabidopsis (Arabidopsis t
199 ation of DNA replication, the essential CckA histidine kinase is activated by phosphorylation, which
200 udies showed that cheA(2), a gene encoding a histidine kinase, is essential for the chemotaxis of B.
201 ct positions in the Bacillus subtilis sensor histidine kinase KinA and by restoration of activity in
202 N-terminal sensor domain of the cytoplasmic histidine kinase KinA is responsible for detection of th
204 iofilm formation was dependent on the sensor histidine kinase KinD and in particular on an extracellu
207 ranscription of either response regulator or histidine kinase leads to the coexistence of an approxim
208 presence of homologous domains in bacterial histidine kinase-like ATP binding region-containing prot
209 e demonstrate that the flavin-binding sensor histidine kinase, LovhK (bab2_0652), functions as a prim
211 Caulobacter crescentus encodes a soluble LOV-histidine kinase, LovK, that regulates the adhesive prop
213 f microrchidia Gyrase, Heat Shock Protein90, Histidine Kinase, MutL (GHKL) ATPases, were previously s
220 tomach, the organism expresses two pH-sensor histidine kinases, one, HP0165, responding to a moderate
221 s known about the signals sensed by the WalK histidine kinase or the function of the WalJ ancillary p
223 ain response regulator (SDRR) SdrG and seven histidine kinases, PakA to PakG, belonging to the HWE/Hi
224 domain of the Bacillus subtilis PhoR sensor histidine kinase, part of a two-component system involve
225 ese data indicate that Nla28S is the in vivo histidine kinase partner of Nla28 and that the primary f
226 d through phosphorylation from their cognate histidine kinase partners, which in turn facilitates an
228 erichia coli, it was recently shown that the histidine kinase PhoQ is also modulated by at least two
230 orrespond to different states of the sensory histidine kinase PhoR: an inhibition state, an activatio
232 ect the localization of two polar cell cycle histidine kinases, PleC and DivJ, and the pole-specific
234 rA and the FPI-encoded pdpD, and KdpD is the histidine kinase primarily responsible for phosphorylati
235 interaction screen we further identified the histidine kinase protein KdpD that in many bacteria is a
236 has the in vitro biochemical properties of a histidine kinase protein: it hydrolyzes ATP and undergoe
238 how a single amino acid substitution in the histidine kinase receptor AgrC of ST22 strains determine
239 oorganisms, and each comprises a homodimeric histidine kinase receptor and a cytoplasmic response reg
241 CS) are signalling complexes manifested by a histidine kinase (receptor) and a response regulator (ef
244 xperimental and calculated distances for the histidine-kinase region when both subunits are in a para
245 le, while the C-terminal module, including a histidine kinase-related domain (HKRD), does not partici
247 Two-component signaling pathways involve histidine kinases, response regulators, and sometimes hi
248 designated Rrp1, and BB0420 encodes a hybrid histidine kinase-response regulator designated Hpk1.
251 We also establish that KinD is a principal histidine kinase responsible for sensing the presence of
252 indicated that the TCS comprising the sensor histidine kinase RgfC and the response regulator RgfA me
255 and some other S. aureus strains, the sensor histidine kinase SaeS has an L18P (T53C in saeS) substit
256 e its importance, the mechanism by which the histidine kinase SaeS recognizes specific host stimuli i
257 ion of RpaA is regulated by two antagonistic histidine kinases, SasA and CikA, which are sequentially
258 periplasmic sensor domain of a transmembrane histidine kinase sensor, which in turn relays a signal t
259 a template for signal transduction in sensor histidine kinases.Sensor histidine kinases (SHK) consist
260 lases, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases and
261 nsduction in sensor histidine kinases.Sensor histidine kinases (SHK) consist of sensor, linker and ki
264 , usually via phosphotransfer from a cognate histidine kinase, stabilizes the active conformation.
265 where they are often found in operons with a histidine kinase, suggesting that H-NOX proteins serve a
266 In Vibrio species, CqsS is a membrane-bound histidine kinase that acts as the receptor for the CAI-1
267 l system consists of a membrane-bound sensor histidine kinase that autophosphorylates in response to
269 sitive autoregulatory loop involving KinC, a histidine kinase that is activated by potassium leakage.
272 y, we identified and characterized Nla28S, a histidine kinase that modulates the activity of this imp
273 ion pathways, typically composed of a sensor histidine kinase that receives the input stimuli and the
274 g pathways, which typically involve a sensor histidine kinase that specifically phosphorylates a sing
275 ulation is regulated by at least five sensor histidine kinases that are activated in response to vari
276 ial phytochromes are dimeric light-regulated histidine kinases that convert red light into signaling
277 Most species encode numerous paralogous histidine kinases that exhibit significant structural si
278 ermosensor DesK is a multipass transmembrane histidine-kinase that allows the bacterium Bacillus subt
279 ammable redirection of phosphate flux from a histidine kinase to response regulators based on targeti
280 to follow the flow of phosphate groups from histidine kinases to the cognate response regulators in
281 gate the contribution of the localization of histidine kinases to the establishment of cellular asymm
282 A interacts with DcuS, the membrane embedded histidine kinase, to transfers DcuS to the responsive st
283 rotein was engineered as a functional sensor histidine kinase (TolRSK) and an independent response re
287 is activated by phosphorylation by multiple histidine kinases via a multicomponent phosphorelay.
288 dy, we report the identification of a sensor histidine kinase, VpsS, which can control biofilm format
289 sion levels (> 10-fold) of phoR, a P-sensing histidine kinase, were only observed under conditions of
290 autophosphorylation of the operon-associated histidine kinase, whereas the ligand-free H-NOX has no e
291 old greater than the amount of the WalK(Spn) histidine kinase, which is present at approximately 460
292 d RpBphP3, are configured as light-regulated histidine kinases, which initiate a signal transduction
295 sma0114, encode the proteins Sma0113, an HWE histidine kinase with five PAS domains, and Sma0114, a C
296 echanism underlying interaction of a protein histidine kinase with this tight-binding inhibitor.
298 ilarly, photoreduction of the engineered LOV histidine kinase YF1 to the NSQ modulates activity and d
299 mesS) encoding the predicted cognate sensor (histidine) kinase yielded a mutant with the same inabili
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