ライフサイエンスコーパス: histone

1 ed viral DNA is not associated with cellular histones.

2 e testis and showed that it can ubiquitinate histones.

3 e treatment of apelin-13, which deacetylates histones.

4 tryptase truncates nucleosomal histone 3 and histone 2B (H2B) and that its absence results in accumul

5 ncer types and was associated with decreased histone 3 (H3) acetylation and increased Bcl-xL expressi

6 DNA hypomethylation and histone 3 acetylation were found on the p66(Shc) promote

7 We show that tryptase truncates nucleosomal histone 3 and histone 2B (H2B) and that its absence resu

8 and divergent enhancer activity as marked by histone 3 containing the acetylated lysine 27 (H3K27ac).

9 The latter induces the expression of the histone 3 lysine 27 (H3K27) demethylase Jumonji d3 (Jmjd

10 recipitation-PCR detected increased ETS1 and histone 3 lysine 4 trimethylation (H3K4Me3) at the CDKN2

11 The genes encoding the histone acetyl-transferases (HATs) CREB binding protein

12 f STAT3 phosphorylation and demonstrate that histone acetylation and STAT3 tyrosine705 phosphorylatio

13 er, but the impact of diet on acetyl-CoA and histone acetylation in these tissues remains unknown.

14 CoA in the nucleus and cytosol and regulates histone acetylation levels in many cell types.

15 ne (GSNO) increased the abundance of several histone acetylation marks in Arabidopsis (Arabidopsis th

16 sm-associated changes in gene expression and histone acetylation require TRbeta1.

17 Efforts to manipulate locus-specific histone acetylation to assess their causal role in gene

18 is increased pS81 enhances p300 recruitment, histone acetylation, BRD4 binding and subsequent further

19 l memory, a cognitive process that relies on histone acetylation.

20 he pancreas, HFD also impacted the levels of histone acetylation; in particular, histone H3 lysine 23

21 Histone acetyltransferase 1 (HAT1), which catalyzes H4K5

22 l roles in protein activation, including the histone acetyltransferase p300 acetylated in its activat

23 The histone acetyltransferase p300 is normally associated wi

24 The histone acetyltransferase paralogues p300 and CREB-bindi

25 MYST histone acetyltransferases have crucial functions in tra

26 ng proteins important for the recruitment of histone acetyltransferases of the MYST family to chromat

27 -wide correlation studies have revealed that histone activation marks and repression marks are associ

28 ling that concentrations of acyl-CoAs affect histone acyl-PTM abundances by both enzymatic and non-en

29 Finally, we showed that histone and cell cycle genes in general are exempt from

30 eaks through bivalent interactions with both histone and DNA components of the nucleosome.

31 We propose that ORCA coordinates with the histone and DNA methylation machinery to establish a rep

32 ly controlled at the chromatin level through histone and DNA modifications.

33 the ability of ATRX to interact with H3K9me3 histone and HP1.

34 cell invasion and apoptosis by demethylating histone and the non-histone protein p53, respectively.

35 iently and specifically removing Ser-ADPr of histones and other proteins.

36 Thus, chaperone-assisted eviction of linker histones and Shugoshins is a fundamental step in mammali

37 ults demonstrate that the relative levels of histones and transcription factors regulate the onset of

38 n for DNA binding between nucleosome-forming histones and transcription factors regulates zebrafish g

39 in histone H3 and trimethylated lysine 9 in histone), and gene-expression profiles in naive, effecto

40 ess in which DNA-based structures containing histones are extruded to ensnare and kill bacteria.

41 Dictyostelium histones are modified in response to DNA double strand b

42 nuclei of mast cells where it truncates core histones at their N-terminal ends.

43 cus on the molecular mechanisms underpinning histone binding, selectivity, and regulation of these hi

44 s are amenable to cooperative, high-affinity histone binding.

