ライフサイエンスコーパス: hnRNP

1 hnRNP and SR proteins also regulate the expression of ot

2 hnRNP F stimulated Sirtuin-1 transcription via hnRNP F-r

3 hnRNP K directly binds to C-rich single-stranded DNA wit

4 hnRNP K protein was bound to antioxidant NFE2L2 transcri

5 hnRNP K regulates cellular programs, and changes in its

6 hnRNP L and NF90 were found to associate with HCV RNA in

7 hnRNP L undergoes two previously unrecognized, condition

8 hnRNP-Q1 is an mRNA-binding protein that regulates mRNA

9 hnRNP-Q1 is highly expressed in brain tissue, suggesting

10 G motifs enriched within approximately 2,500 hnRNP A2/B1 binding sites and an unexpected role for hnR

11 Interestingly, AS targets of the QKI-6-hnRNP F/H pathway in OLs are differentially affected in

12 Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a multipurpose RNA-binding protein (RBP) in

13 heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), a protein with multiple roles in mRNA metabol

14 heterogeneous nuclear ribonucleoprotein A1 (hnRNP-A1) has been implicated in telomere protection and

15 uence called the A2 response element (A2RE), hnRNP A2 proteins that bind specifically (with high affi

16 y attenuates viral replication by abrogating hnRNP A1 interactions.

17 Although hnRNP I and AUF1 can interact with many RNA species and

18 n-dependent interplay between a miRNA and an hnRNP that regulates their functions in a bidirectional

19 We have identified an hnRNP E1 consensus-binding motif and genomically resolve

20 Thus, AtGRP7 is an hnRNP-like protein with a role in processing of pri-miRN

21 sses CGG repeat-triggered mis-splicing of an hnRNP A2/B1-targeted transcript.

22 eported that competition between miR-297 and hnRNP L to bind a 3UTR-localized CA-rich element (CARE)

23 and functional interplay between TDP-43 and hnRNP A/B orthologs might play a crucial role in the pat

24 With 120-180 s incubation, IMC-48 and hnRNP LL destabilize i-motifs, which has been previously

25 ognition algorithm, we found that IMC-48 and hnRNP LL share 80% similarity in stabilizing i-motifs wi

26 oly(C) binding proteins, PCBPs (alphaCPs and hnRNP E proteins), are encoded by a highly conserved and

27 RNA foci with SRSF2, hnRNP H1/F, ALYREF and hnRNP A1 in cerebellar granule cells and with SRSF2, hnR

28 nuclear ribonucleoprotein (hnRNP)-A2/B1 and hnRNP-R as interactors binding directly to the ASCL1 mRN

29 rong correlation between hnRNP L binding and hnRNP L-dependent splicing regulation.

30 Mutations of human Slo2 channel and hnRNP U are strongly linked to epileptic disorders and i

31 expression level, suggesting that Chtop and hnRNP H regulate intron 2 retention of Chtop mRNA antago

32 Inhibition of HSP90 and hnRNP A2/B1 reduced the activation of AKT and Slug expre

33 PCBP2, IGF2BP1, and hnRNP L binding were blocked by preannealing the single-

34 PCBP2, IGF2BP1, and hnRNP L bound single-stranded RNA, while DHX9, ADAR1, an

35 ron-bound Rbfox is associated with LASR, and hnRNP M motifs are enriched adjacent to Rbfox crosslinki

36 rentially spliced gene isoforms in LIN28 and hnRNP A1 small interfering RNA (siRNA)-treated cells.

37 between miR-574-3p, a CA-rich microRNA, and hnRNP L.

38 ibrium perspective, that small molecules and hnRNP LL can modulate bcl-2 transcription through intera

39 kinetics of the consensus-binding motif and hnRNP E1, its various K-homology (KH) domains and p-hnRN

40 ding proteins, such as hnRNP L, PTB/nPTB and hnRNP A1/A2.

41 We observed that SR and hnRNP proteins tend to act coordinately with each other,

42 vestigate the protein connectivity of SR and hnRNP proteins to the core spliceosome using probabilist

43 g of each factor demonstrated that SRSF1 and hnRNP H antagonistically modulate splicing by binding ex

44 Overexpression of ARVCF, p68, SRSF1, and hnRNP H2 induces a significant increase in splicing acti

45 anslation initiation factors, helicases, and hnRNPs.

