ライフサイエンスコーパス: histone deacetylase

1 fications and chromatin localization of Sir2 histone deacetylase.

2 by DUSP2 were similar to those controlled by histone deacetylase.

3 ated repression via recruitment of the Set3C histone deacetylase.

4 tion of nuclear targets, including class IIa histone deacetylases.

5 and mediating transcriptional repression via histone deacetylases.

6 of PKD1 nuclear targets, including class IIa histone deacetylases.

7 ut-off and nuclear accumulation of class IIa histone deacetylases.

8 apy targeting both the KDM5A demethylase and histone deacetylases.

9 d form (FTY720-P) is an inhibitor of class I histone deacetylases.

10 The induced heterochromatin required histone deacetylase 1 (HDA-1), with an intact catalytic

11 ssion of FBP1 correlated with high levels of histone deacetylase 1 (HDAC1) and HDAC2 proteins in HCC

12 responsible for the neurotoxic potential of histone deacetylase 1 (HDAC1) and its subcellular locali

13 e report that MDM2-induced ubiquitination of histone deacetylase 1 (HDAC1) mediates VC.

14 to the DNA-binding domain of Slug, impeding histone deacetylase 1 (HDAC1) recruitment and antagonizi

15 ment to c-Myc target promoters and increased histone deacetylase 1 (HDAC1) recruitment, thereby decre

16 otein complex comprised of MRG15, Sin3B, and histone deacetylase 1 (HDAC1) that functions as a transc

17 Calcium-dependent nuclear export of histone deacetylase 1 (HDAC1) was shown previously to pr

18 Histone deacetylase 1 activates PU.1 gene transcription

19 We found that 2-aminoacetophenone regulates histone deacetylase 1 expression and activity, resulting

20 Inhibition of histone deacetylase 1 prevented the immunomodulatory eff

21 ated by DNA methyltransferase1/3 (DNMT1/3)-, histone deacetylase 1/2/4 (HDAC1/2/4)-, Setdb1/Suv39h1-,

22 ses approximately 10 subunits, including the histone deacetylases 1 and 2 (HDAC1 and HDAC2), and is d

23 In the nucleus, SK2 binds to and inhibits histone deacetylases 1 and 2 (HDAC1/2).

24 mice correlate with a widespread increase of histone-deacetylase 1 (Hdac1) expression that is linked

25 e, we show that endothelial morphogenesis is histone deacetylase-1- (HDAC1) dependent and that inters

26 Here we report that histone deacetylase 10 (HDAC10) is a robust polyamine de

27 e demonstrate a previously undefined role of histone deacetylase 11 (HDAC11) in regulating T-cell eff

28 Histone Deacetylase 11 (HDAC11) is highly expressed in t

29 A reduction in histone deacetylase 2 (HDAC2) activity and expression ha

30 ng to the glucocorticoid response element of histone deacetylase 2 (HDAC2) promoter, resulting in the

31 e repressor CoREST (also known as RCOR1) and histone deacetylase 2 in these early dividing cells; and

32 icosteroid resistance though inactivation of histone deacetylase 2.

33 Histone deacetylase-2 (HDAC2), an epigenetic regulator,

34 Histone deacetylase 3 (HDAC3) and linker histone H1 are

35 revents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neur

36 In mice selectively ablated for histone deacetylase 3 (HDAC3) in skin keratinocytes, GC-

37 show that SCI resulted in an upregulation of histone deacetylase 3 (HDAC3) in the innate immune cells

38 Here we show that histone deacetylase 3 (HDAC3) is required to activate br

39 Histone deacetylase 3 (HDAC3) is the catalytic component

40 se development, the histone-modifying enzyme histone deacetylase 3 (Hdac3) regulates the formation of

41 Here we show that histone deacetylase 3 (HDAC3) regulates WAT metabolism a

42 ind that depletion of the epigenome modifier histone deacetylase 3 (HDAC3) specifically in skeletal m

43 oid-hormone receptors (SMRT) corepressors or histone deacetylase 3 (HDAC3), Dex-induced tethered tran

44 We show that a histone deacetylase 3 (Hdac3)-mediated epigenetic pathwa

45 Histone deacetylase 3 and its cofactor NCOR1 regulate he

46 3 and its cofactor NCOR1 regulate hepcidin; histone deacetylase 3 binds chromatin at the hepcidin lo

47 eraction with nuclear receptor corepressor 2/histone deacetylase 3 for its repression.

