ライフサイエンスコーパス: histone chaperone

1 leosome assembly in vitro and is therefore a histone chaperone.

2 (Nap proteins) represent a distinct class of histone chaperone.

3 ulated protein APLF as a DNA-damage-specific histone chaperone.

4 f the yeast Anti-silencing function 1 (Asf1) histone chaperone.

5 tein) has been reported to be an H1-specific histone chaperone.

6 ires a complex of two proteins: Rtt109 and a histone chaperone.

7 subunits, Spt16 and Pob3, and functions as a histone chaperone.

8 terodimer of Spt16 and Pob3, is an essential histone chaperone.

9 lso find TONSL-MMS22L to function as a H3-H4 histone chaperone.

10 at1) catalytic subunit and the Hat2 (rbap46) histone chaperone.

11 otetramers is a common feature of NAP-1 fold histone chaperones.

12 ructurally related, evolutionarily conserved histone chaperones.

13 cked histones accompanying a decline in four histone chaperones.

14 d action of ATP-dependent motor proteins and histone chaperones.

15 emonstrate roles in VSG ES silencing for two histone chaperones.

16 P) is a human homolog of the N1/N2 family of histone chaperones.

17 mulate high levels of endogenous histones on histone chaperones.

18 sic factors such as chromatin remodelers and histone chaperones.

19 nal factors such as chromatin remodelers and histone chaperones.

20 ent by H2A-H2B dimers without any additional histone chaperones.

21 ion and has overlapping functions with known histone chaperones.

22 of this region and mediate interactions with histone chaperones.

23 r of the nucleoplasmin superfamily of acidic histone chaperones.

24 tor which is a member of the H3/H4 family of histone chaperones.

25 f proteins, whose members are H3/H4-specific histone chaperones.

26 matin, a poorly understood process, requires histone chaperones.

27 rtant for their assembly into nucleosomes by histone chaperones.

28 cycle regulation defective homolog A (HIRA) histone chaperone accounts for these effects.

29 We further demonstrate that APLF exhibits histone chaperone activities in a manner that is depende

30 e early steps of gene activation through its histone chaperone activities that serve to open the chro

31 found that SART3 has previously unrecognized histone chaperone activities.

32 We also demonstrate that Brd2 has intrinsic histone chaperone activity and is required for transcrip

33 which couples transcription elongation with histone chaperone activity and the regulation of H3 lysi

34 d ES derepression is a direct consequence of histone chaperone activity by FACT at the G2/M cell cycl

35 lecular interactions negatively regulate Npm histone chaperone activity in vitro.

36 modynamic explanation for the specific H3-H4 histone chaperone activity of CAF-1.

37 Nucleolin, a protein with histone chaperone activity, interacts with RAD50 via its

38 ge or transcription events trigger transient histone chaperone activity.

39 osely related ASF1b and does not require its histone chaperone activity.

40 ally binds to the H2A-H2B dimer and exhibits histone chaperone activity.

41 ence the oncogenic effect of SET/TAF-Ibeta's histone chaperone activity.

42 Histone chaperones affect chromatin structure and gene e

43 Via altering DNA accessibility, histone chaperones affect the transcriptional competence

44 Vps75 is also one of two histone chaperones, along with antisilencing factor 1, t

45 In this study, we show the histone chaperone and epigenetic regulator CHAF1A functi

46 Thus, in addition to serving as a histone chaperone and transcription elongation factor, S

47 gs establish a hitherto unknown link between histone chaperones and abiotic stress response in plants

48 tin assembly involves the combined action of histone chaperones and ATP-dependent motor proteins.

49 that alter nucleosome configurations such as histone chaperones and chromatin remodeling complexes.

50 eome, with emphasis on its interactions with histone chaperones and components of the replication for

51 acetylation, chromatin remodelling enzymes, histone chaperones and histone turnover.

