ライフサイエンスコーパス: homeostatic

1 e highly organized systems with a remarkable homeostatic ability to maintain morphology through regul

2 llectively, these observations highlight the homeostatic actions of JAK2 in podocytes and the importa

3 Homeostatic activation of the UPR enforces adaptive prog

4 pare osmoprotective, prosurvival, and matrix homeostatic activities.

5 opment of neuropathic pain involves abnormal homeostatic activity regulation of somatosensory cortex,

6 ion in the HSC niche represents a juxtacrine homeostatic adaptation of the hematopoietic system in st

7 ar neurosecretory neurons (MNCs), as well as homeostatic adaptive responses to a physiological challe

8 These effects appear to reflect a homeostatic, adaptive response of auditory nerve synapse

9 sensory responses to surviving nerve fibers, homeostatic adjustments in PV-mediated inhibition during

10 ples that underlie stem cell dynamics during homeostatic aging and muscle regeneration.

11 Consistent with the previously described homeostatic and anti-inflammatory properties of IL-20 on

12 alveolar lining fluid (ALF), which contains homeostatic and antimicrobial hydrolytic activities, ter

13 During sleep deprivation, homeostatic and circadian processes interact to build up

14 ntegrin receptor binding to ECM proteins for homeostatic and diseased livers.

15 istinguished by expression of proliferative, homeostatic and effector genes.

16 Remarkably, homeostatic and IFNgamma-dependent programs enrich acros

17 'niche', regulates hematopoiesis both under homeostatic and immune stress conditions.

18 xytocin administration reduces activation in homeostatic and increases activation in cognitive contro

19 a CB2 receptors play important roles in both homeostatic and inflammatory processes.

20 ng mature EE cells, comprises a reservoir of homeostatic and injury-inducible ISCs, extending our und

21 mics, we identified two GRP78 fractions, one homeostatic and one induced by ER stress.

22 es in regulating corneal tissue structure in homeostatic and pathological conditions is unknown.

23 linkage of cell extrusion to developmental, homeostatic and pathological processes such as cancer me

24 of transcription factor networks that direct homeostatic and pro-inflammatory programs.

25 ssion of genes corresponding to an "M2"-like homeostatic and reparative phenotype.

26 get to regulate hematopoietic trafficking in homeostatic and stress conditions.

27 The contribution of MAFB to the homeostatic/anti-inflammatory macrophage profile is furt

28 of the IL-1 family play an important role in homeostatic as well as "emergency" hematopoiesis and are

29 These responses may alter the homeostatic balance and wound-healing response of gingiv

30 The homeostatic balance between quiescence, self-renewal, an

31 play a role in autoimmunity by changing the homeostatic balance of proinflammatory cytokines and the

32 the endothelia of adult mice did not affect homeostatic BBB integrity, but resulted in BBB disruptio

33 d as meiosis proceeds, however, illustrating homeostatic behavior of DSB regulatory systems.

34 lood-brain barrier (BBB) provides a constant homeostatic brain environment that is essential for prop

35 These truncations were homeostatic but primate-specific events.

36 re commonly thought to be stoichiometrically homeostatic but their stoichiometric plasticity has rare

37 ar elemental ratios of Noctiluca were nearly homeostatic, but the ratio of its intracellular NH4(+) a

38 ess expression of CD127 indicating a lack of homeostatic cell control through IL-7 signalling.

39 ance of renewal and differentiation in these homeostatic cells.

40 Reasoning that this homeostatic challenge confronts all pulsatile organs, we

41 Homeostatic changes in Purkinje neuron morphology that h

42 Here we investigated the spatial scale of homeostatic changes in spine size following sensory depr

43 These fast homeostatic changes were independent of l-type Ca(2+) ch

44 CXCL14 is a homeostatic chemokine with unknown receptor selectivity

45 y drives of sleep and wakefulness, including homeostatic, circadian, and motivational processes.

46 his evidence, we envisage a model where this homeostatic circuit maintains a constant lipid compositi

47 ophysiological recordings indicate that this homeostatic co-regulation of neurite and synapse develop

48 hematopoietic stem cells during unperturbed homeostatic condition.

49 cultures from follicular epithelium in human homeostatic conditions (h7H medium).

50 tivity, as well as reduced bleeding times in homeostatic conditions and during sepsis.

