ライフサイエンスコーパス: histone methyltransferase

1 n) and enhancer of zeste homolog 2 (EZH2) (a histone methyltransferase).

2 thus potentially connecting PRC2 to another histone methyltransferase.

3 U(Z)12 assembly with E(Z) and stimulation of histone methyltransferase.

4 thermophila, we identified TXR1, encoding a histone methyltransferase.

5 cific inhibitor (BIX-01294) of the human G9a histone methyltransferase.

6 cence-associated down-regulation of the EZH2 histone methyltransferase.

7 ities are determined by PRDM9, a DNA-binding histone methyltransferase.

8 teracts with a complex containing repressive histone methyltransferases.

9 ghting regulatory specificity for MLL family histone methyltransferases.

10 aining family, calcium channel subunits, and histone methyltransferases.

11 n, and these effects are distinct from other histone methyltransferases.

12 gh selectivity (>4500-fold) over three other histone methyltransferases.

13 tion 3-9-homologous (SUVH) group of putative histone methyltransferases.

14 bryonic fibroblasts (MEFs) lacking key H4K20 histone methyltransferases.

15 -bond and/or have steric repulsion for other histone methyltransferases.

16 = 6 nM) with broad selectivity against other histone methyltransferases.

17 st a universal regulation mechanism for most histone methyltransferases.

18 TOR pathway effectors, SWI/SNF subunits, and histone methyltransferases.

19 interacts with and activates all MLL family histone methyltransferases.

20 ations or deletions of the human Euchromatin Histone Methyltransferase 1 (EHMT1) gene are the main ca

21 caused by haploinsufficiency of euchromatic histone methyltransferase-1 (EHMT1).

22 The euchromatin histone methyltransferase 2 (also known as G9a) methylat

23 the SETD1A gene, which encodes a subunit of histone methyltransferase, a finding unlikely to have oc

24 ion of AKT enhances the activity of the EZH2 histone methyltransferase, a subunit of the epigenetic r

25 Although SUVH2 and SUVH9 resemble histone methyltransferases, a crystal structure reveals

26 function to EZH2 that is independent of its histone methyltransferase activity and reconcile how EZH

27 Silencing EZH2 or inhibiting its histone methyltransferase activity conferred increased a

28 presence of a PRDI-BF1-RIZ1 (PR) domain with histone methyltransferase activity in the ME isoform.

29 ons tested and the EED mutation reduced PRC2 histone methyltransferase activity in vitro, demonstrati

30 riguingly, ectopic EZH2 mutant deficient for histone methyltransferase activity is also able to confe

31 Importantly, catalytic inactivation of the histone methyltransferase activity of MLL3 also severely

32 Recent studies suggest that the histone methyltransferase activity of MMSET plays an imp

33 d (btd) locus in an active state through the histone methyltransferase activity of the SET1/MLL compl

34 itylation of histone 2B lysine 34 stimulates histone methyltransferase activity on nucleosomes, a fin

35 ammalian homolog, DOT1L (DOT1-Like), possess histone methyltransferase activity toward histone H3 Lys

36 at exhibited Ras-mediated dependence on PRC2 histone methyltransferase activity, a finding that is si

37 In vitro, both noncoding RNAs inhibit PRC2 histone methyltransferase activity, but, in vivo, only t

38 at they are only partially dependent on EZH2 histone methyltransferase activity.

39 nd H3K36 methylation by interfering with the histone methyltransferase activity.

40 d plays an important role in CSR through its histone methyltransferase activity.

41 selective aminonucleoside inhibitor of DOT1L histone methyltransferase activity.

42 x 2 (PRC2), silences gene expression via its histone methyltransferase activity.

43 mediated gene repression, which requires its histone methyltransferase activity.

