ライフサイエンスコーパス: histone demethylase

1 t Fbxl10 is rather a H3K4me3 than a H3K36me2 histone demethylase.

2 to be a potent inhibitor of a host cellular histone demethylase.

3 that includes two orthologs of human Lsd1, a histone demethylase.

4 ecently identified human lysine (K)-specific histone demethylase.

5 histone demethylation by the JMJD2 family of histone demethylases.

6 Ni-induced inhibition of the JMJD2 family of histone demethylases.

7 ule inhibitor of Jumonji C domain-containing histone demethylases.

8 n-containing proteins are generally known as histone demethylases.

9 e dioxygenases, including the jumonji-domain histone demethylases.

10 and the Msc1 protein related to a family of histone demethylases.

11 h recent findings that many Jmj proteins are histone demethylases.

12 d irreversible until the recent discovery of histone demethylases.

13 evolutionarily conserved signature motif for histone demethylases.

14 activities of histone methyltransferases and histone demethylases.

15 methyltransferases and the newly discovered histone demethylases.

16 ydroxyglutarate caused inhibition of several histone demethylases.

17 (HDAC), histone methyltransferases (HMT) and histone demethylases.

18 as unclear whether any of them functioned as histone demethylases.

19 catalytic activity of JmjC-domain containing histone demethylases.

20 rogenase (ALDH) activity and upregulation of histone demethylases.

21 n and chromatin remodeling at CpG islands by histone demethylases.

22 transcription factor (REST)-lysine-specific histone demethylase 1 (LSD1) co-repressor complex associ

23 urthermore, we find that the lysine-specific histone demethylase 1 (LSD1), the protein arginine N-met

24 e, histone deacetylases, and lysine-specific histone demethylase 1) are additionally involved as a co

25 an Arabidopsis JHDM2 (JmjC domain-containing histone demethylase 2) family protein, which modulates d

26 c demethylase JHDM2A (JmjC-domain-containing histone demethylase 2A, also known as JMJD1A) is essenti

27 t JHDM3A (jumonji C (JmjC)-domain-containing histone demethylase 3A; also known as JMJD2A) is capable

28 This targeted processing triggers localized histone demethylase activity and results in reduced FLC

29 s et al. reveal key roles for transient LSD1 histone demethylase activity in activation of a single o

30 of aberrant development can be initiated by histone demethylase activity in developing sperm, withou

31 These studies link RBP2 histone demethylase activity to tumorigenesis and nomina

32 A JmjC-dependent histone demethylase activity was exhibited by NO66, whic

33 JMJD1A (wild type or mutant lacking histone demethylase activity) bound to HUWE1, attenuated

34 ring conserved domains critical for putative histone demethylase activity.

35 umonji C domain, but is devoid of detectable histone demethylase activity.

36 ntaining proteins have been shown to possess histone demethylase activity.

37 trimethylated peptides and determination of histone demethylase activity.

38 The Jumonji C (JmjC)-domain-containing histone demethylases also require ascorbate as a cofacto

39 ced synthesis and recruitment of a repressor histone demethylase, alter the chromatin configuration o

40 ha; however, they are dependent on the KDM4A histone demethylase and are blocked by inhibition of KDM

41 not only reveal an intimate link between the histone demethylase and deacetylase enzymes but also ide

42 2 protein so that the proper balance between histone demethylase and histone methyltransferase activi

43 rmline variants in JMJD1C, which codes for a histone demethylase and is a coactivator of the androgen

44 Thus, our work identifies a histone demethylase and links its function to hormone-de

45 ggesting an inverse correlation between NO66 histone demethylase and the activity of IGF1R/Akt signal

46 However, the roles of histone demethylases and activating histone modification

47 ly of DNA demethylases and Jumonji family of histone demethylases and cause epigenetic changes that l

48 nhibit alpha-KG-dependent enzymes, including histone demethylases and DNA hydroxylases, potentially l

49 The mRNA of several histone demethylases and methyltransferases was also dif

50 dentified three novel JmjC domain-containing histone demethylases and their sites of action in buddin

51 escribed here will be useful for identifying histone demethylases and their target sites in other org

52 ng hypoxia inducible factor hydroxylases and histone demethylases, and K(D) values were determined fo

53 We show that mammalian JmjC-domain histone demethylases are also vulnerable to succinate in

54 In addition to HIFs, multiple histone demethylases are altered in their expression and

55 The KDM4 histone demethylases are conserved epigenetic regulators

56 We demonstrate that these histone demethylases are direct HIF targets, and their u

57 -specific demethylase 4 (KDM4) A-D family of histone demethylases are dysregulated in several types o

58 The jumonji (JMJ) family of histone demethylases are Fe2+- and alpha-ketoglutarate-d

59 Jmj domain-containing histone demethylases are involved in gene expression in

60 known about how the catalytic activities of histone demethylases are regulated.

