ライフサイエンスコーパス: histone acetylation

1 ion in cells by Western blotting (tubulin vs histone acetylation).

2 combination; and (iii) a general increase in histone acetylation.

3 ted histones stimulate transcription through histone acetylation.

4 ch precludes recruitment of CBP and prevents histone acetylation.

5 is disrupted by histone H3K4 methylation and histone acetylation.

6 etabolites, resulting in re-establishment of histone acetylation.

7 r development and cell viability but not for histone acetylation.

8 logical disorders, and one such mechanism is histone acetylation.

9 lates transcription to a greater degree than histone acetylation.

10 s, however, it is unknown whether NO affects histone acetylation.

11 n quantified the effects of METH exposure on histone acetylation.

12 where it induces nucleosome displacement and histone acetylation.

13 he function of HDAC-complex-mediated dynamic histone acetylation.

14 function and its role in gene regulation by histone acetylation.

15 ne deacetylase to erase prior c-Myc-promoted histone acetylation.

16 which the PKCdelta gene can be regulated by histone acetylation.

17 proposed to directly alter the epigenome via histone acetylation.

18 ing genes that display putative NO-regulated histone acetylation.

19 (KDACs) in regulating transcription through histone acetylation.

20 e that PAF up-regulates CXCR4 expression via histone acetylation.

21 cancer cell nuclei where it plays a role in histone acetylation.

22 anscriptional activator, p65, which promotes histone acetylation.

23 s mutagenic process can be regulated through histone acetylation.

24 duction and this was accompanied by enhanced histone acetylation.

25 l mechanism of transcriptional regulation is histone acetylation.

26 ulated neuronal genes near sites of elevated histone acetylation.

27 l memory, a cognitive process that relies on histone acetylation.

28 RNAs (eRNAs) and display CBP/p300-dependent histone acetylation.

29 ) indicating it is not a global activator of histone acetylation.

30 actin increased HDAC activity and decreased histone acetylation.

31 one deacetylases (HDACs), enhancing specific histone acetylations.

32 nsive promoter), S15A-p53 does not stimulate histone acetylation (a measure of chromatin relaxation),

33 on, replication, and repair are regulated by histone acetylation, a process that requires the generat

34 Starting with early work on histone acetylation, a variety of residue-specific modif

35 PARalpha, increased Ifng gene expression and histone acetylation across the Ifng locus.

36 To investigate how histone acetylation affects skin morphogenesis and homeo

37 one deacetylases (HDACs) compete to modulate histone acetylation, allowing for rapid changes in acety

38 by Wnt3a corresponds to a global decrease in histone acetylation, an epigenetic modification that is

39 nf retention by activators or high levels of histone acetylation and (2) Snf2 acetylation-mediated re

40 The presence of histone acetylation and activator-dependent recruitment

41 OFD Type I cells exhibit reduced histone acetylation and altered chromatin dynamics in re

42 Finally, eIF6 levels modulate histone acetylation and amounts of rate-limiting fatty a

43 acetyltransferase, a domain-wide increase in histone acetylation and assembly of RNA Polymerase II in

44 tivity through locus-specific alterations of histone acetylation and associated gene expression.

45 ne promoters systematically harbor competing histone acetylation and butyrylation marks at H4 K5 and

46 eals a previously unknown connection between histone acetylation and cell-type-specific gene regulati

47 Changes in histone acetylation and class IIa histone deacetylases e

48 ssible (Gcn) 5, which we hypothesize lead to histone acetylation and consequent transcription activat

49 om abnormal epigenetic alterations including histone acetylation and deacetylation has been demonstra

50 servations also point to a critical role for histone acetylation and deacetylation in the response of

51 SKI controls histone acetylation and deacetylation of the Rorc locus

52 ense mutations in genes that are involved in histone acetylation and deacetylation result in multiple

53 genetic regulatory machinery, SCFAs increase histone acetylation and decrease repressive histone trim

54 Amyloid pathology impaired histone acetylation and decreased expression of plastici

55 s in a Sox2-dependent manner and coordinates histone acetylation and DNA demethylation at SEs.

