ライフサイエンスコーパス: histone deacetylase 1

1 n the recruitment of the co-repressor HDAC1 (histone deacetylase 1).

2 ing its sumoylation-dependent recruitment of histone deacetylase 1.

3 1 in cooperation with DNMT1 and, apparently, histone deacetylase 1.

4 is increase is reversed by overexpression of histone deacetylase 1.

5 with histone deacetylase 2 and of REST with histone deacetylase 1.

6 cued, at least in part, by the inhibition of histone deacetylase 1.

7 strain of Neurospora crassa with inactivated histone deacetylase 1.

8 and decreased expression of the corepressor histone deacetylase 1.

9 including the mSin3A protein and (for PLZF) histone deacetylase-1.

10 amily of multiprotein complexes that contain histone deacetylase 1/2 (HDAC1/2) and the histone demeth

11 r receptors and Atrophin-2 selectively binds histone deacetylase 1/2 (HDAC1/2) through its ELM2 (EGL-

12 h is associated with Sp1 directly or through histone deacetylase 1/2, respectively, at the promoter.

13 b dephosphorylation and its interaction with histone deacetylase 1/2.

14 ated by DNA methyltransferase1/3 (DNMT1/3)-, histone deacetylase 1/2/4 (HDAC1/2/4)-, Setdb1/Suv39h1-,

15 80, and a PHD zinc-finger subunit as well as histone deacetylases 1/2 and an MTA-like subunit, the tr

16 how that MUC1-C increases the recruitment of histone deacetylases 1/3, deacetylation of core histones

17 reporter system, we established that HDAC-1 (histone deacetylase 1), a gene that is frequently overex

18 coding ICP22 mediated the phosphorylation of histone deacetylase 1, a function of U(S)3 protein, but

19 Histone deacetylase 1 acted as a corepressor of VEGF-C e

20 Histone deacetylase 1 activates PU.1 gene transcription

21 The role of histone deacetylase 1 and 2 (HDAC1 and HDAC2) in regulat

22 Histone deacetylase 1 and 2 (HDAC1/2) regulate chromatin

23 ation was associated with the recruitment of histone deacetylase 1 and 2 to the endogenous c-myc gene

24 histone deacetylase 1 and combined knockdown histone deacetylase 1 and 2.

25 ne 3 (H3) methylation and the recruitment of histone deacetylase 1 and 3 with the concomitant deacety

26 Histone deacetylase 1 and a corepressor, mSin3A, were id

27 rescued the BPA effects as did knockdown of histone deacetylase 1 and combined knockdown histone dea

28 enhancer factor 1 and Pitx2, by dismissal of histone deacetylase 1 and loss of its enzymatic activity

29 The TATA binding protein, p53, histone deacetylase-1 and mSin3a could be co-immunopreci

30 This was associated with increased levels of histone deacetylase-1 and surprisingly an increase in H4

31 Cellular proteins such as histone deacetylases 1 and 2 (HDAC1 and -2) also contain

32 Here we show histone deacetylases 1 and 2 (HDAC1 and HDAC2) as crucia

33 ses approximately 10 subunits, including the histone deacetylases 1 and 2 (HDAC1 and HDAC2), and is d

34 We show here that histone deacetylases 1 and 2 (HDAC1/2) are essential for

35 Histone deacetylases 1 and 2 (HDAC1/2) form the core cat

36 enitors in the lung endoderm is regulated by histone deacetylases 1 and 2 (Hdac1/2).