61 During developmental transitions, histone demethylases are required to dramatically alter

62 Histone demethylases are the most recent family of histo

63 n and serotonin signalling, identifying this histone demethylase as a potential target for the treatm

64 uggest a novel pharmacologic basis to target histone demethylases as an indirect MYC-targeting approa

65 ancer Cell, Mohammad et al. describe LSD1, a histone demethylase, as a therapeutic target in SCLC wit

66 in histone deacetylase 1/2 (HDAC1/2) and the histone demethylase BHC110 (LSD1).

67 r domain of JMJD2A, a Jmjc domain-containing histone demethylase, binds methylated histone H3-K4 and

68 rated in Saccharomyces cerevisiae, which has histone demethylases but not DNA methylases or demethyla

69 stinct classes of E3 ubiquitin ligases and a histone demethylase by BCOR suggests that BCOR uses a un

70 Flavin-dependent histone demethylases catalyze the posttranslational oxid

71 scription factor corepressor 1 (LSD1/CoREST) histone demethylase complex interacts with BCL11A and is

72 The LSD1-CoREST histone demethylase complex is required to repress neuro

73 The LSD1 (also known as KDM1A) histone demethylase complex modifies chromatin and repre

74 Here, we show that TAL1 is associated with histone demethylase complexes containing lysine-specific

75 Rph1 is a histone demethylase containing a Jumonji C (JmjC) domain

76 Recent discoveries of histone demethylases demonstrate that histone methylatio

77 y effects of Jmjd3 are produced through both histone demethylase-dependent and -independent pathways.

78 BHC110/LSD1 was the first histone demethylase described to reverse dimethyl histon

79 Enzymes termed histone demethylases directly remove the methyl marks fr

80 Here, we examine these and related facets of histone demethylases discovered to date, focusing on the

81 nteraction between Drosophila HP1a and H3K36 histone demethylase dKDM4A reported in this issue of Mol

82 Temporally, AA-dependent histone demethylase effects are important early, whereas

83 L) effector repeat domains fused to the LSD1 histone demethylase efficiently remove enhancer-associat

84 Drosophila testis niche an H3K27me3-specific histone demethylase encoded by Ubiquitously transcribed

85 We show that the histone demethylase enzyme Kdm5b (Jarid1b) negatively re

86 repressor implicated in breast cancer, as a histone demethylase enzyme that has the ability to rever

87 The discovery of histone demethylase enzymes capable of directly removing

88 able modification, but the identification of histone demethylase enzymes has demonstrated the reversi

89 o be irreversible, but the identification of histone demethylase enzymes has revealed that this modif

90 The most extensive family of histone demethylase enzymes identified so far contains a

91 Mutations in genes encoding histone demethylase enzymes were identified as cofactors

92 However, inactivation of the putative histone demethylase Epe1 allows H3K9 methylation and sil

93 We suggest that, rather than being a histone demethylase, Epe1 may be a protein hydroxylase t

94 w-cycling cells with high Notch activity and histone demethylase expression are present in primary gl

95 tion of emerging targeted inhibitors of this histone demethylase family in cancer therapy.

96 r model for substrate selection by the JMJD2 histone demethylase family.

97 d member of the JHDM (JmjC domain-containing histone demethylase) family.

98 d member of the JHDM (JmjC-domain-containing histone demethylase) family.

99 d knockdown of the jumonji domain-containing histone demethylase fbxl10/kdm2bb, a repressor of riboso

100 n 66 (NO66), the Jumonji C-domain-containing histone demethylase for methylated histone H3K4 and H3K3

101 findings indicate that a general function of histone demethylases for H3 Lys(36) is to promote transc

102 re, we use a nuclease-deficient Cas9 (dCas9)-histone demethylase fusion to functionally characterize

103 ruitment of OCT4 to the promoter of Kdm2b, a histone demethylase gene that promotes reprogramming by

104 Recent studies have shown that the histone demethylase genes JMJD1A, JMJD2B, and JARID1B ar

105 ripts involving histone methyltransferase or histone demethylase genes were detected in 111 samples (

106 Although an increasing number of histone demethylases have been identified and biochemica

107 Histone demethylases have been shown to play a key role

108 is conserved among a family of proteins with histone demethylase (HDM) activity.