44 e capability of clemastine in elevating H3K9 histone methyltransferases activity in cultured primary

45 ve interaction of the tail peptides with G9a histone methyltransferase and histone deacetylase 1 (HDA

46 udy reveals the alteration of WNT, hedgehog, histone methyltransferase and now N-CoR pathways across

47 IRT1 transcription recruits the Set2 histone methyltransferase and the Set3 histone deacetyla

48 abolism can alter the expression of specific histone methyltransferases and acetyltransferases confer

49 unction mutations to inhibit a wide range of histone methyltransferases and are thought to promote tu

50 binding protein 2, histone deacetylases, and histone methyltransferases and demethylase in the fronta

51 Dysregulated expression of histone methyltransferases and demethylases is an emergi

52 lymerase chain reaction array, we found that histone methyltransferases and demethylases that regulat

53 ebellum; no changes in histone deacetylases, histone methyltransferases and demethylases, or methyl C

54 regulation that is dynamically modulated by histone methyltransferases and demethylases.

55 It interacts with histone methyltransferases and facilitates their recruit

56 le, we will review the emerging functions of histone methyltransferases and histone demethylases in A

57 is mediated by the counteracting activity of histone-methyltransferases and histone-demethylases, is,

58 Growing evidence suggests that histone methyltransferases are associated with the devel

59 ease the catalytic activity of EZH2 and NSD2 histone methyltransferases are found in distinct subsets

60 Although histone methyltransferases are key epigenetic regulators

61 ing epigenetic landscapes in organisms where histone methyltransferases are uncharacterized.

62 its coactivator, the mixed-lineage leukemia histone methyltransferase, are recruited to the BRCA1, R

63 (SET domain, bifurcated 1), an H3K9-specific histone methyltransferase, as the most significantly up-

64 cilitates the binding of the trithorax group histone methyltransferases ASH1 and TRX to active genes,

65 mice carrying a hypomorphic mutation of the histone methyltransferase Ash1l [(absent, small, or home

66 Here, we took advantage of an in vitro histone methyltransferase assay employing a reconstitute

67 , including HP1, the NuRD complex, H2A.Z and histone methyltransferases at the DSB.

68 eins, including histone deacetylases (HDAC), histone methyltransferases, bromodomain-containing prote

69 tro indicating that PRDM9 is a highly active histone methyltransferase catalyzing mono-, di-, and tri

70 lation of histone H3 at lysine 9 (H3K9) by a histone methyltransferase, Clr4.

71 tes: an "off state" mediated by the polycomb histone methyltransferase complex and a histone acetyltr

72 The histone methyltransferase complex PRC2 controls key step

73 nd nascent RNAs in the nucleus and recruit a histone methyltransferase complex that catalyzes chromat

74 MEN1, which encodes menin, a component of a histone methyltransferase complex, and 43% had mutations

75 promoter by CFP1, a component of the COMPASS histone methyltransferase complex, and promoter-specific

76 omponent of the mixed-lineage leukemia (MLL) histone methyltransferase complex, and transcription fac

77 P complex that regulate the function of this histone methyltransferase complex.

78 ses in Ash2l mRNA, encoding a component of a histone methyltransferase complex.

79 WDR5 proteins are conserved components of histone methyltransferase complexes normally associated

80 s affect alternative exon usage by targeting histone methyltransferase complexes to form localized fa

81 alian Dpy-30, a core subunit of the SET1/MLL histone methyltransferase complexes, modulates H3K4 meth

82 ate independently of its established role in histone methyltransferase complexes.