37 In the nucleus, SK2 binds to and inhibits histone deacetylases 1 and 2 (HDAC1/2).

38 This report examines the effects of histone deacetylases 1 and 2 (HDAC1/HDAC2) on MHC-II gen

39 The interaction of the co-repressors histone deacetylases 1 and 2 as well as lysyl oxidase-li

40 how that REST assembles with CoREST, mSin3A, histone deacetylases 1 and 2, histone methyl-transferase

41 conserved from nematodes to man and contains histone deacetylases 1 and 2, the MIDEAS corepressor pro

42 Cabin1 recruits mSin3 and its associated histone deacetylases 1 and 2; Cabin1 also competes with

43 s Mi-2beta, Sin3A, and Sin3B and the Class I histone deacetylases 1 and 2; the N-terminal domain can

44 sed presence of corepressor proteins such as histone deacetylases 1 and 3 and silencing mediator of r

45 ing motifs is also sufficient for binding to histone deacetylases 1 and 3, and both of these domains

46 termined whether MS-275, an inhibitor of the histone deacetylases 1 and 3, can inhibit these changes.

47 ubiquitin-related modifier-1, interacts with histone deacetylase 1, and represses c-Myb-mediated tran

48 65 acetylation was reversed by inhibitors of histone deacetylase 1, and the inhibitors partially rest

49 ding protein 2, Enhancer of Zeste homolog 2, histone deacetylase 1, and UHRF1, but it does require an

50 his work, we found that the levels of HDAC1 (histone deacetylase 1) are increased in quiescent livers

51 mediator for retinoid and thyroid receptors/histone deacetylase 1-associated repressor protein (SHAR

52 tion of a single nucleosome, to which it and histone deacetylase 1 bind.

53 promoted the interaction of p68 and p72 with histone deacetylase 1 but had no effect on binding to hi

54 s mediated by CCAAT/Enhancer Binding Protein/histone deacetylase 1 (C/EBPbeta-HDAC1) complexes, which

55 ion in rhabdoid cells by directly recruiting histone deacetylase 1 complex to its promoter, leading t

56 These factors include histone deacetylase 1, de novo DNA methyltransferase 3A,

57 lear role for beta-catenin in preventing the histone deacetylase 1-dependent inhibitory functions of

58 roperties of purified recombinant Drosophila histone deacetylase 1 (dHDAC1, also known as dRPD3).

59 ocytes from SLE patients through a gene-wide histone deacetylase 1-directed deacetylation of histone

60 We show that chromium cross-links histone deacetylase 1-DNA methyltransferase 1 (HDAC1-DNM

61 We found that 2-aminoacetophenone regulates histone deacetylase 1 expression and activity, resulting

62 STAT3, DNMT1, and histone deacetylase 1 form complexes and bind to the SHP

63 lation of retinoblastoma protein, release of histone deacetylase 1 from the retinoblastoma protein in

64 increased histone acetylation by inhibiting histone deacetylase 1 function and enhanced transcriptio

65 In contrast, directing histone deacetylase-1 (HD1) to a promoter using the GAL4

66 bition of maternal and zygotic expression of histone deacetylase 1 (HDA-1) causes embryonic lethality

67 The induced heterochromatin required histone deacetylase 1 (HDA-1), with an intact catalytic

68 DNA methylation is deficient in a histone deacetylase 1 (HDA1) mutant (hda-1) strain of Ne

69 hat nuclear Bcl-3 associates with STAT-1 and histone deacetylase 1 (HDAC-1), increasing HDAC-1 recrui

70 ctivity of p300 and inhibits the activity of histone deacetylase 1 (HDAC-1), which then leads to an i

71 ng C-terminal-binding protein-1 (CtBP-1) and histone deacetylase-1 (HDAC-1) at the silencer E2-box.

72 way combinations of PLK1 inhibitors with the histone deacetylase-1 (HDAC-1) inhibitor Entinostat and

73 Here, we show that deregulation of histone deacetylase 1 (HDAC1) activity by p25/Cdk5 induc

74 Both kinases phosphorylate histone deacetylase 1 (HDAC1) and HDAC2 and enable the e

75 Histone deacetylase 1 (HDAC1) and HDAC2 are components o

76 Furthermore, we found that histone deacetylase 1 (HDAC1) and HDAC2 are recruited by

77 ssion of FBP1 correlated with high levels of histone deacetylase 1 (HDAC1) and HDAC2 proteins in HCC

78 we show that DeltaNp63alpha associates with histone deacetylase 1 (HDAC1) and HDAC2 to form an activ

79 ly ORF66p results in hyperphosphorylation of histone deacetylase 1 (HDAC1) and HDAC2.