109 umber of histone methyltransferase (HMT) and histone demethylase (HDM) enzymes as regulators of ER si

110 was recently identified as the major H3K4me3 histone demethylase (HDM) in Saccharomyces cerevisiae.

111 rs, including chromatin-associated proteins, histone demethylases (HDMs) and methyltransferases.

112 The JumonjiC (JmjC)-containing histone demethylases (HDMs) catalyze the demethylation o

113 The roles of histone demethylases (HDMs) in these programs are incomp

114 The histone demethylase IBM1 suppresses DNA methylation and

115 known as Ndy1, FBXL10, and JHDM1B), an H3K36 histone demethylase implicated in bypass of cellular sen

116 Our studies establish Jhd1 as a histone demethylase in budding yeast and suggest that Jh

117 east cancer and targeted inhibition of GASC1 histone demethylase in cancer could provide potential ne

118 shed light on the biological functions of a histone demethylase in vivo.

119 functions of histone methyltransferases and histone demethylases in AML, especially MLL-rearranged l

120 nale to support the therapeutic targeting of histone demethylases in breast cancer patients.

121 he evidence strongly supports a key role for histone demethylases in eukaryotic transcription and oth

122 ver a conserved role for the JMJD2 family of histone demethylases in promoting replication within sil

123 s unique among the Jumonji domain-containing histone demethylases in that there is an atypical insert

124 estion of the conservation of this family of histone demethylases in the oyster.

125 36 is linked to transcription, the roles of histone demethylases in transcription regulation are not

126 hibits the activity of the Jumonji family of histone demethylases in vitro, in cancer cells, and in t

127 e complexity of functional interplay between histone demethylases in vivo, providing insights into th

128 cer of zeste 2 and mixed lineage leukemia 2, histone demethylases including ubiquitously transcribed

129 Ciclopirox targeted several histone demethylases, including KDM4B implicated in MYC

130 one code, imposes a requirement for specific histone demethylases, including LSD1, to permit ligand-

131 e expression of RBP2 and other JARID1 family histone demethylases, including PLU-1, SMCX, and LSD1, v

132 activating H3K4 methylation is catalyzed by histone demethylases, including the Jumonji C (JmjC) KDM

133 The Jmj family was identified as histone demethylases, indicating epigenetic regulation b

134 now demonstrate that the overexpression of a histone demethylase induces transient copy gain of speci

135 Here we show that multiple histone demethylases influence the viability and poor pr

136 Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the t

137 Hence, histone demethylase inhibitor-based therapy may represen

138 e antifungal agent ciclopirox as a novel pan-histone demethylase inhibitor.

139 Conversely, treatment with histone demethylase inhibitors increases heterochromatin

140 his screen, we identified several known JmjC histone demethylase inhibitors, including 2,4-pyridinedi

141 GASC1 is a histone demethylase involved in the deregulation of hist

142 ity of the double tudor domain of hJMJD2A, a histone demethylase involved in transcriptional repressi

143 gulation of p21(WAF-1), suggesting that this histone demethylase is involved in the priming of the p2

144 The KDM4/JMJD2 family of histone demethylases is amplified in human cancers.

145 JMJD3, a histone demethylase, is simultaneously recruited to thes

146 1, a member of the Jarid1 family of putative histone demethylases, is required for chromosome stabili

147 g activity of histone-methyltransferases and histone-demethylases, is, however, not well understood.

148 d transcriptional complex also recruited the histone demethylase JARID1B and histone deacetylase HDAC

149 Controlled by the histone demethylase JARID1B, MANTIS was downregulated in

150 y exon-array analysis after knockdown of the histone demethylase JARID1B.

151 For example, the histone demethylase JARID1C is frequently inactivated in

152 in sulfur metabolism, and alphaKG-dependent histone demethylase Jhd1.

153 ne methytransferases (Dot1 and Set1) and one histone demethylase (Jhd2) to the dynamics of silencing.

154 H3K4 mono- and trimethylation) and two yeast histone demethylases, Jhd2 and Rph1, which were previous

155 ive inhibitor of jumonji C domain-containing histone demethylases (JHDMs).