83 of zeste homolog 2 (EZH2), which encodes the histone methyltransferase component of the polycomb repr

84 atalyzed, respectively, by a conserved SUV39 histone methyltransferase, DIM-5, and a DNMT1-like cytos

85 sing small-molecule inhibitors targeting the histone methyltransferase disruptor of telomeric silenci

86 target genes in part via recruitment of the histone methyltransferase DOT1L (disruptor of telomeric

87 Specifically, inhibition of the H3K79 histone methyltransferase DOT1L by shRNA or a small mole

88 Histone methyltransferase Dot1L is a coactivator for thy

89 inhibitor studies have demonstrated that the histone methyltransferase DOT1L is required for the deve

90 t MLL-AF6 requires continued activity of the histone-methyltransferase DOT1L to maintain expression o

91 Histone methyltransferase, DOT1L, is also up-regulated b

92 indings strongly support the contention that histone methyltransferase, DOT1L-associated epigenetic c

93 , H2AK119ub and H2BK120ub, and two important histone methyltransferases, Dot1L and PRC2.

94 imals, the HDAC2-dependent downregulation of histone methyltransferase Ehmt2 (G9a) led to the loss of

95 with RA and coactivator Rere/Atrophin2 and a histone methyltransferase Ehmt2 to regulate embryonic sy

96 We also identify the Rere-binding histone methyltransferase Ehmt2/G9a, as a RA coactivator

97 product H3K27me3, a process catalyzed by the histone methyltransferase enhancer of zeste homolog 2 (E

98 ls and activity of the epigenetic repressor, histone methyltransferase enhancer of zeste homolog 2 (E

99 is epigenetically controlled by the polycomb histone methyltransferase enhancer of zeste homolog 2 (E

100 Inactivating mutations in histone methyltransferase enhancer of zeste homolog 2 (E

101 The histone methyltransferase Enhancer of Zeste Homolog 2 (E

102 Here, we investigated the function of the histone methyltransferase enzyme enhancer of zeste homol

103 zyme are similar to previously characterized histone methyltransferase enzymes from other organisms,

104 Histone methyltransferases EZH1 and EZH2 catalyse the tr

105 vely regulated by miR-101 expression include histone methyltransferase EZH2 (enhancer of zeste homolo

106 which was associated with recruitment of the histone methyltransferase Ezh2 and downregulation of the

107 inding of histone H1, thereby recruiting the histone methyltransferase EZH2 and elevating H3K27me3 le

108 Here, we identified loss of the histone methyltransferase EZH2 and subsequent reduction

109 , FoxP3 was inactive when complexed with the histone methyltransferase EZH2 and transcription factors

110 ivated STAT3 and increased expression of the histone methyltransferase EZH2 are independently associa

111 SAFB1 formed a complex with the histone methyltransferase EZH2 at AR-interacting chromat

112 Herein, we show that the histone methyltransferase Ezh2 controls CD8(+) T memory

113 one morphogenetic protein signaling, and the histone methyltransferase Ezh2 have modulatory roles in

114 A cytosolic role for the histone methyltransferase Ezh2 in regulating lymphocyte

115 The histone methyltransferase EZH2 is a central epigenetic r

116 The histone methyltransferase EZH2 is frequently mutated in

117 Our data show that the histone methyltransferase EZH2 is overexpressed in ACC i

118 The histone methyltransferase EZH2 is required for B and T c

119 urther reveal a novel mechanism that reduced histone methyltransferase EZH2 leads to a lower trimethy

120 Here, we show that the histone methyltransferase Ezh2 maintains integrity of th

121 ate the epigenetic modifications mediated by histone methyltransferase EZH2 or miR-150 and thus calib

122 me3 histone mark and binding of the Polycomb histone methyltransferase Ezh2 persisted at differentiat

123 hosphorylation of Rb and release of E2F1.The histone methyltransferase EZH2 silences genes by generat

124 ylation of histone H3 lysine 27, deplete the histone methyltransferase Ezh2 specific to trimethylatio

125 The Polycomb histone methyltransferase Ezh2 stabilizes transcription

126 between allogeneic T-cell responses and the histone methyltransferase Ezh2, which catalyzes histone

127 ow that upregulation of the Polycomb protein histone methyltransferase EZH2, which limits differentia

128 alterations in DNA methylation at potential histone methyltransferase EZH2-binding sites.

