ライフサイエンスコーパス: homeoprotein

1 n A1 is a transcriptional target of the Six1 homeoprotein.

2 OXA9, which decreases the DNA binding of the homeoprotein.

3 has not been reported for any other NK class homeoprotein.

4 iously shown to bind to the Meis/Prep family homeoproteins.

5 cating potentially common PTF function among homeoproteins.

6 mouse proteins that interact with Lim-domain homeoproteins.

7 nd potentiate the repressor activities of NK homeoproteins.

8 ndirectly controlled by most or all selector homeoproteins.

9 specifying the transcriptional activities of homeoproteins.

10 elected two candidate sites for binding Meis homeoproteins.

11 ns a composite binding site for Meis and Pbx homeoproteins.

12 omothorax (Hth) and vertebrate Meis and Prep homeoproteins.

13 transcription factor Cartilage paired-class homeoprotein 1 (CART1), and we confirm that rs17023457 a

14 rase chain reaction to assess caudal-related homeoprotein 2 (CDX2) messenger RNA (mRNA) levels.

15 We conclude that Six1 homeoproteins act as a rheostat system to ensure proper

16 advances have shed new light on how the Q50 homeoproteins act in Drosophila.

17 nce promotes the passage of a retina-derived homeoprotein along the visual pathway, which nurtures su

18 Here we show that the UNC-4 homeoprotein and its transcriptional corepressor protein

19 VA-specific inputs are defined by the UNC-4 homeoprotein and its transcriptional corepressor, UNC-37

20 The UNC-4 homeoprotein and the Groucho-like corepressor UNC-37 spe

21 NKX3.1 is a prostate-specific homeoprotein and tumor suppressor that is affected by th

22 ese results demonstrate the first example of homeoprotein and zinc finger protein interaction in vert

23 separated from a domain that interacts with homeoproteins and hence are termed homeodomain-interacti

24 ghly conserved throughout several classes of homeoproteins and interacts specifically with the Grouch

25 Members of the Hox family of homeoproteins and their cofactors play a central role in

26 , to control the timing of expression of the homeoprotein ANTP specifically in the antennal imaginal

27 The selector homeoproteins are a highly conserved group of transcript

28 Analysis of these data suggests that the Prx homeoproteins are critical for mesenchymal-epithelial si

29 Here we show that the Meis1 and Meis2 homeoproteins are direct regulators of Pax6 expression i

30 factor, supporting a model in which the Mix homeoproteins are downstream effectors of growth factor

31 Homeoproteins are known to participate in development an

32 Homeoproteins are transcription factors that act as mast

33 pecific transcription factors, including the homeoprotein Arix, and second messengers, including cycl

34 ed by Eve and probably by the other selector homeoproteins as well.

35 We propose that combinatorial homeoprotein-based transcriptional control, a core featu

36 ing technique, we show that three classes of homeoprotein bind at significant levels to the majority

37 on these and other data, we suggest that Q50 homeoproteins bind many of their recognition sites witho

38 The mechanisms by which homeoproteins bind selectively to target genes in vivo h

39 We showed previously that homeoproteins bind to multiple DNA sites throughout the

40 Homeoprotein binding activity was confirmed by Farwester

41 lyses of the 5' promoter have identified two homeoprotein binding motifs that can be occupied and act

42 MV IE gene, which contains multiple putative homeoprotein binding motifs.

43 zyme recognition sequences that overlap with homeoprotein binding sites are less accessible on inacti

44 DNA binding specificities, we suggested that homeoprotein binding sites on actively transcribed genes

45 D-Gsc is a 'passive repressor' of activator homeoproteins binding to the same sites and an 'active r

46 even though they contain many high affinity homeoprotein-binding sites.

47 n is present not only in all engrailed-class homeoproteins but also in all known members of several o

48 confers DNA-binding specificity on the Msx1 homeoprotein by regulating its subnuclear localization a

49 These data show a novel mechanism by which a homeoprotein can affect DNA damage repair and act as a t

50 Thus, different levels of a homeoprotein can regulate distinct patterns of dendrite

51 The homeoproteins CCAAT displacement protein (CDP) and speci

52 y target sites recognized by various Pbx-Hox homeoprotein complexes.

53 HOX homeoproteins control cell identities during animal deve

54 ate that the pro-tumorigenic/metastatic Six1 homeoprotein decreases p53 levels through a mechanism th

55 Mirror is a member of the class of homeoproteins defined by the human proto-oncogene PBX1.

56 n mice carrying a null mutation in the PDX-1 homeoprotein, demonstrating a key role for this factor i

57 rone circuit points to an ancient origin for homeoprotein-dependent mechanisms of neuronal differenti

58 ted on the proximodistal axis, and that Meis homeoproteins directly regulate the promoter on this axi

59 binding complexes containing HoxA9 and TALE homeoproteins display cooperative transcriptional activi

60 sults, we suggest how the in vivo pattern of homeoprotein DNA binding is determined.