52 homology structure is common to these three histone chaperones and reports that Pob3 and Rtt106 doub

53 ignificant discoveries regarding the role of histone chaperones and specifically FACT have come over

54 itment of a cascade of regulators, including histone chaperones and the histone-acetyltransferase gen

55 e discuss our current knowledge of the known histone chaperones and their histone partners, focusing

56 The role of these histone chaperones and Yta7 differed markedly among the

57 es interaction with HJURP (a CENP-A-specific histone chaperone) and abrogates localization of CENP-A

58 ces cerevisiae, Fpr4 has been described as a histone chaperone, and is in addition implicated in epig

59 reaction that has remained elusive for other histone chaperones, and it advances our understanding of

60 d nucleophosmin are previously characterized histone chaperones, and TAP/p32 has no known function in

61 sized H3-H4 is directly transferred from the histone chaperone anti-silencing factor 1 (Asf1) to chro

62 The histone chaperone anti-silencing factor 1a (ASF1a) inter

63 The CBP bromodomain also interacts with the histone chaperone anti-silencing function 1 (ASF1) via a

64 evisiae PHO5 and PHO8 genes, mediated by the histone chaperone anti-silencing function 1 (Asf1), is e

65 Histone chaperone, anti-silencing function-1 A (ASF1A),

66 Histone chaperones are a diverse class of proteins that

67 Histone chaperones are a non-catalytic group of proteins

68 tantly, sequence-based predictions show that histone chaperones are highly enriched in intrinsically

69 Histone chaperones are proteins that interact with histo

70 Histone chaperones are responsible for binding the highl

71 ork sheds further light on the importance of histone chaperones as general regulators of transcriptio

72 Recent works identify histone chaperones as key regulators of damaged chromati

73 Newly synthesized histones H3-H4 first bind histone chaperone Asf1 and are then transferred to other

74 s75-H3-H4 interaction is compatible with the histone chaperone Asf1 and deduce a structural model of

75 cordingly, the association of H3/H4 with the histone chaperone ASF1 and importin 4 is disrupted and t

76 ouble-strand break (DSB) repair requires the histone chaperone Asf1 and that absence of Asf1 causes c

77 The histone chaperone Asf1 and the checkpoint kinase Rad53 a

78 In particular, the histone chaperone Asf1 functions in telomere peripheral

79 with Rtt109 being the catalytic subunit, and histone chaperone Asf1 is required for this modification

80 Indeed, yeast lacking the histone chaperone Asf1 or acetylation of histone H3 on l

81 g a slowly repaired DSB does not require the histone chaperone Asf1 to resume cell cycle progression

82 Here, we show that yeast lacking histone chaperone Asf1 undergo reproducible rDNA repeat

83 es encoding homologs of the highly conserved histone chaperone Asf1, however, little is known of thei

84 acetyltransferase (HAT) that associates with histone chaperones Asf1 and Vps75 to acetylate H3K56, H3

85 During S phase the histone chaperones Asf1, CAF-1, and Rtt106 coordinate to

86 ein-1 (UBN1) and CABIN1, cooperates with the histone chaperone ASF1a to mediate H3.3-specific binding

87 The histone chaperones ASF1A in humans and Asf1 in Drosophil

88 HIRA bound to another histone chaperone, ASF1a, drives formation of SAHF.

89 histone fold domains of H3 and H4 and/or the histone chaperone Asf1b are important for Importin-histo

90 SV DNA replication proteins and the cellular histone chaperone Asf1b, a protein that regulates the pr

91 es this by functionally cooperating with the histone chaperone Asf1p to maintain normal chromatin str

92 on these data, we propose a model for HAT-B/histone chaperone assembly and acetylation of H3-H4 comp

93 Additionally, NAP1 histone chaperones, ATP-dependent chromatin remodeling f

94 Histone chaperones bind specific histones to mediate the

95 or acetylation of H3K56 in vivo, whereas the histone chaperone CAF-1 (chromatin assembly factor 1) in

96 H3.1-H4 molecules are assembled by histone chaperone CAF-1 in a replication-coupled process

97 t the interaction between histone H3-H4 with histone chaperone CAF-1 or Rtt106 increases in cells lac

98 Together, our findings reveal the histone chaperone CAF-1 to be a novel regulator of somat

99 ucleosome assembly shaped by the replication histone chaperone CAF-I.

100 The histone chaperones CAF-1 and Rtt106p are required for he

101 ted Src identified the replication-dependent histone chaperone CAF1 as an important factor for Src-me

102 ing Hat1, Hat2, and a histone H3-H4 specific histone chaperone called Hif1 (NASP).