48 In iron deficient mice, the histone deacetylase 3 inhibitor RGFP966 increases hepcid

49 3 binds chromatin at the hepcidin locus, and histone deacetylase 3 knockdown counteracts hepcidin sup

50 expression involves epigenetic regulation by histone deacetylase 3.Hepcidin controls systemic iron le

51 on reduced AAV9 transduction, while reducing histone deacetylase 4 (HDAC4) expression enhanced AAV tr

52 n the gene for the transcriptional repressor histone deacetylase 4 (HDAC4) is associated with the ris

53 Because histone deacetylase 4 (HDAC4) is highly expressed in liv

54 in Ca(2+) to dephosphorylate and translocate histone deacetylase 4 (HDAC4) to the nucleus for repress

55 ith circadian nucleocytoplasmic shuttling of Histone deacetylase 4 (HDAC4), a SIK3 phosphorylation ta

56 aissance was governed by liver kinase b1 and histone deacetylase 4 in white adipocytes.

57 f CpG sites in the HDAC4 gene, which encodes histone deacetylase 4, and is involved in long-term memo

58 Deletion of histone deacetylase-4 (HDAC4) partially recapitulates th

59 icroRNAs and a considerable up-regulation of histone deacetylase-4.

60 Here we identify histone deacetylase 5 (HDAC5) as a regulator of leptin s

61 We found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (

62 Mutating HISTONE DEACETYLASE 6 (HDA6), or the cytosine methyltran

63 Here, we have observed that the levels of histone deacetylase 6 (HDAC6) and the related family mem

64 Histone deacetylase 6 (HDAC6) catalyzes the removal of a

65 Ablation of histone deacetylase 6 (HDAC6) expression and its activit

66 Here, we studied the role of histone deacetylase 6 (HDAC6) in regulating cyst growth

67 l inhibition as well as genetic silencing of histone deacetylase 6 (HDAC6) increase alpha-tubulin ace

68 Herein we report that histone deacetylase 6 (HDAC6) modulates TGF-beta1-mediat

69 ted by the ubiquitin-proteasome pathway, and histone deacetylase 6 (HDAC6) serves as an ubiquitin E3

70 At the same time, the abundance of histone deacetylase 6 (HDAC6) was diminished.

71 Histone deacetylase 6 (HDAC6), a class IIb HDAC, plays a

72 servations that tau is a direct substrate of histone deacetylase 6 (HDAC6), we sought to map all HDAC

73 RelA in the nucleus, by which MIIP prevents histone deacetylase 6 (HDAC6)-mediated RelA deacetylatio

74 zation was rescued by inhibition of ROCK and histone deacetylase 6 but not by a GAP-mutant form of AR

75 ession of the cytoplasmic deacetylase HDAC6 (Histone Deacetylase 6) and that FGFR3 accumulation is co

76 Knock down of histone deacetylase-6 (HDAC6) increased the acetylation

77 tissue that is correctable by inhibition of histone deacetylase-6 (HDAC6).

78 Here, we show that inhibition of the histone deacetylase 8 (HDAC8) by either the HDAC8-specif

79 ns of the structurally characterized isozyme histone deacetylase 8 (HDAC8).

80 as potent inhibitors of Schistosoma mansoni histone deacetylase 8 (smHDAC8).

81 5.99E-9, odds ratio (OR) = 1.22] and confirm histone deacetylase 9 (HDAC9) as a major risk gene for L

82 EGF) and hypoxia-inducible factor by using a histone deacetylase abexinostat in combination with pazo

83 Chemical inhibition of histone deacetylase activity by trichostatin A suppresse

84 and implicates epigenetic mechanisms such as histone deacetylase activity.