80 Herein we report that CBHA and SAHA inhibit histone deacetylase 1 (HDAC1) and histone deacetylase 3

81 romoter DNA, resulting in the recruitment of histone deacetylase 1 (HDAC1) and inhibition of the asso

82 responsible for the neurotoxic potential of histone deacetylase 1 (HDAC1) and its subcellular locali

83 HDRP also interacts with histone deacetylase 1 (HDAC1) and recruits it to the c-J

84 d that Nkx3.2 forms a complex, in vivo, with histone deacetylase 1 (HDAC1) and Smad1 and -4 in a BMP-

85 that PIASy can interact constitutively with histone deacetylase 1 (HDAC1) and that addition of HDAC

86 roximal promoter of Pdx1, recruitment of the histone deacetylase 1 (HDAC1) and the corepressor Sin3A,

87 tides with G9a histone methyltransferase and histone deacetylase 1 (HDAC1) and the disruption of thei

88 we demonstrated that the acetylase PCAF and histone deacetylase 1 (HDAC1) are in close spatial proxi

89 n cycling cells, estrogen receptor alpha and histone deacetylase 1 (HDAC1) are recruited to the proxi

90 munoprecipitation that Twist interacted with histone deacetylase 1 (HDAC1) at the ER promoter, causin

91 acid and thyroid hormone receptor (SMRT) or histone deacetylase 1 (HDAC1) at the same sites.

92 Furthermore, histone deacetylase 1 (HDAC1) bound the AR both in vivo

93 GSK3beta promoter is repressed by C/EBPbeta-histone deacetylase 1 (HDAC1) complexes, leading to the

94 expectedly, it also interacts with Sin3A and histone deacetylase 1 (HDAC1) corepressors via its zinc

95 N-CoR, mammalian Sin3 (mSin3A and B), and histone deacetylase 1 (HDAC1) form a complex that alters

96 n with metals or VEGF led to dissociation of histone deacetylase 1 (HDAC1) from the promoter, leading

97 Histone deacetylase 1 (HDAC1) has been linked to cell gr

98 e hTERT promoter via deacetylation of Sp3 by histone deacetylase 1 (HDAC1) in A549 human lung adenoca

99 delling factor and transcriptional repressor Histone deacetylase 1 (Hdac1) in endodermal organogenesi

100 histone lysine methyltransferase G9a and the histone deacetylase 1 (HDAC1) in order to modify the chr

101 Further mechanism analyses show that histone deacetylase 1 (HDAC1) interacts with Daxx and bi

102 demonstrate that the recently characterized histone deacetylase 1 (HDAC1) interacts with Sin3A and S

103 al regulation of p73 by HDACs and found that histone deacetylase 1 (HDAC1) is a key regulator of TAp7

104 Histone deacetylase 1 (HDAC1) is a nuclear enzyme involv

105 a chromatin-remodeling NuRD complex in which histone deacetylase 1 (HDAC1) is associated with several

106 Since the chromatin remodeling enzyme histone deacetylase 1 (HDAC1) maintains latency of integ

107 e report that MDM2-induced ubiquitination of histone deacetylase 1 (HDAC1) mediates VC.

108 in helicase DNA-binding protein 4 (CHD4) and histone deacetylase 1 (HDAC1) occupy the promoters of se

109 In this study, we have analyzed the role of histone deacetylase 1 (HDAC1) on HTLV-1 gene expression

110 that C/EBPalpha diminishes the occupation of histone deacetylase 1 (HDAC1) or HDAC3 on the endogenous

111 Pharmacological treatment or silencing of histone deacetylase 1 (Hdac1) or histone deacetylase 2 (

112 how that the NRE constitutively binds to the histone deacetylase 1 (HDAC1) present in GH(3 )cells.