56 module and established a direct link between histone acetylation and DOT1L-mediated H3K79 methylation

57 rexpression of which results in elevation of histone acetylation and enhanced ethylene-inducible gene

58 or nuclear acetyl-CoA synthesis required for histone acetylation and epigenetic regulation.

59 in landscape of esa1 cells, finding impaired histone acetylation and eviction.

60 chnique, we elucidated the temporal order of histone acetylation and gene activation, as well as the

61 sa) cells to characterize the alterations in histone acetylation and gene expression as well as the i

62 a crucial chromatin regulator that controls histone acetylation and gene expression during neural de

63 the hippocampus, inhibits HDACs and enhances histone acetylation and gene expression programs associa

64 glucose and acetate uptake is important for histone acetylation and gene expression.

65 acetyl coenzyme A (acetyl-CoA) is linked to histone acetylation and gene regulation, but the precise

66 This effect was accompanied by inappropriate histone acetylation and genome-wide mis-regulation of ge

67 Peripheral blood histone acetylation and HDAC2 gene expression were assoc

68 igenetic mechanisms such as DNA methylation, histone acetylation and histone phosphorylation.

69 ashion, with concomitant global reduction of histone acetylation and increased sensitivity of leukemi

70 g elements in response to TGF-beta, reducing histone acetylation and inhibiting transcription.

71 g appears to correlate with residue-specific histone acetylation and is able to counteract the detrim

72 Both the histone acetylation and ISC division defects could be re

73 ytosolic concentration of acetyl-CoA affects histone acetylation and links metabolism and chromatin s

74 romoter, thereby licensing CBP/p300-mediated histone acetylation and local chromatin opening.

75 their well-characterized effects on nuclear histone acetylation and long-terminal-repeat (LTR) trans

76 Histone acetylation and methylation affect the conformat

77 Targeting histone acetylation and methylation by selected reaction

78 Furthermore, histone acetylation and methylation in human neural stem

79 This long-range repressor mediates histone acetylation and methylation in large blocks, wit

80 that microbial colonization regulates global histone acetylation and methylation in multiple host tis

81 es are accompanied by dynamic alterations to histone acetylation and methylation levels that are larg

82 ens (NAc), and epigenetic mechanisms-such as histone acetylation and methylation on Lys residues-have

83 Histone acetylation and methylation play an important ro

84 strictly ordered epigenetic markers such as histone acetylation and methylation, as well as recruitm

85 Several chromatin modifications, including histone acetylation and methylation, have been implicate

86 data define the molecular connection between histone acetylation and Nr4a gene expression after learn

87 Histone acetylation and nucleosome occupancy assays indi

88 animals to environmental enrichment enhances histone acetylation and reopens juvenile-like plasticity

89 Lack of DD4/5 alters histone acetylation and RNA polymerase II recruitment an

90 DTPs exhibited reduced histone acetylation and sensitivity to HDAC inhibitors (

91 f STAT3 phosphorylation and demonstrate that histone acetylation and STAT3 tyrosine705 phosphorylatio

92 chromatin-associated proteins that regulate histone acetylation and the accessibility of DNA to tran

93 ng adipocyte differentiation is regulated by histone acetylation and the binding protein bromodomain

94 Histone acetylation and the families of enzymes responsi

95 yl-CoA generation 'on-site' at chromatin for histone acetylation and the transcription of key neurona

96 to immune-cell enhancers, many of which gain histone acetylation and transcribe enhancer-associated R

97 ncentrations of acetyl-coenzyme A to enhance histone acetylation and transcription of Ifng Ablation o

98 enhancer elements that demonstrates dynamic histone acetylation and transcription upon TP53 binding.

99 hich is required for GlcNAc-induced promoter histone acetylation and transcription.

100 resumptive neuroectoderm, resulting in their histone acetylation and transcriptional activation.

101 Both histone acetylation and trimethylation of H3K4 (H3K4me3)

102 ll type-specific responses of three selected histone acetylations and two histone methylations on fiv

103 ls increases RNA polymerase II processivity, histone acetylation, and baseline HIV-1 transcription.

104 e, an endogenous HDAC inhibitor, and reduced histone acetylation, and display deficits in spatial mem

105 rhythms of epigenetic modification including histone acetylation, and DNA methylation.