51 itions under anesthesia may lead to unstable homeostatic conditions in rodents and therefore may alte

52 tion of resident neocortical microglia under homeostatic conditions was low, microglial proliferation

53 gan-specific functions in development, under homeostatic conditions, and in regeneration and liver pa

54 Under homeostatic conditions, as well as in various diseases,

55 of tissue microenvironments; each day under homeostatic conditions, billions of cells die and must b

56 Under homeostatic conditions, gain- or loss-of-function of NXF

57 Here, we have found that under homeostatic conditions, the mRNA-destabilizing protein t

58 Under homeostatic conditions, we found that neocortical reside

59 lung parenchymal tissue or the airway under homeostatic conditions.

60 contributing to its amounts and functions in homeostatic conditions.

61 ilising motifs are strongly restrained under homeostatic conditions.

62 optotic regulation that is not present under homeostatic conditions.

63 mune interactions and their mechanisms under homeostatic conditions.

64 g strictly as transit amplifying cells under homeostatic conditions.

65 thalamus that are activated under these 'non-homeostatic' conditions, but the molecular nature of the

66 lation of ATP7A abundance may serve as a key homeostatic control for Cu export into the circulation.

67 Homeostatic control of breathing, heart rate, and body t

68 (PlexB) receptors to mediate the retrograde, homeostatic control of presynaptic neurotransmitter rele

69 low density lipoprotein assembly and allows homeostatic control of serum triglyceride in a fasted st

70 also inhibits Rim15 activity, which enables homeostatic control of Whi5 phosphorylation and cell cyc

71 In sum, classic homeostatic control regions are sufficient but not indiv

72 Muscle is emerging as a key mediator of this homeostatic control through consumption of lipids, carbo

73 the liver secretes triglyceride under tight homeostatic control.

74 urinergic signalling and gliotransmission in homeostatic control.

75 ss model, integrating both a circadian and a homeostatic controller.

76 Hedonic controls interact with homeostatic controls to regulate body weight in a flexib

77 Increased availability of homeostatic cytokines is considered a major mechanism by

78 unctional characteristics when cultured with homeostatic cytokines.

79 aptic potentiation during wake, and that its homeostatic decrease during the night is associated with

80 rapid eye movement sleep predicted a reduced homeostatic decrease in the slope of sleep slow waves du

81 rt specific behavioral, cognitive, and sleep homeostatic defects in the after hours (Afh) circadian m

82 ignaling is essential for cell surface AMPAR homeostatic downscaling in response to an increase in ne

83 (2+) influx is a critical molecular event in homeostatic downscaling of glutamatergic synaptic transm

84 inding of CFH to CD11b, which obstructed the homeostatic elimination of MPs from the subretinal space

85 n neural tissues from the blood, providing a homeostatic environment for proper neural function.

86 ed diseases and are known to reach a lasting homeostatic equilibrium following a dynamic priming peri

87 e Mettl3-deficient T cells failed to undergo homeostatic expansion and remained in the naive state fo

88 Finally, under conditions of homeostatic expansion, SHP-1-deficient CD4(+) T cells re

89 a suggest that this increase was mediated by homeostatic expansion-like mechanisms.

90 rincipal physiological mechanisms underlying homeostatic failure during cold exposure in this diverse

91 antioxidant defense genes to defends against homeostatic failure.

92 ricular (AVPV) and arcuate nuclei, providing homeostatic feedback on episodic GnRH/LH release as well

93 he VTA is sufficient to significantly reduce homeostatic feeding and effort-based intake of palatable

94 y, 5-HT2CRs are positioned to influence both homeostatic feeding circuits within the hypothalamus and

95 studied neural processing hub for reward and homeostatic feeding signals.

96 and the A-type K(+) current (IA ) influences homeostatic firing responses of magnocellular neurosecre

97 mDCs exhibit alterations of their fine-tuned homeostatic function and contribute to dysregulated immu

98 d cell death signalling, however its role in homeostatic function and disease is controversial.

99 he maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders.

100 Our data also suggest a homeostatic function ofTgPEPCKmt in cohesive operation o

101 Evolutionary patterns indicate homeostatic functions for this type of methylation.

102 Normal homeostatic functions of adult stem cells have rhythmic

103 ling may affect virtually all aspects of the homeostatic functions of the kidney.

