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1 n each structure is roughly 18 basepairs per histone protein.
2 DNA into nucleosomes that contain a core of histone proteins.
3 cation that is found on both histone and non-histone proteins.
4 consists of DNA wound around a core of eight histone proteins.
5 is wrapped around largely positively charged histone proteins.
6 nucleosomes, where the DNA is wrapped around histone proteins.
7 ugh changes in the local environment and the histone proteins.
8 e future study of acetylated histone and non-histone proteins.
9 DNA is packaged into chromatin by canonical histone proteins.
10 at this Rtt106:HIR complex included Asf1 and histone proteins.
11 cription factors (NRF2, C/EBP, and E2F1) and histone proteins.
12 ssing, resulting in severe depletion of core histone proteins.
13 binding events and chemical modifications of histone proteins.
14 cently been found to also associate with non-histone proteins.
15 moval of post-translational modifications on histone proteins.
16 of acetyl groups from both histones and non-histone proteins.
17 zymes, and chromatin, the complex of DNA and histone proteins.
18 ylation of lysyl residues in histone and non-histone proteins.
19 ression by deacetylation of histones and non-histone proteins.
20 cally by post-translational modifications of histone proteins.
21 matin must be unwound and the DNA cleared of histone proteins.
22 me: 147bp of DNA wrapped about an octamer of histone proteins.
23 ription, through methylating histone and non-histone proteins.
24 d intermediates that associate with cellular histone proteins.
25 al macro domain that is not present in other histone proteins.
26 cell death acting through acetylation of non-histone proteins.
27 configuration imposed by the binding of the histone proteins.
28 s have been developed to purify and separate histone proteins.
29 ed in part by lysine methylation of the core histone proteins.
30 ode on the DNA and an epigenetic code on the histone proteins.
31 mmetric arrangement with respect to the core histone proteins.
32 report that RAG2 binds directly to the core histone proteins.
33 er lysine acylations in both histone and non-histone proteins.
34 n the acetylation state of the N terminus of histone proteins.
35 acetylation of acetylated lysine residues on histone proteins.
36 s a dynamic PTM occurring on histone and non-histone proteins.
37 tead exhibits significant homology to linker histone proteins.
38 tion of the binding properties of individual histone proteins.
39 yl group from lysine residues of several non-histone proteins.
40 so increases acetylation of histones and non-histone proteins.
41 f acetyl groups from histones as well as non-histone proteins.
42 ally recognize methylated lysine residues on histone proteins.
43 versible epigenetic modifications of DNA and histone proteins.
44 ulated by chemical modifications of the core histone proteins.
45 binding partner of Bcl6 which ubiquitinates histone proteins.
46 n and increasingly through regulation of non-histone proteins.
47 ove active marks and add repressive marks to histone proteins.
48 of DNA wrapped around a symmetric octamer of histone proteins.
49 o known as TP53) was an early example of non-histone protein acetylation and its precise role remains
53 on, a process catalyzed by distinct types of histone/protein acetyltransferases (HATs) that regulate
55 ctivity is regulated post-translationally by histone/protein acetyltransferases and histone/protein d
56 table for the preparation of fully synthetic histone proteins, allowing for site-specific incorporati
57 Furthermore, an comparism of Khib sites in histone proteins among human, mouse and P. patens found
58 hromatin proteins, with the family of linker histone proteins among the most critical structural dete
59 The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal uni
62 Thus, H2O2 and CSC enhance acetylation of histone proteins and decrease histone deacetylase activi
63 and disassembly of chromatin structures from histone proteins and DNA are mediated by histone chapero
65 , with differing preferences for the various histone proteins and for specific sites on individual hi
66 ty increased, including deacetylation of non-histone proteins and functional diversification in mamma
67 , such as post-translational modification of histone proteins and incorporation of histone variants,
68 s mRNA abnormalities through modification of histone proteins and may prove to be of therapeutic valu
69 one chaperone Rtt106 binds newly synthesized histone proteins and mediates their delivery into chroma
70 atens found conserved sites in the H3 and H4 histone proteins and novel sites in H1, H2A and H2B hist
71 three HDAC classes precede the evolution of histone proteins and raises the possibility that the pri
72 al processes by acetylating histones and non-histone proteins and regulating chromatin and gene-speci
73 romatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA.