106 ents transcription factor C/EBPbeta binding, histone acetylation, and further H3K4me3 deposition and

107 myelination depends on chromatin remodeling, histone acetylation, and methylation, which all affect S

108 etyltransferases and deacetylases, increased histone acetylation, and polymerase II recruitment to G6

109 to ROREs in their promoter region, increased histone acetylation, and reporter and mutation analysis

110 e in ACSS2 lowers nuclear acetyl-CoA levels, histone acetylation, and responsive expression of the co

111 KG2D ligands include PI-3 kinase activation, histone acetylation, and the integrated stress response.

112 Ethanol markedly changes histone acetylation, and the sirtuin Sir2/SIRT1 that dea

113 Consistent with a role for Ankrd11 in histone acetylation, Ankrd11 was associated with chromat

114 results indicate that DNA demethylation and histone acetylation are coordinated to generate the tran

115 , and histone acetyltransferase activity and histone acetylation are diminished.

116 hylation, few protein modules that recognize histone acetylation are known.

117 Chromatin modifications, especially histone acetylation, are critically involved in gene reg

118 of early and late inflammatory genes rely on histone acetylation associated with recruitment of histo

119 ssion via activating NF-kappaB and modifying histone acetylation associated with the promoter region

120 istic of mature chromatin, and low levels of histone acetylation at a relatively small number of loci

121 ; this is correlated with elevated levels of histone acetylation at a subset of seed-specific loci.

122 ACLY facilitates histone acetylation at double-strand break (DSB) sites,

123 e determined how Geminin deficiency affected histone acetylation at gene promoters during this proces

124 We measured DNA methylation and histone acetylation at genes encoding the glucocorticoid

125 ng (ChIP-seq) revealed genome-wide shifts in histone acetylation at growth and stress genes as cells

126 LCR and E6 MAR sequences, thereby decreasing histone acetylation at H3K9 and H3K18, leading to reorie

127 y binds to the promoter of IL-6 and inhibits histone acetylation at IL-6 promoter region.

128 te that Geminin associates with and promotes histone acetylation at neurodevelopmental genes, while G

129 ith TFIIB but for transit into elongation by histone acetylation at other genes.

130 e acetyltransferases (KATs) catalyze dynamic histone acetylation at regulatory and coding regions of

131 +MS-275 groups were correlated with elevated histone acetylation at the c-fos promoter region in aged

132 data support the notion that the balance of histone acetylation at the Nr4a promoters is critical fo

133 hieve a high expression level through active histone acetylation at the promoter and 5' regions of ta

134 ransferase, p300/CBP, resulting in increased histone acetylation at the promoter of Puma.

135 odifications were associated with changes of histone acetylation at the promoter of these genes and p

136 terations, but no changes in the patterns of histone acetylation at the proximal regulatory regions o

137 cetylases, which corresponded with decreased histone acetylation at the TNF and IL6 promoters.

138 ith histone deacetylase (HDAC) and decreased histone acetylation at the TRPC6 promoter.

139 istone acetyltransferase EP300 and increased histone acetylation at the Trpv1 promoter and expression

140 This recruitment associated with reduced histone acetylation at these sites.

141 ed cancer cells show widespread increases in histone acetylation at transcriptionally enhanced genes,

142 hose regions with significant differences in histone acetylation between tissues.

143 Finally, inhibiting histone acetylation blocked p300 upregulation and suppre

144 ted production of acetyl-CoA, which promotes histone acetylation, BRCA1 recruitment, and subsequent H

145 is increased pS81 enhances p300 recruitment, histone acetylation, BRD4 binding and subsequent further

146 om quiescence involves dramatic increases of histone acetylation but not of histone methylation.