61 and genetic experiments suggest that the Q50 homeoproteins do not regulate very distinct sets of gene

62 The expression of the Distal-less (Dll) homeoprotein during arthropod limb outgrowth and of Dll

63 If the Q50 homeoproteins each interact differently with cofactors,

64 The homeoprotein encoded by the extradenticle (exd) gene can

65 Here, we show that the homeoprotein engrailed 1 (EN1) is expressed during embry

66 ember Wingless confront cells expressing the homeoprotein Engrailed.

67 Previously, the Drosophila selector homeoproteins Eve and Ftz were shown to bind with simila

68 The selector homeoprotein Even skipped (Eve) plays a very specific ro

69 The HOXA9 homeoprotein exerts dramatic effects in hematopoiesis.

70 Alx3 is a paired class aristaless-like homeoprotein expressed during embryonic development.

71 n the ceh-18 gene, which encodes a POU-class homeoprotein expressed in sheath cells, result in oocyte

72 specificity when they bind together with the homeoprotein Extradenticle (or Pbxl in mammals).

73 at representative members of the Msx and Dlx homeoprotein families form homo- and heterodimeric compl

74 tion factors that include members of the Msx homeoprotein family.

75 nteractions are a common means of regulating homeoprotein function, we tested whether SATB1 and CDP i

76 Our data support the notion that the HOX-11 homeoprotein functions as an oncogenic transcription act

77 own that Nkx3.2, a member of the NK class of homeoproteins, functions as a transcriptional repressor

78 Two homeoproteins, Gsp1 and Gsm1, contributed by gametes of

79 cofactors that differentially interact with homeoproteins have been identified via a yeast two-hybri

80 As Meis homeoproteins have been previously demonstrated to regul

81 Cellular homeoproteins have been shown to regulate the transcript

82 current model suggests that, because the Q50 homeoproteins have distinct biological functions, they m

83 nding studies indicate that at least two Q50 homeoproteins have very broad and similar DNA-binding sp

84 helix-loop-helix protein, and Arix/Phox2a, a homeoprotein, have been demonstrated to play a role in t

85 neurotransmitter phenotype, the Apterous LIM homeoprotein helps define neurotransmitter expression wi

86 nteraction between T-bet and its target, the homeoprotein Hlx.

87 CDP, a ubiquitous homeoprotein homologous to Drosophila cut, is implicated

88 A9(-/-) mice demonstrate a key role for this homeoprotein in blood cell development.

89 that transcriptional repression by the Msx1 homeoprotein in myoblast cells requires the recruitment

90 Accumulation of non-cell autonomous Otx2 homeoprotein in postnatal mouse visual cortex (V1) has b

91 findings point to a novel role of the PREP1 homeoprotein in the control of the TGF-beta pathway, EMT

92 ere, we examined the involvement of cellular homeoproteins in regulating the activity of the human cy

93 nserved mechanism of Pax6 regulation by Meis homeoproteins in two different organs.

94 ranscriptional targets of both DLX1 and DLX2 homeoproteins in vivo Further gain- and loss-of-function

95 ulatory event for DNA-binding specificity by homeoproteins in vivo is their appropriate targeting to

96 g the transcriptional actions of Msx and Dlx homeoproteins in vivo.

97 features that are not often associated with homeoproteins, including an atypical homeodomain of the

98 recent reports on the paracrine activity of homeoproteins, including Engrailed, we asked whether Eng

99 Unlike most other known examples of homeoprotein interactions, association of Msx and Dlx pr

100 intact cells via fusion to the Antennapedia homeoprotein internalization domain.

101 red blood cells (RBCs) via the Antennapedia homeoprotein internalization domain.

102 transfer of (orthodenticle homeobox 2) Otx2 homeoprotein into GABAergic interneurons expressing parv

103 regulating protein-1 (Prep1) is a ubiquitous homeoprotein involved in early development, genomic stab

104 The engrailed homeoprotein is a dominantly acting or 'active' transcri

105 The Six1 homeoprotein is an important mediator of normal developm

106 entiated keratinocytes, suggesting that this homeoprotein is an important regulator of epidermal diff

107 Our findings show that the MOX2 homeoprotein is an important regulator of vertebrate lim

108 During embryogenesis, the Six1 homeoprotein is essential for the expansion of precursor

109 The DNA binding activity of the NK-3 homeoprotein is greatly enhanced by HIPK2, but this effe

110 The expression of the Mix family homeoproteins is differentially regulated by activin, Vg

111 genes, ceh-12, a member of the HB9 family of homeoproteins, is normally restricted to VBs.