46 tors and repressors, such as SR proteins and hnRNPs, modulate spliceosome assembly and regulate alter

47 by additional RNA-binding proteins, such as hnRNP L, PTB/nPTB and hnRNP A1/A2.

48 nts on 19 RBPs involved in splicing (such as hnRNPs, U2AF2, ELAVL1, TDP-43 and FUS) and processing of

49 ALS-associated hnRNP A2/B1 D290V mutant patient fibroblasts and motor n

50 erogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) bound PBT-1 in CL1-5 cells.

51 o a thermodynamically stable complex between hnRNP K and the unfolded i-motif.

52 ecifically show a strong correlation between hnRNP L binding and hnRNP L-dependent splicing regulatio

53 High-affinity interactions between hnRNP A2 and conditional GA-type RNA targeting motifs ar

54 further exploration of the interplay between hnRNP K (or other hnRNPs) and Nrf2-mediated antioxidant

55 control of IDR-mediated interactions between hnRNPs represents an important and recurring mechanism u

56 native name for TOG protein) that binds both hnRNP A2 molecules and RNA.

57 underlying neurological disorders caused by hnRNP U mutations.

58 We show that splicing repression mediated by hnRNP M is stimulated by Rbfox.

59 basis for the recognition of the i-motif by hnRNP LL is determined, and we demonstrate that the prot

60 within the 4CT element and is recognized by hnRNP K, which leads to a low level of transcription act

61 ntly, analysis of several exons regulated by hnRNP L shows a clear relationship between the potential

62 of either RRM impairs splicing repression by hnRNP A1.

63 Genes that are translationally silenced by hnRNP E1 and expressed by its dissociation are highly im

64 trast, suppression of CGG repeat toxicity by hnRNP A2/B1 is not affected by RNAi-mediated knockdown o

65 e heterogeneous nuclear ribonucleoprotein C (hnRNP C) family.

66 e heterogeneous nuclear ribonucleoprotein-C (hnRNP)-like proteins interacts with the nascent transcri

67 We used RNA sequencing (RNA-seq) to confirm hnRNP A1 and A2/B1 motif-dependent roles genome-wide, pr

68 ng and in vitro evolution identify consensus hnRNP A1 binding motifs; however, such data do not revea

69 574-3p, acting as a decoy, binds cytoplasmic hnRNP L and prevents its binding to the CARE and stimula

70 s heterogeneous nuclear ribonucleoprotein D [hnRNP D]) binds to numerous mRNAs and influences their p

71 ng to known splicing factors including DDX5, hnRNP K, and PRPF6.

72 Overall, our studies demonstrate hnRNP K to be a multifunctional protein that supports VS

73 he G2 and M phases and that DNA-PK-dependent hnRNP-A1 phosphorylation promotes the RPA-to-POT1 switch

74 our results indicate that DNA-PKcs-dependent hnRNP-A1 phosphorylation is critical for capping of the

75 cells lacking hnRNP-A1 or DNA-PKcs-dependent hnRNP-A1 phosphorylation, impairment of the RPA-to-POT1

76 ovel HILDA (hypoxia-inducible hnRNP L-DRBP76-hnRNP A2/B1) complex that coordinates a three-element RN

77 Drosophila hnRNP A1, Hrp38, is required for germ line stem cell mai

78 heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) at serine-43 (p-hnRNP E1).

79 y preventing U2AF65 binding to Alu elements, hnRNP C plays a critical role as a genome-wide sentinel

80 These findings establish hnRNP K as a new critical regulator of synaptic transmis

81 ed survival in long-term culture and exhibit hnRNP A2/B1 localization to cytoplasmic granules as well

82 f heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D

83 The RNA processing factor hnRNP L is required for T cell development and function.

84 C repeat RNA in vitro is the splicing factor hnRNP H, and that this interaction is linked to G-Q form

85 MC-76 or IMC-48) or the transcription factor hnRNP LL are compared to reveal the MPD of different spe

86 otif (RRM1) of putative transcription factor hnRNP LL containing nucleobase amino acids at specific p

87 ugh interaction with a host splicing factor, hnRNP A1, and regulates E6 and E7 expression of the earl

88 -dependent rescue does, however, require fly hnRNP A2/B1 homologues Hrb87F and Hrb98DE.

