ライフサイエンスコーパス: histone code

1 iously reported H4K20me1-H3K9me1 trans-tail 'histone code'.

2 dues communicate information via a specific 'histone code'.

3 ntenance of the H4K20me1-H3K9me1 trans-tail 'histone code'.

4 ndicate that unmodified H3K4 is part of the 'histone code'.

5 ls and thereby facilitate the reading of the histone code.

6 code' that underlies the instructions of the histone code.

7 ssibility of a complex DNA damage responsive histone code.

8 stone modifications that may contribute to a histone code.

9 his modification is a part of the DNA-repair histone code.

10 chromatin-associated factors in reading the histone code.

11 g chromatin modifications that establish the histone code.

12 ptional elongation and in the development of histone code.

13 tin remodeling complex can read a DNA repair histone code.

14 at the domain is involved in deciphering the histone code.

15 ecificity generate further complexity of the histone code.

16 th epigenetic "writers" and "erasers" of the histone code.

17 ions of conserved readers and writers of the histone code.

18 ors of gene transcription and readers of the histone code.

19 switch mark recognition by "readers" of the histone code.

20 n histones and can be considered part of the histone code.

21 modifications (erasers), and readers of the histone code.

22 anslational modification 'codes' such as the histone code.

23 ng on chromatin substrates and 'setting' the histone code.

24 ranscriptional outcome is referred to as the histone code.

25 ethyltransferase to establish the trans-tail histone code.

26 ression, which broadens our understanding of histone code.

27 tic examination of proteins that interpret a histone code.

28 within a protein complex to read a specific histone code.

29 n of histone marks known collectively as the histone code.

30 pression may be further regulated beyond the histone code.

31 V) is accompanied by specific alterations of histone codes.

32 e Set2, thereby influencing both the CTD and histone codes.

33 ty and the integrity of both the tubulin and histone codes.

34 provide evidence for a potential apoptotic "histone code."

35 cinal residues as part of the syntax of the 'histone code.'

36 Modifications of the histone code alone are not sufficient to account for the

37 epigenetic characteristics, particularly the histone code, along the length of the hepatic IGF-1 gene

38 de." PTMs of histones comprise an analogous "histone code," although the "readers, writers, and erase

39 veals a new kinase involved in composing the histone code and adds haspin to the select group of kina

40 e a powerful approach for elucidation of the histone code and identification of histone post-translat

41 se methods provide tools for analysis of the histone code and its role in chromatin function.

42 complex plays critical roles in altering the histone code and repressing transcription of a broad ran

43 arget promoters, where it likely impacts the histone code and/or methylates other chromatin-associate

44 odifications that constitute the DNA damage "histone code" and suggest a model for the underlying chr

45 that Brd4 specifically recognizes acetylated histone codes, and this recognition is passed onto the c

46 Yet little is known how different histone codes are translated and put into action.

47 ications, which collectively constitute the 'histone code', are capable of affecting chromatin struct

48 presence or absence of multiple HMs, or the histone codes, are believed to coregulate important biol

49 The histone code associated with the XL boxes and that of th

50 ggest that the nature of the heterochromatin histone code associated with X inactivation may be more

51 riments provide an in-depth analysis of the "histone code" associated with chromatin replication and

52 ion, maintain key repressive elements of the histone code at a hypermethylated gene promoter in cance

53 llowed by the establishment of a restrictive histone code at the viral LTR.

54 IV-1) latency is controlled by a restrictive histone code at, or DNA methylation of, the integrated v

55 stone domains may constitute a layer of the "histone code" at imprinted genes.

56 at allows comprehensive characterization of 'histone codes' at the molecular level.

57 er, changes in DNA methylation can reset the histone code by impacting multiple H3 modifications.

58 We therefore propose that an ordered histone code can promote progression through the transcr

59 als for transcriptional regulation, specific histone "codes" can coordinate and target multiple activ

60 etween aberrant DNA hypermethylation and key histone code components at a hypermethylated, silenced t

61 ith open chromatin and have a characteristic histone code comprised of significantly high levels of h

62 of a plant gene and expand the evidence for histone code conservation among eukaryotes.

