ライフサイエンスコーパス: hitherto

1 k wind in V404 Cyg, which is unlike any seen hitherto.

2 n bacteria, no inhibitor has been identified hitherto.

3 Hitherto, a viable device platform to electrically probe

4 e this discrepancy by using PEG to perform a hitherto absent negative control.

5 Hitherto, all reconstructions of the colors of reptile i

6 Hitherto, ancient frozen soils have proved excellent in

7 ring BRCA1/BRCA2 deficiency (up to 22%) than hitherto appreciated ( approximately 1-5%) who could hav

8 rging of state-of-the-art phenomena that was hitherto attainable in media that demonstrated these tra

9 12p35 subunit has immunoregulatory functions hitherto attributed to IL-35.

10 ning realistic models of neural networks has hitherto been a task for computing professionals rather

11 integrity of the neurovascular unit has not hitherto been assessed.

12 res; however, no confident measurements have hitherto been available.

13 However, no investigation has hitherto been conducted to investigate the hysteretic or

14 ite enhanced persistent currents, which have hitherto been considered a prerequisite for resurgent cu

15 One factor that has not hitherto been considered is ovulation order, although it

16 Direct air capture (DAC) of CO2 has hitherto been deemed unviable because of the higher ener

17 revious city-scale UF assessments which have hitherto been dependent on proxy data for UF.

18 ve efficacy of the three forms of F have not hitherto been directly compared.

19 y disparate products from strictosidine have hitherto been elusive.

20 ior, during and after nova eruptions has not hitherto been found.

21 d stellar objects to the Galactic medium has hitherto been found.

22 Surveys of their biodiversity have hitherto been geographically restricted and have not acc

23 ly be expected, but no individual system has hitherto been identified that must have been formed by m

24 nised by the VanSA sensory component has not hitherto been identified.

25 ically plausible form of pleiotropy that has hitherto been ignored in treatments of IRSC and arrive a

26 direct evidence from disruptive studies has hitherto been lacking.

27 ever, infrared spectroscopic techniques have hitherto been limited either by narrow bandwidth and lon

28 Investigations of microscale impact have hitherto been limited to post-mortem analysis of impacte

29 iffusion on this small scale in situ has not hitherto been possible, yet this knowledge is critical f

30 The inflammasome pathway has hitherto been reported as a principal pathway promoting

31 is visual rotation was more complex than has hitherto been reported, consisting broadly of two consec

32 emperatures of more than 100 kelvin) has not hitherto been seen, as it generally lies very close to t

33 ale also applies to plants, where it has not hitherto been tested.

34 It has hitherto been unclear whether the same holds for more co

35 This competing reaction, which has hitherto been underestimated as a source of side product

36 D shape and surface electrostatics with few, hitherto best known inhibitors of SOCE.

37 t hair phenotype, as seen for mutants of all hitherto characterized extensin glycosylation enzymes; b

38 ositely charged polyelectrolytes, which were hitherto deemed "impossible" to process, since they are

39 N-glycopeptides and N-glycoproteins that are hitherto difficult to obtain for structural and function

40 determinate nature of this interface made it hitherto difficult to study structure/function relations

41 stage for single-molecule studies of several hitherto difficult-to-investigate multi-molecular transa

42 ) N-oxides to acrylate equivalents to afford hitherto elusive 2-tert-alkyl azaaryl adducts with high

43 provides a clean gas-phase synthesis of this hitherto elusive cyclic radical species 1,2,4,7-cyclooct

44 abling the clean gas-phase synthesis of this hitherto elusive cyclic species from acyclic precursors

45 The hitherto elusive disilavinylidene (H2 SiSi) molecule, wh

46 e captured in three conformations, revealing hitherto elusive states of tRNA engagement with the ribo

47 ad swivel and biasing IRES translocation via hitherto-elusive intermediates with PKI captured between

48 c Sxl alternative splicing reveals that this hitherto enigmatic mRNA modification constitutes an anci

49 This is markedly different from the hitherto established chemical reactivity of Ar.

50 BLAST jobs that hitherto failed or slogged inefficiently to completion n

51 spastic ataxias, accounting for about 3% of hitherto genetically unclassified autosomal recessive an

52 t is predicted by theory and experiment, but hitherto has not been documented at the population level

53 The test we developed exposes a hitherto hidden layer of personal variants that promise

54 The synthesis and characterization of hitherto hypothetical Au(III) pi-alkyne complexes is rep

55 ial positions of single objects has not been hitherto identified in any arthropod.