89 While Linc-RoR is required for hnRNP I to bind to c-Myc mRNA, interaction of Linc-RoR w

90 /B1 binding sites and an unexpected role for hnRNP A2/B1 in alternative polyadenylation.

91 iments using the individual RRM domains from hnRNP LL confirm the role of this transcription factor i

92 nformational change to assemble a functional hnRNP A1-RNA complex.

93 ified a broad spectrum of in vivo functional hnRNP F/H targets in OLs that contain conserved exons fl

94 ex containing the proteins hnRNP M, hnRNP H, hnRNP C, Matrin3, NF110/NFAR-2, NF45, and DDX5, all appr

95 ciated mutations in Alu elements that hamper hnRNP C binding.

96 How hnRNP K contributes to the analgesic effects of morphine

97 Drosophila Hrp38, a homolog of human hnRNP A1, has been shown to regulate splicing, but its f

98 anner similar to the cognate region of human hnRNP-C.

99 /CG9983, the fruit fly ortholog of the human hnRNP A1/A2 factors.

100 A screen identified hnRNP A1 (A1) and RPS25 as IRES-binding trans-acting fac

101 In this study, we identified hnRNP U as an RNA trans-factor associated with C9/E3.

102 d several novel proteins, including IGF2BP1, hnRNP L, DHX9, ADAR1, and NF90 (ILF3).

103 Together, these data implicate hnRNP K in the development of hematological disorders an

104 omain, the domain most frequently mutated in hnRNP-related proteins that cause ALS.

105 We provide evidence that morphine increases hnRNP K protein expression via MOR activation in rat pri

106 We describe a novel HILDA (hypoxia-inducible hnRNP L-DRBP76-hnRNP A2/B1) complex that coordinates a t

107 ns, which correlates with elevated insoluble hnRNP H/G-Q aggregates.

108 s, likely due to increased nuclear-insoluble hnRNP A2/B1.

109 esented here provide the first insights into hnRNP A1-RNA interactions.

110 Heterogeneous nuclear ribonucleoprotein K (hnRNP K) binds to the promoter region of mu-opioid recep

111 h heterogeneous nuclear ribonucleoprotein K (hnRNP K) in the nucleus and acts as a transcription fact

112 e heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a member of the family of hnRNPs and was rec

113 Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA-binding protein implicated in RNA met

114 r heterogeneous nuclear ribonucleoprotein K (hnRNP K) was found to bind selectively to the i-motif sp

115 d heterogeneous nuclear ribonucleoprotein K (hnRNP K).

116 These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 si

117 The K17-hnRNP K partnership is regulated by the ser/thr kinase R

118 rate dysregulated splicing of multiple known hnRNP H-target transcripts in C9 patient brains, which c

119 loops represent an important class of known hnRNP A1 targets, yet little is known about the structur

120 Consequently, in cells lacking hnRNP-A1 or DNA-PKcs-dependent hnRNP-A1 phosphorylation,

121 e cross-link distribution of the full-length hnRNP C on short uridine tracts.

122 enrichment of numerous splicing factors like hnRNP proteins before ZGA was surprising, because matern

123 ion with the ribonucleoprotein hnRNP L-like (hnRNP LL) has prompted a more detailed study of the natu

124 ric complex containing the proteins hnRNP M, hnRNP H, hnRNP C, Matrin3, NF110/NFAR-2, NF45, and DDX5,

125 tions of HRPU-2, a worm homolog of mammalian hnRNP U, result in dysfunction of a Slo2 potassium chann

126 For maximal hnRNP K transcription activation, two additional cytosin

127 re modulated by a bivalent adaptor molecule (hnRNP A2).

128 Moreover, hnRNP K knockdown prevents ERK cascade activation and Gl

129 Laccase2 gene product but rather by multiple hnRNP (heterogeneous nuclear ribonucleoprotein) and SR (

130 formation of tyrosine-dependent multivalent hnRNP assemblies that, in turn, function to globally reg

131 degeneration, regulated by normal and mutant hnRNP A2/B1.

132 esembles sequence elements of several native hnRNP A1-RNA stem loop targets.

133 and the principal constituent of the nuclear hnRNP core particle.