45 disordered interdomain linker modulates the histone-binding affinity by interacting with the PHD dom

46 lopment.Polycomb repressive complexes modify histones but it is unclear how changes in chromatin stat

47 Thus, in addition to serving as a histone chaperone and transcription elongation factor, S

48 suggesting that IDRs are often critical for histone chaperone function and play key roles in chromat

49 Chromatin assembly factor 1 (CAF-1) is the histone chaperone responsible for histone (H3-H4)2 depos

50 Histone chaperones are a non-catalytic group of proteins

51 Histone chaperones are responsible for binding the highl

52 y the SWR-C complex, which relies on several histone chaperones including Nap1 and Chz1 to deliver H2

53 Strikingly, NAP1-like histone chaperones interact with CSB and greatly enhance

54 Although most histone chaperones perform these common functions, recen

55 recent structural studies of many different histone chaperones reveal that there are few commonaliti

56 ly after completion of repair, suggests that histone chaperones sequester the repair complex for oxid

57 reaction that has remained elusive for other histone chaperones, and it advances our understanding of

58 ls and thereby facilitate the reading of the histone code.

59 The reduction in nuclear histone concentration that coincides with genome activat

60 Our findings indicate that the histone core of a nucleosome is more plastic than previo

61 otting on mouse cervix confirmed large scale histone de-acetylation in labor.

62 t parturition is associated with broad scale histone de-acetylation.

63 Even though histone deacetylase (HDAC) inhibition has shown remarkab

64 rt the multicomponent synthesis of a focused histone deacetylase (HDAC) inhibitor library with peptoi

65 of latency reversing agents (LRAs), such as histone deacetylase (HDAC) inhibitors and protein kinase

66 f resistance include activation of the mTOR, histone deacetylase (HDAC), MAPK, and ERBB4 pathways.

67 ssed in telomerase-negative human cells in a histone deacetylase (HDAC)-dependent manner, replicating

68 a new class of anticancer agents that target histone deacetylase (HDAC).

69 We demonstrate that a histone deacetylase (Hdac3) organizes heterochromatin at

70 r localization and nucleosome remodeling and histone deacetylase (NuRD) complex binding are required

71 Calcium-dependent nuclear export of histone deacetylase 1 (HDAC1) was shown previously to pr

72 se development, the histone-modifying enzyme histone deacetylase 3 (Hdac3) regulates the formation of

73 expression involves epigenetic regulation by histone deacetylase 3.Hepcidin controls systemic iron le

74 We found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (

75 zation was rescued by inhibition of ROCK and histone deacetylase 6 but not by a GAP-mutant form of AR

76 ns of the structurally characterized isozyme histone deacetylase 8 (HDAC8).

77 ly identified peptide sequence from the Clr3 histone deacetylase and a previously identified sequence

78 an essential component of the mammalian Sin3-histone deacetylase corepressor complex, severely impair

79 epressor of ZRS activity, interacts with the histone deacetylase HDAC2 and ensures that the poised ZR

80 In vitro, pan-histone deacetylase inhibition elevates hepcidin express

81 We show that the small-molecule histone deacetylase inhibitor M344 reduces beta-amyloid

82 In particular, the histone deacetylase inhibitor sodium butyrate (SB) may i

83 fic overexpression of Ascl1, together with a histone deacetylase inhibitor, enables adult mice to gen

84 Panobinostat (pano) is an FDA-approved histone deacetylase inhibitor.

85 azole and its analogues are isoform-targeted histone deacetylase inhibitors and potent LRAs.

86 with TEPP-46 and shikonin or treatment with histone deacetylase inhibitors produced similar results.

87 Treatment of mammalian cells with histone deacetylase inhibitors to increase euchromatin o

88 HDAC6 is a cytoplasmic histone deacetylase regulating multiple pro-survival mec

89 Histone deacetylase-2 (HDAC2), an epigenetic regulator,

90 by DUSP2 were similar to those controlled by histone deacetylase.

91 ue to histone deacetylation as inhibition of histone deacetylases (HDACs) not only induced acetylatio

92 Here, we present evidence that specific histone deacetylases (HDACs) play essential roles in the

93 Histone deacetylases (HDACs) remove acetyl groups from l

94 In PV, inhibitors of histone deacetylases and human double minute 2 have acti

95 Our lab has previously shown histone deacetylases are modulated in cells derived from

96 that the activity of plant-encoded enzymes (histone deacetylases) can be modulated to alter acetylat

97 ibits fatty acid metabolism and WAT browning.Histone deacetylases, such as HDAC3, have been shown to

98 y, HDAC3 activity is largely responsible for histone deacetylation and inflammatory responses of prim

99 Silencing of the HLA class-I APM is due to histone deacetylation as inhibition of histone deacetyla

100 n and serotonin signalling, identifying this histone demethylase as a potential target for the treatm

101 w-cycling cells with high Notch activity and histone demethylase expression are present in primary gl

102 ruitment of OCT4 to the promoter of Kdm2b, a histone demethylase gene that promotes reprogramming by

103 e antifungal agent ciclopirox as a novel pan-histone demethylase inhibitor.

