ライフサイエンスコーパス: histone modification

1 and thus the propagation of this repressive histone modification.

2 TRIM24 as a histone reader can recognize histone modification.

3 d to involve epigenetic processes, including histone modification.

4 may be regulated in an epigenetic manner via histone modification.

5 irectly connecting methionine metabolism and histone modification.

6 n, as well as the stability of the installed histone modification.

7 a molecular mechanism of ZIC2-mediated local histone modification.

8 the nucleosome dyad axis and is regulated by histone modifications.

9 regulatory elements and may modulate certain histone modifications.

10 ogram, involving in both DNA methylation and histone modifications.

11 on of pathogen recognition receptors induced histone modifications.

12 C1 and PRC2 can communicate independently of histone modifications.

13 -wide profiling of transcription factors and histone modifications.

14 on, has added to the functional diversity of histone modifications.

15 f chromatin enriched in genes and activating histone modifications.

16 changes in the abundance and distribution of histone modifications.

17 xpression via enrichment of their respective histone modifications.

18 A Polymerase II pausing to cotranscriptional histone modifications.

19 s involved in transcriptional elongation and histone modifications.

20 lators to chromosomal loci carrying specific histone modifications.

21 association of the complex and the resulting histone modifications.

22 cations in oral epithelial cells mediated by histone modifications.

23 rough DNA methylation and post-translational histone modifications.

24 promoter-related marks, and enhancer-related histone modifications.

25 3, and subsequent accumulation of repressive histone modifications.

26 ons displayed distinctive enhancer-signature histone modifications.

27 smission depends on genomic architecture and histone modifications.

28 ized by the appearance of non-coding RNA and histone modifications.

29 chromatin structure, especially on covalent histone modifications.

30 in binding, TRIM28 recruitment, and specific histone modifications.

31 itively affected the abundance of activating histone modifications.

32 ral megabases in the case of heterochromatic histone modifications.

33 enzymatic actions of DNA methylation and/or histone modifications.

34 d human cell line and measured PRDM9-induced histone modifications.

35 Which is the physiological time course of histone modifications?

36 mobile siRNAs are associated with different histone modifications 543 VII.

37 nctions, dynamic DNA methylation levels, and histone modification abundances.

38 in sex-specific chromatin accessibility and histone modifications accompanied these cGH-induced sex-

39 PARP1, leading to a decrease in a repressive histone modification, accompanied by induction in expres

40 ast, Sp7 gene activation involves changes in histone modifications, accompanied by decreased nucleoso

41 concurrently map relative levels of multiple histone modifications across multiple samples, each comp

42 ial cells to lipopolysaccharides resulted in histone modifications, activation of transcriptional coa

43 primary tumor- and cell line-derived global histone modification analyses and epigenetic drug treatm

44 (PRC1) and PRC2 repress target genes through histone modification and chromatin compaction.

45 se findings reveal an important mechanism of histone modification and demonstrate that local generati

46 ntal context is influenced by IBM1-regulated histone modification and DNA methylation on the gene bod

47 ween two conserved epigenetic modifications: histone modification and DNA methylation.

48 impairs the acquisition of such differential histone modification and expression patterns at MAC-/OC-

49 ablish a novel regulatory pathway connecting histone modification and hormone activation with mitocho

50 ndings suggest that LRRK2 affects epigenetic histone modification and neuronal survival by facilitati

51 28ph) as the principal stimulation-dependent histone modification and observed its enrichment at indu

52 9 variant, specific pre-existing patterns of histone modification and open chromatin conformations th

53 re loci-dependent and emerge in concert with histone modification and other chromatin features.

54 peaks were co-localized to regions of active histone modification and transcription factor binding si

55 Altered histone modification and transcriptional dysfunction hav

56 Prolonged stress exposure can induce altered histone modification and transcriptional dysfunction, wh

57 e is reversed at the level of distal element histone modification and transcriptional reactivation of

58 nduced recognition" is then proposed to link histone modification and TRIM24 binding.