85 ses in SIRT1, a well characterized class III histone deacetylase, after chronic social defeat suggest

86 and provides mechanistic insights into how a histone deacetylase along with a chromatin-binding prote

87 atic activities of Sir2 and Top1 proteins, a histone deacetylase and a DNA topoisomerase, respectivel

88 ly identified peptide sequence from the Clr3 histone deacetylase and a previously identified sequence

89 ein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodell

90 and over-expression of Sirtuin 1 (SIRT1), a histone deacetylase and gene silencer, in the eutopic en

91 derlying acetylated chromatin from attack by histone deacetylases and allows acetylation to spread al

92 inked to VEGFA-induced release of repressive histone deacetylases and concurrent recruitment of the h

93 In PV, inhibitors of histone deacetylases and human double minute 2 have acti

94 dopsis (Arabidopsis thaliana) interacts with histone deacetylases and quantitatively determines histo

95 ng ABA response, including interactions with histone deacetylases and the co-repressor TOPLESS.

96 ng ABA response, including interactions with histone deacetylases and the co-repressor TOPLESS.

97 Although histone deacetylases are already being clinically target

98 Our lab has previously shown histone deacetylases are modulated in cells derived from

99 n Drosophila and identify HDAC6, a cytosolic histone deacetylase, as a suppressor of EFA.

100 conditions, local recruitment of the Rpd3(L) histone deacetylase by transcriptional repressors blocks

101 that the activity of plant-encoded enzymes (histone deacetylases) can be modulated to alter acetylat

102 mselves and the genes encoding components of histone deacetylase Clr6 complex II suppress the defects

103 We have previously shown that the Histone Deacetylase Complex 1 (HDC1) protein from Arabid

104 f2/HDAC-containing repressor complex (SHREC) histone deacetylase complex and the anti-silencing prote

105 The Eaf3/5/7 complex and the Rpd3C(S) histone deacetylase complex have both been shown to bind

106 l PHD fingers of Rco1, a member of the Rpd3S histone deacetylase complex recruited to transcribing ge

107 reover, cytoplasmic SAP130 (a subunit of the histone deacetylase complex) was expressed in PDA in a R

108 expression, and relies on Set2 and the Set3 histone deacetylase complex.

109 Here, we show that MSI1 is part of a histone deacetylase complex.

110 an integral subunit of a well-characterized histone deacetylase complex.

111 an essential component of the mammalian Sin3-histone deacetylase corepressor complex, severely impair

112 bitors against DNA methyltransferases (DAC), histone deacetylases (Depsi), histone demethylases (KDM1

113 ts with the NF-kappaB protein Relish and the histone deacetylase dHDAC1, selectively repressing Relis

114 Changes in histone acetylation and class IIa histone deacetylases expression, following pulmonary inf

115 The histone deacetylase family comprises 18 enzymes that cat

116 nd identified HDAC1, a member of the class I histone deacetylase family.

117 nscription factors, chromatin modifiers, and histone deacetylases have undergone strong directional s

118 The histone acetyl transferase GCN5 and the histone deacetylase HDA19 are required for H3K36ac homeo

119 this whole network is directly dependent on histone deacetylase HDA6.

120 he onset of SC differentiation by recruiting histone deacetylases HDAC 1 and 2 (HDAC1/2) and nucleoso

121 Histone deacetylase (HDAC) 6 exists exclusively in cytop

122 -acylhydrazone (NAH) derivatives that act as histone deacetylase (HDAC) 6/8 dual inhibitors and were

123 e design of a turn-on fluorescence assay for histone deacetylase (HDAC) activity and for inhibitor sc

124 tylation, which can be ascribed to intrinsic histone deacetylase (HDAC) activity in Tcf1 and Lef1.

125 ll molecule that is designed to inhibit both histone deacetylase (HDAC) and PI3K enzymes, which are m

126 In mammalian cells, histone deacetylase (HDAC) and Sirtuin (SIRT) are two fa

127 Here we describe a Cas9-based histone deacetylase (HDAC) and the design principles req

128 al corepressor that acts as a scaffold for a histone deacetylase (HDAC) complex.