103 irected recruitment of a generally expressed histone chaperone can lead to tissue-restricted changes

104 Histone chaperones can also participate in the distribut

105 ow that OsNAPL6 is a nuclear-localized H3/H4 histone chaperone capable of assembling a nucleosome-lik

106 It is a histone chaperone capable of reassembling nucleosomes, a

107 embers, the cohesin component Rad21, and the histone chaperone CHAF1A (CAF-1 p150).

108 Histone chaperones (Chaf1a/b), sumoylation factors (Sumo

109 The histone chaperone Chromatin Assembly Factor 1 (CAF-1) de

110 How histone modifications and histone chaperones collaborate to reassemble nucleosomes

111 We describe a histone chaperone complex containing Asf1 and HIRA that

112 The HIRA histone chaperone complex deposits histone H3.3 into nuc

113 roaches revealed that HP1 interacts with the histone chaperone complex FACT (facilitates chromatin tr

114 hey displayed phenotypes similar to those of histone chaperone complex FACT mutants, including an inc

115 of histone methylation was dependent on the histone chaperone complex FACT.

116 vel role for the replication-independent HIR histone chaperone complex in fungal morphogenesis.

117 The ATRX-DAXX histone chaperone complex incorporates the histone varia

118 ACT (facilitates chromatin transcription), a histone chaperone complex predominantly expressed in und

119 omatin assembly factor 1 (CAF1), a conserved histone chaperone complex that deposits H3-H4 during DNA

120 The mammalian HIRA/UBN1/ASF1a complex is a histone chaperone complex that is conserved from yeast (

121 o histone gene regulatory regions by the HIR histone chaperone complex to ensure S-phase-specific exp

122 The HIRA histone chaperone complex, composed of HIRA, ubinuclein-

123 omatin incorporation is mediated by the HUCA histone chaperone complex.

124 ion together as a multiprotein H3.3-specific histone chaperone complex.

125 e facilitates chromatin transcription (FACT) histone chaperone complex.

126 Specific histone chaperone complexes control the correct depositi

127 studies suggested that feedback mediated by histone chaperone complexes plays a pivotal role in regu

128 ndothelial gene regulation and indicate that histone chaperones could be new targets for angiogenesis

129 hromatin transcription), is categorized as a histone chaperone critical for nucleosome reorganization

130 ociated function of PTEN in complex with the histone chaperone DAXX and the histone variant H3.3.

131 Here, we analyze the role of the histone chaperone DAXX in the regulation of H3.3 incorpo

132 mediated ALT suppression is dependent on the histone chaperone DAXX.

133 stering is not disrupted by loss of the HIRA histone chaperone, despite high levels of expression, an

134 erizes the alpha/beta domain is found in all histone chaperones, despite the absence of homology in s

135 emodeling complex, and ASF1, which encodes a histone chaperone, distinct sets of gene promoters carry

136 that shows preference for AT-rich DNA and a histone chaperone domain that promotes specific loading

137 Finally, we discuss the importance of histone chaperones during development and describe how m

138 the FACT chromatin reorganizer, and the Asf1 histone chaperone each required for nucleosome eviction

139 ATPases and histone chaperones facilitate RNA polymerase II (pol II)

140 ied Spt16 and SSRP1, subunits of the H2A-H2B histone chaperone facilitates chromatin transcription (F

141 ubsequent replisome progression requires the histone chaperone FACT (facilitates chromatin transcript

142 The histone chaperone FACT (facilitates chromatin transcript

143 The subunits of the histone chaperone FACT (facilitates chromatin transcript

144 In yeast, the essential histone chaperone FACT (FAcilitates Chromatin Transcript

145 f the tetranucleosomal unit is attenuated by histone chaperone FACT (facilitates chromatin transcript

146 residue is part of the binding site for the histone chaperone FACT (facilitator of chromatin transcr

147 Histone chaperone FACT binds rapidly to the same regions

148 The histone chaperone FACT is an essential and abundant hete

149 We show that the histone chaperone FACT specifically binds UIF, but not R

150 d displayed a synthetic interaction with the histone chaperone FACT.

151 merase II (RNA Pol II) elongation-associated histone chaperones FACT and Spt6 both contribute to rest

152 ome and in H2A/H2B dimers complexed with the histone chaperone, FACT, suggesting that SAGA could targ

153 ciates with RNAPII and collaborates with the histone chaperone, FACT, which facilitates RNAPII elonga

154 e identify and characterize a new NAP family histone chaperone from budding yeast, named Vps75.

