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1 sed and was essentially mediated by the p300-histone acetyltransferase.
2 lation were associated tightly with EP300, a histone acetyltransferase.
3 romoter (-98 to -94) and recruiting the p300 histone acetyltransferase.
4 lase (HDAC) 2, and decreased expression of a histone acetyltransferase.
5 ue 3.4 x 10(-6)) in the intron of CCDC101, a histone acetyltransferase.
6 er protein of H3K36me3, and the KAT5 (TIP60) histone acetyltransferase.
7 obvious similarities between TAF1 and known histone acetyltransferases.
8 , including the transcription factor p53 and histone acetyltransferases.
9 with sequence similarity to the GCN5 family histone acetyltransferases.
10 e Il9 locus through direct interactions with histone acetyltransferases.
11 understanding the structure/function of non-histone acetyltransferases.
12 h can be used to identify substrate sites of histone acetyltransferases.
13 -B is a multisubunit complex composed of the histone acetyltransferase 1 (Hat1) catalytic subunit and
18 1.9-A resolution crystal structure of human histone acetyltransferase 1 in complex with acetyl coenz
21 ; guanylate cyclase 1, soluble, beta 3; MYST histone acetyltransferase 1; protein phosphatase 3 (form
22 tion with its reciprocally imprinted ligand, histone acetyltransferase-1 (HAT1), a gene involved in c
26 In embryonic stem cells (ESCs), the Tip60 histone acetyltransferase activates genes required for p
27 ylase inhibitor to determine the rate due to histone acetyltransferase activity alone and in the abse
28 e histone acetyltransferase enzyme p300, and histone acetyltransferase activity and histone acetylati
29 ranscriptional corepressor with inhibitor of histone acetyltransferase activity and is a potent suppr
30 nd -b and global DNA methylation and reduced histone acetyltransferase activity and TET1, -2, and -3
31 TAF7 acts as a dissociable inhibitor of TAF1 histone acetyltransferase activity and that this event e
32 This caused a significant decrease in Gcn5 histone acetyltransferase activity in vitro and in vivo
34 rsor proliferation was rescued by inhibiting histone acetyltransferase activity or expressing HDAC3.
35 transcriptional coactivator associated with histone acetyltransferase activity that is stabilized by
36 hat a primary function of ATF4 is to recruit histone acetyltransferase activity to a sub-set of AAR t
46 o, alphasyn reduced p300 levels and its HAT (histone acetyltransferase) activity, thereby contributin
47 t that CSRP2BP, a coactivator for CRP2, is a histone acetyltransferase and a driver of smooth muscle
50 firm that nucleosomal H3K4me3 stimulates the histone acetyltransferase and H2Av exchange activities o
51 ensitivity to depletion and/or inhibition of histone acetyltransferases and CDK9 and less sensitivity
52 tion of histones and non-histone proteins by histone acetyltransferases and deacetylases (HDACs) play
53 factor Sp1, with commensurate recruitment of histone acetyltransferases and deacetylases, increased h
54 on residue T34 upregulates the activities of histone acetyltransferases and deacetylases, which then
57 y, we ectopically overexpressed 21 different histone acetyltransferases and found that KAT6A, KAT6B a
58 tion status is modulated antagonistically by histone acetyltransferases and histone deacetylases (HDA
60 ion, is controlled by the opposing action of histone acetyltransferases and histone deacetylases (HDA
61 d because of the limited specificity of most histone acetyltransferases and histone deacetylases.
62 ction of Elk-1 with co-activators, including histone acetyltransferases and the Mediator complex.