129 How remodeler and histone deacetylase (HDAC) cooperate within NuRD complex

130 We show that the histone deacetylase (HDAC) enzyme inhibitor trichostatin

131 Even though histone deacetylase (HDAC) inhibition has shown remarkab

132 e mechanism and that both effects are due to histone deacetylase (HDAC) inhibition possibly linked to

133 etylation/deacetylation balance, in part via histone deacetylase (HDAC) inhibition.

134 The oral histone deacetylase (HDAC) inhibitor (vorinostat) is saf

135 rt the multicomponent synthesis of a focused histone deacetylase (HDAC) inhibitor library with peptoi

136 ion revealed that pretreating cells with the histone deacetylase (HDAC) inhibitor SAHA led to detecta

137 In this study, we found that histone deacetylase (HDAC) inhibitor suberoylanilide hyd

138 D expression in NK cells is inhibited by the histone deacetylase (HDAC) inhibitor valproic acid (VPA)

139 The histone deacetylase (HDAC) inhibitor vorinostat (VOR) ca

140 oduct (-)-depudecin, a unique and unexplored histone deacetylase (HDAC) inhibitor, is reported.

141 Second, in a separate group of rats, the histone deacetylase (HDAC) inhibitor, MS275, was deliver

142 Treatment with 109, a class I histone deacetylase (HDAC) inhibitor, resulted in increa

143 Histone deacetylase (HDAC) inhibitor, suberoylanilide hy

144 ed that a first-in-class selective class IIa histone deacetylase (HDAC) inhibitor, TMP195, influenced

145 venetoclax, alone and in combination with a histone deacetylase (HDAC) inhibitor, vorinostat or romi

146 Histone deacetylase (HDAC) inhibitors (HDIs) are promisi

147 Histone deacetylase (HDAC) inhibitors and DNA-damaging a

148 of latency reversing agents (LRAs), such as histone deacetylase (HDAC) inhibitors and protein kinase

149 -resistant, but not parental, CRC cells with histone deacetylase (HDAC) inhibitors can effectively ov

150 We examined the role of histone deacetylase (HDAC) inhibitors in regulating sGCa

151 be overcome for the continued improvement of histone deacetylase (HDAC) inhibitors is finding alterna

152 Previous studies showed that either histone deacetylase (HDAC) inhibitors or tumor necrosis

153 e, the prototypical hydroxyamic acid-derived histone deacetylase (HDAC) inhibitors Panobinostat and V

154 Increasing speculation about the use of histone deacetylase (HDAC) inhibitors to treat skin dise

155 aralleled by treatment with three additional histone deacetylase (HDAC) inhibitors, but not other ant

156 nt by a class of broad-acting drugs known as histone deacetylase (HDAC) inhibitors.

157 ion as follows: increased stability, reduced histone deacetylase (HDAC) interaction, and increased DN

158 t BTK in primary CLL cells and show that the histone deacetylase (HDAC) repressor complex is recruite

159 Inhibition of histone deacetylase (HDAC) signalling with trichostatin

160 f resistance include activation of the mTOR, histone deacetylase (HDAC), MAPK, and ERBB4 pathways.

161 information regulator 1 (SIRT1), a class-III histone deacetylase (HDAC), resulting in epigenetic tran

162 ssed in telomerase-negative human cells in a histone deacetylase (HDAC)-dependent manner, replicating

163 a new class of anticancer agents that target histone deacetylase (HDAC).

164 inase (PI3K) activity, and decreased nuclear histone deacetylase (HDAC)2 levels.

165 -gamma markedly reduced the nuclear level of histone deacetylase (HDAC)2, an essential epigenetic enz

166 ichia coli K12, we showed that inhibition of histone deacetylases (HDAC) by trichostatin A dramatical

167 Histone deacetylases (HDAC) contain eighteen isoforms th

168 it epigenetic regulatory proteins, including histone deacetylases (HDAC), histone methyltransferases,

169 Here we demonstrate that the histone deacetylase Hdac1/Rpd3 functions together with s

170 n a poised state in neural stem cells by the histone deacetylase Hdac1/Rpd3.

