ライフサイエンスコーパス: histidine residue

1 ion, probably driven by protonation of a key histidine residue.

2 site cysteine of Grx3/4, glutathione, and a histidine residue.

3 he orientation of the GGQ domain without the histidine residue.

4 -dependent autophosphorylation reaction to a histidine residue.

5 site cysteine of Grx3/4, glutathione, and a histidine residue.

6 contain copper bound by two cysteines and a histidine residue.

7 n of HPr by the PTS enzyme EI at a conserved histidine residue.

8 ect almost entirely arises from a protonated histidine residue.

9 factor in the active site is replaced with a histidine residue.

10 ein family despite the lack of the signature histidine residue.

11 a potential cross-strand interaction with a histidine residue.

12 ffinity and the surface accessibility of the histidine residue.

13 le and protonation of the leaving group by a histidine residue.

14 lection via the dynamic flipping of a single histidine residue.

15 activated by a point mutation of a catalytic histidine residue.

16 rangement of three cysteine residues and one histidine residue.

17 ive-site serine and stable modification of a histidine residue.

18 ed to the difference in the charged state of histidine residues.

19 eptide chain via proximal (CXXCH) and distal histidine residues.

20 tonable residues, including the cysteine and histidine residues.

21 ated by imidazole nitrogens of six conserved histidine residues.

22 rate release mechanism based on a cluster of histidine residues.

23 destabilization of one of two heme-ligating histidine residues.

24 highly mobile segment rich in methionine and histidine residues.

25 d a copper atom (Cu(B)) coordinated by three histidine residues.

26 dioxygenase (CDO), and is composed of three histidine residues.

27 by the native E7 histidine and two nonnative histidine residues.

28 osphorylation/dephosphorylation of conserved histidine residues.

29 nechocystis 6803, which binds zinc via three histidine residues.

30 osphorylation/dephosphorylation at conserved histidine residues.

31 C-clamp" structure via four tyrosine and one histidine residues.

32 g is tighter at low pH due to protonation of histidine residues.

33 [2Fe-2S] cluster via three cysteine and one histidine residues.

34 thyroid cells independently of extracellular histidine residues.

35 ss between one of the photoacids to proximal histidine residues.

36 ayload bound to the Fc region, presumably to histidine residues.

37 to the pK(a) of the imidazole side chain of histidine residues.

38 the protonation/deprotonation of TIA-1 RRM3 histidine residues.

39 ta indicating important roles for lysine and histidine residues.

40 a series of peptides composed of lysine and histidine residues.

41 reveal the binding of two ruthenium atoms to histidine residues 146 and 242, which are both located w

42 Histidine residue 208 in BglG is essential for this phos

43 he alanine mutants, it was proposed that the histidine residues acted as acid-base catalysts, whereas

44 nvolves one of the two conserved active site histidine residues acting as a general base abstracting

45 g mechanism of catalysis and suggests that a histidine residue acts as the general acid.

46 ings indicate that mutations to the proximal histidine residues affect MtrA expression, leading to lo

47 A truncated form of sCD14, carrying a histidine residue affinity tag for purification, was inc

48 r) composed of various numbers of lysine and histidine residues alone are not sufficient to mediate e

49 The tail histidine residues, along with two previously identified

50 Mutating this histidine residue also abolishes the ability of Cif to r

51 identified as the sole absolutely conserved histidine residue among family members.

52 ferential surface modification of lysine and histidine residues analyzed by mass spectrometry has bee

53 sphate molecule coordinated to the catalytic histidine residue and a second phosphate molecule in a p

54 center coordinated by a bidentate N-terminal histidine residue and another histidine ligand.

55 eing the formation of a C-C bond between the histidine residue and the 3-amino-3-carboxypropyl group

56 toNEET homodimer are each coordinated by one histidine residue and three cysteine residues.

57 s we mutated all extracellular glutamate and histidine residues and 4 of 11 aspartates.

