ライフサイエンスコーパス: homeostatic mechanism

1 epend on continued stimulation, suggesting a homeostatic mechanism.

2 creased polyamines is an important polyamine homeostatic mechanism.

3 ecific H:L ratio is part of a basic cellular homeostatic mechanism.

4 stress while also functioning as a cellular homeostatic mechanism.

5 own-regulation of YycF activity affects this homeostatic mechanism.

6 e with the regulatory elements composing the homeostatic mechanism.

7 tissues, is likely the efferent arm of this homeostatic mechanism.

8 even though it is likely to be an important homeostatic mechanism.

9 tween rapid-acting antidepressants and local homeostatic mechanisms.

10 y" (VM) CD8 T cells, arise via physiological homeostatic mechanisms.

11 ain growth and survival and engage necessary homeostatic mechanisms.

12 leep may be regulated by both allostatic and homeostatic mechanisms.

13 lls can also be produced from naive cells by homeostatic mechanisms.

14 d striatopallidal neurons is compatible with homeostatic mechanisms.

15 loss maintenance is hampered by anti-famine homeostatic mechanisms.

16 t might include the disruption of normal gut homeostatic mechanisms.

17 l mature T cell pool is regulated by complex homeostatic mechanisms.

18 process is served by motors, scaffolds, and homeostatic mechanisms.

19 cycle progression in response to organ size homeostatic mechanisms.

20 T cells appear to be controlled by different homeostatic mechanisms.

21 es have shed new insights into acidophile pH homeostatic mechanisms.

22 n of primary immune defects and compensatory homeostatic mechanisms.

23 or-reactive T cells, as would be expected by homeostatic mechanisms.

24 ring development, suggesting the presence of homeostatic mechanisms.

25 el of cortical excitability that may involve homeostatic mechanisms.

26 d Na(+) result in interactions between their homeostatic mechanisms.

27 havioral dynamics demonstrating the need for homeostatic mechanisms.

28 lcium during and after a stress to the ionic homeostatic mechanisms.

29 release but is also implicated in many other homeostatic mechanisms.

30 and memory T cells are tightly regulated by homeostatic mechanisms.

31 cal and genetic dissection of presynaptic pH homeostatic mechanisms.

32 nous organisms working in concert to disrupt homeostatic mechanisms.

33 ormally held in balance through a variety of homeostatic mechanisms.

34 e regulation of sleep by circadian clock and homeostatic mechanisms.

35 cumulated in this tissue, bypassing existing homeostatic mechanisms.

36 through tissues is regulated via a number of homeostatic mechanisms.

37 microbial killing pathways but also cellular homeostatic mechanisms [3-5].

38 Our comparisons reveal consistent homeostatic mechanisms across both long- and short-lived

39 At present, it is unclear how vital cellular homeostatic mechanisms affect these early steps in the a

40 r the GABA(A) receptor in triggering several homeostatic mechanisms after activity perturbations, inc

41 evolution of cellular timekeeping with redox homeostatic mechanisms after the Great Oxidation Event a

42 cyclase C (GUCY2C), disrupting a network of homeostatic mechanisms along the crypt-surface axis.

43 nism by which viruses like HIV-1 may subvert homeostatic mechanisms and induce inflammation in the in

44 Defects in this equilibrium can disrupt the homeostatic mechanisms and lead to chronic intestinal in

45 omain is relevant to the evolution of copper homeostatic mechanisms and suggests new models for coppe

46 een functionally incorporated into essential homeostatic mechanisms and suppresses expression of evol

47 f AML1+/- progenitors remained responsive to homeostatic mechanisms and thus the number of mature cel

48 robust antiviral adaptive immunity, neuronal homeostatic mechanisms, and neuroprotective factors on o

49 Our findings highlight the robust homeostatic mechanisms, and role of pioneering neurons i

50 Sleep is regulated by homeostatic mechanisms, and the low-frequency power in t

51 that vasopressin-independent facets of this homeostatic mechanism are under the control of A-Kinase

52 mostat under conditions of glucose scarcity, homeostatic mechanisms are able to carry out metabolic a

53 n describe multiple instances in which these homeostatic mechanisms are altered by donor T cells or c

54 Our results suggest that activity-dependent homeostatic mechanisms are better suited than Hebbian me

55 mpair circuit function, depending on whether homeostatic mechanisms are in place to regulate the resu

56 Similar homeostatic mechanisms are likely to be utilized in othe

57 These results argue that homeostatic mechanisms are more likely than Hebbian mech

58 spiration while minimizing toxicity, but the homeostatic mechanisms are not well understood.