171 Here, we show that the class I histone deacetylases HDAC1 and HDAC2 contribute to maint

172 sion abrogated ISL1-dependent recruitment of histone deacetylases HDAC1/5, inhibiting Nkx2.5 expressi

173 y binding to the promoter and recruiting the histone deacetylase, HDAC1.

174 epressor of ZRS activity, interacts with the histone deacetylase HDAC2 and ensures that the poised ZR

175 Here, we show that the histone deacetylase Hdac3 controls oligodendrocyte-speci

176 The histone deacetylase HDAC3 is a critical mediator of hepa

177 We demonstrate that a histone deacetylase (Hdac3) organizes heterochromatin at

178 Previous studies suggest that nuclear histone deacetylase HDAC5 has a dynamic relationship wit

179 hanism by maintaining high expression of the histone deacetylase HDAC9.

180 We observed that expression of histone deacetylases (HDACs) 1 and 9, and Silent informa

181 Histone deacetylases (HDACs) 1, 2 and 3 form the catalyt

182 tic writers/erasers and chromatin-binding of histone deacetylases (HDACs) and Polycomb-group (PcG) pr

183 Histone acetyltransferases and histone deacetylases (HDACs) are important epigenetic co

184 Histone deacetylases (HDACs) are important modulators of

185 Class I histone deacetylases (HDACs) are known to remove acetyl

186 Class IIa histone deacetylases (HDACs) are very important for tiss

187 Histone deacetylases (HDACs) catalyze deacetylation of a

188 Histone acetyltransferases (HATs) and histone deacetylases (HDACs) compete to modulate histone

189 een lysine-specific demethylase 1 (LSD1) and histone deacetylases (HDACs) facilitates breast cancer p

190 Class I histone deacetylases (HDACs) Hdac1 and Hdac2 can associa

191 To investigate the specific roles of histone deacetylases (HDACs) in rod differentiation in n

192 Inhibiting class I histone deacetylases (HDACs) increases energy expenditur

193 Histone deacetylases (HDACs) modulate acetylation of lys

194 ue to histone deacetylation as inhibition of histone deacetylases (HDACs) not only induced acetylatio

195 Here, we present evidence that specific histone deacetylases (HDACs) play essential roles in the

196 However, the mechanisms by which specific histone deacetylases (HDACs) regulate differentiation in

197 Histone deacetylases (HDACs) regulate myriad cellular pr

198 Histone deacetylases (HDACs) remove acetyl groups from l

199 rs fed pharmacological inhibitors of CBP and histone deacetylases (HDACs) revealed hundreds of genes

200 One approach, the inhibition of histone deacetylases (HDACs), has been reported to suppr

201 sed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), is a major epigenetic regu

202 ing action of histone acetyltransferases and histone deacetylases (HDACs).

203 In addition to binding histone deacetylases, HDC1 directly interacted with hist

204 is thaliana paralogs encoding plant-specific histone deacetylases, HDT1 and HDT2, regulate a second s

205 LHX2 binds to the nucleosome remodeling and histone deacetylase histone remodeling complex subunits

206 ivotal role of Arabidopsis HDA9 (a RPD3-like histone deacetylase) in promoting the onset of leaf sene

207 ation 11 homolog (MRE11) is downregulated by histone deacetylase inhibition (HDACi), resulting in red

208 Moreover, histone deacetylase inhibition abrogates the decreased h

209 In vitro, pan-histone deacetylase inhibition elevates hepcidin express

210 of action, such as antimicrotubule activity, histone deacetylase inhibition, mitotic checkpoint inhib

211 provide a method for resetting via transient histone deacetylase inhibition.

212 ransferases and CDK9 and less sensitivity to histone deacetylase inhibition.