104 eactivity that can be dissociated from their homeostatic functions.

105 tin system plays a major role in controlling homeostatic functions.

106 nous opioid system supports both hedonic and homeostatic functions.

107 osensory information which controls critical homeostatic functions.

108 spike activity for either motor learning or homeostatic functions.

109 chanism for telomere-dependent regulation of homeostatic gene expression.

110 st pathogens while also performing important homeostatic housekeeping functions.

111 dus, putamen, hippocampus, and amygdala) and homeostatic (hypothalamus) food motivation and hyperacti

112 omic, and behavioral responses that mitigate homeostatic imbalance and ensure survival.

113 eloping fetus and indicate that they mediate homeostatic immune-suppressive responses during gestatio

114 , promotes induction of Th17 cells and tones homeostatic immunity at the gingiva.

115 Moreover, the mechanisms mediating homeostatic immunity at this interface are not yet fully

116 ciated with our current understanding of the homeostatic immunological dialogue between the host and

117 The low homeostatic impact of Hcrt(ko/ko) mouse spontaneous waki

118 Some of these adaptations were homeostatic, including a drop in intrinsic excitability

119 It also considers the possibility that these homeostatic increases in excitability have potential neg

120 and transduce environmental, metabolic, and homeostatic information from the gut directly to the ner

121 lammation is associated with deregulation of homeostatic interactions between intestinal microbes and

122 Gpr182 knockdown had no effect on homeostatic intestinal proliferation in vivo, but led to

123 mouse models, we found that CT induction of homeostatic intestinal Th17 responses was supported not

124 citatory and inhibitory synaptic scaling and homeostatic intrinsic plasticity.

125 required for resetting ISC pool size to the homeostatic level after tissue repair.

126 it ensures that autophagy is maintained at a homeostatic level that promotes and ensures the cell's s

127 ns expression from each enhancer at distinct homeostatic levels.

128 0) is an essential component of the cellular homeostatic machinery in eukaryotes.

129 , but their developmental origin and mode of homeostatic maintenance are unknown.

130 insight into the role of nuclear YAP/TAZ in homeostatic maintenance of an adult tissue.

131 gly, these animals displayed a defect in the homeostatic maintenance of splenic CD8alpha(+) DCs and i

132 ons, the intrinsic requirement of Blimp1 for homeostatic maintenance of these T cell subsets had not

133 nimals undergoing brain regeneration and not homeostatic maintenance or regeneration-induced remodeli

134 This results in a breakdown of homeostatic maintenance that likely contributes to ECM p

135 tiate and renew in other locations, ensuring homeostatic maintenance.

136 Thermogenesis is an important homeostatic mechanism essential for survival and normal

137 the response to sinusoidal stimulation, the homeostatic mechanism feeds back a rectified version of

138 The integrated stress response (ISR) is a homeostatic mechanism induced by endoplasmic reticulum (

139 PMs in the vasculature may represent a novel homeostatic mechanism of relevance to vascular health an

140 esh-mediated signalling pathway is a central homeostatic mechanism of the insect gut.

141 N10-dependent degradation of WRI1 provides a homeostatic mechanism that favors lipid biosynthesis whe

142 over parameters, the auditory system uses a homeostatic mechanism that increases the robustness of i

143 Autophagy is a fundamental cellular homeostatic mechanism, whereby cells autodigest parts of

144 stress while also functioning as a cellular homeostatic mechanism.

145 n describe multiple instances in which these homeostatic mechanisms are altered by donor T cells or c

146 ial utility for investigating alterations in homeostatic mechanisms associated with brain disorders a

147 In this review we describe the sophisticated homeostatic mechanisms by which fungi acquire, utilize,

148 onment they could not at first control, with homeostatic mechanisms developing only later.

149 While circadian and homeostatic mechanisms generally ensure sufficient sleep

150 ture that correlates with a constellation of homeostatic mechanisms in both health and illness.

151 esults provide a greater understanding of Zn-homeostatic mechanisms in wheat, demonstrating an expand

152 bone mineral phenotype through compensatory homeostatic mechanisms involving Cyp24a1 We found that C

153 Surprisingly, homeostatic mechanisms that regulate circuit output have

154 lity to activate protein-synthesis-dependent homeostatic mechanisms that restore top-down excitatory

155 ate how innate receptors engage multilayered homeostatic mechanisms to promote immunity and survival

156 w they engage a neuron's or neural network's homeostatic mechanisms to self-correct.