156 ongs to the JmjC domain-containing family of histone demethylases (JHDMs).

157 ition, we show that PBAF cooperates with the histone demethylase, JMJC-1/NO66, to promote expression

158 Using histone demethylase JMJD1A and DNA repair enzyme ABH2 as

159 The messenger RNA that encodes the histone demethylase JMJD1A is a direct target of miR-627

160 The histone demethylase JMJD1A, which controls gene expressi

161 complex consisting of LANA and the H3K9me1/2 histone demethylase JMJD1A/KDM3A.

162 Here we demonstrate that the histone demethylase JMJD1C functions as a coactivator fo

163 ion of Lgr4 down-regulated the expression of histone demethylases Jmjd2a and Fbxl10 through cAMP-CREB

164 recruitment of histone methylase (COMPASS)-, histone demethylase (Jmjd2a/Jmjd3)-, and SWI/SNF-contain

165 tment of the transcription factor RelA and a histone demethylase, JMJD2A.

166 Here, we show the histone demethylase JMJD2B is regulated by both ERalpha

167 t systems for the double Tudor domain of the histone demethylase JMJD2C.

168 tivator activating signal cointegrator-2 and histone demethylase JMJD2d participated in this CAR-depe

169 ved deubiqutination and stabilization of the histone demethylase Jmjd2d.

170 the ES cell factor Tbx3 associates with the histone demethylase Jmjd3 at the enhancer element of the

171 The present report documents that the histone demethylase JMJD3 is an activating transcription

172 ration alone transiently increased the H3K27 histone demethylase Jmjd3, persistently increased bone m

173 The JmjC domain-containing H3K4 histone demethylase jumonji AT-rich interactive domain 1

174 We report that the histone demethylase jumonji domain containing protein 2C

175 Here, we investigated the influence of the histone demethylase Jumonji/ARID1 B (JARID1B) on miR reg

176 microarray experiments, we have identified a histone demethylase, jumonji domain containing 5 (JMJD5)

177 The histone demethylase, JumonjiD2A (JmjD2A/KDM4A), is expre

178 several histone methyltransferases (KMT) and histone demethylases (KDM) that mediate histone methylat

179 PELP1 interactions with histone demethylase KDM1 play a critical role in its onc

180 of NOTCH ICD, RBPJ recruits L3MBTL3 and the histone demethylase KDM1A (also known as LSD1) to the en

181 H3K4me2 at each promoter via recruitment of histone demethylase KDM1A.

182 ferases (DAC), histone deacetylases (Depsi), histone demethylases (KDM1A inhibitor S2101), and histon

183 We previously demonstrated that the histone demethylase KDM2A is specifically recruited to C

184 Here, we identified histone demethylase KDM2B as a critical regulator of def

185 contains the BCL6 co-repressor BCOR and the histone demethylase KDM2B.

186 Sustained expression of the histone demethylase, KDM2B (Ndy1/FBXL10/JHDM1B), bypasse

187 K1 interacts with the estrogen receptor (ER)/histone demethylase KDM3A (JHDM2a) complex, which modifi

188 Our studies further identify the H3K9me1/2 histone demethylase KDM3A (JMJD1A/JHDM2A) as a new miR-2

189 Together, our studies identify the histone demethylase KDM3A as a new, miR-regulated, tumor

190 onal pathway in Ewing Sarcoma, involving the histone demethylase KDM3A, previously identified by our

191 hich is in part through association with the histone demethylase KDM3A.

192 In conditions where the histone demethylase KDM4A is depleted or inactive, H3K9m

193 Up-regulation of the histone demethylase KDM4A promotes transient site-specif

194 Here we report that histone demethylase KDM4A/JMJD2A, which is involved in t

195 We report that histone demethylase KDM4B is dynamically expressed durin

196 e have determined that the hypoxia-inducible histone demethylase KDM4B is expressed in approximately

197 This effect appeared to be mediated by the histone demethylase KDM4C (Figure 4D).

198 n natural variation in the gene encoding the histone demethylase, KDM4C, which promotes transcription

199 Previously, we identified the histone demethylase KDM5A (lysine [K]-specific demethyla

200 In this issue, Gong et al. identify the histone demethylase KDM5A as a critical editor of the ce

201 s study, we report the identification of the histone demethylase KDM5A as a key regulator of the brom

202 unction, cobound by the MYC oncogene and the histone demethylase KDM5A.