113 to the DNA-binding domain of Slug, impeding histone deacetylase 1 (HDAC1) recruitment and antagonizi

114 ment to c-Myc target promoters and increased histone deacetylase 1 (HDAC1) recruitment, thereby decre

115 otein complex comprised of MRG15, Sin3B, and histone deacetylase 1 (HDAC1) that functions as a transc

116 pressors DNA methyltransferase 1 (DNMT1) and histone deacetylase 1 (HDAC1) through its distinct domai

117 BRG1 (Brahma-related gene 1) cooperates with histone deacetylase 1 (HDAC1) to regulate Nanog expressi

118 desensitizes c-fos expression by recruiting histone deacetylase 1 (HDAC1) to the c-fos gene promoter

119 st factors YY1 and LSF cooperatively recruit histone deacetylase 1 (HDAC1) to the HIV-1 long terminal

120 n and its DNA-binding activity by recruiting histone deacetylase 1 (HDAC1) to the protein complexes.

121 er (ASE) region in Pitx2 gene and recruiting histone deacetylase 1 (HDAC1) to this region.

122 Calcium-dependent nuclear export of histone deacetylase 1 (HDAC1) was shown previously to pr

123 Ago1), DNA methyltransferase 3a (DNMT3a) and histone deacetylase 1 (HDAC1) were required for the init

124 factor that has been shown to interact with histone deacetylase 1 (HDAC1) when cotransfected in huma

125 Association of histone deacetylase 1 (HDAC1) with the promoter decrease

126 Interestingly, histone deacetylase 1 (HDAC1), a major HDAC responsible

127 ing viral UL69 and cellular cyclin T1, Brd4, histone deacetylase 1 (HDAC1), and HDAC2.

128 g transcription factor corepressor (CoREST), histone deacetylase 1 (HDAC1), and histone deacetylase 2

129 US in DDR involved a direct interaction with histone deacetylase 1 (HDAC1), and the recruitment of FU

130 n with its known cofactors, Brm, mSin3A, and histone deacetylase 1 (HDAC1), but not with G9a, and dec

131 IL-1beta, (GRIK2/3), TGF-beta2, TGF-betaR1, histone deacetylase 1 (HDAC1), death associated protein

132 sely, on cFLIP promoter, NF-kappaB increases histone deacetylase 1 (HDAC1), decreases p300 and histon

133 ases p300 and CREB-binding protein (CBP) and histone deacetylase 1 (HDAC1), HDAC2, and HDAC3.

134 that several deacetylase enzymes, including histone deacetylase 1 (HDAC1), HDAC8, and HDAC6, influen

135 f repressive epigenetic modifiers, including histone deacetylase 1 (HDAC1), SET domain, bifurcated 1

136 s bound VDR but exhibited reduced binding to histone deacetylase 1 (HDAC1), suggesting that the impai

137 DNMT3B also interacts with histone deacetylase 1 (HDAC1), the co-repressor SIN3A an

138 ut rather through its ability to deconjugate histone deacetylase 1 (HDAC1), thereby reducing its deac

139 dy, we demonstrate that bICP0 interacts with histone deacetylase 1 (HDAC1), which results in activati

140 cells is because of lack of a p50-dependent histone deacetylase 1 (HDAC1)-mediated repression of TNF

141 egulatory factors such as retinoblastoma and histone deacetylase 1 (HDAC1).

142 e (HAT)-containing co-activator proteins, or histone deacetylase 1 (HDAC1).

143 with the normal interactions between FUS and histone deacetylase 1 (HDAC1).

144 We observed that pUL97 associates with histone deacetylase 1 (HDAC1).

145 n of CCAAT enhancer binding protein beta and histone deacetylase 1 (HDAC1).

146 ar receptor corepressors (NCoR and SMRT) and histone deacetylase 1 (HDAC1).

147 ication state of chromatin by recruitment of histone deacetylase 1 (HDAC1).

148 ation decreases the association of NF-Y with histone deacetylase 1 (HDAC1).