56 WAS) enable systematic searches for loci not hitherto implicated in the etiology of AD, many true fin

57 of biochemical and structural data that was hitherto impossible to evaluate.

58 cular analyses of multiple disease states as hitherto impossible.

59 ment of a novel class of drugs to combat the hitherto intractable disorder of chronic asthma.

60 ificantly increase their accuracy and enable hitherto intractable simulations.

61 Thus, there is no reason to assume that the hitherto intriguing resistance of DTM-bound PEX5 to alka

62 scale and has allowed the observation of the hitherto invisible property of phospholipid membranes us

63 anostructures in an electron microscope, but hitherto it has not been possible to map vibrational mod

64 Hitherto it has remained difficult to quantify the effec

65 However, hitherto it remains unknown if grid-like representations

66 This signal is not compatible with any hitherto known ERP signature of spatial selection and al

67 practical value of this work in providing a hitherto lacking design tool for a novel technology.

68 tribe Gnaphalieae (Asteraceae), based on the hitherto largest taxon sampling, a total of 835 terminal

69 diazo compound partner in a mild fashion has hitherto limited their general use and the scope of the

70 nic pollutants (POP) in fish tissue has been hitherto limited to application in lipid-rich tissue.

71 arene arylations and benzylations, which was hitherto limited to the use of halide electrophiles.

72 s for racemization in aqueous conditions was hitherto limited.

73 is and spectroscopic characterization of the hitherto longest periacene analogue with oxygen-boron-ox

74 enerated transgenic mice and reveal that the hitherto methods determining total cAMP levels do not re

75 Our results provide a hitherto missing understanding of the nature of the halo

76 These were compared to the hitherto-most-extensive genome dataset characterized for

77 That said, there have been hitherto no successful measurements of NEMS resonators i

78 sts that some should have been detected, yet hitherto none has been seen.

79 whole series of alpha/beta-substituted enals hitherto not amenable to NHC-catalyzed transformations.

80 ng" microtubule at crossovers, and reveals a hitherto not appreciated role for microtubule bundling.

81 es mapped to ribosomal proteins, a signature hitherto not associated with linezolid toxicity.

82 to the brain with no peripheral exposure has hitherto not been demonstrated with brain quantification

83 t substance groups were identified that have hitherto not been described in horseradish.

84 while well explored in modeling studies, has hitherto not been documented in proxy data from the SAMS

85 he icy moons of Jupiter and Saturn, but have hitherto not been observed near bodies with refractory r

86 rds the elucidation of human disease, it has hitherto not been possible to tune up or down the level

87 on system including the premotor cortex, has hitherto not been provided.

88 rent and efferent connections of the IP have hitherto not been systematically investigated with sensi

89 The expression and function of two proteins hitherto not described in skin mast cells was investigat

90 formed potentially mutagenic substances were hitherto not identified and may result from the reaction

91 This study unveils a hitherto not recognized structural basis for the feature

92 is very different from the adduct alignments hitherto observed in free or protein-bound DNA.

93 Early Jurassic origin (226-187 Ma) it is the hitherto oldest dated endemic lineage of animal or plant

94 s been reported, the underlying mechanism is hitherto only poorly understood.

95 he formation of hydroxyaluminosilicates were hitherto only theoretical and plausibly only accessible

96 They reveal a hitherto overlooked dependence on (or 'propensity rule'

97 s challenge conventional wisdom and define a hitherto poorly characterized reaction class forming com

98 ons of enzymes led to a working model of the hitherto, poorly understood innermost xyloglucan-rich he

99 yield a more accurate antigenic picture than hitherto possible of a genuinely untriggered and functio

100 In this review, we summarize the hitherto proposed mechanisms involved in diabetic hyperf

101 Investigators have hitherto relied on candidate protein-based tools to corr

102 hand, full mapping of the magnetic field has hitherto remained challenging.

103 ganic frameworks toward this application has hitherto remained elusive.

104 d what underlies individual differences have hitherto remained unanswered.