134 ere not adversely affected in the absence of hnRNP K, whereas viral genome transcription and replicat

135 utes to the morphine-induced accumulation of hnRNP K protein in regions of the central nervous system

136 ed whether morphine-mediated accumulation of hnRNP K resulted from translational control.

137 sphorylation and cytoplasmic accumulation of hnRNP K.

138 We determined the affinity of hnRNP A1 for all possible sequence variants (n = 16,384)

139 ittle is known about the structural basis of hnRNP A1-RNA recognition.

140 ionship between the potential for binding of hnRNP A1 and U1 snRNA and the effect of hnRNP L on splic

141 Binding of hnRNP C1 to the HPV16 early, untranslated region activat

142 dentify the role of translational control of hnRNP K in morphine-induced analgesia through activation

143 small interfering RNA-mediated depletion of hnRNP L and NF90 significantly impaired viral replicatio

144 tiple RNA recognition motif (RRM) domains of hnRNP L, synergizes with miR-297, reduces VEGFA mRNA tra

145 g of hnRNP A1 and U1 snRNA and the effect of hnRNP L on splicing.

146 eded to assemble an EDC with the eviction of hnRNP proteins, the late recruitment of SR proteins, and

147 Most importantly, the expression of hnRNP A1/A2 and PTB/nPTB is significantly altered in pat

148 e for inducing EMT by aberrant expression of hnRNP E1 silenced targets.

149 more RPTC apoptosis and lower expression of hnRNP F, SIRTUIN-1, and FOXO3alpha than nondiabetic kidn

150 NA processing, including selective groups of hnRNP proteins, through its N-terminal region, and direc

151 inhibitory effect of ISTL1 is independent of hnRNP A1/A2B1 and PTB1 previously implicated in SMN2 exo

152 f hnRNP L, we validate numerous instances of hnRNP L-dependent alternative splicing of genes critical

153 s methylation facilitates the interaction of hnRNP A1 with IRES RNA to promote IRES-dependent transla

154 species and destabilizes the interaction of hnRNP K with the Mid-region i-motif.

155 to the hnRNP A1-binding site or knockdown of hnRNP A1 expression promoted 233^416 splicing and reduce

156 TGFbeta treatment or knockdown of hnRNP E1 relieves silencing of the inhibin betaA transcr

157 ing T cell differentiation, and knockdown of hnRNP L or hnRNP A1 results in the lower induction of Tr

158 gh abundance of p-hnRNP E1 and low levels of hnRNP E1.

159 required for the cytoplasmic localization of hnRNP K and for its role in regulating the expression of

160 Loss of hnRNP C leads to formation of previously suppressed Alu

161 Loss of hnRNP U expression in cardiomyocytes also leads to aberr

162 tablished a strong link between mutations of hnRNP U and human epilepsies and intellectual disability

163 However, it is unclear how mutations of hnRNP U may cause such disorders.

164 ed by the AKT pathway via phosphorylation of hnRNP L.

165 Importantly, based on the binding profile of hnRNP L, we validate numerous instances of hnRNP L-depen

166 his post-translational modification (PTM) of hnRNP E1 promotes its dissociation from a 3' untranslate

167 ts located in the 5' untranslated regions of hnRNP K transcripts that were regulated by morphine.

168 Finally, we found that down-regulation of hnRNP K mediated by siRNA attenuated morphine-induced hy

169 Down-regulation of hnRNP U led to a decrease in the caspase-9a/9b mRNA rati

170 suggest that a prominent down-regulation of hnRNP-A2/B1 during hypoxia is associated with the post-t

171 Here, we investigated the role of hnRNP K in synapse function.

172 To decipher the role of hnRNP K in VSV infection, we conducted studies which sug

173 ells, in agreement with the critical role of hnRNP L throughout T cell biology.

