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1 a mechanism for chromatin remodeling (i.e., histone deacetylation).
2 ic gene lateral root primordium 1 (LRP1) via histone deacetylation.
3 s that induce DNA hypomethylation or inhibit histone deacetylation.
4 ocess concomitant with Rpd3p recruitment and histone deacetylation.
5 s Id2 and Gadd153 by a process that involves histone deacetylation.
6 romatic marks that are maintained by ongoing histone deacetylation.
7 an epigenetic identity that is initiated by histone deacetylation.
8 78 transcriptional activity independently of histone deacetylation.
9 reated with inhibitors of DNA methylation or histone deacetylation.
10 pression of these genes requires blocking of histone deacetylation.
11 ppression of the rDNA promoter also involves histone deacetylation.
12 vity by binding to MEF2 and catalyzing local histone deacetylation.
13 ndently of HP1 through a mechanism involving histone deacetylation.
14 lve DNA methylation, histone methylation, or histone deacetylation.
15 ption in a manner that is not dependent upon histone deacetylation.
16 omous pathway regulates flowering in part by histone deacetylation.
17 oxia causes decreased Mlh1 transcription via histone deacetylation.
18 ts target DNA sequence and is independent of histone deacetylation.
19 required for transcriptional inhibition and histone deacetylation.
20 ively repress transcription in parallel with histone deacetylation.
21 s tested, activator binding is unaffected by histone deacetylation.
22 m(s) other than promoter hypermethylation or histone deacetylation.
23 oxide, and inhibitors of DNA methylation and histone deacetylation.
24 d the level of activation, not the extent of histone deacetylation.
25 cancer development by a mechanism involving histone deacetylation.
26 2)D(3) are suppressed by a process involving histone deacetylation.
27 induced by inhibition of DNA methylation and histone deacetylation.
28 Hdac2 and repressed transcription of Il6 via histone deacetylation.
29 f cancer cells can be manifested by improper histone deacetylation.
30 s vulval developmental target genes by local histone deacetylation.
31 d transcriptional repression associated with histone deacetylation.
32 been known about the developmental roles of histone deacetylation.
33 iganded TR represses transcription involving histone deacetylation.
34 tion via a mechanism that involves localized histone deacetylation.
35 ts affected by trichostatin, an inhibitor of histone deacetylation.
36 reak repair, meiotic checkpoint control, and histone deacetylation.
37 hrough alterations in DNA methylation and in histone deacetylation.
38 ducing epigenetic modifications that include histone deacetylation.
39 siveness gradually declines as a function of histone deacetylation.
40 cytoplasm by acetylation eventually affects histone deacetylation.
41 presses antisense transcription by promoting histone deacetylation.
42 enetic modifications such as methylation and histone deacetylation.
43 rinciples required to achieve locus-specific histone deacetylation.
44 stent with the idea that repression involves histone deacetylation.
45 methylation in the absence of HDA6-mediated histone deacetylation.
46 ng, recombination, DNA repair, and aging via histone deacetylation.
47 ir ability to remodel chromatin and modulate histone deacetylation.
48 cancer cells does not involve inhibition of histone deacetylation.