155 suggesting that IDRs are often critical for histone chaperone function and play key roles in chromat

156 Histone chaperones function in chromatin assembly and di

157 o neurons can be achieved by knocking down a histone chaperone gene and ectopic expression of a termi

158 p1 is one of the best-studied members of the histone chaperone group.

159 Multiple involved histone chaperones have been identified, but how nucleos

160 In addition, loss of the histone chaperone Hif1p, when combined with an allele of

161 We investigated the role of the histone chaperone HIRA (histone cell cycle regulation-de

162 The histone chaperone HIRA complex, consisting of histone ce

163 Histone chaperone HIRA deposits variant histone H3.3 and

164 The histone chaperone HIRA is involved in depositing histone

165 ong with histone H4, at genic regions by the histone chaperone HIRA, whereas H3.1 is assembled into n

166 Furthermore, the histone chaperones HIRA and NAP-1 (NAP111), which are im

167 Our results for the first time decipher a histone chaperone (HIRA)-dependent molecular mechanism i

168 rowth factor receptor 1) is dependent on the histone chaperone, HIRA (histone cell cycle regulation-d

169 H3.3-dependent interaction of PRC2 with the histone chaperone, Hira, and that Hira localization to c

170 the senescence program is translocation of a histone chaperone, HIRA, into promyelocytic leukemia (PM

171 Formation of SAHF is driven by a complex of histone chaperones, HIRA and ASF1a, and depends upon pri

172 lation suppresses the interaction of H3 with histone chaperones, histone exchange over coding regions

173 Previously, we showed that a complex of histone chaperones, histone repressor A (HIRA) and antis

174 New CENP-A recruitment requires the CENP-A histone chaperone HJURP.

175 s in early G(1) phase by the CENP-A-specific histone chaperone Holliday junction recognition protein

176 e have assessed the global roles of the HIRA histone chaperone in Schizosaccharomyces pombe.

177 om Drosophila melanogaster that can act as a histone chaperone in vitro.

178 ecting chromatin dynamics, the role of plant histone chaperones in abiotic stress response and adapta

179 in H3.3 deposition and emphasize the role of histone chaperones in adjusting genome expression.

180 This review focuses on the roles of the histone chaperones in assembling and disassembling chrom

181 The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, hav

182 ate the molecular roles of the Hif1 and Asf1 histone chaperones in HAT-B histone binding and acetyltr

183 ly, these findings define the involvement of histone chaperones in poly(ADP-ribose)-regulated DNA rep

184 motor proteins, such as ISWI, cooperate with histone chaperones in the assembly and remodeling of chr

185 that much more H4 and H3 were bound to these histone chaperones in the case of the H4 mutants than in

186 To further our understanding of histone chaperones in transcription elongation, we ident

187 y the SWR-C complex, which relies on several histone chaperones including Nap1 and Chz1 to deliver H2

188 Histone chaperones, including the FACT (facilitates chro

189 rom histone proteins and DNA are mediated by histone chaperones, including the histone H3/H4 chaperon

190 Inhibiting topoisomerases or depleting histone chaperones increased unwrapping, whereas inhibit

191 also associated with HIRA, the H3.3-specific histone chaperone, independent of BRD4 and P-TEFb.

192 eased levels of damage and that Asf1 plays a histone chaperone-independent role in facilitating compl

193 hat the Xnp chromatin remodeler and the Hira histone chaperone independently bind nucleosome-depleted

194 Strikingly, NAP1-like histone chaperones interact with CSB and greatly enhance

195 assembly in part through regulating histone-histone chaperone interactions.

196 also show reduced binding of H3 to CAF-1, a histone chaperone involved in RC nucleosome assembly.

197 Spt6 is a multifunctional histone chaperone involved in the maintenance of chromat

198 Nap1 is a histone chaperone involved in the nuclear import of H2A-

199 transcription), an evolutionarily conserved histone chaperone involved in transcription and other DN

200 Recently, histone chaperones, involved in the assembly and disasse

201 Thus, the HIRA histone chaperone is required to maintain the protective

202 The assembly of nucleosomes by histone chaperones is an important component of transcri

203 The nucleoplasmin family of histone chaperones is identified by a pentamer-forming d

204 f H3-H4 from the Asf1-H3-H4 complex to other histone chaperones is regulated by a conserved E3 ligase

205 Histone chaperones, like nucleosome assembly protein 1 (

206 g that the TD/RS interface may operate as a "histone chaperone-like platform."