174 onclusive evidence for the essential role of hnRNP U in heart development and function and in the reg

175 The role of hnRNP-A1 in telomere protection also involves DNA-depend

176 n addition, we show by NMR that both RRMs of hnRNP A1 can bind simultaneously to a single bipartite m

177 The RNA recognition motifs (RRMs) of hnRNP LL were expressed individually, and both RRM1 and

178 icate C9 expansion-mediated sequestration of hnRNP H as a significant contributor to neurodegeneratio

179 IP-seq) to identify the RNA binding sites of hnRNP L within the transcriptomes of human CD4(+) and cu

180 sults reveal general rules of specificity of hnRNP A1 and provide a quantitative framework for unders

181 rotein 43 (Gap-43) mRNA as a novel target of hnRNP-Q1 and have demonstrated that hnRNP-Q1 represses G

182 However, the spectrum of direct targets of hnRNP L activity in T cells has yet to be defined.

183 criptome-wide analysis of the RNA targets of hnRNP L in lymphoid cells and add to the functional unde

184 s and add to the functional understanding of hnRNP L in human biology.

185 ence that cytoplasmic QKI-6 acts upstream of hnRNP F/H, which forms a novel pathway to control AS in

186 ein K (hnRNP K) is a member of the family of hnRNPs and was recently shown in a genome-wide small int

187 ngs suggest that PBT-1 binds to HSP90 and/or hnRNP A2/B1 and initiates antitumor activities by affect

188 cold inducible RNA-binding protein (CIRP or hnRNP A18) as a telomerase-interacting factor.

189 neous nuclear ribonucleoprotein (hnRNP) L or hnRNP A1 are Akt substrates during Treg induction and ha

190 differentiation, and knockdown of hnRNP L or hnRNP A1 results in the lower induction of Treg cells.

191 Overexpression of RALYL or hnRNP C1 induced HPV16 late gene expression from HPV16 s

192 n of the interplay between hnRNP K (or other hnRNPs) and Nrf2-mediated antioxidant signaling is warra

193 sgenic (Tg) mice specifically overexpressing hnRNP F in their RPTCs.

194 onucleoprotein E1 (hnRNP E1) at serine-43 (p-hnRNP E1).

195 a signature high level of Akt2, p-Akt2 and p-hnRNP E1 protein expression, coupled to a significantly

196 1, its various K-homology (KH) domains and p-hnRNP E1.

197 n cellular models by the high abundance of p-hnRNP E1 and low levels of hnRNP E1.

198 Levels of p-hnRNP E1 are highly upregulated in metastatic cancer cel

199 Also, phospho-hnRNP L recruits DRBP76 (double-stranded RNA binding pro

200 lasmic accumulation of Tyr359-phosphorylated hnRNP L sequesters miR-574-3p, overcoming its decoy acti

201 of Sirtuin-1 small interfering RNA prevented hnRNP F stimulation of Foxo3alpha and downregulation of

202 lect transcripts via the RNA-binding protein hnRNP E1 during EMT.

203 t K17 interacts with the RNA-binding protein hnRNP K, which has also been implicated in cancer.

204 ing site for the pre-mRNA processing protein hnRNP A1.

205 is heterogenous nuclear ribonuclear protein (hnRNP) has multiple functions in RNA processing includin

206 a splicing-suppressing RNA-binding protein, hnRNP H.

207 a multimeric complex containing the proteins hnRNP M, hnRNP H, hnRNP C, Matrin3, NF110/NFAR-2, NF45,

208 complex, consisting of RNA-binding proteins (hnRNP K, FXR1, and FXR2), PUF60 and SF3B3, that is requi

209 heterogeneous nuclear ribonuclear proteins (hnRNPs).

210 two, primarily nuclear RNA-binding proteins, hnRNP L and NF90, with previously unrecognized proviral

211 plicing, and three NonO-interacting proteins-hnRNP M, Ywhaz and Ppp1ca.

212 Mechanisms and putative hnRNP A1-RNA interactions have been inferred primarily f

213 hnRNP L represses CD45 exon 4 by recruiting hnRNP A1 to a sequence upstream of the 5' splice site.

214 Reduced hnRNP K expression attenuated p21 activation, downregula

215 duced negative superhelicity, where relative hnRNP K and nucleolin expression shifts the equilibrium

216 voring recruitment of the splicing repressor hnRNP A1 and interfering with that of U2AF65 at the 3' s

217 the heterogeneous nuclear ribonucleoprotein hnRNP H2.

218 the heterogeneous nuclear ribonucleoprotein hnRNP K.

219 n via interaction with the ribonucleoprotein hnRNP L-like (hnRNP LL) has prompted a more detailed stu

220 ng, heterogeneous nuclear ribonucleoprotein (hnRNP) A/B proteins.