49 tion recruits the methyltransferase Set2 and histone deacetylation activities in cis, leading to stab
53 e element binding protein (CREB), leading to histone deacetylation and altered neuronal gene expressi
54 rs for selected genes, (ii) by inhibition of histone deacetylation and attendant chromatin remodeling
55 tylase 1 (HDAC1) at the ER promoter, causing histone deacetylation and chromatin condensation, furthe
58 esults unveil an important crosstalk between histone deacetylation and citrullination, suggesting tha
60 ivity is triggered by Lsd1-Mi2/NuRD-mediated histone deacetylation and demethylation at these pluripo
61 key epigenetic regulators necessary for (i) histone deacetylation and demethylation, (ii) binding to
64 ated with gene silencing, and a link between histone deacetylation and DNA methylation has been estab
67 s osteoblast differentiation in part through histone deacetylation and epigenetic suppression of an a
68 we treated cultures with a drug that impairs histone deacetylation and examined spontaneous synaptic
69 to the nucleation region in vivo, promoting histone deacetylation and FLC transcriptional silencing,
70 ranscription repression activity of Tet2 via histone deacetylation and for the prevention of constant
73 HA treatment suppressed the effects of PH on histone deacetylation and hepatocellular bromodeoxyuridi
74 y, HDAC3 activity is largely responsible for histone deacetylation and inflammatory responses of prim
76 alpha activity via indirect association with histone deacetylation and interaction with the basal tra
77 ed for microRNAs (miRs) that are affected by histone deacetylation and investigated the effects in he
83 g and demonstrate distinct contributions for histone deacetylation and nucleosome binding in the sile
86 Various genes controlling transcription, histone deacetylation and proteasome-mediated protein de
87 The two SANT motifs synergistically promote histone deacetylation and repression through unique func
88 itutively bind the latent HIV LTR and induce histone deacetylation and repressive changes in chromati
89 ollowed by iterative cycles of NAD-dependent histone deacetylation and spreading of SIR complexes ove
90 e analyses uncover a role for Asf1 in global histone deacetylation and suggest that HP1-associated hi
91 a local increase in chromatin remodeling and histone deacetylation and suppression of lymphoid cell-s
92 results of our study show that PML modulates histone deacetylation and that loss of this function in
93 gene expression screenings demonstrates that histone deacetylation and transcriptional dysregulation
95 as N-CoR, to its target promoter, leading to histone deacetylation and transcriptional repression.
96 se unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel com
97 tocin receptor, were dominantly regulated by histone deacetylation and were also frequently downregul
99 two deacetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of ge
103 cted by the inhibition of DNA methylation or histone deacetylation, and may thus involve other mechan
105 the contributions of nucleosome positioning, histone deacetylation, and Mediator interference in the
106 promoting H3K36 methylation, which leads to histone deacetylation, and preventing the 3' spread of H
107 echanisms involving negative feedback loops, histone deacetylation, and recognition of the cognate DN
108 results link the MRG family protein Alp13 to histone deacetylation, and suggest that Clr6 and its ass
111 rt a model in which cytosine methylation and histone deacetylation are each upstream of one another i
112 wide epigenetic modifications such as global histone deacetylation are essential for the binding of A
115 ures, including aberrant DNA methylation and histone deacetylation, are among the most prevalent modi
116 ata implicate inactive chromatin mediated by histone deacetylation as a critical component of ER gene
118 Silencing of the HLA class-I APM is due to histone deacetylation as inhibition of histone deacetyla
119 richostatin A, pharmacological inhibitors of histone deacetylation, as well as viral Ski protein, a d
121 Our data reveal that loss of FBP1 due to histone deacetylation associates with poor prognosis of
124 orward mechanism that promotes and maintains histone deacetylation at genomic sites of SMRT recruitme
125 eptor (LHR) gene is subject to repression by histone deacetylation at its promoter region, where a hi
126 We have also observed a distinct pattern of histone deacetylation at the donor locus during homologo
130 and seizures, in which it binds and triggers histone deacetylation at the promoter of the calbindin g
131 encing was influenced by DNA methylation and histone deacetylation because both 5-aza-2'-deoxycytidin
132 cing is enforced by cytosine methylation and histone deacetylation, but the initial discrimination me