147 of its proposed causes is defective neuronal histone acetylation, but important aspects of this hypot

148 In addition, inhibition of histone acetylation by anacardic acid reduces the UV-B i

149 ween the remodeling activity of SMARCAD1 and histone acetylation by CBP sheds light on the function o

150 ogens, inhibited HDAC activity and increased histone acetylation by inducing endogenous NO production

151 These data suggest that NO affects histone acetylation by targeting and inhibiting HDAC com

152 terfere with a fundamental cellular process, histone acetylation, by targeting an evolutionarily high

153 We performed histone acetylation ChIP-seq on 57 human lymphoblastoid

154 lex with beta-catenin and p300, resulting in histone acetylation, chromatin reorganization, and enhan

155 ryonic stem cells Myst2 is part of H3 and H4 histone acetylation complexes similar to those described

156 nalyses to RNA sequence, DNA methylation and histone acetylation data from the dorsolateral prefronta

157 d to modulate epigenetic mechanisms, such as histone acetylation/deacetylation balance, in part via h

158 B (H2B) ubiquitination/de-ubiquitination and histone acetylation/deacetylation, the repressive histon

159 l and ligand-inducible Ah responsiveness and histone acetylation, demonstrating that acetate was an H

160 odulated by epigenetic mechanisms, including histone-acetylation dependant pathways.

161 umor suppressor protein (pVHL) function, the histone acetylation dependence upon glucose, the epigeno

162 Brd2, Brd3, and Brd4) govern the assembly of histone acetylation-dependent chromatin complexes.

163 use hepatocytes in association with specific histone acetylation, DNA damage, and the activation of n

164 Whether acutely and locally enhancing histone acetylation during early consolidation processes

165 SET, and that it is essential for regulating histone acetylation during gene transcription.

166 estigated a role for metabolic regulation of histone acetylation during the DNA damage response.

167 eraction of recent cognitive experience with histone acetylation dynamics is disrupted in the aged hi

168 XAB2 also promotes histone acetylation events linked to HR proficiency.

169 SRC-1-p300 complex to promote H4K5 and H4K16 histone acetylation, facilitating transcription of CXCR4

170 ZRS, recruits p300, which is associated with histone acetylation (H3K27ac) indicative of an active en

171 This resulted in decreased histone acetylation (H3K9) at cyclin E promoter leading

172 Histone acetylation has a regulatory role in gene expres

173 Neuronal histone acetylation has been linked to memory consolidat

174 Aberrant histone acetylation has been observed in carcinogenesis

175 inked to memory consolidation, and targeting histone acetylation has emerged as a promising therapeut

176 The discovery of acyl marks, besides histone acetylation, has added to the functional diversi

177 involved in activator binding, TBP binding, histone acetylation (HAT) and deubiquitination (DUB).

178 Thus, bromodomain readers of histone acetylation have emerged as attractive targets f

179 Among multiple histone acetylations, histone H3 lysine 27 (H3K27) acety

180 tribution of histone deacetylase 3 modulated histone acetylation in an actomyosin-dependent manner.

181 Since in vivo studies show a role for histone acetylation in cognitive performance and memory

182 ype, while histone methylation in D2-MSNs or histone acetylation in D1-MSNs increases resilience to s

183 We report that Fosb-targeted histone acetylation in D2-MSNs or histone methylation in

184 rowth factors to the nucleus and by altering histone acetylation in host cells.

185 The decreased histone acetylation in kidneys after hemorrhagic shock/r

186 e the significance of nuclear ACSS2-mediated histone acetylation in maintaining cell homeostasis and

187 reatment enhanced DEX-induced GR binding and histone acetylation in monocytes from both patient group

188 he effects of HFD on levels of acyl-CoAs and histone acetylation in mouse white adipose tissue (WAT),

189 -CoA synthetase 2 (ACSS2) directly regulates histone acetylation in neurons and spatial memory in mam

190 ing oligomerization domain protein 1 induced histone acetylation in oral epithelial cells.

191 The role of histone acetylation in plant defense is well established

192 Here we demonstrate a role for histone acetylation in regulating intracellular pH (pH(i

193 How can we regulate histone acetylation in the adult brain in a noninvasive

194 2 activity and Bcl-2 expression, as well as histone acetylation in the DG previously observed follow

195 Induction of histone acetylation in the nucleus accumbens (NAc), a ke

196 d CREB phosphorylation, CBP recruitment, and histone acetylation in these promoters.

197 er, but the impact of diet on acetyl-CoA and histone acetylation in these tissues remains unknown.

198 ltiple HDACs to maintain the proper level of histone acetylation in transcribed coding sequences.

199 at a time after learning marked by promoter histone acetylation in wild-type mice.

200 uch as histone 4 lysine 4 trimethylation and histone acetylation, in RASF.