105 The IL-based processes hitherto reported, such as IL-based solid-liquid extract

106 ased on compilation and analysis of the data hitherto reported, we provide a judicious assessment of

107 ring devices for alpha-amylase detection has hitherto restricted the clinical progress of such applic

108 orium-arsenic multiple bonding interactions, hitherto restricted to cryogenic matrix isolation experi

109 Hitherto, such Pi sensing has not been documented in met

110 No study has hitherto systematically assessed daily fluctuations of h

111 and velocities up to 1.4 m/s this represents hitherto the fastest protonic communication observed.

112 rties on synaptic currents and thus provides hitherto the most detailed analysis of synaptic transmis

113 cisely organometallic polymers) appear to be hitherto the only characterized polymers with a backbone

114 Hitherto, the catalytic formation of versatile pyridiniu

115 Hitherto, the clinical manifestation of ATR deficiency h

116 Hitherto, these cross-allergies are predominantly report

117 y feature relevant for current goals nor one hitherto thought to be involved in attentional control.

118 ansport and storage in Earth's interior than hitherto thought.

119 We reveal a hitherto un-described dichotomy within V. longisporum li

120 Soil biota, hitherto unaccounted for in climate models, interacts wi

121 d boron nitride nanotubes exhibit unique and hitherto unanticipated catalytic properties, resulting i

122 se that Rim15/Gwl regulation of PP2A plays a hitherto unappreciated role in cell size homeostasis dur

123 In this context, simple production of hitherto unattainable new inorganic glass blends from al

124 Thus, this antibody represents a reliable, hitherto unavailable and a valuable tool to study PKC ac

125 oscytalin, a natural 3-spirotetramic acid of hitherto uncertain absolute configuration, was synthesiz

126 Our work highlights a hitherto uncharacterized effect of alcohol on BAT functi

127 cellular loop of ENaC-alpha, as well as to a hitherto uncharacterized internal site.

128 Here, we present investigation of AlmG, the hitherto uncharacterized member of the AlmEFG pathway.

129 Surprisingly, we uncovered a hitherto uncharacterized monosynaptic connection between

130 Rather, AutoN cooperated with a hitherto uncharacterized motif, termed AcidicN, to confe

131 As a second target, we identified ssr1528, a hitherto uncharacterized nitrogen-regulated gene.

132 Here we report that this hitherto uncharacterized protein possesses branch migrat

133 we describe pyocyanin demethylase (PodA), a hitherto uncharacterized protein that oxidizes the pyocy

134 in known signalling pathways, and identifies hitherto uncharacterized signalling cascades.

135 presently known proteases, suggesting that a hitherto uncharacterized, membrane-associated protease a

136 ctivating protein (GAP) and Spred1 acting on hitherto undefined components of the pathway.

137 These hitherto undefined motion components unify the results o

138 Taken together, our work detects a hitherto under-appreciated and clinically important clas

139 that the latent reservoir has important, and hitherto under-appreciated, roles in both within- and be

140 To obtain new insights into hitherto underappreciated aspects of keloid pathobiology

141 peripheral somatosensory ganglia represent a hitherto underappreciated site of somatosensory signal i

142 and 5-HT, a dual neurotransmitter phenotype hitherto undescribed in the brain of any vertebrate.

143 The potential of hitherto undescribed polyketides from P. malabarica as n

144 This discovery represents a hitherto undescribed vertebrate pathway that links lumin

145 stal structures of such trinaphthylenes were hitherto undescribed.

146 d by first-principles calculations, reveal a hitherto undetected but crucial feature: a (2 x 2) elect

147 planetary disks, there should be a large but hitherto undetected population of terrestrial planets or

148 SPT) that is coupled to dehydration or via a hitherto undisclosed pathway that involves photoionizati

149 Our studies thus reveal a hitherto undiscovered novel interaction pattern that con

150 We describe hitherto undocumented practices of personal ornamentatio

151 ed for efficient occlusion, which provides a hitherto unexpected design rule for the incorporation of

152 dation but rather by peptidyl transfer and a hitherto unexpected step at the P site.

153 l response, and also offer new mechanisms to hitherto unexplained observations.