104 epression of hepatic autophagy by recruiting histone demethylase LSD1 in response to a late fed-state

105 he function of LSD1 in AD and FTD."LSD1 is a histone demethylase that plays many roles during develop

106 that VRS3 encodes a putative Jumonji C-type histone demethylase that regulates expression of other V

107 In addition to HIFs, multiple histone demethylases are altered in their expression and

108 Here we report that the KDM3 family of histone demethylases plays an important role in tumorige

109 JARID1 proteins are histone demethylases that both regulate normal cell fate

110 Ciclopirox targeted several histone demethylases, including KDM4B implicated in MYC

111 work elucidates the molecular mechanism for histone deposition by CAF-1, a reaction that has remaine

112 that HIRA and ATRX function in complementary histone deposition pathways.

113 at RPA functions as a platform for targeting histone deposition to replication fork, through which RP

114 iption, which is affected by the strength of histone-DNA interactions.

115 functional PTMs are found on the N-terminal histone domains (tails) of approximately 50 residues pro

116 9 undergoes heterodimerization with Dtx3L, a histone E3 ligase involved in DNA damage repair.

117 alled Bucentaur (BCNT), is essential for the histone exchange activity of SWR, whereas an acidic regi

118 iotherapy, little is known about the role of histone expression in chemoresistance.

119 -specific posttranslational modifications of histones forming the nucleosome core that are often regu

120 increases chromatin accessibility, enhances histone gene transcription, and promotes HLB formation.

121 nteractions connecting replication-dependent histone genes on chromosome 6, potentially representing

122 Adding linker histone H1 further increased compaction of the A-tract a

123 Remarkably, we discovered that linker histone H1 phosphorylated at S/T18 decorated the inter-c

124 Histone H1 shifts the conformational landscape of the nu

125 nk between NPCs and chromatin via Nup133 and histone H1.

126 MacroH2A1 is a variant of the histone H2A and an epigenetic regulator of stem-cell fun

127 immunity, increased serum levels of IgM anti-histone H2A autoantibodies significantly correlated with

128 PCGF3/5-PRC1-mediated ubiquitylation of histone H2A signals recruitment of other noncanonical PR

129 PRC1), the E3 ligase complex responsible for histone H2A ubiquitination and gene silencing.

130 H2A.Z is a histone H2A variant that contributes to transcriptional

131 observed a clear association of Gene 33 with histone H2AX and that ectopic expression of Gene 33 prom

132 33 promotes the interaction between ATM and histone H2AX without triggering DNA damage.

133 tin complex, which trimethylates lysine 4 on histone H3 (H3K4me3), regulates lifespan in Caenorhabdit

134 e dUTP nick end labeling (TUNEL) and phospho-histone H3 (PH3) staining to assess apoptosis and cell p

135 CREBBP-mutant DLBCL clones exhibited reduced histone H3 acetylation, expressed significantly less MHC

136 ion, histone marking (acetylated lysine 9 in histone H3 and trimethylated lysine 9 in histone), and g

137 defects converge on altering methylation of histone H3 at K36 (H3K36), subsequently blocking cellula

138 rs are commonly marked by monomethylation of histone H3 at lysine 4 (H3K4me1) in a cell-type-specific

139 se 1/2 (MSK1/2)-catalyzed phosphorylation of histone H3 at serine 10 or 28 and expression of immediat

140 ) ortholog and show that ATRX is involved in histone H3 deposition.

141 tations affecting crucial lysine residues in histone H3 genes significantly contribute to a variety o

142 replication in S phase, and dimethylation of histone H3 in mitosis/cytokinesis.

143 Furthermore, lysine 9 on histone H3 is necessary for maximal pol II pause release

144 ), previously characterized as a euchromatic histone H3 K36 demethylase and transcriptional regulator

145 activates BRD4 acetyltransferase activity on histone H3 Lys (K) 122, demonstrating that RSV infection

146 red gene expression and aberrant patterns of histone H3 Lys27 acetylation at enhancers and promoters,

147 atic environments, and promote deposition of histone H3 Lys9 trimethylation (H3K9me3) for transcripti

148 evels of histone acetylation; in particular, histone H3 lysine 23 acetylation was lower in HFD-fed mi

149 x 2 (PRC2) is responsible for methylation of histone H3 lysine 27 (H3K27), and trimethylated H3K27 (H

150 of PRC2, the latter leading to deposition of histone H3 lysine 27 methylation chromosome-wide.