221 The heterogeneous nuclear ribonucleoprotein (hnRNP) A1 protein is a multifunctional RNA binding prote

222 tor heterogeneous nuclear ribonucleoprotein (hnRNP) A2 form the basis for activity-dependent dendriti

223 Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 binds this element and promotes readthrough

224 B), heterogeneous nuclear ribonucleoprotein (hnRNP) F/H and E/K are identified as interacting SRE pai

225 the heterogeneous nuclear ribonucleoprotein (hnRNP) family of proteins that bind thousands of pre-mRN

226 ith heterogeneous nuclear ribonucleoprotein (hnRNP) I and AU-rich element RNA-binding protein 1 (AUF1

227 hat heterogeneous nuclear ribonucleoprotein (hnRNP) K is a transactivator of Th transcription.

228 ly, heterogeneous nuclear ribonucleoprotein (hnRNP) L or hnRNP A1 are Akt substrates during Treg indu

229 E), heterogeneous nuclear ribonucleoprotein (hnRNP) L regulates switch assembly and function.

230 ied heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 and hnRNP-R as interactors binding directly

231 ast heterogeneous nuclear ribonucleoprotein (hnRNP)-like proteins that heterodimerize and bind RNA.

232 The heterogeneous nuclear ribonucleoprotein, hnRNP A1, is an IRES transacting factor (ITAF) that regu

233 he heterogeneous nuclear ribonucleoproteins (hnRNP) form a large family of RNA-binding proteins that

234 ed heterogeneous nuclear ribonucleoproteins (hnRNPs) A1 and A2/B1, which are required for transcript

235 an heterogeneous nuclear ribonucleoproteins (hnRNPs) A2B1 and A1, known TDP-43 partners, in the patho

236 nd heterogeneous nuclear ribonucleoproteins (hnRNPs) are families of sequence-specific, posttranscrip

237 in heterogeneous nuclear ribonucleoproteins (hnRNPs) binding to A3B.

238 rs, heterologous nuclear ribonucleoproteins (hnRNPs) F and H.

239 he heterogeneous nuclear ribonucleoproteins (hnRNPs) family cause ALS.

240 of heterogeneous nuclear ribonucleoproteins (hnRNPs) in the control of alternative splicing at cis-ac

241 he heterogeneous nuclear ribonucleoproteins (hnRNPs) R, Q and L, and nucleolin (NCL), appeared to int

242 of heterogeneous nuclear ribonucleoproteins (hnRNPs) regulates the posttranscriptional fate of RNA du

243 ed heterogeneous nuclear ribonucleoproteins (hnRNPs).

244 Silencing hnRNP K expression in the spinal cord increased nocicept

245 in cerebellar granule cells and with SRSF2, hnRNP H1/F and ALYREF in motor neurons, the primary targ

246 ated co-localization of RNA foci with SRSF2, hnRNP H1/F, ALYREF and hnRNP A1 in cerebellar granule ce

247 omal degradation, whereas hypoxia stimulates hnRNP L phosphorylation at Tyr(359), inducing binding to

248 pment of hematological disorders and suggest hnRNP K acts as a tumor suppressor.

249 We conclude that hnRNP and NF90 are important host factors for HCV replic

250 Our results demonstrate that hnRNP F protects kidneys against oxidative stress and ne

251 Here, we demonstrate that hnRNP L represses CD45 exon 4 by recruiting hnRNP A1 to

252 We further demonstrate that hnRNP-A2/B1 is a key positive regulator of ASCL1, findin

253 We demonstrated that hnRNP K regulates dendritic spine density and long-term

254 ecent evidence has further demonstrated that hnRNP-A1 plays a crucial role in maintaining newly repli

255 arget of hnRNP-Q1 and have demonstrated that hnRNP-Q1 represses Gap-43 mRNA translation and consequen

256 We find that hnRNP L binds preferentially to transcripts encoding pro

257 These results indicate that hnRNP K is likely involved in virus assembly and/or rele

258 Here we report that hnRNP-A1 is phosphorylated by DNA-PKcs during the G2 and

259 Our results reveal that hnRNP-Q1 knockdown increased nascent axon length, total

260 We analyze RNA-Seq data to show that hnRNP C is a potential regulator of SMN6B expression and

261 In addition, we show that hnRNP H accelerates intron 2 splicing of Chtop mRNA in a

262 xpressing TDP-43Q331K mutation, we show that hnRNP K expression is impaired in urea soluble extracts

