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1 ription factors including Prox1, an atypical homeodomain protein.
2 direct interaction with the UNC-86/Brn3 POU homeodomain protein.
3 opment requires the REDUCED COMPLEXITY (RCO) homeodomain protein.
4 nteraction with Extradenticle (Exd), another homeodomain protein.
5 by the cooperative actions of an ncRNA and a homeodomain protein.
6 also regulated by interaction with a partner homeodomain protein.
7 FD neurons and is regulated by the TTX-1 OTX homeodomain protein.
8 rform a structure/function analysis for this homeodomain protein.
9 epression and activation domains of vnd/NK-2 homeodomain protein.
10 nt disorder caused by mutations in the PITX2 homeodomain protein.
11 -1, which encodes a deltaEF1/ZFH-1 Zn-finger-homeodomain protein.
12 fferential expression of the Nkx6-type COG-1 homeodomain protein.
13 important decision is regulated by the UNC-4 homeodomain protein.
14 tetranucleotide ATTA commonly recognized by homeodomain proteins.
15 anocortin is potentiated by lineage-specific homeodomain proteins.
16 es of TALE (Three Amino acid Loop Extension) homeodomain proteins.
17 ural homology with the DNA-binding domain of homeodomain proteins.
18 many of which are developmentally important homeodomain proteins.
19 with each other as well as the PBX family of homeodomain proteins.
20 unctions in part as a cofactor for Hox class homeodomain proteins.
21 e consensus site for Antennapedia superclass homeodomain proteins.
22 lular subtypes in conjunction with other LIM/homeodomain proteins.
23 to the Cart1/Alx3/Alx4 family of vertebrate homeodomain proteins.
24 uence identified previously for paired class homeodomain proteins.
25 inguishes HNF-1alpha from other flexible POU-homeodomain proteins.
26 y at positions 24 and 25 compared to related homeodomain proteins.
27 bers of the Pitx gene family of bicoid-class homeodomain proteins.
28 sequence distinct from those of other fungal homeodomain proteins.
31 he product of the C15 gene, which is another homeodomain protein, a homolog of the human Hox11 oncoge
32 s were enriched in alpha cells; in contrast, homeodomain proteins accounted for 51% of a total of 45
34 s identified near the N terminus of vnd/NK-2 homeodomain protein (amino acid residues 154-193), which
35 NKX3.1 transcription factor is an NK family homeodomain protein and a tumor suppressor gene that is
37 n the 5' leader of the mRNA encoding the Gtx homeodomain protein and showed that shorter nonoverlappi
38 include Oct4, a member of the POU family of homeodomain proteins and a second recently identified ho
39 pped to 8p21, is a member of the NK class of homeodomain proteins and is expressed primarily in the p
40 uggesting that the associations between TALE homeodomain proteins and Oct-1 regulate neuron-specific
41 y of transcriptional complexes involving LIM-homeodomain proteins and other transcription factors tha
42 Several transcription factors, including homeodomain proteins and T-box proteins, are essential f
43 direct transcriptional targets of clustered homeodomain proteins and that different homeodomain prot
44 nalogous to the N-terminal arm of eukaryotic homeodomain proteins and the "wings" of winged-helix pro
46 KNOX proteins interact with BEL1-like (BELL) homeodomain proteins and together bind a target sequence
48 ely half of the NUP98 fusion partners encode homeodomain proteins, and at least 5 NUP98 fusions invol
49 ing development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes.
50 y by E1A, Twist, Pu.1, and the Hox family of homeodomain proteins-and suggest that E47 and EBF play d
56 echanism by which the activities of bHLH and homeodomain proteins are temporally and spatially integr
57 genes, and prep, which encodes a TALE-family homeodomain protein, are expressed at the anterior pole.
59 s in the highly conserved Aristaless-related homeodomain protein ARX have been shown to underlie mult
61 vations, we suggest that the function of Bar homeodomain proteins as cell-type-specific inhibitors of
62 that successfully predicts binding sites for homeodomain proteins as distant from mouse as Drosophila
64 ne products: the silkworm orthologues of LIM homeodomain protein Awh, LIM domain-binding protein (Ldb
66 imers containing Pbx/Prep1 or Pbx/Meis1 TALE homeodomain proteins bind to four functional elements wi
67 r reporter genes demonstrated that the three homeodomain protein binding sites located between -80 an
68 observed between the R2 site and an adjacent homeodomain protein-binding site previously characterize
69 lity shift assay, we report that Lhx2, a LIM-homeodomain protein, binds to the homeodomain site in th
70 mber of studies that HOX11, similar to other homeodomain proteins, binds DNA and transactivates trans
72 he interactions between Clone A and vnd/NK-2 homeodomain protein by mobility-shift assay, DNase I foo
73 w that the Caenorhabditis elegans Six family homeodomain protein C. elegans homeobox (CEH-34) and the
78 st-muscle gene expression, thus showing that homeodomain proteins can direct bHLH proteins to establi
79 have demonstrated that in RCC, the Cut-like homeodomain protein (CDP/Cut) is involved in FIH transcr
82 ha (HNF-1 alpha), GATA-4, and caudal related homeodomain proteins Cdx2 and Cdx1 are the primary trans
83 de operating in DVC was defined from the LIM-homeodomain protein CEH-14 through CEH-63 to the helix-t
85 ivates the CC specification factor, the Six2 homeodomain protein CEH-34, and functions cooperatively
90 d is the founding member of the K50 class of homeodomain proteins, containing a lysine residue at the
91 ctions are established, in part, through LIM homeodomain protein control of EphA receptors and ephrin
97 zinc finger protein Hindsight and suppresses homeodomain protein Cut to regulate the mitotic/endocycl
98 Lz causes transcriptional activation of the homeodomain protein Cut, which can then stabilize a Lz r
100 bdomains, we characterized expression of the homeodomain protein Dbx1 and the bHLH protein Olig2.