151 rved aberrant upregulation of Skp2, Ezh2 and histone H3 lysine 27 trimethylation (H3K27me3) in both P

152 nsporters, derepression of genes marked with histone H3 lysine 27 trimethylation (H3K27me3), and inhi

153 Histone H3 lysine 36 methylation (H3K36me) is critical f

154 The balance of methylation levels at histone H3 lysine 4 (H3K4) is regulated by KDM1A (LSD1).

155 s associated with EPO signaling, we compared histone H3 lysine 4 dimethylation (H3K4me2) in EPO treat

156 es to complementary nascent RNAs to initiate histone H3 lysine 9 di- and trimethylation (H3K9me2 and

157 h co-occurred with epigenetic alterations in histone H3 N-terminal lysine 4 trimethylation (H3K4me3)

158 A heterozygous point mutation of histone H3 occurs in more than 80% of these tumors and r

159 M1 and confirmed BD2-mediated association to histone H3 peptides acetylated at lysine 14 (H3K14Ac), v

160 ep in this process is the recognition of the histone H3 variant CENP-A in the centromeric nucleosome

161 fied epigenetically by a centromere-specific histone H3 variant, CENP-A.

162 Centromere protein (CENP) A, a histone H3 variant, is a key epigenetic determinant of c

163 led selectively in ubiquitin and synthesized histone H3 with succinylation at its K4 position (H3K4su

164 The ACCT group had more phospho-histone H3+ (a marker of mitosis) cardiomyocytes (p = 0.

165 e lymphoid enhancer-binding factor 1 (Lef1), histone H3, and Brahma-related gene-1 proteins.

166 models, we now identify sites of CENP-A and histone H3.1 binding within the megabase, alpha-satellit

167 Their combination with mutants of the histone H3.3 chaperone HIRA (Histone Regulator A) result

168 We find that histone H3.3 stabilizes DAXX protein levels and can affe

169 -1) is the histone chaperone responsible for histone (H3-H4)2 deposition following DNA synthesis.

170 Mechanistically, DEX-bound GR recruits histone H3K27 acetyltransferase CBP to promote activatio

171 n together, our study identifies YEATS2 as a histone H3K27ac reader that regulates a transcriptional

172 Trimethylation of histone H3K36 is a chromatin mark associated with active

173 d factor, BRWD2/PHIP, which colocalizes with histone H3K4 methylation genome-wide in human cells, mou

174 , the spread of repressive epigenetic marks (histone H3K9me2) to nearby DNA occurs at >50% of euchrom

175 ot attributable to differences in repressive histone H3K9me3 or H3K27me3 levels.

176 PRMT5 methylation of histone H3R2me1 induced transcriptional activation by re

177 Tudor domain with dimethylated lysine 20 of histone H4 (H4K20me2).

178 The results demonstrate that histone H4 acetylation is absolutely dependent on CA-ind

179 so known as MOF) mediates the acetylation of histone H4 at lysine 16 (H4K16ac) and is crucial for mur

180 g kinase IKKbeta cooperatively downregulated histone H4 expression, which increased cisplatin-induced

181 pha-terminal acetylation (Nt-acetylation) of histone H4 known to be involved in cell growth.

182 hila, regulates gene activity by acetylating histone H4 preferentially at lysine 16.

183 issues further corroborate the importance of histone H4K16 acetylation in CRC.

184 regulates PPARgamma gene expression through histone H4R3me2a methylation at the PPARgamma promoter.

185 Post-translational modifications of histones have been shown to regulate cellular energy met

186 as a paradigm to explore the role of linker histones in bio-signaling processes.

187 port the pathogenic effects of extracellular histones in that pulmonary injury during influenza was e

188 ases (HDACs) not only induced acetylation of histones in the respective promoter regions but also re-

189 Vertebrates have multiple H2A variant histones, including H2AZ and H2AX that are present in mo

190 diated by post-translational modification of histone is extensively studied in carcinogenesis and can

191 Arginine methylation on histones is a central player in epigenetics and in gene

192 Since modulation of histones is important at many steps in spermatogenesis,

193 presenting the chromatin architecture at the histone locus body.