133 onclude that the U(S)3 protein kinase blocks histone deacetylation by a mechanism distinct from that
135 hese results implicate the importance of non-histone deacetylation by HDAC9 and confirm and further e
139 n chromatin and ageing has mostly focused on histone deacetylation by the Sir2 family, but less is kn
142 d the Sfmbt2 gene followed the inhibition of histone deacetylation caused by glucose deprivation-indu
143 ctivity of the Sin3-Rpd3 complex, and excess histone deacetylation causes mitotic arrest in ess1 muta
144 lation is usually associated with triggering histone deacetylation, chromatin condensation, and gene
145 onent of the NuRD (Nucleosome Remodeling and Histone Deacetylation) co-repressor complex, and NuRD-me
146 sion of the Dleu2 promoter via inhibition of histone deacetylation combined with BSAP knockdown incre
147 a component of the nucleosome remodeling and histone deacetylation complex, is widely up-regulated in
149 r Rb and the NuRD (nucleosome remodeling and histone deacetylation) complex have been implicated in t
150 n ZMYND8 and NuRD (nucleosome remodeling and histone deacetylation) complex in the DNA damage respons
152 These data suggest that MSI1, HDA19, and HISTONE DEACETYLATION COMPLEX1 protein form a core compl
154 entiation and that mechanisms in addition to histone deacetylation contribute to activation of late g
155 itors, we show that both DNA methylation and histone deacetylation contribute to CFTR transcriptional
156 clusion in a subset of occluded genes, while histone deacetylation contributes to the implementation
157 deacetylation, we tested the hypothesis that histone deacetylation contributes to the maintenance of
158 tinct from that of ICP0 and that debilitated histone deacetylation contributes to the permissiveness
159 pigenetic modifications (DNA methylation and histone deacetylation), contributes in different ways to
160 we delineated a novel pathway through which histone deacetylation could contribute to CORT regulatio
161 rmacologic inhibition of DNA methylation and histone deacetylation, coupled with expression microarra
162 ion initiation timing supports the idea that histone deacetylation directly influences initiation tim
163 n-activated protein kinase, calcium flux, or histone deacetylation) do not significantly induce virus
164 o effect on XPc1 repression, suggesting that histone deacetylation does not form the basis for Pc-G-m
165 It appears that, unlike DNA methylation, histone deacetylation does not target the promoter, and
166 We have previously shown that, in rodents, histone deacetylation favors oligodendrocyte differentia
169 ated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stabi
170 results suggest that the domain of localized histone deacetylation generated by recruitment of Rpd3 m
171 repression through chromatin remodelling and histone deacetylation has been postulated to represent a
172 that global inhibition of DNA methylation or histone deacetylation has complex, nonredundant effects
174 ant CpG island promoter hypermethylation and histone deacetylation, have not been thoroughly investig
175 (SPB) is currently under investigation as a histone deacetylation (HDAC) inhibitor in Huntington dis
177 Significantly, these enzymes also catalyze histone deacetylation in a reaction that absolutely requ
178 t to understand how H3-K9 methylation led to histone deacetylation in both H3 and H4, we found that H
180 ciation allows OGT to act cooperatively with histone deacetylation in gene repression by catalyzing t
181 nd supports a central role of HDA-1-mediated histone deacetylation in heterochromatin spreading and g
182 es IL-6 transcription through HDAC1-mediated histone deacetylation in LPS-induced macrophages, acting
183 mmalian cells, and recent findings implicate histone deacetylation in methylation-mediated repression
185 a potential role for DNA methylation and/or histone deacetylation in negative regulation of hTERT.
186 richostatin A, suggesting the involvement of histone deacetylation in negative regulation of PSA prom
187 rmacologic inhibition of DNA methylation and histone deacetylation in non-small cell lung cancer (NSC
188 ion.SIGNIFICANCE STATEMENT The importance of histone deacetylation in normal brain functions and path
190 s, prompting an investigation of the role of histone deacetylation in replication timing control in S
191 dominance of methylation over TSA-sensitive histone deacetylation in silencing genes with a high CpG
192 notion of the dominance of methylation over histone deacetylation in silencing through CpG-rich sequ
193 ulators of differentiation through continual histone deacetylation in stem cells enables self-renewal
195 dditional evidence also suggested a role for histone deacetylation in the regulation of DsRed transge
200 demethylating drug 5-aza-2 deoxycytidine and histone deacetylation inhibiting drug trichostatin A.