213 n agent that promotes chromatin opening, the histone deacetylase inhibitor (HDACi) AR-42, ameliorates

214 that RAE-1 is transcriptionally repressed by histone deacetylase inhibitor 3 (HDAC3) in healthy cells

215 Romidepsin is a histone deacetylase inhibitor approved for the treatment

216 of the retinoic acid receptor (RAR)-beta The histone deacetylase inhibitor entinostat is emerging as

217 A number of analogues of the marine-derived histone deacetylase inhibitor largazole incorporating ma

218 A2, or suppressing HMGA2 expression with the histone deacetylase inhibitor LBH589, inhibits epithelia

219 We show that the small-molecule histone deacetylase inhibitor M344 reduces beta-amyloid

220 how the effector molecule HC-toxin (HCT), a histone deacetylase inhibitor produced by the fungal pat

221 hput sequencing (ATAC-seq), we show that the histone deacetylase inhibitor promotes accessibility at

222 In particular, the histone deacetylase inhibitor sodium butyrate (SB) may i

223 in Cpt2M(-/-) hearts, but trichostatin A, a histone deacetylase inhibitor that improves cardiac remo

224 ic assessments of response and resistance to histone deacetylase inhibitor therapy.

225 ivation of HDAC9 expression and sensitive to histone deacetylase inhibitor treatment.

226 a combination regimen of bortezomib and the histone deacetylase inhibitor trichostatin A abolished H

227 gated the mechanism of MMP-13 suppression by histone deacetylase inhibitor vorinostat (SAHA).

228 lowed to devise an inactive precursor of the histone deacetylase inhibitor vorinostat that was effici

229 Panobinostat (a pan histone deacetylase inhibitor) is approved in combinatio

230 d) obtained by conjugation to valproic acid (histone deacetylase inhibitor) via an ester bond, exhibi

231 fic overexpression of Ascl1, together with a histone deacetylase inhibitor, enables adult mice to gen

232 Previously known functions include histone deacetylase inhibitor, endoplasmic reticulum str

233 When treated with the histone deacetylase inhibitor, Trichostatin A, genes nea

234 disruption of the human Sin3 network with a histone deacetylase inhibitor.

235 th suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor.

236 Panobinostat (pano) is an FDA-approved histone deacetylase inhibitor.

237 howcased by the formal synthesis of a potent histone deacetylase inhibitor.

238 agents (IMiDs), proteasome inhibitors (PIs), histone deacetylase inhibitors (DACIs), and monoclonal a

239 been proposed for DNA methyltransferase and histone deacetylase inhibitors (DNMTi and HDACi), primar

240 relevant doses of DNA methyltransferase and histone deacetylase inhibitors (DNMTi and HDACi, respect

241 Controversially, histone deacetylase inhibitors (HDACi) are in clinical t

242 ing a chemical library screen, we identified histone deacetylase inhibitors (HDACi) as agents reducin

243 Clinical response to histone deacetylase inhibitors (HDACi) is strongly assoc

244 By using a "drug repurposing" strategy, histone deacetylase inhibitors (HDACi), which are presen

245 ies include PKC and MAPK agonists as well as histone deacetylase inhibitors (HDACis) and bromodomain

246 s on CD8+ T cell phenotype and function: the histone deacetylase inhibitors (HDACis) and protein kina

247 Histone deacetylase inhibitors (HDACIs) can disrupt the

248 methyltransferase inhibitors [DNMTis]) with histone deacetylase inhibitors (HDACis) holds promise fo

249 Recent evidence suggests histone deacetylase inhibitors (HDACis) may represent a

250 We found that histone deacetylase inhibitors (HDACis) significantly in

251 We showed previously that the histone deacetylase inhibitors (HDACIs) trichostatin A a

252 Among the most effective compounds were histone deacetylase inhibitors (HDACIs).

253 0 antibodies and confirmed with nonselective histone deacetylase inhibitors (HDACis).

254 ndicating a potential therapeutic benefit of histone deacetylase inhibitors (HDIs), and preclinical d

255 Indeed, treatment with novel histone deacetylase inhibitors abolished hypoxia-induced

256 SAMHD1-dependent antiretroviral activity of histone deacetylase inhibitors acting via p53 activation

257 We further observed strong synergy between histone deacetylase inhibitors and EZH2 inhibitors.

258 azole and its analogues are isoform-targeted histone deacetylase inhibitors and potent LRAs.