194 Histone Lys-to-Met (K-to-M) mutations act as gain-of-fun

195 these results emphasize the significance of histone lysine methylation in normal human development a

196 Histone lysine methylation, mediated by mixed-lineage le

197 Histone lysine methyltransferases (KMTs) represent an im

198 They show that the histone mark H3K27ac and pluripotency transcription fact

199 ide modification of sites bearing the active histone mark H3K4me2 in primary human colorectal cancers

200 med genome-wide analysis of DNA methylation, histone marking (acetylated lysine 9 in histone H3 and t

201 minated, but neither compartment domains nor histone marks are affected.

202 ges to gene expression, DNA methylation, and histone marks but these investigations have only been ca

203 ion factors, enhancer regions, and different histone marks were enriched in the T2D-associated DMRs.

204 iling of scarcely investigated low-abundance histone marks, revealing that concentrations of acyl-CoA

205 Yuan et al. found that mutation of the histone methyl transferase SEDT2 affects alternative spl

206 nd can be combined with inhibitors targeting histone methylation for synergistic effects while still

207 and testis, with a corresponding increase in histone methylation in these tissues.

208 ChIPseq analysis for FOXF1 and histone methylation marks identified DNA regulatory regi

209 in developing lead compounds specific to key histone methylation-modifying enzymes have revealed new

210 d by widespread redistribution of repressive histone methylation.

211 cting the molecular regulation and targeting histone methylome in AML together with the success in de

212 at exhibited Ras-mediated dependence on PRC2 histone methyltransferase activity, a finding that is si

213 We also identify the Rere-binding histone methyltransferase Ehmt2/G9a, as a RA coactivator

214 Herein, we show that the histone methyltransferase Ezh2 controls CD8(+) T memory

215 tylase inhibitors to increase euchromatin or histone methyltransferase inhibitors to decrease heteroc

216 The EZH2 histone methyltransferase is required for B cells to for

217 y essential genes in ES cells, including the histone methyltransferase Setdb1.

218 unction mutations to inhibit a wide range of histone methyltransferases and are thought to promote tu

219 ing epigenetic landscapes in organisms where histone methyltransferases are uncharacterized.

220 of proteins associated with Set1) family of histone methyltransferases is known to activate transcri

221 Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from

222 se findings reveal an important mechanism of histone modification and demonstrate that local generati

223 impairs the acquisition of such differential histone modification and expression patterns at MAC-/OC-

224 e2s following excision of Cdc73 placing this histone modification downstream of the PAFc and revealin

225 protein MeCP2 and with the active chromatin histone modification H3K4me2 in mouse neurons.

226 eq gene transcripton and up to four ChIP-seq histone modification measurements.

227 n of DNA methylation triggers changes in the histone modification profile and chromatin-remodeling ev

228 Thus, chromatin histone modification state is a major determinant of nuc

229 in sex-specific chromatin accessibility and histone modifications accompanied these cGH-induced sex-

230 mice exhibited more transcriptionally active histone modifications at M2 gene promoters than did macr

231 on the identification of DNA methylation and histone modifications at specific genes.

232 the memory T cells are marked by activating histone modifications even in the resting state.

233 the potential impact of that small RNAs and histone modifications have in regulation of NAT expressi

234 analysis were used to measure the levels of histone modifications in human bronchial epithelial BEAS

235 Many ASHCEs show differential histone modifications that may participate in regulation

236 suggest a novel candidate mechanism linking histone modifications to hESC fate decision.

237 tion of ZIC2 shifted the balance of bivalent histone modifications toward more active forms and induc

238 interaction enrichment, enhancer-associated histone modifications were evident, and known functional

239 igated the relationship among ERK signaling, histone modifications, and transcription factor activity

240 K4me3 (activating) and H3K27me3 (repressive) histone modifications, are a key property of pluripotent

241 Alongside DNA methylation and histone modifications, bromodomain and extra-terminal re

242 nomic locations of active enhancers based on histone modifications, but the accuracy and resolution o

243 s, typical enhancer-associated proteins, and histone modifications, we determine that both enhancer c

244 promoter-related marks, and enhancer-related histone modifications.