59 epigenetic marks (REPTILE), which integrates histone modification and whole-genome cytosine DNA methy

60 the nucleus correlates with loss of specific histone modifications and a block in ZGA.

61 esponses during bacterial infections through histone modifications and altered euchromatin formation,

62 e genome-wide association between particular histone modifications and alternative splicing remains u

63 e investigated the effects of FA exposure on histone modifications and chromatin assembly.

64 oci and was associated with broad changes in histone modifications and chromatin localization of Sir2

65 ulate linear and looping-driven spreading of histone modifications and compare both models to recent

66 how it can reveal shared covariance between histone modifications and DNA binding proteins, such as

67 hierarchical cooperation mechanism by which histone modifications and DNA coordinate to target chrom

68 ever, there was a considerable difference in histone modifications and DNA methylation at the locus b

69 on as epigenetic regulators that affect both histone modifications and DNA methylation patterning.

70 gulation are discussed, including microRNAs, histone modifications and DNA methylation.

71 ow a total of 29), as well as positions of 4 histone modifications and DNase hypersensitive sites, Wi

72 ivation of CD4(+) T cells invokes changes in histone modifications and enhancer RNA transcription tha

73 ies for quantifying the relationship between histone modifications and gene expression levels either

74 e that the genome-wide relationships between histone modifications and mRNA transcription are lineage

75 ude DNA methylation, DNA hydroxymethylation, histone modifications and noncoding RNAs.

76 to remodeling of the chromatin structure by histone modifications and recruitment changes of transcr

77 rked with bivalent activating and repressing histone modifications and resembled hypermethylation in

78 Here, we integrate histone modifications and RNAPII states derived from bul

79 an assessment of their profile of epigenetic histone modifications and their phenotypic characteristi

80 elevant to expression data, DNA methylation, histone modifications and transcription factor occupancy

81 ly identifying genomic regions enriched with histone modifications and transcription factors is key t

82 nfaip3 complex can modulate Hmgb1-associated histone modifications and, ultimately, transactivation o

83 Transcription factor binding, histone modification, and chromatin accessibility studie

84 al gene expression, chromatin accessibility, histone modification, and transcription factor binding d

85 We linked these patterns to gene expression, histone modifications, and chromatin accessibility, and

86 ata, such as transcription factor occupancy, histone modifications, and chromatin interaction frequen

87 ed as a key component by which DNA-sequence, histone modifications, and chromatin remodelers could in

88 ion at OriP to regulate viral transcription, histone modifications, and episome maintenance.

89 he parasite, including nucleosome landscape, histone modifications, and nuclear architecture.

90 oordinated actions of transcription factors, histone modifications, and other chromatin features at p

91 it induces nucleosome eviction, alters local histone modifications, and remodels local chromatin arch

92 igated the relationship among ERK signaling, histone modifications, and transcription factor activity

93 i are enriched in regions of open chromatin, histone modifications, and transcription factor binding,

94 le genes/enzymes that play a role in DNA and histone modifications are also altered in various cancer

95 Histone modifications are among the most important facto

96 Although histone modifications are associated with gene activitie

97 Histone modifications are associated with transcriptiona

98 Bivalent histone modifications are defined as repressive and acti

99 Upon DNA damage, histone modifications are dynamically reshaped to accomm

100 Notably, Spt16 and distinct histone modifications are enriched at this subgroup of n

101 Histone variants and histone modifications are essential components in the es

102 Histone modifications are frequently used as markers for

103 information is rich, mechanistic studies on histone modifications are largely restricted to two yeas

104 transcription start sites (TSSs) or certain histone modifications are likely to regulate gene expres

105 ur results suggest that so-called repressive histone modifications are not sufficient for gene repres