58 The three tail histidine residues and His 63 in the recognition helix a

59 nd functional assays to show that pH-sensing histidine residues and K(+) ions mutually interact elect

60 h the catalytic zinc atom coordinated by two histidine residues and one aspartate residue approximate

61 active site pocket contains a group of three histidine residues and one serine that appear to confer

62 romophores (biliverdin), autophosphorylating histidine residues and the ATP molecules in the kinase d

63 sults also suggest tight binding between the histidine residues and the Cu(II) ion, which is likely t

64 aled several basic residues surrounding this histidine residue, and the mutation of these residues al

65 teine nucleophiles are often deprotonated by histidine residues, and histidine-235 was identified as

66 Thus, the C-terminal histidine residues are critical for the transition from

67 Four conserved histidine residues are demonstrated to be critical for e

68 The radical trapping properties of histidine residues are discussed.

69 Histidine residues are especially important for stabiliz

70 the conformational change are not known, but histidine residues are implicated because the pK(a) of h

71 In contrast, mutations to the distal histidine residues are less detrimental to protein expre

72 hyperstable variant of RAP-D3, in which four histidine residues are replaced with phenylalanine, has

73 Beta sheets containing histidine residues are used as a model system due to the

74 odel implicate displacements of the proximal histidine residue as the likely cause.

75 and in cells confirm that the protonation of histidine residues as a consequence of the pH changes mo

76 occurs around pH 6.5, we have looked toward histidine residues as a potential biophysical origin of

77 onophosphate end of the RNA is linked to the histidine residue at position 1,227 (H1227) of the L pro

78 I, binding to MCT1 and MCT4 is mediated by a histidine residue at position 64.

79 binding mechanism involves protonation of a histidine residue at the binding site.

80 ctivity, achieved by introducing a catalytic histidine residue at the terminus of a pH-responsive pep

81 eplicon engineered to have the tick-specific histidine residue at this position is replication defect

82 esence of a stacked pair of symmetry-related histidine residues at a central pivot point in the dimer

83 rimeric isoleucine zipper GCN4-pII, contains histidine residues at core d-positions of alternate hept

84 Depending on the position of the histidine residue, both enantiomers of the salsolidine p

85 ec residue farther away from the protonating histidine residue, but the lower pKa of Sec in compariso

86 ntiate side chain orientations in individual histidine residues, by correlating features in scanning

87 ntain a unique post-translationally modified histidine residue called diphthamide, which is the targe

88 and that the unique microstructure around a histidine residue can be identified by identifying the a

89 assignment of the p K a values to individual histidine residues can be achieved simultaneously based

90 t on their photodegradation kinetics and for histidine residues can explain most of the variation in

91 The high density of histidine residues combined with an abundance of basic r

92 zinc finger domain contains 15 cysteine and histidine residues configured in two potential zinc coor

93 is able to bind two b-type hemes through the histidine residues conserved between the MsrQ and NOX pr

94 w that introduction of a suitably positioned histidine residue contributes to firmly anchor, via a da

95 enclose a large cavity where three conserved histidine residues coordinate a zinc ion.

96 Subtle motions of the catalytic serine and histidine residues coordinated with translation of the s

97 ncentrations, the binding site consists of 4 histidine residues coordinating the copper through epsil

98 reacts with lysine, cysteine, tyrosine, and histidine residues, damaging critical immunogenic epitop

99 Ref, including several putative active site histidine residues, defines a new subclass of HNH-family

100 al alanine substitution of each cysteine and histidine residue demonstrated that eight sites are impo

101 Histidine residues direct oxidative coupling of boronic

102 ces, indicating that the paired cysteine and histidine residues do not function as a zinc finger DNA

103 te before and after Cu binding suggests that histidine residues dominate Cu binding.

104 ilarity, except the presence of cysteine and histidine residues: eight in most B-box1 domains and sev

105 m long fibrils with the hydrophobic edge and histidine residues extending in an ordered array as the

106 Mutation of the catalytic cysteine and histidine residues for either p29 or p48 was tolerated b

107 active site, the role of the two active site histidine residues for polarization of the substrate C h

108 Replacing the histidine residues forming the Zn(2+) binding site, His(

109 It is proposed that the histidine residue forms a hydrogen bond to a water/hydro

110 the protonable head group, and removing the histidine residue from the linker, both resulted in impr