245 Histone modifiers regulate proper cellular activities in

246 mb repressive complexes (PRCs) are important histone modifiers, which silence gene expression; yet, t

247 we showed that during mouse development, the histone-modifying enzyme histone deacetylase 3 (Hdac3) r

248 s those encoding ribosomal proteins, DNA and histone-modifying enzymes and proteins involved in post-

249 ever, the cellular and molecular etiology of histone-modifying enzymes in craniofacial disorders is u

250 , including other AP2 transcription factors, histone-modifying enzymes, and regulators of nucleosome

251 In metazoans, histone mRNAs are not polyadenylated but end in a conser

252 Histone mRNAs are rapidly degraded when DNA replication

253 Expression of this histone mutant is accompanied by a reduction in the leve

254 Second, histone nanodomain clusters decompact into mononucleosom

255 ion is typically ascribed to roles in either histone nuclear import or deposition.

256 e of unwrapping the nucleosomal DNA from the histone octamer (HO).

257 despite the steric constraints placed by the histone octamer remains unknown.

258 The CBS interacts with the histone octamer, engaging the H2A-H2B acidic patch in a

259 in the cell cycle to determine the levels of histones or histone PTMs in each stage of the cell cycle

260 DNAs in the presence of H3K36me3-containing histone peptides.

261 Histone phosphorylation by M6CK results in a dramatic de

262 M6CK histone phosphorylation, in turn, regulates transcriptio

263 he decades-old observation of mitotic linker histone phosphorylation, serving as a paradigm to explor

264 sed methods for quantifying the abundance of histone post-translational modifications.

265 On a genome-wide scale, some of the histone posttranslational modification landscapes show s

266 association between alternative splicing and histone posttranslational modifications in the nucleus a

267 istant to MjAgo degradation, and recombinant histones protect DNA from cleavage in vitro.

268 However, non-histone protein lysine 2-hydroxyisobutyrylation remains

269 optosis by demethylating histone and the non-histone protein p53, respectively.

270 Lysine acetylation of histone proteins is a fundamental post-translational mod

271 Post-translational modifications of histone proteins regulate numerous cellular processes.

272 We conclude that unlike DNA or individual histone proteins, human intact NETs do not directly init

273 are responsible for binding the highly basic histone proteins, shielding them from non-specific inter

274 eomics can define significant differences in histone PTM patterns in submillimetric layers of three-d

275 nitoring drug localization and regulation of histone PTMs after drug treatment.

276 46 individual histone PTMs and 30 co-existing PTMs were fully quantifi

277 Euchromatic histone PTMs are abundant during schizogony and late gam

278 cycle to determine the levels of histones or histone PTMs in each stage of the cell cycle.

279 mutants of the histone H3.3 chaperone HIRA (Histone Regulator A) results in impaired plant survival,

280 A framework for histone release and function in host defense in vivo was

281 Histones released during influenza induced cytotoxicity

282 ectively, and measurement of the fraction of histones remaining chromatin-bound in the individual nuc

283 irulence factor, was required for high-level histone resistance.

284 ne expression in developing male gametes and histone retention in mature spermatozoa, potentially pri

285 Incorporation of variant histone sequences, in addition to post-translational mod

286 dition to post-translational modification of histones, serves to modulate the chromatin environment.

287 However, the full spectrum of non-histone substrates of PRC2 that might also contribute to

288 sferase activity of KAT2A is instrumental in histone succinylation, tumour cell proliferation, and tu

289 r, HMGNs affect the interactions of the core histone tail domains with nucleosomal DNA, redirecting t

290 t two tyrosines (Y24 and Y48) bind to a Kme3-histone tail peptide via cation-pi interactions, but lin

291 e extensively and significantly enriched for histone-tail modifications and transcription factor bind

292 omains bind to acetylated lysine residues on histone tails and thereby facilitate the reading of the

293 remove acetyl groups from lysine residues on histone tails, promoting transcriptional repression via

294 e canonical histones, there are also variant histones that often have pivotal roles in regulating chr

295 In addition to the canonical histones, there are also variant histones that often hav

296 romatin-bound in the individual nuclei using histone type- or posttranslational modification- (PTM-)

297 We show that PALB2 indirectly recognizes histone ubiquitylation by physically associating with ub

298 ple and powerful method involving elution of histones using intercalators or salt, to assess stabilit

299 vision, with intriguing mechanistic links to histone variants and DNA replication.

300 he lung, whereas the GPVI ligands fibrin and histone were induced during pneumonia.