106 To probe the mechanisms by which histone modifications are read out, we designed an oblig

107 Seq and RNA-Seq data, we found that specific histone modifications are strongly associated with vario

108 K4me3 (activating) and H3K27me3 (repressive) histone modifications, are a key property of pluripotent

109 Furthermore, hyperthermia blocked this histone modification as efficiently as pharmacologic inh

110 TSSs, DNase hypersensitivity sites, and six histone modifications as the genomic annotations for the

111 et and identified H2BK20ac, a little-studied histone modification, as the most predictive mark of act

112 genes that are involved in DNA methylation, histone modification, as well as epithelial-mesenchymal

113 ue opportunities for the analysis of DNA and histone modifications, as well as the first map of the n

114 monly used to obtain genome-wide profiles of histone modifications associated with different types of

115 pheralization of heterochromatin and reduced histone modifications associated with euchromatin.

116 ed reductions in mTOR activity, translation, histone modifications associated with gene activity and

117 We identify several histone modifications associated with oncogenic transfor

118 tion of the associated H3K27me3 and H3K36me3 histone modifications at FLC We propose the physical cou

119 y extensive changes in the transcriptome and histone modifications at gene promoters; however, the en

120 mice exhibited more transcriptionally active histone modifications at M2 gene promoters than did macr

121 r HCF1 deregulated latency transcription and histone modifications at OriP, as well as the OriP-regul

122 on the identification of DNA methylation and histone modifications at specific genes.

123 his allows us to uncouple transcription from histone modifications at the centromere.

124 We sought to examine the role of histone modifications at the murine Cdk5 (cyclin-depende

125 Primary chromatin shapers include histone modifications at the nucleosome lateral surface

126 Trabid facilitated TLR-induced histone modifications at the promoters of Il12 and Il23,

127 hromatin comprises activating and repressing histone modifications at the same location.

128 ypomethylation and concurrent gain of active histone modifications, at cis-regulatory elements such a

129 amplified MYCN Transcriptome integration and histone modification-based definition of enhancer elemen

130 filing also demonstrated similar patterns of histone modifications between LIF-independent iOCT4 and

131 Alongside DNA methylation and histone modifications, bromodomain and extra-terminal re

132 nomic locations of active enhancers based on histone modifications, but the accuracy and resolution o

133 ed activities at these genes include various histone modifications, but we did not examine histone ph

134 Genome-wide profiling of histone modifications can provide systematic insight int

135 Histone modifications can redistribute along the genome

136 In fact, 5mC oxidation precedes differential histone modification changes between MACs and OCs.

137 The association of histone modification changes with autism spectrum disord

138 stages are highly reproducible, recapitulate histone modification changes, and reveal key regulatory

139 gments to cleavage by RAG is associated with histone modifications characteristic of active chromatin

140 ack loops between DNA methyltransferases and histone modifications characteristic of heterochromatin

141 ol2 insertions were associated with bivalent histone modifications characteristic of silent and induc

142 A methylation in the HGE region inhibits the histone modifications characterizing enhancer and is inv

143 chmarks for transcription factor binding and histone modification ChIP-Seq data.

144 enomic regions enriched for enhancer-marking histone modifications (chromatin immunoprecipitation (Ch

145 by microRNAs and epigenetic factors such as histone modification, chromatin remodeling, and DNA meth

146 Here we assess histone modification, chromatin remodeling, and DNA meth

147 s have pronounced defects in the DSB-induced histone modification, chromatin remodelling and DSB-repa

148 y associating domains (TADs) from 1D maps of histone modifications, chromatin accessibility and RNA-s

149 Encyclopedia of DNA Elements data regarding histone modifications, chromatin state, and transcriptio

150 regulatory factors-transcription factors and histone modifications-co-localized at particular genomic

151 Epigenetic patterns of histone modifications contribute to the maintenance of t

152 ic components, including DNA methylation and histone modifications, control PD-1 expression.

153 The magnitude of the increase in histone modification correlated well with changes in tra

154 tope-labeled nucleosomes to study asymmetric histone modification crosstalk by time-resolved NMR spec

155 e the utility of this system for analysis of histone modification crosstalk, using mass spectrometry

156 al network to classify gene expression using histone modification data as input.