129 mouse subventricular zone (SVZ) express the histone methyltransferase EZH2.

130 sttranslational modification mediated by the histone methyltransferase EZH2.

131 (E(kappai)), which led to recruitment of the histone methyltransferase Ezh2.

132 rent mutations in the gene encoding the EZH2 histone methyltransferase (EZH2), but the carcinogenic r

133 The H3K27 histone methyltransferase, Ezh2 (enhancer of zeste 2), i

134 key epigenetic regulators, whether and how a histone methyltransferase forms a network with miRNAs an

135 e essential nature of cross-talk between the histone methyltransferase G9a and the demethylase Jarid1

136 Histone methyltransferase G9a has been understood primar

137 Here we present evidence that histone methyltransferase G9a mediates E4BP4-dependent r

138 The results indicated that histone methyltransferase G9a, but not GLP, was involved

139 ly, dyclonine also inhibited the activity of histone methyltransferase G9a, known to methylate histon

140 tment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.

141 g KAP1, histone deacetylases HDAC1/2 and the histone methyltransferase G9a/GLP and modulates the inte

142 pigenetic regulators, such as Dnmt3l and the histone methyltransferases G9a and Prdm9, have been repo

143 B family member RelB, and RelB recruited the histone methyltransferases G9a and SETDB1 to the Il17 lo

144 Cre-mediated reduction of the histone methyltransferase, G9a, in NAc promoted increase

145 d with high expression of the E2F target and histone methyltransferase gene EZH2.

146 was abolished in cells upon depletion of the histone methyltransferase gene SET-domain containing 2 (

147 The MLL1 histone methyltransferase gene undergoes many distinct c

148 Several histone methyltransferases have been implicated in 53BP1

149 al regulators of chromatin structure such as histone methyltransferases, histone deacetylases, or the

150 hares common structural domains, has similar histone methyltransferase (HMT) activity, and belongs in

151 ng evidence has implicated a small number of histone methyltransferase (HMT) and histone demethylase

152 ntaining protein 5 (WDR5), a core subunit of histone methyltransferase (HMT) complexes.

153 We found that embryonic deletion of the histone methyltransferase (HMT) Ezh2 from all retinal pr

154 Cocaine-mediated repression of the histone methyltransferase (HMT) G9a has recently been im

155 gene loci encoding adipogenesis regulators, histone methyltransferase (HMT) G9a-mediated repressive

156 Here, we used gene targeted inactivation of histone methyltransferase (HMT) multiple myeloma SET dom

157 MMSET/WHSC1 is a histone methyltransferase (HMT) overexpressed in t(4;14)

158 s a member of the trithorax (TrxG) family of histone methyltransferases (HMT) that methylate H3K4 at

159 Histone methyltransferases (HMTases), as chromatin modif

160 histone H4, which facilitates recruitment of histone methyltransferases (HMTases), SET8 and SUV4-20H,

161 nosyl homocysteine (SAH) detection assay for histone methyltransferases (HMTs) and its applications i

162 ct other mixed-lineage leukemia (MLL) family histone methyltransferases (HMTs), revealing a unique re

163 ding to H3K9me marks and interacting to H3K9 histone methyltransferases (HMTs), such as SUV39H1, whic

164 e defined a role for activated STAT3 and G9a histone methyltransferase in epigenetic silencing of miR

165 volves Enhancer of Zeste Homolog 2 (EZH2), a histone methyltransferase in head and neck cancers.

166 Setd8 is the sole histone methyltransferase in mammals capable of monometh

167 We identified EZH2, a histone methyltransferase in the Polycomb repressive com

168 Although the role of some histone methyltransferases in establishing the transcrip

169 dependent kinase [CDK] inhibitor), and Set8 (histone methyltransferase) in S phase.