104 y shift assays identified AP-2 gamma and the homeodomain protein, Dlx 3, as the transcription factors
105 fy a and alpha cell identity, whereas the a1 homeodomain protein drives meiosis and sporulation and f
110 ssential transcriptional regulators: Otx2, a homeodomain protein expressed broadly in head ectoderm i
112 We now provide genetic evidence that Vax2, a homeodomain protein expressed in the ventral retina, is
119 ardment, we show that TTG1, GL3, GL1 and the homeodomain protein GL2 do not move between adjacent epi
120 rsal expansion of ventral markers (e.g., the homeodomain protein GSH2) into the ventralmost pallial r
122 ered homeodomain proteins and that different homeodomain proteins have distinct effects on the promot
124 he VB gene ceh-12 (encoding a homolog of the homeodomain protein HB9) in unc-4 mutants results in the
126 xpressed homeodomain protein or proline-rich homeodomain protein (HHEX/PRH), which thereby lose their
130 to cDNA library screening we identified two homeodomain proteins, Hoxa10 and Hoxb8, which are expres
133 ns, 84 homeodomain DNA-binding sites and 114 homeodomain proteins implicated in human genetic disorde
136 ive chromatin and reveals a critical role of homeodomain proteins in marking specific genes for activ
137 have investigated the role of Isl-class LIM homeodomain proteins in motor neuron diversification usi
138 -1/Oct-2 suggests an important role of these homeodomain proteins in the overall regulation of the Ig
142 pools is governed by coordinately acting LIM-homeodomain proteins including the Islet-class factor Is
143 CNS pattern along the dorsoventral axis, the homeodomain protein Ind and the Sox-domain protein Dicha
144 e Pbx TALE (three-amino-acid loop extension) homeodomain proteins interact with class 1 Hox proteins,
146 ribe the use of 10 linked copies of the Gtx (homeodomain protein) IRES (abbreviated as SIRES) in plac
147 that one of these targets, the Iroquois-like homeodomain protein, IRX-1, functions as a key regulator
150 he pancreatic and duodenal homeobox 1 (PDX1) homeodomain protein is critical for the initiation of al
153 er, a physical interaction between these two homeodomain proteins is necessary for induction of these
155 lisation of VAN, like that of the animal PBC homeodomain protein, is also regulated by interaction wi
156 We have previously shown that lmx1b, a LIM homeodomain protein, is expressed in the pronephric glom
162 a plant with dissected leaves, KNOTTED1-like homeodomain proteins (KNOX) are positive regulators of l
165 ctivity by maintaining expression of the LIM homeodomain proteins Lhx3/4 in spinal motor neurons.
167 ate that the redundant activities of the LIM homeodomain proteins Lhx6 and Lhx7 are critical for cran
170 lation in mice, we demonstrate here that the homeodomain protein LIM homeobox (Lhx)7 is essential for
171 on of their LIM domains with cofactor of LIM homeodomain proteins (LIM-HDs) (CLIM, also known as Ldb
172 less has been shown to function with the LIM-homeodomain protein LIM1 to regulate leg development.
176 One of the downstream targets of VegT, the homeodomain protein Mixer, is expressed at high levels a
184 show regulation of the Runx2 gene by several homeodomain proteins: MSX2 and CDP/cut repress whereas D
187 on somatic cells, a process promoted by the homeodomain protein Nanog, which is central to the maint
190 ession and maintaining the expression of key homeodomain proteins necessary for MN identity and survi
191 nation of transcriptional programs, with the homeodomain protein NKX2-5 being one of the key transcri
193 tricle during late gestation and require the homeodomain protein Nkx2.1 for their specification.