63 duce a distinct bi-modular 'syllable' in the histone 'code' conveying different meaning on specific g

64 rate under the assumption that a restrictive histone code could govern latent infection and that eith

65 This histone code determines the expression status of individ

66 cleotide sequence and epigenetically by the "histone code," DNA methylation, and higher-order packagi

67 Finally, we analyzed the histone code, DNMT1, DNMT3B, and PRC2 binding by chromat

68 ntitatively the relative enrichment of these histone code elements on the Xi relative to the Xa.

69 at discriminate robustly among many kinds of histone code elements.

70 equential histone modifications establish a "histone code" essential for the epigenetic inheritance o

71 mpacts transcription and interfaces with the histone code, far less is known about how it regulates g

72 cipitation assays were used to establish the histone code for pIII and determine the differences betw

73 finding implies a further complexity to the histone code for regulation of chromatin structure and s

74 by an unknown enzyme provide a combinatorial histone code for the recruitment of CMT3 to silent loci.

75 ly and remodeling, in effect constituting a "histone code" for epigenetic signaling.

76 rylation of serine are important PTMs in the histone code found to modulate chromatin packing, which

77 he first genome-wide characterization of the histone code from a stramenopile and a marine phytoplank

78 The histone code guides many aspects of chromosome biology i

79 The histone code has developed as a new layer of our appreci

80 The regulation of gene expression via the histone code has, for the most part, revealed that histo

81 We propose that MOF, through H4K16ac (histone code), has a critical role at multiple stages in

82 as novel reagents for the evaluation of the histone code hypothesis and analysis of epigenetic signa

83 tone H2A phosphorylation with respect to the histone code hypothesis and found that it is required fo

84 hese results provide further support for the histone code hypothesis and raise specific concerns with

85 The histone code hypothesis holds that covalent posttranslat

86 l for studying epigenetic mechanisms and the Histone Code Hypothesis in human cancer.

87 The histone code hypothesis predicts that the post-translati

88 The histone code hypothesis proposes that covalently modifie

89 According to the histone code hypothesis, histone variants and modified h

90 a review that provides a current view of the histone code hypothesis, the lessons we have learned ove

91 In the histone code hypothesis, these exposed and unstructured

92 Ten years ago, we put forward the histone code hypothesis, which provided a model to expla

93 and we compare this interpretation with the histone code hypothesis.

94 one modification, a stated prediction of the histone code hypothesis.

95 results of experiments designed to test the histone code hypothesis.

96 sine nine of histone H3, consistent with the histone code hypothesis.

97 better understanding the molecular basis of histone code hypothesis.

98 e findings provide critical support for the "histone code" hypothesis, demonstrating that multivalent

99 By analogy with the "histone code" hypothesis, we propose that the multiple b

100 our understanding of the plasticity of the "histone code" hypothesis.

101 between modifications has strengthened the 'histone code' hypothesis, in which histone modifications

102 This led to the 'histone code' hypothesis, which proposes that combinatio

103 onal DNA elements, providing support to the 'histone code' hypothesis.

104 The 'histone-code' hypothesis proposes that cell fate 'decisi

105 least in part on an HMT-dependent inhibitory histone code, imposes a requirement for specific histone

106 he SMRT HID participates in interpreting the histone code in a feed-forward mechanism that promotes a

107 ts such as dynamic nucleosomes and a dynamic histone code in gene transcription are explored.

108 F diet resulted in modifications of the Pck1 histone code in livers of offspring.

109 studies aimed at evaluating the role of the histone code in regulating gene expression.

110 eats and that CENP-C and DNMT3B regulate the histone code in these regions, including marks character

111 nd DNA damage, suggesting the presence of a "histone code" in these nuclear processes.

112 lts suggest a specialized adaptation of the "histone code" in which distinct histone tail-protein int

113 tin biology and is proposed to constitute a 'histone code' in epigenetic regulation.

114 of epigenetic histone modifications and the "histone code," in regulating dendrite morphology.

115 Our results are consistent with a histone code index for each cell type and uncover potent

116 hat patterns of epigenetic modifiers and the histone code influence the propensity of a gene to becom

117 pattern of histone modifications, called the histone code, influences transitions between chromatin s

118 This finding suggests a novel histone code interaction in which the input chromatin en

119 ed for epigenetic reading and writing of the histone code involved in hormone-stimulated gene program

120 asting gene activities and may be part of a 'histone code' involved in establishing and maintaining f

121 indicate a need for revising aspects of the histone code involving H3 lysine methylation.