111 e consists of an Fe(II) ion ligated by three histidine residues from the protein, an interesting vari

112 Murine HSP47 has 14 histidine residues grouped into three clusters, known as

113 lts suggest that the mutation of a conserved histidine residue (H108) in CCMB1 alters the redox homeo

114 phenotype was due to mutation of a conserved histidine residue (H108Y) in a protein that displayed hi

115 Three histidine residues (H152, H155, and H156), located in fu

116 A mutation of the active-site histidine residue, H162G, does not eliminate cysteine nu

117 udies of mutant proteins, suggests that four histidine residues (H17 and H27 of S100A8; H91 and H95 o

118 Mutation of conserved histidine residues H200N, H293N, and H295N, expected to

119 Site-directed mutagenesis of a critical histidine residue (H233A) in the predicted active site o

120 In contrast, a cluster of three histidine residues (H245, H304, and H430) located near t

121 gests that it is a zinc metalloprotein, with histidine residues H32 and H82 required for NO. resistan

122 ort that replacement of the three C-terminal histidine residues, H322, H323, and H372, in triple-R or

123 ion for SFV zinc resistance identified a key histidine residue, H333 on E1 DIII, while other conserve

124 ransition state stabilization by tyrosine or histidine residues H50 and L94.

125 des an arginine replacement of the conserved histidine residue (H508R) located within the DEVH-contai

126 tive metal binding site with three conserved histidine residues (H73, H77 and H186).

127 ight into the role of the strictly conserved histidine residue, H79, in the reaction mechanism of the

128 Moreover, a single histidine residue, H906, was reported to be critical for

129 An invariant histidine residue has been proposed to function in the T

130 variant form of choline oxidase in which the histidine residue has been replaced with asparagine was

131 Specifically, protonation of histidine residues has been implicated in pH-dependent c

132 is unclear, and protonation of conserved E1 histidine residues has been proposed as a possible mecha

133 Histidine residues have been hypothesized to function as

134 Histidine residues have been suggested as triggers due t

135 and in contact with catalytically essential histidine residue (His(126)).

136 iated by the change in ionization state of a histidine residue (His(4)) that is not within the HA-bin

137 CN(-) and comparison of mutants identified a histidine residue (His-156) that coordinates the cobalt

138 ely eliminated by mutation of an active site histidine residue (His-287, murine ferrochelatase number

139 By site-directed mutagenesis we show that a histidine residue (His-347) downstream of S6 reduces inh

140 In Ngb, the imidazole of a histidine residue (His-64) in the distal position, above

141 the pH affinity curves indicate that another histidine residue, His(45), is largely responsible for t

142 Pr; a domain that carries the phosphorylated histidine residue, His-189; and a PEP-binding domain.

143 The p K a values of three of four histidine residues (His12, -105, and -119) in RNase A we

144 c function of HS-2OST appears to involve two histidine residues (His140 and His142), whereas only one

145 taneously transfer a proton to a pore-lining histidine residue (His168).

146 nificantly reduced by the protonation of two histidine residues, His187 and His155.

147 t NDPK2 is phosphorylated only on its active histidine residue His197 and the presence of serine/thre

148 e due to a damaged H-bonding with the active histidine residue His197 in the nucleotide-binding pocke

149 tivity is enhanced by phosphorylation of the histidine residue (His232) located in its activation loo

150 ots were identified, which include conserved histidine residues His292 and His440 in the Fc region an

151 octahedral coordination for Fe(2+) with two histidine residues (His331 and His367), a bidentate carb

152 tion to calcium, phosphorylation of a single histidine residue (His358) in the cytoplasmic region, by

153 Four histidine residues (His37) in the center of the channel

154 ociated linkers, contains a phosphorylatable histidine residue (His455).