154 The hitherto-unexplained experimental behavior of sulfonylal

155 Together, our data elucidate the hitherto unexplored mechanism of centrosome migration an

156 The broad applicability of the hitherto unexplored reagent combination PPh3.HBr-DMSO is

157 te slices and in vivo promises to unveil the hitherto unexplored, potentially fundamental aspects of

158 cell transformation and EBV latency that was hitherto unexplored.

159 O3-delta, the brownmillerite SrCoO2.5, and a hitherto-unexplored phase, HSrCoO2.5.

160 A hitherto unidentified hydride transfer pathway involving

161 that of IL-17, which inhibits Del-1 through hitherto unidentified mechanism(s).

162 A hitherto unidentified N-ethyl-N-nitrosourea (ENU)-induce

163 The presence of hitherto unidentified polar compounds present in PAH-con

164 ed in neutron-star mergers, giving rise to a hitherto unidentified population of radio, ultraviolet,

165 f plastid-localized proteins and establish a hitherto unidentified post-translational regulatory mech

166 In addition, a hitherto unidentified restoration of the varnish has bee

167 opic, and kinetic evidence further support a hitherto unknown (bpy(*-))Co(I)(THF)2 ground state that

168 rapes indicate stereotypical avian behaviour hitherto unknown among Cretaceous theropods, and most li

169 Moreover, by revealing a hitherto unknown aspect of lysosomal biology under stres

170 The obtained nanoCT data revealed hitherto unknown aspects of the onychophoran limb muscul

171 nt an aberrant basal ichthyosauriform with a hitherto unknown body design that suggests a fast radiat

172 performs two consecutive reactions by using hitherto unknown catalytic mechanisms.

173 Here, we report the discovery of a hitherto unknown chemical class, dihydroxymagnesium carb

174 Hitherto unknown cis- and trans-1-amino-3-hydroxy-3-meth

175 the extracellular medium, possibly through a hitherto unknown communication signal transduction pathw

176 Trapping a hitherto unknown degradation product with OPD yielded 1,

177 This hitherto unknown Del-1 function in the HSC niche represe

178 opy (SERS) was used to successfully identify hitherto unknown dimeric methylalumina surface species d

179 Here we investigated the hitherto unknown effects of resistant starch type 4 (RS4

180 In summary, our findings illuminate a hitherto unknown epigenetic function for eHsp90 and supp

181 Familiar faces also recruited two hitherto unknown face areas at anatomically conserved lo

182 The perturbation also reveals a hitherto unknown feature of sensorimotor integration: th

183 Our results identified hitherto unknown features of attenuation of virulence th

184 These findings identify a hitherto unknown function for Fgf20 in mammary budding a

185 Our study thus reveals a hitherto unknown function of DTD in cracking the univers

186 se Vhs1 and its substrate Sip5, a protein of hitherto unknown function.

187 ROSC, which encodes a PLP-binding protein of hitherto unknown function.

188 factor alpha-inducing protein Tipalpha) and hitherto unknown functional genes.

189 RAN-binding protein 6 (RanBP6), a protein of hitherto unknown functions.

190 Our analyses revealed a hitherto unknown generic mechanism for large-scale metab

191 styryl)-1,2,4-benzothiadiazine-1,1-dioxides, hitherto unknown heterocycles.

192 An optimized synthesis of the hitherto unknown hexaphosphane (LGa)2P6 (3) is presented

193 by a C2-symmetric salen ligand which shows a hitherto unknown high activity for the ROP of rac-lactid

194 A hitherto unknown IgE-binding site was mapped on the stal

195 In line with this, here we propose a novel, hitherto unknown interaction between the complement inhi

196 Among them are many hitherto unknown interaction partners of NFATc1 and NFAT

197 Taken together, we identify IkappaBzeta as a hitherto unknown key regulator of IL-17A-driven effects

198 Taken together, our findings establish a hitherto unknown link between histone chaperones and abi

199 Experimental confirmation of this hitherto unknown macromolecular target expands the bioac

200 Among the fossils of hitherto unknown mammals that Darwin collected in South

201 We identified known and hitherto unknown mass ambiguities in high- and ultrahigh

202 We present a hitherto unknown mechanism of how temperature-induced ch

203 n the primate brain and that this includes a hitherto unknown mechanism that attenuates sensory adapt

204 tes to initiate sexual development through a hitherto unknown mechanism.