157 iability of epigenetic function across fifty histone modification data-sets from variety of cancerous

158 the chromatin interaction map by integrating histone modification data.

159 igenomic data such as DNase I sensitivity or histone modification data.

160 Without normal histone modification-dependent communication between PRC

161 ggests that activity-based communication and histone modification-dependent thresholds create a local

162 ere we report genome-wide maps for 17 TFs, 3 histone modifications, DNase I hypersensitive sites, and

163 Here, we show that the histone modification domain (HMD) of Paf1C subunit Rtf1

164 e2s following excision of Cdc73 placing this histone modification downstream of the PAFc and revealin

165 s associated with the deposition of positive histone modifications during memory T cell differentiati

166 between the methylome, hydroxymethylome, and histone modifications during tumorigenesis.

167 her regulators of H3 lysine 4 methylation, a histone modification enriched at promoters and enhancers

168 the memory T cells are marked by activating histone modifications even in the resting state.

169 signalling and in combination with balanced histone modification events establishes the restricted,

170 These histone modification events resulted in an open, flexibl

171 Induction of histone modifications following ERK stimulation is thus

172 an conservation, DNase hypersensitivity, and histone modification from ENCODE and the Roadmap Epigeno

173 dered by technical difficulties in profiling histone modifications from small quantities of cells.

174 nes by blocking generation of the inhibitory histone modification H3K27me3 through PARP1 activation.

175 We generate genome-wide profiles of the histone modifications H3K4me1, H3K27ac, H3K4me3, and H3K

176 protein MeCP2 and with the active chromatin histone modification H3K4me2 in mouse neurons.

177 ed by promoter associated post-translational histone modifications (H3K4me3, H2A.Z) and RNA polymeras

178 chanism underlying the dynamic enrichment of histone modification H4K20me1 on hermaphrodite X chromos

179 Histone modification H4K20me3 and its methyltransferase

180 Different combinations of histone modifications have been proposed to signal disti

181 the potential impact of that small RNAs and histone modifications have in regulation of NAT expressi

182 tures including DNase I hypersensitivity, 11 histone modifications (HMs) and GC content.

183 TETs' role in the crosstalk with specific histone modifications, however, is largely elusive.

184 epigenetic marks, i.e., DNA methylation and histone modifications; (ii) genome-wide reduction of DNA

185 Altered histone modifications implicated in gene silencing assoc

186 , and liver cancer via LSD1-mediated H3K4me2 histone modification in liver cancer development.

187 By analysing histone modifications in a morphologically-simple, early

188 odifying enzymes, the prevalent landscape of histone modifications in any cell type is a snapshot of

189 ions and global levels of post-translational histone modifications in Bangladeshi men and women.

190 sion, the histone variant H2A.Z, and various histone modifications in E. salsugineum and in Arabidops

191 ic pathways involving a complex interplay of histone modifications in functionally-relevant biologica

192 analysis were used to measure the levels of histone modifications in human bronchial epithelial BEAS

193 Here, we review the broad functions of histone modifications in initiating cell fate transition

194 es a selective review of the role of DNA and histone modifications in neuronal signal-induced gene ex

195 Although the implication of histone modifications in orchestrating biotic stress-ind

196 receptor binding sites and enhancer-specific histone modifications in primary alveolar epithelium and

197 nucleosome positioning, and determination of histone modifications in promoters of proinflammatory ge

198 nd the interplay between DNA methylation and histone modifications in the process of selective imprin

199 on-B DNA structure, recombination rates, and histone modifications) in +/-32 kb of these ERVs' integr

200 mplicate DNA modifications (DNA methylation, histone modifications) in memory formation, the contribu

201 Thus mitotic transcription plus histone modifications including H3K9ac constitute the 'e

202 ffects of SAM were observed on stress-evoked histone modifications, including H3S10p-K14ac (histone H

203 er DDM1 (DECREASE IN DNA METHYLATION 1), and histone modifications, including histone H3 Lys 27 monom

204 DNA methylation and histone modifications interact to modulate gene expressi

205 nstrates that histone variants and different histone modifications interact with aberrant DNA methyla

206 This indicates that histone modification is essential for the imprinting of

207 fic recognition mechanism between TRIM24 and histone modification is unsolved.