170 activated primary HSCs we found a number of histone methyltransferases including MLL1, MLL5, Set1 an

171 2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a, and Pr-

172 38, a selective inhibitor of EHMT1 and EHMT2 histone methyltransferases, induces gamma-globin express

173 Histone deacetylase or histone methyltransferase inhibition also increases Mpl-

174 Demethylation of H3K27 mediated by the histone methyltransferase inhibitor GSK343 in primary re

175 eatment of cultured pancreatic islets with a histone methyltransferase inhibitor leads to colocalizat

176 In contrast, a histone methyltransferase inhibitor selectively promotes

177 e 1 IFN-stimulated genes and inhibition with histone methyltransferase inhibitor.

178 Histone methyltransferase inhibitors (HMTis) and histone

179 creening and in vivo characterization of new histone methyltransferase inhibitors and accelerate the

180 ng histone methylation status in response to histone methyltransferase inhibitors in living animals.

181 In contrast, certain histone methyltransferase inhibitors stimulate metastati

182 tylase inhibitors to increase euchromatin or histone methyltransferase inhibitors to decrease heteroc

183 The yeast Set2 histone methyltransferase is a critical enzyme that play

184 The EZH2 histone methyltransferase is a member of the polycomb re

185 otein with a SET domain, also called SETDB1) histone methyltransferase is expressed in articular cart

186 The EZH2 histone methyltransferase is highly expressed in germina

187 The EZH2 histone methyltransferase is required for B cells to for

188 of proteins associated with Set1) family of histone methyltransferases is known to activate transcri

189 Mutation in MLL2, encoding a histone methyltransferase, is a driver in numerous diffe

190 rt hairpin RNAs were used to inhibit several histone methyltransferases (KMT) and histone demethylase

191 The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of th

192 transferase CHROMOMETHYLASE3 (CMT3) and H3K9 histone methyltransferase KRYPTONITE/SUVH4 (KYP).

193 tored by mutations in the genes encoding the histone methyltransferase KYP and DNA methyltransferase

194 The EZH2 histone methyltransferase mediates the humoral immune re

195 A third interactor, the histone methyltransferase MES-4, is also enriched in het

196 of histone H3K9 through the activity of the histone methyltransferase met-2 and the nuclear co-facto

197 1, LIN-13, LIN-61, LET-418/Mi-2, and H3K9me2 histone methyltransferase MET-2/SETDB1 also show functio

198 The histone methyltransferase Mixed Lineage Leukemia (MLL) i

199 ive H3K9me2 marks, but also helps to recruit histone methyltransferase MLL1 to promote H3K4 methylati

200 novo enhancers is primarily dependent on the histone methyltransferases Mll1, Mll2/4, and Mll3 and is

201 to be due to a lack of interaction with the histone methyltransferase, MLL1, resulting in decreased

202 shown that this program is controlled by two histone methyltransferases, MLL1 and DOT1L, as deletion

203 tin remodelling genes, ARID1A and ARID1B, in histone methyltransferase MLL3, in histone deacetylase m

204 g et al. describe an unexpected role for the histone methyltransferases MLL3 and MLL4 in the repressi

205 ding more than twofold overexpression of the histone methyltransferase MLL5 and LINE-1 elements trans

206 hylation of H4K20 at DSBs is mediated by the histone methyltransferase MMSET (also known as NSD2 or W

207 The histone methyltransferase MMSET/WHSC1 (Multiple Myeloma

208 The histone methyltransferase MMSET/WHSC1 has recently been

209 In contrast, compounds targeting histone methyltransferases modulate the expression of re

210 Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2

211 Here we show that mice lacking the histone-methyltransferase myeloid/lymphoid or mixed-line

212 iochemical purification identifies the H3K36 histone methyltransferase NSD/dMes-4 as a novel IBP cofa

213 indicate that inactivating mutations in the histone methyltransferase NSD1 define an intrinsic subty

214 MT3A, and DNMT1, as well as mutations in the histone methyltransferases NSD1, EZH2, and MLL3.

215 disability syndrome caused by mutations in a histone methyltransferase, NSD1.