74 ns decrease the attractive force between the histone proteins and the DNA but also stabilize H2A/H2B
75 tone gene transcription and depletion of the histone proteins, and (4) repression of E2F1-dependent g
76 ple peptides from various known prohormones, histone proteins, and DNA- and RNA-binding proteins as b
78 ts of purified NET components including DNA, histone proteins, and neutrophil enzymes on coagulation
79 s a common posttranslational modification of histone proteins, and the interaction of acetylated lysi
80 romatin self-assembly, starting from DNA and histone proteins, and use these to understand the constr
81 ific post-translational modifications of the histone proteins are associated with specific DNA-templa
82 of this, post-translational modifications of histone proteins are central to the regulation of chroma
83 to DNA replication, focusing on how parental histone proteins are chaperoned around the replication f
84 anslational modifications in histone and non-histone proteins are crucial to DNA replication, DNA rep
85 genomes, and which variant forms of the core histone proteins are deposited is incompletely understoo
87 INGS: Chemical modifications of DNA and core histone proteins are epigenetic marks that constitute th
93 Epigenetic modifications of both DNA and histone proteins are now emerging as fundamental mechani
99 Methylation marks on the lysine residues of histone proteins are thought to contribute to epigenetic
100 intrinsically disordered terminal regions of histone proteins, are key modulators of the structure an
101 ails, which are the terminal segments of the histone proteins, are prominent IDPs that are implicated
102 that epigenetic methylation modification on histone protein arginine residues is a regulatory mechan
106 (immediate early, early, and late) bind with histone proteins at the start of viral gene expression.
107 methylarginine residues to citrulline, with histone proteins being among its best-described substrat
108 ow that LPS treatment reduces acetylation of histone proteins bound to the NAPE-PLD promoter, an effe
110 e reversible acetylation of histones and non-histone proteins by histone acetyltransferases and deace
116 ositions within nucleosomes reveals that the histone proteins catalyze strand scission and increase t
117 episomes and recruit the diatom centromeric histone protein CENH3, suggesting nonnative sequences ca
118 the elaborate combination of histone and non-histone protein complexes defines chromatin organization
120 ast promoters are predominantly bound by non-histone protein complexes, with little evidence for frag
121 ed by acetylation including histones and non-histone proteins component of transcription factors cont
123 ay of posttranslational modifications of the histone protein constituents of chromatin and regulatory
124 e covalent methylation of lysine residues on histone proteins constitutes a principal molecular mecha
126 l ligation to the preparation of full-length histone proteins containing site-specific acetylation an
131 rmacologic modulation of Treg function using histone/protein deacetylase inhibitors (HDACi) may allow
132 myces pombe (Sp) Hst4 is an NAD(+)-dependent histone/protein deacetylase involved in gene silencing a
133 duced by the Sir2-catalyzed NAD(+)-dependent histone/protein deacetylase reaction, regulates diverse
137 experimental studies show that inhibition of histone/protein deacetylases (HDAC) can have important a
143 we discuss possible mechanisms whereby these histone/protein deacetylases facilitate the switch betwe
145 mily of enzymes consists of NAD(+)-dependent histone/protein deacetylases that tightly couple the hyd
147 pression is mildly compromised, the maternal histone protein deposits are essential for proper early
149 ) from yeast reversibly removes and replaces histone protein dimer H2A-H2B or histone variant dimers
152 tors, including enzymes that modify the core histone proteins, enzymes that remodel the structure of
153 to systematically dissect their roles on non-histone proteins, especially for their relationships wit
156 , 2 and 3 are members of the SMH (single Myb histone) protein family, which comprises double-stranded
159 ct "code," it is becoming clear that PTMs on histone proteins function in elaborate combinations to r
162 mmunoprecipitated proteins included cellular histone proteins H2A, H3, and H4; the intermediate filam
163 two histone H1 genes, 34 genes encoding core histone proteins (H2a, H2b, H3 and H4) and three genes e
164 e, in vivo, we show that in murine cells the histone protein H2AX prevents nucleases other than Artem
166 differences in basal levels of trimethylated histone protein H3 at lysine 9 (H3K9me3) in hippocampus
168 ly conserved signature N-terminal peptide of histone protein H3 plays crucial roles in gene expressio
170 ting an in vivo dose at which acetylation of histone proteins H3 and H4 increased by 100% or more in
171 rs of ORFs 62 and 63 are associated with the histone protein H3K9(Ac) and thus maintained in a euchro
173 regulatory factors (CRF)] and genes encoding histone proteins harbor recurrent mutations in most huma
177 umber of post-translational modifications on histone proteins have been described and additional site
179 We conclude that unlike DNA or individual histone proteins, human intact NETs do not directly init
181 Finally, AspAlk was shown to modify the core histone proteins, implicating aspirin as a potential che
183 ms are the posttranslational modification of histone proteins in chromatin and the methylation of DNA
185 es encoding chromatin regulatory factors and histone proteins in human cancer, implicating them as ma
186 s have focused on the role of acetylation of histone proteins in modulating transcription, whereas de
187 ine residues in the N-terminal tails of core histone proteins in nucleosome is of fundamental importa
191 atin was gradually degraded, indicating that histone proteins in proper association with DNA may be t
192 s accomplished by the wrapping of DNA around histone proteins in repeating units of nucleosomes to fo
193 Their ability to stabilize highly abundant histone proteins in the cellular environment prevents no
194 enrichment of permissive epigenetic marks on histone proteins in the hippocampus of male cocaine-sire