208 ression in eukaryotes, and interpretation of histone modifications is an essential feature of epigene

209 Delivery of the active histone modifications is therefore likely to be through

210 does not capture quantitative information on histone modification levels, requires large amounts of s

211 ed with gene expression, DNA methylation and histone modification levels.

212 -remodeling complexes and post-translational histone modifications likely play key roles in HIV-1 rea

213 Here, we use ATAC-seq, genome-wide histone modification mapping, and expression analysis to

214 14ac and H3K4me1, we here show that the dual histone modification mark H3K4me1-H3K14ac is recognized

215 d extends into intron 22, possesses enhancer histone modification marks in specific cells and enhance

216 iles of promoters and enhancers using solely histone modification marks, chromatin accessibility and

217 ights about combinatorial interactions among histone modification marks, some of which have recently

218 Dynamic histone modifications may have important roles in MZT, b

219 eq gene transcripton and up to four ChIP-seq histone modification measurements.

220 ine-phosphate diester-guanine dinucleotides, histone modifications, microRNA interactions, and chroma

221 enetic control that include DNA methylation, histone modification, noncoding RNAs, and mitotic gene b

222 several proteins involved in light-regulated histone modification, nor for the involvement of these p

223 e, MA-35 inhibited TGF-beta1-induced H3K4me1 histone modification of the fibrotic gene promoter, lead

224 Second, it has uncovered the stress-induced histone modification of the target gene Nedd4, an E3 lig

225 (HP1) for coordinated chromatin movement and histone modifications of target loci, resulting in trans

226 cell division, as exemplified by changes in histone modifications of the EpCAM promoter, a target of

227 yonic stem cells but premarked with bivalent histone modifications; one allele was silenced during di

228 Here we profiled the genome-wide histone modifications, open chromatin and gene expressio

229 moter nucleosome fragility and the levels of histone modifications or histone variants.

230 , targeted chromatin ligation, that captures histone modification patterns with only 200 cells.

231 nstrated enrichment of novel JIA variants in histone modification peaks and DNase hypersensitivity si

232 ciated with marked deposition of H3K27me3, a histone modification placed by EZH2, within the gene bod

233 Collectively, our data suggest that histone modifications play a major role leading to epige

234 Covalent histone modifications play an essential role in gene reg

235 Histone modifications play an important role in regulati

236 Histone modification plays a key role in gene regulation

237 The readout of histone modifications plays a critical role in chromatin

238 Due to the relative stability of histone modifications postmortem, we anticipate that the

239 mechanisms involved both DNA methylation and histone modifications, producing different repressive ch

240 n of DNA methylation triggers changes in the histone modification profile and chromatin-remodeling ev

241 We have characterized the histone modification profiles of the intronic region sur

242 rochromatin, which is associated with unique histone modification profiles such as the methylation of

243 lity to generate genome-scale expression and histone modification profiles, transcription factor (TF)

244 rsensitive regions not marked with canonical histone modification profiles.

245 methylation, H3K4me3, H3K79me3, and H3K27me3 histone modifications) profiles of the cell derivatives,

246 Genome-wide histone modification profiling revealed remarkable diffe

247 eq) and microRNA sequencing (miRNA-seq), and histone modification profiling to characterize extra-cra

248 gests that arsenic alters post-translational histone modifications (PTHMs), evidence in humans is lim

249 Correlated with enhancer-associated histone modifications, putative CSM loci increased drama

250 nd strongly to H3K23me3, a poorly understood histone modification recently shown to be enriched in me

251 g DSB repair, directing specific patterns of histone modification, recruiting DNA repair proteins and

252 ion, we assessed their location overlap with histone modification regions that indicate transcription

253 interactions among transcription factors and histone modifications regulate Aqp5 expression during al

254 Combinatorial patterns of histone modifications regulate developmental and cell ty

255 tic replication.IMPORTANCE Posttranslational histone modifications regulate the accessibility of tran

256 DNA and histone modifications regulate transcriptional activity

257 Whether and how this histone modification regulates enhancer-dependent transc

258 t alter the genome-wide distribution of this histone modification required for development.

