ライフサイエンスコーパス: histone acetylase

1 eraction between p300/CBP and its associated histone acetylase.

2 r element may harbor a high concentration of histone acetylases.

3 Here, we present evidence for novel roles of histone acetylases.

4 GCN5, and p300/CREB binding protein and that histone acetylase activities are accumulated on the IRF-

5 RbAp48 lowered the K(m) of CBP histone acetylase activity and facilitated p300-mediated

6 DNA topology, and that both SWI/SNF and p300 histone acetylase activity are required for hormone-depe

7 P kinase signaling to Elk-1 enhances the net histone acetylase activity associated with the c-fos pro

8 Antibodies to AMF-1 or E2 immunoprecipitated histone acetylase activity from cell lysates.

9 P-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that comp

10 se that a decline in coactivators containing histone acetylase activity in myometrium may contribute

11 facilitates the recruitment of p300 and its histone acetylase activity into complexes with E2 and re

12 Besides histone acetylase activity on chromatin, the TIP60 compl

13 Ectopic expression of mutated TIP60 lacking histone acetylase activity results in cells with defecti

14 y EID-1's ability to bind and inhibit p300's histone acetylase activity, an essential MyoD coactivato

15 anscriptional coactivators possess intrinsic histone acetylase activity, providing a direct link betw

16 , a component of a multiprotein complex with histone acetylase activity, scored as a significant SB h

17 ntly described c-Myc cofactor TRRAP recruits histone acetylase activity, which is catalyzed by the hu

18 ng histone deacetylases with those that have histone acetylase activity.

19 adaptor complex has been discovered to house histone acetylase activity.

20 inin is likely to involve inhibition of HBO1 histone acetylase activity.

21 a transcriptional coactivator with intrinsic histone acetylase activity.

22 transcription factors through its intrinsic histone acetylase activity.

23 domain, thereby reducing recruitment of the histone acetylase and coactivator CBP/p300 to STAT1; 2)

24 Importantly, manipulating histone acetylase and deacetylase activities established

25 Eaf3, a component of the NuA4 histone acetylase and Rpd3 histone deacetylase complexes

26 The loss of Eaf3, a subunit of the NuA4 histone acetylase and Rpd3 histone deacetylase complexes

27 interacts with CREB-binding protein (CBP), a histone acetylase and transcriptional coactivator.

28 TRRAP links Myc with histone acetylases and appears to be an important mediat

29 machinery bound to tRNA genes function with histone acetylases and chromatin remodelers to restrict

30 e III or polymerase II but requires specific histone acetylases and chromatin remodelers.

31 Modification of chromatin structure by histone acetylases and deacetylases is an important mech

32 NA-binding activators and repressors recruit histone acetylases and deacetylases to promoters, thereb

33 ic process involving chromatin remodeling by histone acetylases and deacetylases, yet the role of thi

34 from a dynamic equilibrium between competing histone acetylases and deacetylases.

35 This mechanism is regulated by histone acetylases and deacetylases.

36 chromatin modification activities, including histone acetylases and enhancer- and insulator-associate

37 shown that Myc can interact indirectly with histone acetylases and have suggested that Myc mediates

38 iption by coordinating the functions of both histone acetylases and HDACs.

39 veral recent studies demonstrated the effect histone acetylases and histone deacetylases (HDACs) have

40 amic interaction of two families of enzymes: histone acetylases and histone deacetylases (HDACs).

41 It is well known that histone acetylases are important chromatin modifiers and

42 g factors and cofactors, including the TIP60 histone acetylase-associated proteins transactivation/tr

43 specific keratin RE (KRE), co-activators and histone acetylase become co-repressors of the RA/T3 rece

44 ybrid protein screen by interaction with the histone acetylase CBP.

45 activation domain-induced recruitment of the histone acetylase CBP/p300.

46 or studies have shown that Sp1, Sp3, and the histone acetylase co-activator p300 are components of th

47 r gene expression via the recruitment of the histone acetylase coactivator paralogs CREB binding prot

48 The Esa1-containing NuA4 histone acetylase complex can interact with activation d

49 lase complex, whereas liganded TR recruits a histone acetylase complex for gene activation.

50 A-binding protein (TBP), TFIIB, and the SAGA histone acetylase complex in vivo.

51 both the transcription factor TFIID and the histone acetylase complex PCAF/SAGA.

52 of TAF17, which is also present in the SAGA histone acetylase complex, causes a decrease in transcri

53 nucleosome-remodeling complex, and the SAGA histone acetylase complex.

54 lymerase II holoenzyme/mediator and the SAGA histone acetylase complex.