216 We report here that histone methyltransferase NSD2 (also known as MMSET or W

217 The histone methyltransferase NSD2/WHSC1/MMSET is overexpres

218 In-frame fusion transcripts involving histone methyltransferase or histone demethylase genes w

219 In contrast, levels of other histone methyltransferases or demethylases, or of other

220 mb group protein Ezh2 is a histone H3 Lys-27 histone methyltransferase orchestrating an extensive epi

221 me1) is mediated by the cell cycle-regulated histone methyltransferase PR-Set7.

222 The histone methyltransferase PRC2 plays a central role in g

223 of chromatin context on the activity of the histone methyltransferase PRC2.

224 Here, we reveal that BCL11A interacts with histone methyltransferase (PRC2) and histone deacetylase

225 ationships between SPO11, chromatin, and the histone methyltransferase PRDM9.

226 L gene, which is an evolutionarily conserved histone methyltransferase, recently identified as a pote

227 All of these histone methyltransferases regulate methylation of lysin

228 Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from

229 Polycomb repressive complex-2 (PRC2) is a histone methyltransferase required for epigenetic silenc

230 Polycomb repressive complex-2 (PRC2) is a histone methyltransferase required for epigenetic silenc

231 Dot1, a histone methyltransferase required for methylation of hi

232 However, the counteracting histone methyltransferase required for the active chroma

233 SETDB1, a histone methyltransferase responsible for methylation of

234 Moreover, depletion of SETDB1, a histone methyltransferase, resulted in a loss of transcr

235 X-01294 and TM2-115 inhibit malaria parasite histone methyltransferases, resulting in rapid and irrev

236 The histone methyltransferase SDG8 functions to regulate the

237 ere, we report a deletion of the Arabidopsis histone methyltransferase SDG8 in this mutant (renamed s

238 The histone methyltransferase SET DOMAIN GROUP 2/ARABIDOPSIS

239 3) complex, composed of ASH-2, WDR-5 and the histone methyltransferase SET-2, regulates Caenorhabditi

240 s a PTM of dynamic microtubules and that the histone methyltransferase SET-domain-containing 2 (SETD2

241 t of H4K20me1 requires the activities of the histone methyltransferases SET-1 and SET-4.

242 GO-9, a HP1 ortholog HPL-2, and two putative histone methyltransferases, SET-25 and SET-32.

243 uired for histone H3K4 methylation, both the histone methyltransferase Set1 and the E3 ubiquitin liga

244 Importantly, we identify the histone methyltransferase Set1 as a GSC-specific self-re

245 down of either SAM synthetase (Sam-S) or the histone methyltransferase Set1 is restored to near norma

246 anges in the number of binding sites for the histone methyltransferase Set2, thereby influencing both

247 f the central players in this pathway is the histone methyltransferase Set2.

248 t in this paper that expression of the H3-K4 histone methyltransferase Set7 is increased when myoblas

249 Cellular studies showed that histone methyltransferase Set7 mediates high glucose-ind

250 he replication licensing factor CDT1 and the histone methyltransferase SET8, are targeted for proteol

251 Ott1, which associates with Hdac3 and the histone methyltransferase, Setd1b, binds to both c-Mpl R

252 to these stage-specific effects, loss of the histone methyltransferase Setd2 had robust tumor-promoti

253 oic acids 1-5 are in vitro inhibitors of the histone methyltransferase SETD8, and nahuoic acid A (1)

254 In this issue, Cuellar et al. find that the histone methyltransferase SETDB1 enables acute myeloid l

255 tinct from that in murine EC cell lines: the histone methyltransferase SETDB1 is required, but the wi

256 y essential genes in ES cells, including the histone methyltransferase Setdb1.

257 t Lid opposes the functions of dLsd1 and the histone methyltransferase Su(var)3-9 in promoting hetero

258 then recruits heterochromatin protein 1a and histone methyltransferase Su(Var)3-9 to the sites.