155 Mutating any of the four conserved histidine residues (His51, 147, 210, or 354) in hSVCT1 t

156 olvent to the high flexibility of the distal histidine residue, His55, that provides a direct pathway

157 We demonstrate here that the distal pocket histidine residue (His64) of horse heart metMb(III) (i.e

158 structural features, including two prominent histidine residues, His685 and His686, which may be impo

159 Previous studies identified a histidine residue (His69) that functions as a pH sensor

160 The bound zinc ion is coordinated by three histidine residues (His78, His161 and His225) and one gl

161 ity in vitro and requires a highly conserved histidine residue identified in alpha/beta hydrolase fam

162 stamine chelation of copper(I) by a terminal histidine residue in copper hydroxylating enzymes activa

163 ed to investigate the function of the distal histidine residue in Cupriavidus metallidurans TDO (cmTD

164 lyzed oxidation of a specific, metal-binding histidine residue in domain 1 of the channel.

165 Our data indicate that mutation of one histidine residue in E1 is detrimental to the assembly o

166 d to be the result of the involvement of the histidine residue in intramolecular interactions.

167 shows two alpha-helical domains, each with a histidine residue in its sequence (H126 and H142).

168 c role was put forward for a fully conserved histidine residue in MraY (His-289 in BsMraY), which has

169 crepancy, we explored the role of the distal histidine residue in muting the reactivity of human neur

170 The Histidine residue in position 265 of the CdtB catalytic

171 that the catalytic proton transfer between a histidine residue in the active site and the 6-4PP, indu

172 riggers autophosphorylation of the catalytic histidine residue in the C-terminal domain to transmit t

173 A highly conserved histidine residue in the distal heme pocket has attracte

174 of this complex reveals that a non-conserved histidine residue in the ETS domain recognition helix he

175 , Schuberth-Wagner et al. (2015) show that a histidine residue in the RNA binding pocket of RIG-I ste

176 acking interaction that positions a critical histidine residue in the substrate specificity loop of c

177 our work suggests a more general role of the histidine residue in the transport of copper by PIB-1-AT

178 This is the first report of a methylated histidine residue in yeast cells, and the first example

179 requires the presence of globally protected histidine residues in a protein's three-dimensional stru

180 tween pH 6.0 and 6.5 upon protonation of the histidine residues in acidic solutions.

181 We provide direct evidence that all three histidine residues in amyloid-beta 1-16 (Abeta 1-16) coo

182 In order to model the syn disposition of histidine residues in carboxylate-bridged non-heme diiro

183 Moreover, the introduction of histidine residues in cholesterol-peptide conjugates led

184 odeling of the dimeric peptide revealed that histidine residues in close vicinity can efficiently coo

185 ing a Ctr1 mutant lacking only extracellular histidine residues in Ctr1-knockout mouse embryonic fibr

186 We identify five histidine residues in eEF2K that are crucial for the act

187 sphorylated serine, threonine, tyrosine, and histidine residues in phosphoproteins.

188 to determine the p K a values of individual histidine residues in proteins.

189 Although histidine residues in the absence of Zn(II) exhibit pNPA

190 on of 1.86 A established the presence of two histidine residues in the active site, which may partici

191 using phylogenetically conserved serine and histidine residues in the active site.

192 he hydrophobic tail, and (3) the presence of histidine residues in the amino acid linker for transfec

193 the role of conserved pairs of cysteine and histidine residues in the C-terminal region of L4-22K.

194 s studies showed that none of the lysines or histidine residues in the carboxyl-terminal protease dom

195 t in canine HSP47, where we have mutated all histidine residues in the collagen binding interface and

196 tify an invariant series of six cysteine and histidine residues in the CTD of G2 that is essential fo

197 scopy establishes that Cu(2+) coordinates to histidine residues in the EcoRI endonuclease homodimer b

198 We investigated a requirement for histidine residues in the envelope (E) protein of West N

199 Thorough mutational analysis of conserved histidine residues in the envelope protein of tick-borne

200 een GAG anomeric position(s) and one or more histidine residues in the fibrils.

201 tivation causes oxidative damage to specific histidine residues in the key proteins in aldose reducta

202 Two conserved histidine residues in the OSBP homology domain ORP4 are

203 ential for FrcB stability, as were conserved histidine residues in the protein that likely coordinate

204 drophilic angle of 140 degrees formed by the histidine residues in the Schiffer-Edmundson helical whe

205 Insertion of histidine residues in the sequence reduced kidney uptake

206 This property is likely caused by histidine residues in the vicinity of the mapped heparin

207 all individual and selected clusters of GP64 histidine residues in triggering and mediating fusion by

208 amino acid substitutions for five conserved histidine residues in two PTS regulatory domains and an

209 nstrate that when arginine 132 is mutated to histidine, residues in the active site are shifted to pr

210 globin in both quail species contained eight histidine residues instead of the nine present in chicke

211 lyltransferases, where a partially conserved histidine residue interacts with the nicotinate ring, th

212 mophore that involves the incorporation of a histidine residue into the conjugated system.