263 Taken together, these findings show that hnRNP U competes with hnRNP L for binding to C9/E3 to en

264 We showed that hnRNP A1 is methylated by PRMT5 on two residues, R218 an

265 Further studies showed that hnRNP K suppresses apoptosis of virus-infected cells, re

266 These results suggest that hnRNP protein levels can play a modulatory role on TDP-4

267 Our results suggested that hnRNP C1 controls HPV16 late gene expression.

268 The hnRNP-like glycine-rich RNA-binding protein AtGRP7 regul

269 ith RNA-seq revealed that exons carrying the hnRNP H-binding GGGGG motif are predisposed to be skippe

270 Introduction of point mutations into the hnRNP A1-binding site or knockdown of hnRNP A1 expressio

271 ary changes impact nearly all members of the hnRNP A and D families of RNA binding proteins.

272 RRM as the primary RNA-binding domain of the hnRNP C tetramer and provides a proof of concept for int

273 RALY is a member of the hnRNP family that binds poly-U-rich elements within seve

274 RNPA1, hnRNPA3 and hnRNPU-all members of the hnRNP family.

275 antagonistic effects on the formation of the hnRNP LL-i-motif complex as well as on the transcription

276 Therefore hnRNP-Q1-mediated repression of Gap-43 mRNA translation

277 iously documented interactions between these hnRNP-like proteins, RNA polymerase II, and the nascent

278 tion, JNK acts posttranscriptionally through hnRNP K to regulate translation of proteins crucial for

279 icing of HPV18 E6E7 pre-mRNAs via binding to hnRNP A1, a well-characterized, abundantly and ubiquitou

280 phorylation at Tyr(359), inducing binding to hnRNP A2/B1, which stabilizes the protein.

281 effects of mutant TDP-43-mediated changes to hnRNP K metabolism by RNA binding immunoprecipitation an

282 organization of the two RRMs is essential to hnRNP A1 function.

283 The domain is structurally homologous to hnRNP-C from higher organisms.

284 ed to a significantly reduced level of total hnRNP E1 in metastatic cells.

285 that cross-seed polymerization of wild-type hnRNP.

286 heterogenous nuclear ribonuclear protein U (hnRNP-U), is phosphorylated on serine 59 by the DNA-depe

287 T Heterogeneous nuclear ribonucleoprotein U (hnRNP U) belongs to a family of RNA-binding proteins tha

288 e heterogeneous nuclear ribonucleoprotein U (hnRNP U) in the heart develop lethal dilated cardiomyopa

289 n heterogeneous nuclear ribonucleoprotein U (hnRNP U), plays an important role in regulating the expr

290 iR-7, which is processed from the ubiquitous hnRNP K pre-mRNA transcript, is achieved by inhibition o

291 is translationally regulated by TGFbeta via hnRNP E1.

292 RNP F stimulated Sirtuin-1 transcription via hnRNP F-responsive element in the Sirtuin-1 promoter.

293 In vitro, hnRNP F overexpression stimulated Sirtuin-1 and Foxo3alp

294 bind to degenerative binding motifs, whereas hnRNP H strictly requires an uninterrupted stretch of po

295 pansion, and more frequently colocalize with hnRNP H.

296 ese findings show that hnRNP U competes with hnRNP L for binding to C9/E3 to enhance the inclusion of

297 e show that lincRNA-p21 acts in concert with hnRNP-K as a coactivator for p53-dependent p21 transcrip

298 By selectively coordinating with hnRNP H/F and U proteins, AKAP95 appears to mainly promo

299 in of TDP-43 that preclude interactions with hnRNP A2/B1 abolish TDP-43-dependent rescue of CGG repea

300 -mediated toxicity through interactions with hnRNP A2/B1 and suggest a convergence of pathogenic casc

301 he discovery that ubiquilin-2 interacts with hnRNP proteins and that mutation in either protein disru

302 of Gap-43 mRNA that directly interacts with hnRNP-Q1 as a means to inhibit Gap-43 mRNA translation.