157 tudy effects of cyclic nucleotides on energy homeostatic mechanisms, mice were generated by targeted

158 ng the molecular understanding of such metal homeostatic mechanisms, natural variation of metal toler

159 citatory-inhibitory balance is maintained by homeostatic mechanisms, we examined the role of MeCP2 in

160 tween rapid-acting antidepressants and local homeostatic mechanisms.

161 cumulated in this tissue, bypassing existing homeostatic mechanisms.

162 ynthesis of non-trimethylated GRP78, whereas homeostatic, METTL21A-dependent lysine 585-trimethylated

163 t reduction of P2RY12, a marker expressed in homeostatic microglia in rodents, which was completely l

164 target that could aid in the restoration of homeostatic microglia.

165 Our study demonstrates the loss of the homeostatic microglial signature in active multiple scle

166 centrations of triglycerides (P = 0.021) and homeostatic model assessment for insulin resistance (P =

167 Insulin resistance was assessed by the homeostatic model assessment index (HOMA), and liver ste

168 We assessed leptin, adiponectin, and homeostatic model assessment of insulin resistance (HOMA

169 A) concentrations was associated with higher homeostatic model assessment of insulin resistance (HOMA

170 ary bout duration) had the highest levels of homeostatic model assessment of insulin resistance (P<0.

171 Homeostatic model assessment of insulin resistance and g

172 9 to 0.72; P = .01), and insulin resistance (homeostatic model assessment of insulin resistance) (Hed

173 oepiandrosterone sulfate, free testosterone, homeostatic model assessment of insulin resistance, and

174 The primary outcome was the change in homeostatic model assessment of IR in those aged >16 yea

175 ts: risk of T2D, presence of prediabetes and homeostatic model of assessment - insulin resistance.

176 We propose a homeostatic model where C. albicans disease pressure is

177 ally, we find that Fife is essential for the homeostatic modulation of neurotransmission.

178 e original observations posit Arc as a major homeostatic modulator of molecular and behavioral respon

179 A sequencing (RNA-seq) reveals enrichment of homeostatic modules in monocytes and DCs from human meta

180 urons, thereby increasing food intake during homeostatic need.SIGNIFICANCE STATEMENT The motivation t

181 tion of the spontaneous network activity and homeostatic network plasticity.

182 ZIPs may have specific roles in the wheat Zn-homeostatic network.

183 erning genes in organizing adult respiratory homeostatic networks that may be perturbed in congenital

184 g made; for example, the rapid regulation of homeostatic neurons by cues that predict future food con

185 To explore homeostatic nuclear positioning, we developed a method t

186 crobiota-activated PPAR-gamma signaling is a homeostatic pathway that prevents a dysbiotic expansion

187 her tissue macrophages owing to their unique homeostatic phenotype and tight regulation by the centra

188 e present in the normal intestine and show a homeostatic phenotype; that is, they participate in the

189 l mutations in Wnt ligands have not revealed homeostatic phenotypes in the intestinal epithelium-an a

190 input, persisting for hours to days, elicit homeostatic plastic changes in the axon initial segment

191 Presynaptic homeostatic plasticity (PHP) controls synaptic transmiss

192 We investigate roles for homeostatic plasticity both locally (local inhibition ad

193 Such branch-specific homeostatic plasticity highlights dendritic branches as

194 pn-2)/plexinA3 (PlexA3) holoreceptor mediate homeostatic plasticity in cortical neurons.

195 ABAA receptor signaling and restores network homeostatic plasticity in Lgdel (+/-) networks.

196 lity underlying neuropathic pain may involve homeostatic plasticity in response to lesion-induced som

197 is a critical effector mechanism underlying homeostatic plasticity in the brain.

198 Presynaptic homeostatic plasticity is a conserved form of neuronal h

199 Synaptic scaling is a key homeostatic plasticity mechanism and is thought to be in

200 Neocortical circuits use a family of homeostatic plasticity mechanisms to stabilize firing, i

201 rrent (mEPSC) amplitudes due to postsynaptic homeostatic plasticity that was dependent on BDNF and it

202 ema2b-PlexB signalling regulates presynaptic homeostatic plasticity through the cytoplasmic protein M

203 Neural systems use homeostatic plasticity to maintain normal brain function

204 ls inhibitory synaptic scaling and intrinsic homeostatic plasticity was unknown.