207 rogramming event requires the removal of the histone chaperone LIN-53 (RbAp46/48 in humans), a compon

208 The tetramerisation of NAP-1 fold histone chaperones may act to shield acidic surfaces in

209 3-H4)2 tetrasome to form the nucleosome by a histone chaperone mechanism.

210 AHF in human cells is driven by a complex of histone chaperones, namely, HIRA and ASF1a.

211 ssembles a nucleosome in the presence of the histone chaperone Nap1 and ATP.

212 ied chromatin assembly system containing the histone chaperone NAP1 and the ATP-dependent motor prote

213 investigated nucleosome assembly mediated by histone chaperone Nap1 and the effects of CpG methylatio

214 DNA binding, and the interaction between the histone chaperone Nap1 and the histone H2A-H2B heterodim

215 that the conserved Saccharomyces cerevisiae histone chaperone Nap1 associates with chromatin.

216 We found that the histone chaperone Nap1 efficiently promotes disassembly

217 evealing an unexpected mechanism used by the histone chaperone Nap1 to prevent aberrant chromatin for

218 SART3, but not the well-characterized histone chaperone Nap1, enhances Usp15 binding to ubH2B

219 ependent nucleosome eviction mediated by the histone chaperone Nap1.

220 ASP-1, a C. elegans homolog of the mammalian histone chaperone NASP, and the histone deacetylase HDA-

221 The ATR checkpoint pathway causes a histone chaperone normally associated with the replicati

222 modeling complex that contains the H1 linker histone chaperone nuclear autoantigenic sperm protein (N

223 position histones H2A/H2A.X-F and H4 and the histone chaperone nucleoplasmin on a conserved motif (GR

224 We found that the cytoplasmic histone chaperone nucleosome assembly protein 1 (Nap1) a

225 The histone chaperone nucleosome assembly protein 1 (NAP1) i

226 emodels structure of chromatin (RSC) and the histone chaperone nucleosome assembly protein 1 (NAP1).

227 tudies reveal the mechanism of action of the histone chaperone nucleosome assembly protein 1 (Nap1).

228 nd approach involved adding an excess of the histone chaperone, nucleosome assembly protein 1 (NAP1)

229 We find that the histone chaperone, nucleosome assembly protein 1 (NAP1),

230 The FACT histone chaperone/nucleosome reorganization factor plays

231 ress-responsive putative rice (Oryza sativa) histone chaperone of the NAP superfamily: OsNAPL6.

232 is homologous to the motif conserved in the histone chaperones of the NAP1L family (NAP1L motif).

233 These results suggest that the histone chaperone OsNAPL6 may serve a regulatory role in

234 The vacuolar protein sorting 75 (Vps75) histone chaperone participates in chromatin assembly and

235 Although most histone chaperones perform these common functions, recen

236 Histone chaperones physically interact with histones to

237 NAP-1 fold histone chaperones play an important role in escorting h

238 including the roles of chromatin remodelers, histone chaperones, post-translational modifications of

239 eacetylation and suggest that HP1-associated histone chaperone promotes nucleosome occupancy to assem

240 Rtt109, in cooperation with various histone chaperones, promotes genomic stability and is re

241 using chicken erythrocyte core histones and histone chaperone protein Nap1 under constant low force.

242 The histone chaperone protein RBBP4, has previously been sho

243 Different histone chaperone proteins mediate the storage and chrom

244 ish a potentially generalizable mechanism of histone chaperone regulation via dynamic and specific in

245 Histone chaperones represent a structurally and function

246 to be a cell-cycle-regulated CENP-A-specific histone chaperone required for centromeric chromatin ass

247 Chromatin assembly factor 1 (CAF-1) is the histone chaperone responsible for histone (H3-H4)2 depos

248 Nucleoplasmin (Npm) is a highly conserved histone chaperone responsible for the maternal storage a

249 recent structural studies of many different histone chaperones reveal that there are few commonaliti

250 The histone chaperone Rtt106 binds histone H3 acetylated at

251 In Saccharomyces cerevisiae, the histone chaperone Rtt106 binds newly synthesized histone

252 In Saccharomyces cerevisiae, the histone chaperone Rtt106 contributes to the deposition o

253 The yeast histone chaperone Rtt106 is involved in de novo assembly

254 the small subunit of FACT and in the related histone chaperone Rtt106, although Spt16-M is distinguis

255 ctions with the genes encoding two different histone chaperones, Rtt106 and CAF-I.