213 to be wholly intolerant to substitution: two histidine residues involved in general acid/base catalys

214 de networks, the imidazole side chain of the histidine residue is deprotonated to afford Zn-imidazola

215 In both structures, a histidine residue is found at the normally hydrophobic p

216 1-16 analogues, in each of which a selected histidine residue is isotopically enriched with (15)N.

217 pH dependent (pK(a) approximately 7) when a histidine residue is located in the neighborhood of the

218 DAM active site with three zinc-coordinating histidine residues is introduced.

219 n of an alpha-helix stabilising sequence and histidine residues, lengthens the pharmacokinetic profil

220 line as a substrate and required a conserved histidine residue located in the FIC domain of the AnkX

221 BK channel requires an aspartic acid and two histidine residues located in the cytoplasmic RCK1 domai

222 tested; only mutations of three consecutive histidine residues, located in a single extracellular lo

223 Finally, two histidine residues near the extracellular surface and th

224 Neither substitution of the phosphoaccepting histidine residue nor deletion of the entire catalytic A

225 ough a mechanism that involves a cytoplasmic histidine residue, not used by other TRPV1 agonists such

226 pecific post-translational modification of a histidine residue of eEF2, is involved in translocation.

227 up from S-adenosyl-l-methionine (SAM) to the histidine residue of EF2, forming a C-C bond.

228 itutions of either the conserved cysteine or histidine residue of SrtA known to be required for catal

229 e, mutation of the conserved phosphoacceptor histidine residue of the AHP, as well as disruption of m

230 A Src revealed the surprising finding that a histidine residue of the N-terminus of a symmetry-relate

231 monstrated that mutation of the two adjacent histidine residues of Abeta40 (H13,14G) resulted in a si

232 in pKa values and tautomer distributions for histidine residues of an invisible on-pathway folding in

233 ents reveal that the six Mn(II)-coordinating histidine residues of Ca(II)- and Mn(II)-bound CP are sp

234 this study, we show the effects of mutating histidine residues of MtrA to arginine on protein expres

235 y structure of the APP CuBD, we examined the histidine residues of the copper binding site (His(147),

236 The pH dependency is due to the conserved histidine residues of the ENTH and ANTH domains, protona

237 Mutagenesis of the three ectodomain histidine residues of the HMPV F protein demonstrated th

238 pathogenicity and that a substitution of the histidine residues of the MHV-A59 ns2 His-x-Thr/Ser moti

239 lysozyme variants, each containing only one histidine residue on its surface, with various surface a

240 ucidation of the myoglobin (Mb) structure, a histidine residue on the E helix (His-E7) has been propo

241 elating Zn2+ ions off specific extracellular histidine residues on Ca(v)3.2 T-channels, thus relievin

242 natures at pH <6.2 due to protonation of key histidine residues on helices 2 and 3.

243 king occurred across two identical conserved histidine residues on two separate heavy chains in the h

244 PduL fused to eight C-terminal histidine residues (PduL-His(8)) was purified, and its k

245 esults suggest that these eight cysteine and histidine residues perform different functions during DN

246 es (AMPs) that contain a large proportion of histidine residues (pK(a) approximately 6) depends on th

247 do not strongly indicate that the conserved histidine residues play a role in the pH regulation of m

248 have investigated the protonation states of histidine residues (potential Bohr groups) in the deoxy

249 vitro and in vivo is enhanced when a single histidine residue present in the fetal cardiac TnI isofo

250 theoretical and experimental study of the 14 histidine residues present in canine HSP47, where we hav

251 We found that N(epsilon) of a histidine residue, presumably H75, carries most of the u

252 sequence, which replaces arginine 887 with a histidine residue (R887H), strongly inhibits PKCalpha-de

253 Mutation of the histidine residues resulted in a mutant with a similar p

254 Mutations to the distal histidine residues resulted in various degrees of ferrih

255 arily arises from salt bridges involving IgG histidine residues, resulting in moderate affinity at mi

256 d surface structure of a protein, that is, a histidine residue's surface accessibility and its potent

257 ngated at pH 9.4, showing the involvement of histidine residue(s) in its folded-back structure.