63 in the absence of the normally required Gcn5 histone acetyltransferase, and HO expression even in the
64 ow that suppressor of Ty (Spt)10, a putative histone acetyltransferase, and its binding partner Spt21
68 s well as peaks of acetylated H4K16 and KAT8 histone acetyltransferase at the transcription start sit
71 on assays demonstrated SP-1, p300, and PCA/F histone acetyltransferase binding and histone H4 hyperac
74 lation leads to a specific activation of the histone acetyltransferase Brd2, which results in histone
75 TAT1 has an overall fold similar to the Gcn5 histone acetyltransferase but contains a relatively wide
76 hanced on nucleosomes acetylated by the NuA4 histone acetyltransferase, but recognition of nucleosome
78 l activity stimulates binding of IPMK to the histone acetyltransferase CBP and enhances its recruitme
81 (MLL) histone methylases (MLL2 and MLL3) and histone acetyltransferase CBP/P300 bind to the EZH2 prom
83 nt a small-molecule (TTK21) activator of the histone acetyltransferases CBP/p300, which, when conjuga
84 BMAL1, a partner and regulator of circadian histone acetyltransferase CLOCK, that both proteins loca
85 L2 suppressed this process by inhibiting the histone acetyltransferase coactivator p300, preventing t
86 nents of the nuclear Hat1p-containing type B histone acetyltransferase complex (NuB4) and have found
88 this study, we show that the conserved Mst2 histone acetyltransferase complex in fission yeast regul
89 Deletion of components of the yeast NuA4 histone acetyltransferase complex in ncr1Delta strains c
90 ic interactions with mutations affecting the histone acetyltransferase complex NuA4, vps15Delta and v
91 hat Ing4 is a subunit of the HB01-JADE-hEAF6 histone acetyltransferase complex responsible for most n
92 plant homeodomain, thus recruiting the HBO1 histone acetyltransferase complex to target promoters.
93 he NuA4, nucleosome acetyltransferase of H4, histone acetyltransferase complex, (ii) the switching de
97 mplexes, including the Mediator and multiple histone acetyltransferase complexes, among which are the
98 folding protein required for the assembly of histone acetyltransferase complexes, where the gene of M
101 actor 4-like 1 (MORF4L1) is a relatively new histone acetyltransferase component that exists as a hom
103 g protein (p38IP) is a component of the GCN5 histone acetyltransferase-containing coactivator complex
105 ent binding (CREB) interaction domain of the histone acetyltransferase CREB-binding protein (CBP).
106 encodes the transcriptional coactivator and histone acetyltransferase CREB-binding protein (CREBBP,
107 overexpression of HDAC8 or knocking down the histone acetyltransferase CREB-binding protein/p300, kno
108 riched for the activating marker H3K27ac and histone acetyltransferase CREBBP after MED25 overexpress
110 comb histone methyltransferase complex and a histone acetyltransferase-dependent "on state." Regulati
111 3 is involved in histone acetylation via its histone acetyltransferase domain (HAT) and, as a result,
114 and pRb into a ternary complex, bringing the histone acetyltransferase domain of CBP/p300 into proxim
119 Once in the nucleus, sSDC1 binds to the histone acetyltransferase enzyme p300, and histone acety
121 , chronic stress increased expression of the histone acetyltransferase EP300 and increased histone ac
123 acetylases and concurrent recruitment of the histone acetyltransferase EP300 to MEF2 target gene regu
124 somal rearrangements of the ZNF384 gene with histone acetyltransferases EP300 and CREBBP ZNF384-rearr
126 resulted in identification of the essential histone acetyltransferase EsaA, able to complement an es
127 eases Acetyl-CREB-binding protein (CBP/p300) histone acetyltransferase expression in a time and dose-
130 ous studies have shown perturbations in SAGA histone acetyltransferase function and transcriptional a
131 Li et al. now show that Mof, a MYST family histone acetyltransferase, functions as a coactivator of
132 ere significantly inhibited by inhibitors of histone acetyltransferase (garcinol and antisense agains
134 /36/37 residues, which specifically recruits histone acetyltransferase GCN5 for subsequent H3 acetyla
136 tz1 inherently enhances the occupancy of the histone acetyltransferase Gcn5 on chromatin to promote h
138 truncating mutations in the highly conserved histone acetyltransferase gene KAT6B (MYST4/MORF)) in th
139 lators, including histone chaperones and the histone-acetyltransferase general control nonderepressib
141 and positively with DOG1 expression, as were histone acetyltransferase genes, with histone deacetylas