203 reduced expression of CDK inhibitors and the histone demethylase KDM5A.

204 PARylation, inhibition, and exclusion of the histone demethylase KDM5B; and (2) promoting the exclusi

205 r GSCs upregulate, and are dependent on, the histone demethylases KDM6A/B.

206 The JmjC histone demethylases (KDMs) are linked to tumour cell pr

207 nes by protein methyltransferases (PMTs) and histone demethylases (KDMs) play an important role in th

208 of the worm ortholog of LSD-1 (T08D10.2), a histone demethylase; knockdown by RNA interference of T0

209 hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and

210 ghts a finely tuned mechanism for regulating histone demethylase levels and emphasizes the need to ti

211 ditionally identified factors, including the histone demethylase little imaginal discs and histone-in

212 nd with their discovery of a lysine-specific histone demethylase (LSD 1).

213 s further OR activation by down-regulating a histone demethylase Lsd1 (also known as Aof2 or Kdm1a),

214 In vivo, histone demethylase LSD1 (KDM1; BCH110) is a component o

215 1 physically interacts with and recruits the histone demethylase LSD1 (KDM1A) to epithelial gene prom

216 ys that read out enzymatic inhibition of the histone demethylase LSD1 (lysine-specific demethylase 1)

217 be functions of epigenetic enzymes including histone demethylase LSD1 and histone acetyltransferase T

218 ere, we identify the transient expression of histone demethylase LSD1 and the OR-dependent expression

219 cells, Esrrb interacts in TS cells with the histone demethylase Lsd1 and with the RNA Polymerase II-

220 oter that is under the control of Rb and the histone demethylase LSD1 in multiple latency types.

221 epression of hepatic autophagy by recruiting histone demethylase LSD1 in response to a late fed-state

222 Thus, our data revealed that histone demethylase LSD1 may negatively regulate SALL4-m

223 1 or MLL1 histone methyltransferases and the histone demethylase LSD1 to promote the installation of

224 t SUMO-1, and CoREST1 bridges binding of the histone demethylase LSD1 to SUMO-2.

225 kage of the TGFbeta pathway or inhibition of histone demethylase LSD1 with small molecule inhibitors

226 The histone demethylase LSD1, a component of the CoREST (cor

227 t among these is the corepressor CoREST, the histone demethylase LSD1, and HDACs 1 and 2.

228 omplex with HDAC1 and HDAC2, mSin3a, and the histone demethylase LSD1, suggesting that it is a compon

229 ich forms a complex with the lysine-specific histone demethylase LSD1.

230 modification produced by the lysine-specific histone demethylase LSD1.

231 entiated cells, here we inducibly delete the histone demethylase LSD1/KDM1A in adult mice.

232 We report a role for the histone demethylase LSD1/KDM1A in the DNA damage respons

233 In this issue, Katz et al. show that the histone demethylase Lsd1/Spr-5 may participate in this r

234 cetylases (HDAC8, Sir2Tm, and SIRT1) and the histone demethylase, LSD1.

235 The recently identified histone demethylase lysine-specific demethylase 1 (LSD1)

236 talytic domain of the flavin-dependent human histone demethylase lysine-specific demethylase 1 (LSD1)

237 Here we show that the histone demethylase lysine-specific demethylase 1 (LSD1;

238 Histone demethylases, members of a newly emerging transc

239 We further show that in UTX H3K27 histone demethylase mutant embryos, these genes are even

240 ly recently, with the discovery of the first histone demethylase nearly five years ago.

241 here elevated PRL-3 protein increases JMJD2C histone demethylase occupancy on Leo1 promoter, thereby

242 2E3 loss promotes the recruitment of LSD1, a histone demethylase of histone 3 lysine 4 di-methylation

243 an affect gene expression through inhibiting histone demethylases, orthologous mutations to those kno

244 prolyl hydroxylases, JmjC domain-containing histone demethylases (part of the JMJD family) and the t

245 gers epigenetic reprogramming of TICs by the histone demethylase PHF2, which promotes their different

246 ieved by NF-kappaB-dependent delivery of the histone demethylase PHF2.