259 Histone deacetylase inhibitors are currently approved to

260 NS and has several advantages over available histone deacetylase inhibitors now in clinical trials, o

261 scent HSPCs are resistant to reactivation by histone deacetylase inhibitors or P-TEFb activation but

262 with TEPP-46 and shikonin or treatment with histone deacetylase inhibitors produced similar results.

263 Treatment of mammalian cells with histone deacetylase inhibitors to increase euchromatin o

264 Treatment of cells with phorbol ester or histone deacetylase inhibitors triggered the expression

265 vated levels of hTdp1 were more sensitive to histone deacetylase inhibitors valproic acid (VPA) and t

266 As a class, histone deacetylase inhibitors were greatly overrepresen

267 Histone deacetylase inhibitors were used to treat cells.

268 -1beta in the absence or presence of various histone deacetylase inhibitors.

269 ions had the highest level of sensitivity to histone deacetylase inhibitors.

270 d increased sensitivity of leukemia cells to histone deacetylase inhibitors.

271 lly, growth of Salmonella in the presence of histone deacetylases inhibitors reduced expression of SP

272 tion regulator 1 (SIRT1), a NAD(+)-dependent histone deacetylase, is an important regulator of variou

273 ts with histone methyltransferase (PRC2) and histone deacetylase (NuRD and SIN3A) complexes through t

274 r localization and nucleosome remodeling and histone deacetylase (NuRD) complex binding are required

275 -containing Sin3B, nucleosome remodeling and histone deacetylase (NuRD), and corepressor of RE1 silen

276 ncrease, followed by slow decrease, in Rpd3L histone deacetylase occupancy.

277 HDAC6 is a cytoplasmic histone deacetylase regulating multiple pro-survival mec

278 Inhibition of sirtuin 6 (SIRT6), a histone deacetylase repressor of glycolytic flux, reprog

279 One gene was the histone deacetylase RPD3, for which there are known inhi

280 one acetylation through association with the histone deacetylase RPD3.

281 han passive stretch via heme oxygenase-1 and histone deacetylase signalling.

282 The NAD-dependent histone deacetylase Sir2 controls ribosomal DNA (rDNA) s

283 ogen: Candida albicans In this organism, the histone deacetylase Sir2, the master regulator of hetero

284 Here we identify the histone deacetylase Sirt1 as a Cdk2 regulator in OPC pro

285 tion, a signaling cascade involving AMPK and histone deacetylase SIRT1 displaces chromatin-bound BRD4

286 Here, we show that histone deacetylase Sirt6 protects against podocyte inju

287 d expression and activation of the class III histone deacetylase sirtuin (SIRT)-1.

288 tic program mediated by the NAD(+)-dependent histone deacetylase Sirtuin 6 (SIRT6) that is critical f

289 up in histone H3 could not be removed by the histone deacetylase sirtuin type 1.

290 dditional interactions between some AFPs and histone deacetylase subunits were observed in yeast two-

291 ibits fatty acid metabolism and WAT browning.Histone deacetylases, such as HDAC3, have been shown to

292 rase decitabine as well as the inhibitors of histone deacetylase tacedinaline and romidepsin.

293 vating Sirtuin 1 (SIRT1), a NAD(+)-dependent histone deacetylase that mediates adaptation to various

294 Sirtuin1 (Sirt1) is a class III histone deacetylase that regulates a variety of physiolo

295 nhibiting SPL is intracellular inhibition of histone deacetylases, thus linking our observations in s

296 SIN3B targets histone deacetylases to chromatin to repress transcripti

297 We show that nuclear NAC1 binds to histone deacetylase type 4 (HDAC4), hindering phosphoryl

298 The Rpd3S histone deacetylase utilizes the chromodomain-containing

299 ide], as inhibitors of nuclear and cytosolic histone deacetylases was substantially lower than that o

300 hages were completely reversed by inhibiting histone deacetylases, which corresponded with decreased