195 e of the highest binding affinities for core histone proteins in the mouse genome were not altered by
196 s post-translational modifications (PTMs) on histone proteins in the nucleosome and by nucleobase mod
197 Here we show that Acr forms adducts with histone proteins in vitro and in vivo and preferentially
198 tors, independently of FOXP3, as well as non-histone proteins, in addition to their effects on chroma
199 shown also to play a role in regulating non-histone proteins, including the tumor suppressor protein
200 n nucleosome core particles reveals that the histone proteins increase strand scission between 130- a
201 phospho-Ser10 and Thr11 mediate significant histone-protein interactions, and nucleate additional in
204 thylation of lysine residues on the tails of histone proteins is a major determinant of the transcrip
206 addition to DNA methylation, modification of histone proteins is also an important regulator of impri
214 mour suppressor p53 is one of only a few non-histone proteins known to be regulated by lysine methyla
215 may be regulating initiation by controlling histone protein levels and/or by affecting origin chroma
216 ucidated the posttranslational regulation of histone protein levels by the ubiquitin-proteasome pathw
218 Different mechanisms operate to regulate histone protein levels, and induction of human histone g
219 ative aging is accompanied by a reduction in histone protein levels, and this is a cause of aging in
221 ated p300, which comprise the KAT3 family of histone/protein lysine acetyltransferases, interact with
222 ar that CBP acetylates both histones and non-histone proteins, many of which are transcription factor
223 s on how acetylation of both histone and non-histone proteins may drive cancer, and we will discuss t
224 Posttranslational modifications (PTMs) of histone proteins may result in altered epigenetic signal
225 ulatory roles of lysine methylation, the non-histone protein methylation may create binding sites for
227 in chromatin structure--hypersensitivity and histone protein modifications--between human embryonic s
228 are involved in binding epigenetic marks on histone proteins, more specifically acetylated lysine re
229 ion and association kinetics under different histone protein (NCP) and NaCl concentrations using sing
230 approximately 146 bp of DNA wrapped around a histone protein octamer that controls DNA accessibility
232 chemical modifications that are found on the histone proteins of eukaryotic cells form multiple compl
233 Post-translational modifications (PTMs) of histones, proteins onto which DNA is packaged, are invol
235 atin is a supramolecular assembly of DNA and histone proteins, organized into nucleosome repeat units
237 , however, as HATs and HDACs also target non-histone proteins particularly transcription factors to a
239 lational modifications of the DNA-associated histone proteins play fundamental roles in eukaryotic tr
242 te, for the first time, that shrimp hemocyte histone proteins possess antimicrobial activity and repr
244 e through post-translational modification of histone proteins, primarily histone H3 phosphorylation a
246 apply MAS NMR to directly probe the dynamic histone protein regions in (13)C,(15)N-enriched recombin
249 methyl groups to the amino terminal tails of histone proteins regulates cellular gene expression at v
251 encoded in covalent modifications of DNA and histone proteins regulates fundamental biological proces
255 ged molecules such as DNA, and any excess of histone proteins results in deleterious effects on genom
257 are responsible for binding the highly basic histone proteins, shielding them from non-specific inter
258 ith circulating autoantibodies to chromatin, histone proteins, Sm/La, and other nuclear and cytoplasm
263 ucho interacts with histone deacetylases and histone proteins, suggesting that it may effect repressi
265 ociated with nucleosomes containing modified histone proteins that are generally found associated wit
266 f select archaea have identified homologs of histone proteins that assemble into tetrameric nucleosom
268 important post-translational modification of histone proteins that defines epigenetic status and cont
269 Yeast Scm3 and human HJURP are conserved non-histone proteins that interact physically with the (CenH
272 Accelerated upregulation of genes encoding histone proteins that support DNA replication is the mos
273 otein modification for both histones and non-histone proteins, the mechanisms of acetylation-mediated
276 es negative feedback on the histone genes by histone proteins through the level of saturation of hist
277 through the regulation of the binding of non-histone proteins to chromatin, based on their location i
278 lls, the genome is packaged and rolled up by histone proteins to create a series of DNA/histone core
280 most of the molecules did not associate with histone proteins to form regularly spaced nucleosomes.
282 echanism in which Rtt106 sensed the level of histone proteins to maintain the proper level of histone
283 sent in unperturbed cells and all sources of histone proteins to the extent of 0.04-0.1% of all lysin
284 icroviscosity in live cells experienced by a histone protein using the photoswitching kinetics of Dro
288 We determined that the levels of multiple histone proteins were markedly decreased in cohorts of i
289 hly flexible N- or C-terminal protrusions of histone proteins which facilitate the compaction of DNA
290 A and a variety of modified histones and non-histone proteins, which have an impact on cell different
291 n requires posttranslational modification of histone proteins, which, in concert with chromatin-remod
292 ctrophoresis; and immunoblotting of isolated histone proteins with modification-specific antibodies.
294 tant post-translational modifications on non-histone proteins, with emphasis on their roles in diseas
295 nts, the DNA unwinds asymmetrically from the histone proteins, with only one of its two ends preferen
297 st-translational modifications (PTMs) of the histone proteins within nucleosomes regulate these DNA p
298 that the posttranslational modifications of histone proteins within the chromosome impact chromatin
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