205 ll retain the ability to express presynaptic homeostatic plasticity, a fundamental and adaptive form

206 Moreover, given the robustness of homeostatic plasticity, these diverse effects on connect

207 ratory motoneurons exhibit a classic form of homeostatic plasticity, up-scaling of AMPA-glutamate rec

208 rally inactive circuit engages mechanisms of homeostatic plasticity, we utilized the respiratory moto

209 measured the induction of all three forms of homeostatic plasticity.

210 r movement, relatively little is known about homeostatic positioning of nuclei, including whether it

211 atched "inhibitory engrams" can form through homeostatic potentiation of inhibition onto postsynaptic

212 f the classic sleep homeostasis model, where homeostatic pressure rises exclusively in TDW rather tha

213 on threat for intracellular pathogens is the homeostatic process of autophagy, through which cells ca

214 of these modifications may likely affect the homeostatic process of colonic epithelium renewal and th

215 Sleep is a fundamental homeostatic process, and disorders of sleep can greatly

216 genase (NOD) enzymes, which facilitate a .NO homeostatic process, i.e., its oxidation to the nitrate

217 al surfaces participate intricately in local homeostatic processes as well as development and functio

218 cing a gradient that sustains many essential homeostatic processes as well as virulence factor secret

219 the expression of genes playing key roles in homeostatic processes in rectal mucosa, such as cell cyc

220 physiological levels are essential for many homeostatic processes, including glycemic control.

221 dings reveal an endogenous mechanism driving homeostatic production of polyreactive IgAs with innate

222 re we show that MZB cells in mice activate a homeostatic program in response to a high-cholesterol di

223 Homeostatic programs balance immune protection and self-

224 ed IL-7-mediated STAT5 activation and T cell homeostatic proliferation and differentiation.

225 fector potential during in vitro and in vivo homeostatic proliferation is coupled to preservation of

226 with larger relative reservoir sizes and/or homeostatic proliferation of cells within the reservoir.

227 l effect on HIV reservoir size in a model of homeostatic proliferation of HIV as well as in acute spr

228 This expansion reflects homeostatic proliferation of infected cells by interleuk

229 h low-level viral replication, longevity and homeostatic proliferation of memory T cells, and most re

230 Processes include homeostatic proliferation that maintains compartment siz

231 These T cells showing homeostatic proliferation were largely found in the medi

232 late biosynthesis rates of the encoded, iron homeostatic proteins.

233 he transient expansion or contraction of the homeostatic range for any given physiological parameter

234 llowing eye-specific resection resulted from homeostatic rates of eye progenitor production and less

235 with feeding, suggesting that metabolic and homeostatic rather than exclusively hedonic responses pl

236 during development and learning, as well as homeostatic re-adjustment to ensure stability.

237 As the UPR is essential for successful ER homeostatic readjustment in the HeLa-micros model, it pr

238 Yet, how the UPR achieves ER homeostatic readjustment is poorly investigated, as in m

239 sue differentiation during regeneration, and homeostatic regeneration of intact limbs.

240 ng mechanisms direct stress-dependent versus homeostatic regeneration, and highlight the importance o

241 me dominated by associative plasticity and a homeostatic regime of tightly constrained synaptic chang

242 iences have expanded the traditional view of homeostatic regulation of body weight by mainly the hypo

243 We hypothesized that there is a homeostatic regulation of body weight.

244 ose that RNF138 plays a critical role in the homeostatic regulation of CaV2.1 protein level and funct

245 Together, these findings suggest a lack of homeostatic regulation of iron homeostasis in young infa

246 ocal action of inflammatory mediators on the homeostatic regulation of sleep continuity and sleep mac

247 Synaptic plasticity and homeostatic regulation of synapses is established to be

248 STDP and implemented multiple mechanisms for homeostatic regulation of synaptic efficacy, including h

249 s during the subsequent day, consistent with homeostatic regulation of the quiescent state.

250 -HT) in regions of the brainstem critical in homeostatic regulation.