112 lts raise the possibility that each selector homeoprotein may directly regulate the expression of mos

113 Suspecting that the selector homeoproteins may affect many more genes than previously

114 ct morphogenic properties of the various Q50 homeoproteins may principally result from the different

115 chemical interactions between HoxA9 and TALE homeoproteins mediate cellular transformation in hematop

116 Here we demonstrate that the HOX-11 homeoprotein mediates transactivation of reporter genes

117 The TALE-class homeoprotein MEIS1 specifically collaborates with HOXA9

118 e CDP/Cux, a homologue of the Drosophila Cut homeoprotein, modulates the promoter activity of cell cy

119 hat the novel nuclear protein MINT binds the homeoprotein Msx2 and coregulates OC during craniofacial

120 ogenetic protein-2 (BMP2) and the osteoblast homeoprotein Msx2.

121 Recently, ten heterozygous CSX/NKX2.5 homeoprotein mutations were identified in patients with

122 ent pathway, defined by the CEH-18 POU-class homeoprotein, negatively regulate meiotic maturation and

123 cal downstream effectors within an essential homeoprotein network that serves a rate-limiting regulat

124 A DNA nonbinding mutant of the NK2 class homeoprotein Nkx2.5 dominantly inhibits cardiogenesis in

125 in level was identified with the paired-like homeoproteins of the CVC-domain family: 92-97% identity

126 Homeoproteins of the Engrailed family are involved in th

127 n be regulated by ectopic expression of Meis homeoproteins or the three finger protein Prod 1 which a

128 The homeoprotein Orthodenticle acts through these sites to a

129 rience triggers cell-to-cell transfer of the homeoprotein Otx2 to cortical interneurons, where it pro

130 Plasticity onset was restored by a homeoprotein Otx2, which binds the major CS-proteoglycan

131 ding activity and does not interact with the homeoprotein partner MSX1.

132 The TALE homeoprotein Pbx1 has been shown to be essential for pro

133 s mutant (-/-) embryos, implicating the TALE homeoprotein Pbx1 in splenic cell specification.

134 To investigate the role of the HOX-like homeoprotein PDX1 in the formation and maintenance of th

135 The homeoprotein PDX1 is expressed throughout pancreatic dev

136 the first work demonstrating that a cellular homeoprotein, PDX1, may be a repressor involved in regul

137 rt here that mice lacking the bicoid-related homeoprotein Pitx3 fail to develop DA neurons of the sub

138 The Six1 homeoprotein plays a critical role in expanding progenit

139 -dependent kinase inhibitors showed that the homeoproteins, pre B-cell leukemia transcription factor

140 The deformed (Dfd) and ultrabithorax (Ubx) homeoproteins regulate developmental gene expression in

141 y by helping to distinguish the way in which homeoproteins regulate targets to which they are already

142 l mutation in a gene encoding a paired class homeoprotein related to Drosophila aristaless.

143 Another homeoprotein repressor, CCAAT displacement protein (CDP)

144 resent specific interactions among Prd-class homeoproteins, several of which act early during develop

145 s show that transgenic mice that express the homeoprotein Six1 in mammary epithelial cells show incre

146 Here we show that overexpression of the homeoprotein Six1, normally a developmentally restricted

147 e describe a novel and specific role for the homeoprotein Six2 in the growth and elongation of the cr

148 VSX1 is a CVC domain homeoprotein specifically expressed in cone bipolar cell

149 and that this cooperation requires all three homeoprotein subunits, including the PDX1 activation dom

150 stretch of 7 aminoacids also found in other homeoproteins such as Engrailed.

151 that TOP2A expression is induced by DLX4, a homeoprotein that is overexpressed in breast and ovarian

152 mapped to three amino acid stretches in the homeoprotein, the glycine-proline-rich region at the ami

153 ress transcription activated by Paired-class homeoproteins through P3K, via specific protein-protein

154 t to explain the mechanism of action of this homeoprotein to regulate transcription of natural target

155 n different tissues is a novel mechanism for homeoproteins to control gene expression and differentia

156 e binding' model, significant binding of Q50 homeoproteins to functional DNA elements in vivo would b

157 e largely accessible, whereas the binding of homeoproteins to inactive and poorly transcribed genes m

158 Nkx3.1 is a homeoprotein transcription factor (TF) that inhibits pro

159 A coordinated regulation of homeoprotein transcription factors was observed during C

160 The DA-specific homeoprotein UNC-4 interacts with UNC-37/Groucho to repr

161 ger RNA of Hoxa4, b4, c4, d4, a5, c5, and b5 homeoprotein were determined by in situ hybridization an

162 on regulatory domains of the Prx1a and Prx1b homeoproteins were analyzed in transient transfection as

163 s fly Extradenticle (Exd) and vertebrate Pbx homeoproteins, whereas the MEIS class includes fly Homot

164 We further found that the Dlx5 homeoprotein, which is able to regulate the osteoblast-s

165 Six1 is a developmentally regulated homeoprotein with limited expression in most normal adul

166 A new gene was isolated which encodes a homeoprotein with strong homology to the other Pitx prot

167 Thus, truncated homeoproteins with no DNA binding domains can have impor

168 r-2B and -2C (MEF-2B and -2C) and a putative homeoprotein within the proximal rat GnRH promoter.

169 -1 with those of the closely related Xenopus homeoprotein XIHbox8.