149 We now show that MyoD associates with a histone deacetylase-1 (HDAC1) in these cells and that th

150 rofoundly represses P2 promoter activity and histone deacetylase-1 (HDAC1) potentiates such inhibitio

151 terminus of Rb protein involved in c-Abl and histone deacetylase-1 (HDAC1) regulation.

152 LRF associated with histone deacetylase-1 (HDAC1), and experiments utilizing

153 t the deacetylation of p53 is mediated by an histone deacetylase-1 (HDAC1)-containing complex.

154 xic roles have previously been described for histone deacetylase-1 (HDAC1).

155 mice correlate with a widespread increase of histone-deacetylase 1 (Hdac1) expression that is linked

156 ntified the methyl CpG binding protein Mbd3, histone deacetylase 1(Hdac1), and components of Brg1 com

157 sphatase inhibitor microcystin-LR identified histone deacetylase 1(HDAC1), HDAC6, and HDAC10 as novel

158 e, we show that endothelial morphogenesis is histone deacetylase-1- (HDAC1) dependent and that inters

159 further show that atrophin 2 associates with histone deacetylase 1 in mouse embryos, providing a bioc

160 Jag1 suppressed fzd expression by retaining histone deacetylase 1 in the complex with the transcript

161 hyperacetylating agent, trichostatin A, and histone deacetylase 1 indicate that growth arrest and p2

162 cetylation with the clinically used specific histone deacetylase 1 inhibitor MS-275 both cognitive an

163 ion, Tax dissociates transcription repressor histone deacetylase 1 interaction with the CREB response

164 Histone deacetylase 1 interacts with the MLL repression

165 This analysis revealed that histone deacetylase 1 is predominantly responsible for t

166 Histone deacetylase 1 is recruited to Myc-Sin3b complexe

167 Additionally Nkx2.2 recruited a histone deacetylase 1-mSin3A complex to the myelin basic

168 Finally, genes affected by A. thaliana histone deacetylase 1 mutation tend to show high levels

169 e SMRT/N-CoR polypeptides, mSin3A or -B, and histone deacetylase 1 or 2.

170 ed by (i) broad spectrum as well as specific histone deacetylase 1 or histone deacetylase 4 inhibitor

171 Depletion of SMRT, but not histone deacetylases 1 or 3, negatively impacts estradio

172 Inhibition of histone deacetylase 1 prevented the immunomodulatory eff

173 methyl binding domain protein-2 (MBD-2) and histone deacetylase 1 proteins but differed from MeCP-1.

174 Interferon-induced PLZF phosphorylation and histone deacetylase 1 recruitment probably mediates the

175 HDAC1 (histone deacetylase 1) regulates a number of biological

176 nuclear factor (NF)-kappaB association with histone deacetylase 1, repressing cytokine production.

177 polymerase 1 recruited the acetylated APE-1/histone deacetylase-1 repressor complex to bax nCaRE.

178 dimensional (2D) gels identified the primary histone deacetylase 1 target as histone H2B.

179 es correlate with reduced acetylation of the histone deacetylase 1 target site H3K18 in mice.

180 ract with the corepressors mSin3A and HDAC1 (histone deacetylase 1) through its zinc finger domain.

181 Mecp2 targeted histone deacetylase 1 to a sharply defined, approximatel

182 els was associated with increased binding of histone deacetylase 1 to p130 in the hepatic extracts.

183 e of the alternative recruitment of p300 and histone deacetylase 1 to the cyclin E promoter in prolif

184 These factors then cooperatively recruit histone deacetylase 1 to the LTR, resulting in inhibitio

185 ated at the CD1D promoter and interacts with histone deacetylase-1 to facilitate the transcriptional

186 ene expression (Tcf4 and Id4), by recruiting histone deacetylase-1 to their promoters during oligoden

187 tine, an indirect inhibitor of p300 HAT, and histone deacetylase-1 transfection completely abolished

188 Histone deacetylase 1, which could be recruited by Sp1,

189 ntagonizing GABPalpha binding and recruiting histone deacetylase 1, which deacetylated the Il7ra prom