205 Our findings identify a hitherto unknown NCLX-mediated pathway that coordinates

206 The impact of our ability to recognize hitherto unknown organisms on plant pathology and trade

207 We report a hitherto unknown overdominant effect (allelic interactio

208 paracyclophanes as small and strained as the hitherto unknown oxa[1.5]metaparacyclophane could be pre

209 enomas, sporadic premalignant lesions with a hitherto unknown pathogenesis, and these lesions can be

210 Such hitherto unknown patterns over the entire North American

211 nabled the spectroscopic identification of a hitherto unknown phenyldioxophosphorane, the long elusiv

212 nscription co-factor in the WNT pathway with hitherto unknown physiological function.

213 it of the F1-ATPase of P. denitrificans by a hitherto unknown quaternary structure that was first mod

214 ry work with human astrocytes has revealed a hitherto unknown range of astrocyte types with potential

215 ine model of melanoma (B16-F0) to identify a hitherto unknown role for C3a-C3aR signaling in promotin

216 Collectively, these data demonstrate a hitherto unknown role for PGI2 in regulating the number

217 These findings collectively demonstrate a hitherto unknown role of MDC1-->And-1-->CtIP axis that r

218 Collectively, our results reveal a hitherto unknown role of mesenchymal IKKbeta in driving

219 ies, including alkylated derivatives and two hitherto unknown series.

220 resentative of some bacterial suspensions, a hitherto unknown static structure is predicted, where pa

221 ociates broadly with cytosolic, nuclear, and hitherto unknown substrate classes of mitochondrial and

222 roscopy to reconstruct PNS neurons and their hitherto unknown synaptic networks in the tadpole larva

223 We sought to identify and characterize a hitherto unknown type of HAE with normal C1-INH and with

224 of potential biological pleiotropy that was hitherto unknown, and represent an opportunity for funct

225 ished the structure of a long-suspected, but hitherto unknown, benzofuran side product (EBI) formed d

226 for confidence and a degree of flexibility, hitherto unknown, in the brain's ability to rapidly and

227 bicyclic olefin whose surface chemistry was hitherto unknown.

228 to (1,7)naphthalenophanes by this method was hitherto unknown.

229 the mechanistic basis for this regulation is hitherto unknown.

230 ical mechanisms that mediate this effect are hitherto unknown.

231 Our study thus reveals a hitherto-unknown mechanism of GRP78 secretion and may al

232 Thus, our findings delineate a hitherto-unknown mechanism of protein deacetylation and

233 E) from the TI surface, which results from a hitherto-unknown resistivity anisotropy induced by an in

234 l approach yields real-time PK curves with a hitherto unmatched time resolution (10 s), and none of t

235 ting structure of quantum mechanics that was hitherto unnoticed.

236 dorsal to the jugular canal, representing a hitherto unobserved combination of derived and primitive

237 Here we report a hitherto unobserved magnetoresistive effect in ultra-cle

238 A hitherto unobserved requirement of short-chain lipids in

239 In a hitherto unobserved state (s4), the gate controlling acc

240 the discovery of a kind of solution assembly hitherto unobserved, to our knowledge.

241 We report the discovery of a hitherto unprecedented enzyme-promoted alpha-hydroxyketo

242 In the present analysis, we provide hitherto unpublished data on the cardiovascular effects

243 ch as micrometer scale electrodes, require a hitherto unrealized means to obtain high signal-to-noise

244 ate that marked phase heterogeneity may be a hitherto unrecognised feature of fish carbonates across

245 ales with spinal onset disease, indicating a hitherto unrecognised gender-mediated effect of the vari

246 These findings suggest a hitherto unrecognised level of social complexity in hump

247 Our results reveal a hitherto unrecognized activation of specific AMPK comple

248 many associated loci contain genes that were hitherto unrecognized as playing a role in fibrosis, ope

249 que to HPV, and thus we may have uncovered a hitherto unrecognized cellular pathway that may be of in

250 ide a roadmap of these advances and identify hitherto unrecognized challenges for this multi- and int

251 We show the existence of a hitherto unrecognized class of sirtuins, found predomina

252 and can also be partially eliminated with a hitherto unrecognized compensatory mechanism that uses t

253 er, these results suggest the existence of a hitherto unrecognized coronin 1-dependent decision switc

254 diated by the tumor suppressor gene GRHL3, a hitherto unrecognized D3 transcriptional inhibitor.