259 of Gr63a/Gr21a and acts in opposition to the histone methyltransferase Su(var)3-9.

260 e deacetylases (HDACs) and a lysine-specific histone methyltransferase, SU(VAR)3-9, play a significan

261 Somatic mutations affecting histone methyltransferases such as enhancer of zeste 2 a

262 We show that depletion of the histone methyltransferase suppressor of variegation 3-9

263 ORC1 binds to RB, the histone methyltransferase SUV39H1 and to its repressive

264 ter site induces stepwise recruitment of the histone methyltransferase Suv39H1, causes local H3K9 tri

265 KLF11 also recruits HP1alpha and its histone methyltransferase, SUV39H1, to promoters to limi

266 Here we find that the histone methyltransferase SUV39H2 methylates histone H2A

267 didate epigenetic factors and identified the histone methyltransferase SUV420H2 (KMT5C) as favoring t

268 onal activation, and DOT1L is the only known histone methyltransferase that catalyzes H3K79 methylati

269 We demonstrated that SetD8, a histone methyltransferase that catalyzes monomethylation

270 Alterations in G9a (Ehmt2), a histone methyltransferase that catalyzes the euchromatic

271 nd siRNA knockdown studies show that EZH2, a histone methyltransferase that catalyzes trimethylation

272 dy, we investigated the role of G9a/Ehmt2, a histone methyltransferase that defines a repressive epig

273 MLL encodes a large histone methyltransferase that directly binds DNA and po

274 Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that is localized to thousands

275 Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that is overexpressed by pancr

276 ning protein 7 (PRDM7) is a primate-specific histone methyltransferase that is the result of a recent

277 ll molecule inhibitor of the DOT1L enzyme, a histone methyltransferase that methylates lysine 79 of h

278 The polycomb group protein Ezh2 is a histone methyltransferase that modifies chromatin struct

279 stently decreased the expression of Prdm2, a histone methyltransferase that monomethylates histone 3

280 e recently demonstrated that WRAD is a novel histone methyltransferase that preferentially catalyzes

281 MLL encodes a histone methyltransferase that regulates chromatin-media

282 Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that trimethylates H3K27, a ma

283 SETD1A is a member of trithorax-related histone methyltransferases that methylate lysine 4 at hi

284 ters of a subset of these genes by the SMYD5 histone methyltransferase through its association with N

285 DD4L and recruit enhancer of zeste homolog 2 histone methyltransferase to repress NEDD4L transcriptio

286 1 also interferes with binding of the SET7/9 histone methyltransferase to the imprinting control regi

287 omatin remodelers, histone deacetylases, and histone methyltransferases to repress transcription.

288 Previous studies have linked histone methyltransferases to the differentiation of mam

289 he H3K4 methyltransferase SMYD3 was the only histone methyltransferase upregulated upon infection.

290 quire the interaction of NKX3.1 with the G9a histone methyltransferase via the homeodomain and are me

291 otic discs 1 (ASH1), and Compass member SET1 histone methyltransferases were O-GlcNAc-modified in oga

292 A number of histone methyltransferases were then tested on these nuc

293 YND domain containing protein 3 (SMYD3) is a histone methyltransferase, which has been implicated in

294 subunits and the transcription-coupled Set2 histone methyltransferase, which is involved in suppress

295 show that TERRA associates with SUV39H1 H3K9 histone methyltransferase, which promotes accumulation o

296 -repressor, together with HP1 and the SETDB1 histone methyltransferase, which results in transcriptio

297 ssembly in fission yeast depends on the Clr4 histone methyltransferase, which targets H3K9.

298 The histone methyltransferase WHSC1 (also known as MMSET) is

299 y to study the global function of a specific histone methyltransferase within a multicellular organis

300 We investigated the role of the histone methyltransferase Wolf-Hirschhorn syndrome candi