196 tiple binding sites for the cardiac-specific homeodomain protein Nkx2.5, and its promoter activity wa
197 hin the rostral hindbrain, the Shh-activated homeodomain proteins Nkx2.2 and Nkx6.1 cooperate to indu
203 NvFollistatin, and NvFollistatin-like), the homeodomain proteins NvGoosecoid (NvGsc) and NvGbx, and
206 16-residue CPP derived from the Antennapedia homeodomain protein of Drosophila, was measured in singl
210 h studies also document co-overexpression of homeodomain proteins of the Meis and Pbx families in poo
211 TALE (three-amino-acid loop extension) class homeodomain proteins of the Pbx and Meis families are al
213 scription factor hematopoietically expressed homeodomain protein or proline-rich homeodomain protein
215 these amino acids are conserved between many homeodomain proteins, our results suggest that CK2 may r
216 oring of hexameric complexes of specific LIM homeodomain proteins over tetramers could dictate the ch
218 Furthermore, we report that the Caudal-like homeodomain protein PAL-1, whose role in early embryogen
219 onstrated the physical association between a homeodomain protein, pancreatic-duodenal homeobox factor
220 h an adjacent protein complex containing the homeodomain protein Pbx, which appears to be constitutiv
221 rs form multimeric complexes with TALE-class homeodomain proteins (Pbx, Meis) to regulate tissue morp
222 resent the first work demonstrating that the homeodomain proteins PBX1 and PREP1 are cellular factors
223 , we demonstrate that the beta cell-specific homeodomain protein Pdx-1 interacts with histone deacety
226 nscriptional regulations, the BarH family of homeodomain proteins play essential roles in cell fate s
228 as found to be identical to WUSCHEL (WUS), a homeodomain protein previously shown to be involved in s
229 at a trans cription factor, the proline-rich homeodomain protein PRH, is a negative regulator of eIF4
232 have shown previously that the Proline-Rich Homeodomain protein (PRH/Hex) self-assembles to form oli
233 sly that phosphorylation of the Proline-Rich Homeodomain protein (PRH/Hhex) by CK2 inhibits the DNA-b
238 ight into the molecular mechanism underlying homeodomain-protein recognition and may serve as a parad
241 ferentiation in vitro, whereas Prx1, another homeodomain protein, regulates SMC differentiation marke
242 s tools, which revealed that the Arabidopsis homeodomain protein REPLUMLESS (RPL) establishes distinc
243 ces upstream of nt -68, and the CDP/cut/Cux1 homeodomain protein represses transcription down-stream
244 Here, we show that expression of Otx2, a homeodomain protein required for the formation of the fo
245 through direct control of the Dlx1 and Dlx2 homeodomain proteins, required for interneuron specifica
246 Examination of mouse orthologs of these homeodomain proteins resulted in the identification of m
247 f Ldb1, which encodes a cofactor for all LIM-homeodomain proteins, resulted in a similar phenotype.
249 otprinting analysis of Clone A with vnd/NK-2 homeodomain protein revealed three strong binding sites
255 The interaction of an arenavirus with a homeodomain protein suggests a mechanism for viral terat
258 /cut homolog (CDP/cut) is a highly conserved homeodomain protein that contains three cut repeat seque
267 nstrate that it regulates human Engrailed, a homeodomain protein that regulates neuronal development
270 stinal barrier function, can be regulated by homeodomain proteins that control the differentiation of
271 rax Complex encodes three well-characterized homeodomain proteins that direct segment identity, as we
272 different transcription factors, 11 of them homeodomain proteins, that act in distinct combinations
273 ranscription regulatory co-factor of the LIM homeodomain proteins, the LIM domain only 4 protein Lmo4
274 cifically with the BEL1-like (BELL) class of homeodomain proteins, through a domain conserved between
276 s further demonstrated by the failure of the homeodomain protein to interact efficiently with two of
278 ption factor GRD acts cooperatively with WOX homeodomain proteins to establish embryonic polarity in
279 ty acts downstream of retinoid signaling and homeodomain proteins to promote the formation of dI6, V1
280 nct co-regulatory proteins (Zelda or Sox/POU-homeodomain proteins) to control a similar pattern of ex
282 which can mediate Wnt signaling and for Vent homeodomain proteins, transcriptional repressors that me
283 results uncover a novel mechanism whereby a homeodomain protein transduces GA signal to promote fibr
284 are binding sites for TRA-1A and a POU-type homeodomain protein UNC-86 and acts as a sensor to regul
285 hat two closely related, ventrally expressed homeodomain proteins-Vax1 and Vax2-control this neuroepi
286 tor Receptor (EGFR), in conjunction with the homeodomain proteins, Ventral nervous system defective,
289 42, MYB43, MYB20, and KNAT7 (a Knotted1-like homeodomain protein), was developmentally associated wit
290 ctly with the N-terminal region of the PDX-1 homeodomain protein, which contains conserved amino acid
291 s regulated the pituitary homeobox 2 (PITX2) homeodomain protein, which modulates developmental gene
292 d the cloning of CD2 revealed it to encode a homeodomain protein, which we propose acts as a key regu
294 alian genes that encode closely related TALE homeodomain proteins, which serve as DNA binding partner
296 SIX3/6 gene family in vertebrate, encodes a homeodomain protein with a SIX protein-protein interacti
297 sociation of transcriptional activators (DLX homeodomain proteins) with key DNA enhancers but repress
298 ranscription factors including Dlx and other homeodomain proteins within the evolutionarily conserved
299 expression level of the stem cell-promoting homeodomain protein WUSCHEL (WUS) in the cells beneath,
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