142 The monocytic leukemic zinc finger (MOZ) histone acetyltransferase (HAT) acetylates free histones
144 iptional coactivator p300/CBP possesses both histone acetyltransferase (HAT) activity and scaffolding
146 pplementation; this microRNA alters HDAC and histone acetyltransferase (HAT) activity, which suggests
147 e exhibited increased renal HDAC and reduced histone acetyltransferase (HAT) activity; on the contrar
148 contains two enzymatic modules, which house histone acetyltransferase (HAT) and deubiquitinase (DUB)
152 Previous studies have established that the histone acetyltransferase (HAT) complex Hat1p/Hat2p medi
154 nstrate that the ATAC (Ada two A containing) histone acetyltransferase (HAT) complex serves as a tran
156 udor domain of PHF20, which recruits the MOF histone acetyltransferase (HAT) complex to ERalpha targe
157 n PHD finger 1) is a core subunit of the MOZ histone acetyltransferase (HAT) complex, critical for no
160 ed factor] and MOZ are catalytic subunits of histone acetyltransferase (HAT) complexes essential in h
161 SEs of the multisubunit Mediator and several histone acetyltransferase (HAT) complexes, including Spt
167 te has been shown to inhibit the activity of histone acetyltransferase (HAT) enzymes in vitro, we hyp
168 tein microarray analysis that identified the histone acetyltransferase (HAT) Hbo1 as a novel cyclin E
170 e ability of garcinol, a naturally-occurring histone acetyltransferase (HAT) inhibitor derived from t
173 contains a separable subcomplex known as the histone acetyltransferase (HAT) module that contains the
180 acetylation state of histones, controlled by histone acetyltransferases (HATs) and deacetylases (HDAC
181 n of histones by chromatin-modifying enzymes histone acetyltransferases (HATs) and histone deacetylas
182 ected histone lysine residues is governed by histone acetyltransferases (HATs) and histone deacetylas
183 lts from the balance between the activity of histone acetyltransferases (HATs) and histone deacetylas
184 rsible acetylation of proteins, catalysed by histone acetyltransferases (HATs) and histone deacetylas
188 ether other histone deacetylases (HDACs) and histone acetyltransferases (HATs) are involved in MSH2 d
189 transformation requires interaction with the histone acetyltransferases (HATs) CBP/p300 and now repor
193 sequencing to screen the levels of all known histone acetyltransferases (HATs) in the hippocampal CA1
194 olvement of histone deacetylases (HDACs) and histone acetyltransferases (HATs) in the regulation of a
196 y, EP300, two highly related histone and non-histone acetyltransferases (HATs) that act as transcript
197 ted 300 kDa protein) are two closely related histone acetyltransferases (HATs) that play a key role i
202 erones, nucleosome remodeling complexes, and histone acetyltransferases have been implicated in nucle
205 total HDAC activity but increased the total histone acetyltransferase/HDAC activity ratio in mouse l
206 l HDAC activity, and it diminished the total histone acetyltransferase/HDAC activity ratio in mouse l
208 other anti-silencing factors, including the histone acetyltransferase IDM1 and the alpha-crystallin
209 histone acetylation marks and for different histone acetyltransferases in long-range gene regulation
210 repeat and Jumonji domain-containing 2C, and histone acetyltransferases including CBP and p300 are re
211 CRE-binding protein-binding protein (CBP), a histone acetyltransferase, induced base-line and IL-13-i
212 anscriptional co-repressor with inhibitor of histone acetyltransferase (INHAT) activity and has previ
213 ly, prevention of histone acetylation by the histone acetyltransferase inhibitor curcumin diminished
214 tion, as reducing JunD acetylation using the histone acetyltransferase inhibitor curcumin reverses th
218 by complexes containing opposing lysine and histone acetyltransferase (KAT and HAT) and deacetylase
219 ORC to the origin, suggesting that multiple histone acetyltransferases may be recruited during origi
220 ssesses an activation domain that couples to histone acetyltransferase-mediated pathways, as well as
223 ng proteins important for the recruitment of histone acetyltransferases of the MYST family to chromat
224 ng proteins important for the recruitment of histone acetyltransferases of the MYST family to chromat
226 tion is accomplished by a dominant action of histone acetyltransferases over repressive histone-modif
227 l roles in protein activation, including the histone acetyltransferase p300 acetylated in its activat
228 )/CD28 stimulation by forming a complex with histone acetyltransferase p300 and NF-kappaB transcripti