201 he pancreas, HFD also impacted the levels of histone acetylation; in particular, histone H3 lysine 23

202 Histone acetylation, including acetylated H3K14 (H3K14ac

203 Histone acetylation increases by cycle 12, but it is not

204 ysis of these with the associated changes in histone acetylation induced in the epigenome.

205 HDACs act as coactivators or corepressors in histone acetylation-induced PKCdelta up-regulation.

206 DNA methylation and histone acetylation inhibitors are widely used to study

207 Histone acetylation is a fundamental epigenetic mechanis

208 ociated with histone modification peaks, and histone acetylation is dynamically correlated with light

209 Histone acetylation is generally associated with active

210 In the absence of Setd5, histone acetylation is increased at transcription start

211 The Wnt-induced decrease in histone acetylation is independent of beta-catenin signa

212 enhancers, a more comprehensive analysis of histone acetylation is required than has previously been

213 Early histone acetylation is strongly associated with regions

214 etic dysregulation, including aberrations in histone acetylation, is also associated with AD.

215 owed that histone methylation-in contrast to histone acetylation-is surprisingly static during quiesc

216 Through histone and non-histone acetylation, KAT6A affects multiple cellular pro

217 y, exposure of histones to acrolein prior to histone acetylation leads to the inhibition of remodelin

218 nce that diet can impact tissue acyl-CoA and histone acetylation levels and that acetyl-CoA abundance

219 CoA in the nucleus and cytosol and regulates histone acetylation levels in many cell types.

220 Finally, basal histone acetylation levels in the coding regions of WRKY

221 nd immunoblotting were used to assess global histone acetylation levels, and gene promoter-specific i

222 cessary for increasing CBP/p300 and specific histone acetylation levels, as well as for immortalizing

223 ifferentiation by controlling acetyl-coA and histone acetylation levels, identifying a link between m

224 e deacetylases and quantitatively determines histone acetylation levels, transcriptional activity, an

225 ed adipocytes also suppressed acetyl-CoA and histone acetylation levels.

226 found that these behaviors are regulated by histone acetylation likely catalyzed by the conserved ac

227 tore ADA3-dependent global or locus-specific histone acetylation marks and cell proliferation in Ada3

228 and deacetylase activities established that histone acetylation marks are necessary for both hot spo

229 CAF complex, and enhances PCAF occupancy and histone acetylation marks at E2F1-target promoters.

230 conclude that there are functional roles for histone acetylation marks at mammalian meiotic recombina

231 uitment, accompanied by decreased activating histone acetylation marks at the mTOR and Gnai1 promoter

232 Although over 35 different histone acetylation marks have been described, the overw

233 ne (GSNO) increased the abundance of several histone acetylation marks in Arabidopsis (Arabidopsis th

234 n, hypoxic activation of HIF-1, and specific histone acetylation marks.

235 DAC1 and licensing the removal of activating histone acetylation marks.

236 ving low LINC00152 expression indicated that histone acetylation may be one mechanism underlying LINC

237 , suggesting that constitutive ELP2-mediated histone acetylation may be required for full activation

238 on manifests in RNA-dependent changes in the histone acetylation mediated by CBP, such as H3K27ac, an

239 , but not p35, is selectively upregulated by histone acetylation-mediated transcription, which underl

240 Data is in the form of genome wide maps of histone acetylations, methylations, and histone variant

241 tional modifications, but it is not known if histone acetylation modulates base excision repair of DN

242 acetylase inhibition abrogates the decreased histone acetylation observed upon iron deprivation and r

243 d colocalized with HDAC3, and expression and histone acetylation of Ankrd11 target genes were altered

244 Chronic stress increases DNA methylation and histone acetylation of genes that regulate visceral pain

245 ng of immune cells occurs via alterations in histone acetylation of immune cytokines in vivo and in v

246 as only slightly superior to TSA in inducing histone acetylation of Rta's promoter, but only VPA indu

247 ith KAT2B and other KATs to catalyze dynamic histone acetylation of the MCL1 alternative exon and alt

248 However, BRLF1 preferentially induces H3K9 histone acetylation of unmethylated promoters in vivo.

249 RD4 depletion reduced P-TEFb recruitment and histone acetylation on the transcribed region of the Adi

250 t), we show that the epigenetic activator of histone acetylation, P300, plays a pivotal role in the d

251 le in SMAD2 promoter activation by acting on histone acetylation, p53 recruitment, and acetylation.