122 ly, these findings define a novel trans-tail histone code involving monomethylated H4 Lys-20 and H3 L

123 We previously discovered a novel trans-tail histone code involving monomethylated histone H4 lysine

124 tin-associated protein-1 (HP1) recognizes a 'histone code' involving methylated Lys9 (methyl-K9) in h

125 ers suggests that the recognition of H3K4me3 histone code is a general feature of the ING/YNG protein

126 tions of nitrate depletion and show that the histone code is dynamic and targets specific sets of gen

127 We determined that this histone code is involved in a transcriptional regulatory

128 nd off will further our knowledge of how the histone code is modulated.

129 ur studies provide an in vivo example that a histone code is not read independently but is recognized

130 impacts the ET-specific reprogramming of the histone code landscape, chromatin remodelling and the ac

131 chromatin modifications, suggesting that the histone code may be a prequel to the splicing code.

132 response, altering chromatin by modifying a histone-code mediator protein, HP1, but not the code its

133 methyl-lysine recognition motif involved in histone code modification and epigenetic regulation of g

134 ude that epigenetic mechanisms consisting of histone code modifications repress skeletal muscle glut4

135 le DNA methylation levels did not affect the histone code of the LHR gene promoter, demethylation of

136 hment and maintenance of the newly proposed "histone code" of chromatin.

137 the posttranslational modification-mediated "histone code" of mH2A, a variant generally associated wi

138 ne modification enzymes may re-establish the histone code on newly assembled unmethylated histones an

139 dies to investigate aberrant methylation and histone code patterns, the two major epigenetic markers.

140 A global histone code profiling of D-CMSC revealed that acetylati

141 , it is unclear how L3MBTL1, a methyl-lysine histone code reader, recognizes equally well both mono-

142 or of nucleosomal dynamics distinct from the histone code readers and writers.

143 by generating or blocking docking sites for histone code readers or by altering the higher order chr

144 the molecular mechanism of the methyl-Lys 27 histone code recognition, we have determined a 1.4-A-res

145 The histone code refers to the complex network of histone po

146 athogenesis of ALS, including changes in the histone code regulating gene transcription.

147 o gene reexpression, and finally to complete histone code reversal.

148 s revealed condensed chromatin structure and histone code switch during silencing.

149 methylation of FLC chromatin is part of the histone code that is required for mitotic stability of t

150 r interaction with unliganded TR generates a histone code that serves to stabilize their own recruitm

151 and other modifications on histones comprise histone codes that govern transcriptional regulatory pro

152 dent methylation of histones is part of the "histone code" that can profoundly influence gene express

153 se KDM5A as a critical editor of the cells' "histone code" that is required to recruit DNA repair com

154 f chromatin has been proposed to generate a 'histone code' that epigenetically regulates gene express

155 ct sequentially or in combination to form a 'histone code' that is, read by other proteins to bring a

156 etic memory of winter is thus mediated by a 'histone code' that specifies a silent chromatin state co

157 posed that these modifications constitute a 'histone code' that specifies epigenetic information for

158 their function as epigenetic readers of the histone code, the BET family of bromodomain-containing p

159 A central question in histone code theory is how various codes are recognized

160 n via a point-by-point interpretation of the histone code through the ordered recruitment of bromodom

161 k an inhibitory methylation component of the histone code to a broadly used strategy that circumvents

162 ent with a model in which PHLPP modifies the histone code to control the transcription of RTKs.

163 Eukaryotic cells utilize this histone code to regulate the usage of the underlying DNA

164 ts and directly extend the principles of the histone code to the regulation of nonhistone proteins.

165 mportance of using the functional readout of histone codes to define the roles of specific pathways.

166 l appearance of the Xi, a range of different histone code types were detected at different sites alon

167 l pathway by which Hsp90 activity alters the histone code via regulation of KDM4B stability.

168 lly, and the postnatal effect of IUGR on the histone code was gender-specific.

169 We propose that a preexisting histone code was recruited into C4 promoter control duri

170 enetic regulation and is a component of the "histone code," which engenders histones with gene regula

171 varied, implying a strong correlation of the histone code with cell type and fate.