203 ed RASSF1A expression, while exposure to the histone deacetylation inhibitor trichostatin A had no ef
204 methylating agent 5-aza-deoxycytidine and/or histone deacetylation inhibitor trichostatin A induced g
209 ion occurs in many cancers and inhibition of histone deacetylation is a promising approach to modulat
212 ptional repression activity, suggesting that histone deacetylation is involved in Dermo-1-mediated tr
214 of histones near silencers, we conclude that histone deacetylation is not sufficient for the full rec
216 er, which is repressed by TGF-beta, and that histone deacetylation is required for repression of Runx
218 s DNA-hypermethylated genes from those where histone deacetylation is responsible for transcriptional
220 P-dependent chromatin remodeling, as well as histone deacetylation, is needed for REST-mediated repre
222 ify HDC1 as a rate-limiting component of the histone deacetylation machinery and as an attractive too
224 transcriptional regulation and suggest that histone deacetylation may be important for the different
225 tion by DNA-binding repressors involves core histone deacetylation, mediated by their interaction wit
226 These data support a cooperative model for histone deacetylation, methylation, and DNA methylation
227 acetylation promotes transcription, whereas histone deacetylation negatively regulates transcription
228 component of the nucleosome remodelling and histone deacetylation (NuRD) complex - were viable but f
229 a component of the nucleosome remodeling and histone deacetylation (NuRD) complex that functions as a
230 that recruits the nucleosome remodeling and histone deacetylation (NuRD) complex to damaged chromati
231 , a subunit of the nucleosome remodeling and histone deacetylation (NuRD) complex, at a subset of HDA
232 a component of the nucleosome remodeling and histone deacetylation (NuRD) complex, is widely upregula
237 associate with the nucleosome remodeling and histone deacetylation (NuRD) transcriptional repression
238 ity underscores the cellular imperative that histone deacetylation occur only in targeted regions of
240 recipitation assays, it is demonstrated that histone deacetylation occurs at the chromatin region of
241 ncing, accompanied by partial Sir2-dependent histone deacetylation, occurs independently of Sir3 and
242 pRb represses the cyclin E promoter through histone deacetylation of a single nucleosome, to which i
245 in repression is due to a failure to mediate histone deacetylation of ribonucleotide reductase, dihyd
247 action leads to preferential association and histone deacetylation of the 3' portions of coding regio
248 irpin RNA indicate that HDAC3 is involved in histone deacetylation of the Il12b promoter by IL-10.
253 Repression by prohibitin correlates with histone deacetylation on promoters and this was reversed
255 tion of miR-193b-3p expression was caused by histone deacetylation on the miR-193b-3p promoter in the
256 ribed but repressed by REST independently of histone deacetylation or DNA methylation and does not co
258 d telomeric DNA, but not by DNA methylation, histone deacetylation, or histone trimethylation at telo
259 Treatment of cells with an inhibitor of histone deacetylation, or transient transfection with co
260 We questioned whether DNA methylation and histone deacetylation overlap in the regulation of endog
264 rtuins catalyze a well characterized protein/histone deacetylation reaction, there are a number of re
268 pressed by an epigenetic mechanism involving histone deacetylation, resulting in increased PGE2 activ
270 tic signal that inhibits gene transcription, histone deacetylation similarly represses transcription
271 pa3' enhancer and experimental inhibition of histone deacetylation suggest changes therein may determ
272 ovide a molecular framework of NAD-dependent histone deacetylation that connects metabolism, genomic
273 lexes to promoters and generating domains of histone deacetylation that extend over a limited number
274 iptional repression is associated with local histone deacetylation that is reversed by the presence o
276 l evidence linking nucleosome remodeling and histone deacetylation to methylated gene silencing.
277 NAc modification, which acts in concert with histone deacetylation to promote gene silencing in an ef
284 associated with the RI gene, suggesting that histone deacetylation was involved in the transcriptiona
285 rtially relieved repression, suggesting that histone deacetylation was necessary but not sufficient f
288 rivative MS-27-275 (MS-275), an inhibitor of histone deacetylation, was evaluated in a series of pedi
289 lase 1 (HDAC1), a major HDAC responsible for histone deacetylation, was shown to interact with maspin
290 mal deposition at the core promoter, but not histone deacetylation, was the cause of transcriptional
291 possibly interfere with DNA methylation and histone deacetylation, we attempted to maintain and expa
292 ional regulation by DNA methylation involves histone deacetylation, we explored whether differences i
294 hase experiments indicated that the rates of histone deacetylation were similar in all cell lines.
295 ir2) enzymes catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the l
296 ion at the MMTV promoter nor does it inhibit histone deacetylation, which accompanies deactivation of
297 dinates G1-specific chromatin remodeling and histone deacetylation with the DNA replication initiatio
300 d that succeeding nucleosomal remodeling and histone deacetylation worked in parallel to establish th
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