259 utants showed that TCF-dependent ERK-induced histone modifications required Elk-1 to be phosphorylate

260 ensitive site (DHS) database that integrates histone modification, RNA sequencing, nucleosome positio

261 ve high-throughput genome, transcriptome and histone modification sequencing data and revisit dosage

262 mponent that directly binds to H3K27me3, the histone modification set by PRC2, and also associates ge

263 al methods that predict gene expression from histone modification signals are highly desirable for un

264 lements are marked by characteristic DNA and histone modification signatures.

265 We show that chromatin histone modification state dictates nuclear rigidity, an

266 Thus, chromatin histone modification state is a major determinant of nuc

267 ustained by epigenetic mechanisms, including histone modifications such as deacetylation, we tested t

268 roles of histone demethylases and activating histone modifications such as trimethylated histone 3 ly

269 Histone modifications, such as the frequently occurring

270 However, the roles of repressive histone modifications, such as trimethylated histone lys

271 developmental gene loci, which have bivalent histone modifications, tend to colocalize in PSCs.

272 replication origins are marked with specific histone modifications that define gene enhancers.

273 Many ASHCEs show differential histone modifications that may participate in regulation

274 e have examined changes in transcription and histone modifications that occur during sporogonic devel

275 regulatory layer in SM biosynthesis involves histone modifications that render the underlying genes e

276 ons, transcription factor (TF) occupancy, or histone modification through next generation sequencing

277 suggest a novel candidate mechanism linking histone modifications to hESC fate decision.

278 the contributions of allele-specific active histone modifications to imprinting remain still unclear

279 nferred increased germline transcription and histone modifications to TRAV12 in double-negative thymo

280 ar mechanisms, including DNA methylation and histone modifications, to repress transcription.

281 tion of ZIC2 shifted the balance of bivalent histone modifications toward more active forms and induc

282 cellular factors that bind OriP and regulate histone modification, transcription regulation, and epis

283 associating domains (TADs) that have similar histone modifications, transcription level, and DNA repl

284 approach to analyze chromatin accessibility, histone modifications, transcription-factor binding, and

285 mic generation and erasure of the repressive histone modification tri-methyl histone H3 lysine 27 (H3

286 Surprisingly, we find that H3K9me3-a histone modification typically associated with transcrip

287 Dynamic changes in histone modifications under various physiological cues p

288 Applying this to five TFs and a histone modification, we mapped thousands of cis-acting

289 s, typical enhancer-associated proteins, and histone modifications, we determine that both enhancer c

290 sualize the combinatorial interactions among histone modifications, we propose a novel optimization-b

291 interaction enrichment, enhancer-associated histone modifications were evident, and known functional

292 transcription, cell signaling pathways, and histone modifications were examined by a variety of appr

293 While Pmp22 enhancers marked by active histone modifications were lost or remodeled after injur

294 that ChIP-seq data of RNA polymerase II and histone modifications were particularly informative in t

295 ed combinations of activating and repressive histone modifications) were enriched for CTCF.

296 ine catabolism and that this binding affects histone modification, which in turn influences gene expr

297 genetic information includes recognition of histone modifications, which is carried out by protein m

298 tion of cell- and gene-specific targeting of histone modifications, which model naturally occurring t

299 erogeneous features of genomic sequences, 16 histone modifications with a multi-label deep neural net

300 the epigenome, including DNA methylation and histone modifications, with several new drugs being test