256 specific histone H3 variant is Cse4, and the histone chaperone Scm3 functions as a Cse4-specific nucl

257 ly after completion of repair, suggests that histone chaperones sequester the repair complex for oxid

258 This study reveals that the histone chaperone SET/TAF-Ibeta interacts with cytochrom

259 DAXX is a metazoan histone chaperone specific to the evolutionarily conserv

260 hich resulted from attenuated recruitment of histone chaperone SPT-16 following anthracycline exposur

261 role is carried out in cooperation with the histone chaperone Spt16, and in the absence of H2B ubiqu

262 Here, we report that the histone chaperone Spt6 counteracts H3K27me3, an epigenet

263 histone H3 acetylase complex that harbors a histone chaperone subunit essential for significant acti

264 cetylation can be altered by factors such as histone chaperones, subunit proteins or external stimulu

265 is regulated by numerous factors, including histone chaperones such as nucleosome assembly protein 1

266 Other histone chaperones, such as Vps75, that also bind histon

267 romatin assembly factor 1 (CAF-1) is a H3-H4 histone chaperone that associates with the replisome and

268 Nucleoplasmin is a histone chaperone that consists of a pentameric N-termin

269 protein complex, an evolutionarily conserved histone chaperone that deposits histone H3-H4 proteins o

270 ons to reorganize nucleosomes by acting as a histone chaperone that destabilizes and restores nucleos

271 Vps75 is a histone chaperone that has been historically characteriz

272 cts with Asf1 (anti-silencing function 1), a histone chaperone that has been reported to be involved

273 Here, we report the discovery of Chz1, a histone chaperone that has preference for H2AZ and can a

274 ow focus on the dynamic features of the DAXX histone chaperone that have been elusive from previous s

275 Spt6 is a highly conserved histone chaperone that interacts directly with both RNA

276 Chz1p is a histone chaperone that interacts physically and function

277 chromatin assembly factor 1 (CAF-1), another histone chaperone that is critical for the deposition of

278 during DSB repair was dependent on the HIRA histone chaperone that is specific to the replication-in

279 T (facilitates chromatin transcription) is a histone chaperone that promotes chromatin recovery durin

280 6 is a transcriptional elongation factor and histone chaperone that reassembles transcribed chromatin

281 otein (NAP) family represents a key group of histone chaperones that are essential for cell viability

282 sNASP and ASF1 are conserved histone chaperones that interact with histones H3 and H4

283 he RSC chromatin-remodeling complex, various histone chaperones [the histone regulatory (HIR) complex

284 Drosophila nucleoplasmin-like protein (dNLP) histone chaperone, the imitation switch (ISWI) ATP-drive

285 nsically disordered regions are common among histone chaperones, their roles in histone binding and c

286 tails of virus reprogramming of an antiviral histone chaperone to promote viral latency and cellular

287 Cells use specific mechanisms such as histone chaperones to abrogate the inherent barrier that

288 ne H3, H3K56Ac enhances the ability of these histone chaperones to assemble DNA into nucleosomes.

289 y in vivo requires assembly factors, such as histone chaperones, to bind to histones and mediate thei

290 9 acetyltransferase activity also requires a histone chaperone, vacuolar protein sorting 75 (Vps75),

291 Rtt109 associates with the NAP1 family histone chaperone Vps75 and stimulates histone acetylati

292 The histone chaperone Vps75 forms a complex with, and stimul

293 The histone chaperone Vps75 presents the remarkable property

294 within the PAT domain for the binding of the histone chaperone Vps75, and mutational analysis identif

295 ivity require association with either of two histone chaperones, Vps75 or Asf1.

296 mbly protein 1 and human SET/TAF-1beta/INHAT histone chaperones, Vps75 shows several unique features

297 In addition, nucleolin, a classic histone chaperone, was demonstrated to physically bind t

298 Histone chaperones, which are proteins that escort histo

299 proteins through the level of saturation of histone chaperones with histone.

300 ese same three types of nucleosomes with the histone chaperone yNAP-1, which causes H2A/H2B release f