229 ough certain chromatin features, such as the histone acetyltransferase P300 and the histone modificat
230 f different epigenetic modifiers showed that histone acetyltransferase p300 could enhance both TALE-V
231 own of GATA6 or transcriptional co-activator/histone acetyltransferase p300 decreased AQP5 expression
237 al activators Sp1 and HIF-1 colocalized with histone acetyltransferase p300 on ncx1-Br with a consequ
238 ain interactions, whereas sites bound by the histone acetyltransferase p300 or the transcription fact
239 ated beta-HPV E6 protein suggesting that the histone acetyltransferase p300 plays a role in promoting
241 d-chromatin association, and associates with histone acetyltransferase p300 to enhance Smad transcrip
242 to the VMP1 promoter and complexes with the histone acetyltransferase p300 to regulate promoter acti
243 hosphatase 6, the sumoylation machinery, the histone acetyltransferase p300, and downstream transcrip
244 tylation upon HDAC inhibition, partly by the histone acetyltransferase p300, and that both NF-kappaB
245 ders Il9 locus accessible via recruitment of histone acetyltransferase p300, and together with inhibi
247 ding histone H3K4 methyltransferase SET1 and histone acetyltransferase p300, whose levels are also el
253 rough systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PC
254 Here, we identify a novel activity of the histone acetyltransferase p300/CREB-binding protein (CBP
258 On the molecular level, hG9a interacted with histone acetyltransferase, p300/CBP, resulting in increa
259 t H3K9 acetylation by the NeuroD1-associated histone acetyltransferase, P300/CBP-associated factor (P
260 II histone deacetylase (HDAC), HDAC4, and a histone acetyltransferase, p300/CREB-binding protein-ass
264 h an E1A mutant that can no longer bind to a histone acetyltransferase (PCAF) is as capable as wild-t
265 II histone deacetylase (HDAC), HDAC4, and a histone acetyltransferase, PCAF, associate with cardiac
266 acterization demonstrated that SMAD2 and the histone acetyltransferase, PCAF, participate in this reg
269 Such an enhanced targeting of NuA4 HAT (histone acetyltransferase) promotes the recruitment of t
270 ponent of the MOF (male absent on the first) histone acetyltransferase protein complex, suggesting it
272 y Naa50p complex with the peptide-bound Gcn5 histone acetyltransferase revealed that the two enzymes
274 from two repairable DSBs also depends on the histone acetyltransferase Rtt109 and the cullin subunit
275 g high-throughput screen (HTS) targeting the histone acetyltransferase Rtt109 were such compounds.
276 genome-wide screen and demonstrated that the histone acetyltransferase SAGA and the activity of histo
277 , namely the chromatin remodeler Swi/Snf and histone acetyltransferases SAGA and NuA4, suggesting tha
278 fferent epigenetic marks and activates three histone acetyltransferases, so it is both a reader and a
279 ltransferase 1 is the founding member of the histone acetyltransferase superfamily and catalyzes lysi
280 nteraction between Arabidopsis MRE11 and the histone acetyltransferase TAF1, a TATA-binding protein A
281 Together, this study identifies the first histone acetyltransferase that activates ERalpha express
282 e ERalpha, suggesting MYST3 functioning as a histone acetyltransferase that activates ERalpha promote
283 Tat-interactive protein 60 (Tip60) is a MYST histone acetyltransferase that catalyses acetylation of
284 is a MOZ, Ybf2/Sas3, Sas2, Tip60 (MYST)-type histone acetyltransferase that functions as a coactivato
285 regulates the availability of acetyl-CoA for histone acetyltransferases, thus representing a link bet
287 normal compaction pathway is defective, the histone acetyltransferase Tip60 is recruited to pericent
288 Foxp3(gfp) was unable to interact with the histone acetyltransferase Tip60, the histone deacetylase
289 cell master regulator Foxp3 mediated by the histone acetyltransferase Tip60, which targeted Foxp3 fo
291 stly, we show that ETS2 cooperates with p300 histone acetyltransferase to remodel chromatin and promo
293 ction in Th9 cells by binding and recruiting histone acetyltransferases to the Il9 locus at sites dis
294 tion of these 2 CpGs impaired binding of the histone acetyltransferase/transcriptional coactivator p3
297 ocytic leukemia zinc finger protein (MOZ), a histone acetyltransferase, we demonstrate that mutation
298 selectively target the catalytic activity of histone acetyltransferases, which may provide effective
299 ne expression and identify KAT8 as the first histone acetyltransferase with an essential function in
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