252 hat ADA3 is required for establishing global histone acetylation patterns and for normal cell cycle p

253 r of cellular transformation than are global histone acetylation patterns.

254 d by nuclear penetration, DNA modifications, histone acetylation, phosphorylation, methylation, nor b

255 um levels, peripheral blood mononuclear cell histone acetylation, plasma HIV RNA single-copy assays,

256 Epigenetic processes that regulate histone acetylation play an essential role in behavioral

257 Histone acetylation plays a pivotal role in transcriptio

258 Since histone acetylation plays important roles in DNA repair

259 The G-SCI test annotated 8,764 of these as histone acetylation QTLs (haQTLs)-an order of magnitude

260 tylation with genotype, we discovered >2,000 histone acetylation quantitative trait loci (haQTLs) in

261 Together, our data identify ENL as a histone acetylation reader that regulates oncogenic tran

262 robust gene activation, whereas MyoD induces histone acetylation, recruits Pol II, and robustly activ

263 Together, these results indicate that histone acetylation regulates PKCdelta expression to aug

264 sm-associated changes in gene expression and histone acetylation require TRbeta1.

265 ent revealed a critical role for CBP/p300 in histone acetylation required for the transcriptional act

266 neurons of rats reduced DNA methylation and histone acetylation, respectively, and prevented chronic

267 Restoring histone acetylation reverses NL positioning.

268 inflammation, suggested a putative role for histone acetylation signaling in the altered hypertrophy

269 , a figure comparable to the known number of histone acetylation sites.

270 emonstrate that label-free quantification of histone acetylation-specific mass shifts by matrix-assis

271 ual cortex, linking this effect to increased histone acetylation, specifically at the BDNF gene level

272 Loss of Charlatan also led to a much reduced histone acetylation staining in precursor cells.

273 Histone acetylation such as H3K27ac is an excellent mark

274 ed, in part, by S-nitrosylation of HDAC2 and histone acetylation, such plasticity is absent for remot

275 nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitoch

276 he crosstalk between ERalpha methylation and histone acetylation that governs the epigenetic regulati

277 f these nucleosomes in a mechanism involving histone acetylation that is poorly understood.

278 s the thermal induction of POR genes through histone acetylation that promotes the accessibility of R

279 gh expression of Myc and patterns of altered histone acetylation that were localized to intragenic re

280 The corepressor SIN3 controls histone acetylation through association with the histone

281 Efforts to manipulate locus-specific histone acetylation to assess their causal role in gene

282 re ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-C

283 to the MSMP enhancer region was decreased by histone acetylation under hypoxic conditions in cancer c

284 I and an induction of euchromatic H3 and H4 histone acetylations upon nicotinamide treatment.

285 Increasing histone acetylation via administration of histone deacet

286 MYST3 is involved in histone acetylation via its histone acetyltransferase do

287 AP1 may potentially mediate ethylene-induced histone acetylation via its interactions with EIN2 C ter

288 the interaction between the YEATS domain and histone acetylation via structure-based mutagenesis redu

289 However, in IR64, histone acetylation was observed only during salt stress

290 To understand the role played by the histone acetylation, we also treated our animals with an

291 ngly, despite a lack of detectable effect on histone acetylation, we show that ACY-738 and ACY-775 sh

292 Changes in histone acetylation were blunted.

293 In the liver, no significant effects on histone acetylation were observed with a HFD despite low

294 These compounds increase histone acetylation, which correlates with the synergist

295 ses the SNIP1's inhibition of p300-dependent histone acetylation, which in turn enables the BCAR4-rec

296 Histone acetylation, which is an important mechanism to

297 (IECs) after allo-BMT resulted in decreased histone acetylation, which was restored after local admi

298 Pharmacologically, modulating histone acetylation with acetyl-L-carnitine (LAC) or ace

299 By correlating histone acetylation with genotype, we discovered >2,000

300 de but have distinct functions: Myf5 induces histone acetylation without Pol II recruitment or robust