247 We identified the histone demethylase PHF8 as a coactivator that is specif

248 The histone demethylase PHF8 has been implicated in multiple

249 Histone demethylase PHF8 is upregulated and plays oncoge

250 Here we report that the KDM3 family of histone demethylases plays an important role in tumorige

251 ifferent environmental cues, suggesting that histone demethylase protein levels must be tightly regul

252 Rph1 is a histone demethylase protein, but it regulates autophagy

253 However, the discovery of histone demethylases raises questions about the stabilit

254 an altered chromatin state that requires the histone demethylase RBP2/KDM5A/Jarid1A.

255 demonstrated that inhibitors of H3K9me2/me3 histone demethylases reduce the ability of HSV-1 to reac

256 he first demonstration that a Jumonji-domain histone demethylase regulates cellular processes require

257 ne (K)-specific demethylase (LSD1) family of histone demethylases regulates chromatin structure and t

258 that LSD1 (lysine-specific demethylase 1), a histone demethylase, regulates brown adipocyte metabolis

259 The KDM5 family of histone demethylases removes the H3K4 tri-methylation (H

260 ly oogenesis, through depletion of the dKDM5 histone demethylase, results in the temporal deregulatio

261 we identify a second JmjC-domain-containing histone demethylase, Rph1, which can specifically demeth

262 The family of KDM4A-D histone demethylases selectively demethylates H3K9 and H

263 So far, all characterized histone demethylases show enzymatic activity towards lys

264 contains a JmjC domain recently defined as a histone demethylase signature motif.

265 a signature motif found in a large family of histone demethylases spanning many organisms.

266 a unique role for the Caenorhabditis elegans histone demethylase SPR-5 in meiotic DNA double-strand b

267 Gene expression levels of various histone demethylases, such as the JARID1 family, show di

268 KDM5C encodes a histone demethylase, suggesting that alterations in chro

269 The recent discovery of a large number of histone demethylases suggests a central role for these e

270 ny enzymes, including JmjC domain-containing histone demethylases, TET 5-methylcytosine hydroxylases,

271 , these antibiotics inhibited jumonji domain histone demethylases, TET DNA demethylases, and collagen

272 KDM6B (also known as JMJD3) is a histone demethylase that might activate gene expression

273 LSD1 is a flavin-dependent histone demethylase that oxidatively removes methyl grou

274 he function of LSD1 in AD and FTD."LSD1 is a histone demethylase that plays many roles during develop

275 noblastoma binding protein RBP2 (KDM5A) is a histone demethylase that promotes gastric cancer cell gr

276 that VRS3 encodes a putative Jumonji C-type histone demethylase that regulates expression of other V

277 Jarid1b/KDM5b is a histone demethylase that regulates self-renewal and diff

278 LSD1 is a lysine-specific histone demethylase that represses transcription by deme

279 (LSD1) was recently identified as the first histone demethylase that specifically demethylates monom

280 hd1, has recently been identified as being a histone demethylase that targets H3K36 modified in the d

281 KDM4A is a histone demethylase that targets tri- and dimethylation

282 JARID1 proteins are histone demethylases that both regulate normal cell fate

283 viral gene induction occurs independently of histone demethylases that remove repressive lysine modif

284 Lsd1 was the first histone demethylase to be identified.

285 r results indicate that JMJ27 functions as a histone demethylase to modulate both physiological (defe

286 y alpha-KG-dependent dioxygenases, including histone demethylases, to cause broad histone hypermethyl

287 Histone demethylase upregulation has been observed in hu

288 The X chromosome-encoded histone demethylase UTX (also known as KDM6A) mediates r

289 Here we found that the H3K27me3 histone demethylase UTX was an essential cell-intrinsic

290 complex 2 (PRC2), and identify the conserved histone demethylase UTX-1 as a crucial GLP-1/Notch targe

291 ic amount of JmjC domain-containing putative histone demethylase UTX.

292 GSK-J4, a specific inhibitor of the H3K27me3 histone demethylases UTX and JMJD3, inhibits HSV-1 react

293 gested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically t

294 main containing 1A (JMJD1A), which encodes a histone demethylase, was found to be a target of miR-627

295 Recently, histone demethylases were found to play important roles

296 se enzymes, KDM6B formally known as JMJD3, a histone demethylase, which removes the trimethyl mark fr

297 s examples, we show that the JMJD2 family of histone demethylases, which are products of putative onc

298 Jumonji (Jmj) proteins are histone demethylases, which control the identity of stem

299 PHF8 is a histone demethylase with specificity for repressive modi

300 Our findings identified a novel S. pombe histone demethylase with specificity toward di- and trim