258 ng from approximately 1 to 12%, and a single histidine residue separated the most and least reactive

259 ort here that the alkylation of an essential histidine residue showed no effect on the one-electron p

260 nation of pKa values for the solvent-exposed histidine residues shows that the surface properties of

261 e-rich (E/Q)XXXE plus PGXSRSXXT motifs and a histidine residue, specific to the bacterial UppP enzyme

262 ia toxin, is a post-translationally modified histidine residue that is found in archaeal and eukaryot

263 in the positions of the proximal and distal histidine residues that appeared during DHP evolution.

264 T activity requires catalytic asparagine and histidine residues that are conserved in this family.

265 a putative catalytic triad consisting of two histidine residues that are hydrogen bonded to an ordere

266 s in S4 that regulate channel gating and two histidine residues that are required for extracellular i

267 We also identify key histidine residues that control this pH-dependent equili

268 In addition to cysteine and histidine residues that form the catalytic site, 2 lysin

269 unique spacial arrangement of nine conserved histidine residues that implies a potentially novel mech

270 in pH have recently been shown to be the two histidine residues that ligate the [2Fe-2S] cluster.

271 Many heme proteins have distal histidine residues that play important roles in determin

272 g by the side chains of an aspartate and two histidine residues; three water molecules complete octah

273 nitroazobenzene chromophore to tyrosine and histidine residues, thus endowing peptides with high pho

274 nsembles presenting either a methionine or a histidine residue to the heme iron for facile binding.

275 binds to uranyl and suggest that binding of histidine residues to uranyl could occur under normal bi

276 hypothesized that protonation of one or more histidine residues triggers this transition.

277 FdtA is characterized by a cluster of three histidine residues, two of which, His(49) and His(51), a

278 e, a plant homolog of KL, revealed that this histidine residue was at the base of the deep catalytic

279 ver, there are three deviant variants, whose histidine residue was found to be involved in site-speci

280 n which the electrostatic environment of the histidine residue was perturbed by altering charged and

281 Although a histidine residue was previously proposed to be the acti

282 tification, and site-directed mutagenesis of histidine residues, we demonstrated that MsrQ is able to

283 this disulfide bond with elimination of key histidine residues, we generated a stable RAP molecule t

284 analyses to assess the protonation state of histidine residues, we propose a new mechanistic scheme

285 s in which tryptophan 51 was replaced with a histidine residue were constructed.

286 These three histidine residues were important for efficient pore exp

287 e, H333 on E1 DIII, while other conserved E1 histidine residues were not involved.

288 (pKa = 7.7), suggesting the protonation of a histidine residue, which could hydrogen bond with the ca

289 reates a single Mn(2+)-binding site from six histidine residues, which distinguishes CP from all othe

290 s for generation of peptide ions with unique histidine residues, which were overcome by employing ETD

291 lding were constructed by replacing interior histidine residues with phenylalanines.

292 H229 residues, not the other methionine and histidine residues, with alanine convert UV-vis spectra

293 d sites susceptible to HNE modification were histidine residues, with most of these sites being flank

294 this subfamily were recently shown to use a histidine residue within a His-Asp dyad contained in a s

295 A histidine residue within NExo that is responsible for it

296 ion proceeds through a covalent guanylylated histidine residue within the histidine triad motif.

297 rk highlighted the importance of a conserved histidine residue within the propeptide of a widely stud

298 FFXRX6RX12PXD motif, two uniquely conserved histidine residues within a PXXYHXXHXP motif, and a uniq

299 site-directed substitutions of cysteine with histidine residues within the PARP-1 zinc finger reveale

300 chment of an osmium bis-bipyrdine complex to histidine residues within the peptide.