255 We identified a hitherto unrecognized function of IL-33 as a potent supp

256 s and variable stoichiometries, suggesting a hitherto unrecognized heterogeneity in the functional un

257 hese observations point to exploitation of a hitherto unrecognized lumenal source of H2O2 by PRDX4 an

258 We identify a hitherto unrecognized modulation of basal BP by myeloid

259 tner NUP205 or XPO5 (encoding exportin 5) as hitherto unrecognized monogenic causes of SRNS.

260 Our findings illuminate a prevalent and hitherto unrecognized mutational process linking cellula

261 Our results reveal a hitherto unrecognized negative feedback between glaciati

262 Our study reveals hitherto unrecognized neuronal mechanisms for the genera

263 Therefore, our results identify a hitherto unrecognized Nox2-mediated intracellular signal

264 H cell inactivation in adult brain induced a hitherto unrecognized overeating phenotype and caused ov

265 Taken together, our findings reveal a hitherto unrecognized role for copper in the regulation

266 we hypothesize that IsoLG modification is a hitherto unrecognized sequelae that contributes to radia

267 tion in the presence of sulfate aerosol is a hitherto unrecognized source of anthropogenic secondary

268 t an expanding unit cell, and are related by hitherto unrecognized structural principles; we call the

269 These data identify an important, hitherto unrecognized, factor that may limit restoration

270 nature, the mechanism could also serve as a hitherto-unrecognized spatial template in many other bac

271 Taken together, our results delineate a hitherto unreported axis of regulation that involves the

272 etate in addition to ethanol, including from hitherto unreported carbon sources.

273 Overall, our study describes a hitherto unreported conserved mechanism of transcription

274 e argue that the data support a further, and hitherto unreported contribution of magma mingling to hi

275 We identified a hitherto unreported disease mechanism (defective linear

276 ned to icosahedral and other faceted shapes, hitherto unreported for liquid droplets.

277 een successfully applied to the syntheses of hitherto unreported imidazo-fused benzimidazoquinazoline

278 which the triazolo N1 atom coordinates in a hitherto unreported monodentate interaction with the act

279 These hitherto unreported products are easily isolated in high

280 The hitherto unreported stereochemical outcome of this synth

281 pression in engineered yeasts and report ten hitherto unreported triterpenoid oxidation activities, i

282 cording past changes in precipitation in the hitherto unsampled core region of the SAMS.

283 from an extreme modification of the clypeus hitherto unseen among living and extinct ants and scythe

284 gement, the fully open form of the integrin, hitherto unseen at high resolution, attaches to an exten

285 against highly contaminating media retaining hitherto unseen mechanical durability.

286 ., uses n samples to predict the number U of hitherto unseen species that would be observed if [Formu

287 ltage sensor in the resting state, providing hitherto unseen structural insight into the general volt

288 Co-evolutionary constraints reveal hitherto unseen structures of functional importance in a

289 r (intramolecular) hydrogen bonds (H-bonds), hitherto unstudied in pCps, between pseudo-ortho-positio

290 We also provide evidence for a hitherto unsuspected additional mechanism that contribut

291 opteran navigation strategies, including the hitherto unsuspected capabilities of high-altitude migra

292 ect in ccRCC that leads to downregulation of hitherto unsuspected epigenetic factors, and suggest tha

293 These findings attribute hitherto unsuspected functionality for 1,5-InsP8 to bioe

294 These results have revealed hitherto unsuspected inflammatory signaling networks at

295 ode of tubular cast formation, revealing the hitherto unsuspected mechanism of vancomycin-associated

296 an anticipated in the absence of ponding and hitherto used in models of ice-shelf fracture and flow.

297 dala but also to the olfactory cortex, which hitherto was considered to arise from the lateral palliu

298 bition mechanism, a canonical principle that hitherto was found to operate mainly in early sensory pr

299 les of country successes in strengthening of hitherto weak systems are emerging.

300 overing the existence of 14 metabolites that hitherto were not identified by NMR.