55 e Swi-Snf chromatin remodeling complex, Gcn5 histone acetylase complexes Ada and SAGA, and Rad6, whic

56 Most importantly, we show that the histone acetylase components of TFIID and SAGA (TAF(II)1

57 e p300/cAMP-response element-binding protein histone acetylase domain reduced ligand-dependent AR fun

58 mbryos without either the MSL complex or MOF histone acetylase, dosage compensation is retained but a

59 -C also promoted the recruitment of the p300 histone acetylase (EP300) and, in turn, induced histone

60 A role for histone acetylase has been implicated in leukemias and d

61 diabetic patients (D-CMSC), identifying the histone acetylase (HAT) activator pentadecylidenemalonat

62 Esa1 is the catalytic subunit of the NuA4 histone acetylase (HAT) complex that acetylates histone

63 e gene expression via their association with histone acetylase (HAT) or deacetylase complexes.

64 Histone deacetylase (HDAC), histone acetylase (HAT), and intracellular cAMP levels w

65 ctivity is required for licensing, because a histone acetylase (HAT)-defective mutant of HBO1 bound a

66 ee of CIITA ubiquitination was controlled by histone acetylases (HATs) and deacetylases (HDACs), indi

67 Having opposing enzymatic activities, histone acetylases (HATs) and deacetylases affect chroma

68 of the SPT10 gene, which encodes a putative histone acetylase implicated in regulation at core promo

69 other coregulators, such as ARA24 or PCAF, a histone acetylase, in an additive manner.

70 ylation and the mof gene product, a putative histone acetylase, in msl mutant males returns to a unif

71 transcription of DNA methyltransferases and histone acetylases including p300, contributing to regul

72 which cannot interact with Sirt1, or p300, a histone acetylase, increased acetylation of FoxO1 and in

73 Histone acetylase inhibition in the hippocampus during c

74 uch stronger than the synergistic effects of histone acetylase inhibitors or additive effects of doxo

75 w that MBF1 and the related Chameau and HBO1 histone acetylases interact with distinct subgroups of b

76 HBO1 histone acetylase is a coactivator both for AP-1 transcr

77 PCAF histone acetylase is found in a complex with more than 2

78 HBO1 histone acetylase is important for DNA replication licen

79 HBO1, an H4-specific histone acetylase, is a coactivator of the DNA replicati

80 fluence of E1A, an inhibitor of the CBP/p300 histone acetylase, on LCR function.

81 Strains lacking Sas2 histone acetylase or the histone methylases that modify

82 histone acetylation, and had identified the histone acetylase P/CAF and the transcription factor NF-

83 gers a cascade involving HSF1 binding to the histone acetylase p300 and positive translation elongati

84 reactive oxygen through its interaction with histone acetylase p300 and the hypoxia-inducible factor

85 XO3 bound to the Trx promoter, recruited the histone acetylase p300 to the Trx promoter, and formed a

86 d insulin gene expression, interact with the histone acetylase p300, suggesting a role for histone ac

87 The histone acetylases p300 and P/CAF directly acetylate the

88 nsferase (garcinol and antisense against the histone acetylase, p300) or activators of histone deacet

89 locked the orchiectomy-induced expression of histone acetylases, p300 and CBP, which are AR cofactors

90 , thereby enhancing its association with the histone acetylase paralogs p300 and CBP (CBP/p300).

91 Whereas the histone acetylase PCAF has been suggested to be part of

92 RFs bound to the ISRE are complexed with the histone acetylases, PCAF, GCN5, and p300/CREB binding pr

93 Coinciding with the induction of histone acetylases, phorbol ester markedly enhanced IFN-

94 PCAF histone acetylase plays a role in regulation of transcri

95 action between the RXR/RAR heterodimer and a histone acetylase presented elsewhere.

96 The TIP60 histone acetylase purifies as a multimeric protein compl

97 Remodeling ATPases or histone acetylases release some of the negative supercoi

98 with the chromatin remodeller, Rsc, and the histone acetylase, Rtt109, to generate a histone-deplete

99 The histone acetylases, SAS-I and NuA4, functioned in insula

100 er TAF48p nor TAF65p are associated with the histone acetylase Spt-Ada-Gcn5 complex or other non-TFII

101 tional activator AceI, and also requires the histone acetylase Spt10 for full induction.

102 ing the access or function of an H4-specific histone acetylase such as Esa1.

103 unction, in part, due to an interaction with histone acetylases, such as CREB-binding protein (CBP).

104 These results indicate that the histone acetylase TIP60-containing complex plays a role

105 laces this histone deacetylase or recruits a histone acetylase to allow the formation of a functional

106 genes coincides with recruitment of the Esa1 histone acetylase to RP gene promoters.

107 omplex specific to males, which sequesters a histone acetylase to the X.

108 s, possibly by preventing the recruitment of histone acetylases to the promoter.

109 Their association with histone acetylases, to mediate activation, or deacetylas

110 ies showed that expression of PCAF and other histone acetylases was markedly induced in U937 cells up

111 monoclonal antibodies raised against p300, a histone acetylase, well-known as a marker of active enha

112 Histone acetylases were originally identified because of

113 n is associated commonly with recruitment of histone acetylases, while repression involves histone de