251 Serotonin is a homeostatic regulator of the mammary gland during lactat

252 However, at 9 mo of age, homeostatic regulatory capacity has developed although,

253 Here, we describe a homeostatic regulatory circuit that controls sphingolipi

254 on of the unfolded protein response (UPR), a homeostatic regulatory network that responds to ER stres

255 The lack of a homeostatic relationship implies that other mechanisms,

256 Thus, ASOX induces a homeostatic remodeling with improved redox signaling in

257 wing adolescence THC exposure may serve as a homeostatic response geared to maintain proper cognitive

258 determine the molecular basis of cholesterol homeostatic responses induced by the early region 3 memb

259 oid release thus also reflects metabolic and homeostatic responses rather than hedonic responses excl

260 rotective strategies that emulate endogenous homeostatic responses to ASOX (e.g., stressless pacemaki

261 dings unveil a novel autocrine/paracrine pro-homeostatic RPE cell signaling that aims to sustain phot

262 ement is necessary for loss of AMPARs during homeostatic scaling down of synapses.

263 ism for controlling synaptic strength during homeostatic scaling in response to global changes in neu

264 out (KO) mice do not show the characteristic homeostatic scaling up of the amplitude of miniature exc

265 Our data suggest that homeostatic scaling-down, a global form of synaptic plas

266 reserve that affords the organelles distinct homeostatic sensing and regulatory abilities in lung cel

267 anical crowding and stretch, it may act as a homeostatic sensor to control epithelial cell numbers, t

268 The homeostatic set point for metabolism is determined by th

269 Homeostatic signalling systems ensure stable but flexibl

270 c plasticity is a conserved form of neuronal homeostatic signalling that is observed in organisms ran

271 underlying molecular mechanisms of neuronal homeostatic signalling will be essential in order to est

272 ain circuits that regulate reinforcement and homeostatic signals that control metabolism.

273 argeting the TREM2-APOE pathway restored the homeostatic signature of microglia in ALS and AD mouse m

274 terial and eukaryotic cells both demonstrate homeostatic size control, which maintains population-lev

275 Homeostatic sleep drive takes longer to build, circadian

276 ollowing SD, both KO and OE mice exhibited a homeostatic sleep rebound.

277 e of performance impairment, sleepiness, and homeostatic sleep-pressure response to sleep deprivation

278 source of calcium-dependent feedback for the homeostatic stabilization of neurotransmission.

279 cellular behaviours used for its return to a homeostatic state.

280 and derive the range of parameters for which homeostatic states exist.

281 uggest that a mu : GPP value of c. 0.13 is a homeostatic steady state for ecosystem carbon fluxes at

282 mechanisms, we examined the role of MeCP2 in homeostatic synaptic plasticity (HSP) at excitatory syna

283 Expression of EEA1 restored homeostatic synaptic plasticity in Mecp2-deficient neuro

284 ynaptic transmission, and both long-term and homeostatic synaptic plasticity were unchanged, suggesti

285 show that Mecp2-deficient neurons also lack homeostatic synaptic plasticity, likely due to reduced l

286 derived TNF-alpha has been shown to regulate homeostatic synaptic scaling [3-6], but TNF-alpha-null m

287 implicated spontaneous neurotransmission in homeostatic synaptic scaling, but few studies have selec

288 ium deprivation, is a classic example of how homeostatic systems interface with learned associations

289 Homeostatic systems that rely on genetic regulatory netw

290 ion of the mechanisms of regulation of other homeostatic systems.

291 Although dispensable for homeostatic Th17 cell development, JunB is required for

292 fied a nonpathogenic signature of intestinal homeostatic Th17 cells, which are actively regulated by

293 that adapts to changes in diet and maintains homeostatic tissue remodeling.

294 The APOE pathway mediated a switch from a homeostatic to a neurodegenerative microglia phenotype a

295 No changes in homeostatic turnover and homing of B cells were detectab

296 he generation of mature myeloid cells during homeostatic turnover and immunological insults; however,

297 stem cell pools is progressively lost during homeostatic turnover in several tissues, suggesting a de

298 while their numbers are replenished through homeostatic turnover in the mLNs.

299 Homeostatic turnover of the extracellular matrix conditi

300 While this mechanism is homeostatic we show that it does not achieve global perf