59 Although similar homeostatic mechanisms are operational in mammalian neur

60 Homeostatic mechanisms are required to control formation

61 ng task; however, emerging data suggest that homeostatic mechanisms are robust enough to maintain a l

62 provide evidence that [Ca(2+)](i) and Ca(2+)-homeostatic mechanisms are significantly altered during

63 critical to brain function, since memory and homeostatic mechanisms are thought to be rooted primaril

64 cell volume regulation as a basic conserved homeostatic mechanism associated with the formation of t

65 ial utility for investigating alterations in homeostatic mechanisms associated with brain disorders a

66 Dysregulation of any of these homeostatic mechanisms at any age can cause severe perio

67 multiple activation pathways may represent a homeostatic mechanism attenuating otherwise uncontrolled

68 In this review we address how homeostatic mechanisms balance synaptic strengths betwee

69 We hypothesize that the network provides a homeostatic mechanism balancing HPC/HSC growth control a

70 ling previously unrecognized IL-15-dependent homeostatic mechanisms between different T-cell subsets

71 MD partially activates homeostatic mechanisms but differentially upregulates mo

72 nmental variation, owing to the breakdown of homeostatic mechanisms, but they also show higher levels

73 dings have enhanced our understanding of the homeostatic mechanism by which cells use one regulator,

74 The integrated stress response (ISR) is a homeostatic mechanism by which eukaryotic cells sense an

75 Homeostatic mechanism by which peripheral T-cell subsets

76 This work defines a fundamental homeostatic mechanism by which the AMPK-GIV axis reinfor

77 In this review we describe the sophisticated homeostatic mechanisms by which fungi acquire, utilize,

78 l activity trigger a variety of compensatory homeostatic mechanisms by which neurons maintain a norma

79 Knowledge of homeostatic mechanisms by which the nervous system contr

80 autophagy, triggered by ischemia, could be a homeostatic mechanism, by which apoptosis is inhibited a

81 lcium concentration ([Ca(2+)](i)) and Ca(2+) homeostatic mechanisms (Ca(2+) dynamics) during the deve

82 However, we find that this homeostatic mechanism can lead to massive over-prolifera

83 t, we show that these endogenous but dormant homeostatic mechanisms can be harnessed to restore synap

84 osis, supporting the notion that miRNA-based homeostatic mechanisms can be usurped by cancer cells to

85 Homeostatic mechanisms can eliminate abnormal cells to p

86 These "homeostatic" mechanisms can target synaptic excitation,

87 ol of ingestive behavior distinguish between homeostatic mechanisms concerned with energy balance, an

88 Specific homeostatic mechanisms confer stability in innate immune

89 llowing prolonged MD, and suggest that these homeostatic mechanisms contribute to the delayed gain of

90 To define better the homeostatic mechanisms contributing to small intestinal

91 integrators of peripheral signals underling homeostatic mechanisms controlling nutrient intake.

92 se data indicate that synaptic and intrinsic homeostatic mechanisms cooperate to increase excitabilit

93 This homeostatic mechanism coordinates rates of G1-->S and G2

94 previously unrecognized role of tPA in vital homeostatic mechanisms coupling NMDA receptor signaling

95 onment they could not at first control, with homeostatic mechanisms developing only later.

96 We conclude that homeostatic mechanisms driven by a gradient of activity

97 This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to

98 intake that is driven by factors other than homeostatic mechanisms (e.g., conditioned eating).

99 ate release when GABA synthesis is impaired, homeostatic mechanisms ensure that the RBC output operat

100 Thermogenesis is an important homeostatic mechanism essential for survival and normal

101 utamate content of synaptic vesicles and (2) homeostatic mechanisms exist to attenuate the excitatory

102 the response to sinusoidal stimulation, the homeostatic mechanism feeds back a rectified version of

103 Our findings identify a homeostatic mechanism for coordinating the status of ene

104 This phenomenon provides a homeostatic mechanism for elevating 2,3-BPG levels, ther

105 Induction of Plks might provide a homeostatic mechanism for global dampening of synaptic s

106 Compartmentalization may be a homeostatic mechanism for isolating these biological rea

107 g angiogenic sprouting and offer a potential homeostatic mechanism for regulating vascular density.

108 caling up of synaptic strength, reflecting a homeostatic mechanism for stabilizing neuronal activity.

109 These findings suggests a homeostatic mechanism for surviving starvation in which

110 he central clock component TIM and suggest a homeostatic mechanism for the regulation of circadian ph

111 These findings identify a major homeostatic mechanism for the regulation of neutrophil p

112 every process in human physiology relies on homeostatic mechanisms for stability, only some have dem

113 While circadian and homeostatic mechanisms generally ensure sufficient sleep

114 Little is known about homeostatic mechanisms governing their plasticity.

115 or the tightly controlled regulation of this homeostatic mechanism has begun to bear fruit in the way

116 -coupled receptors (GPCRs), to regulate this homeostatic mechanism has received much less attention.

117 hydration status are readily compensated by homeostatic mechanisms has been little studied, the infl

118 models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protectiv

119 For the proposed 'homeostatic mechanism', homeostatic pressure increases i

120 In contrast to the homeostatic mechanism, however, bacterial-induced extrus

121 erebral pressure autoregulation, a sensitive homeostatic mechanism important for the control of cereb

122 Our findings begin to delineate B-cell homeostatic mechanisms important for human immune tolera

123 Autophagy may be a protective or homeostatic mechanism in normal cartilage.

124 These results reveal a remarkable homeostatic mechanism in postmitotic epithelia that ensu

125 is an essential component of a novel innate homeostatic mechanism in the mammalian airways to repres

126 portantly, these data provide insight into a homeostatic mechanism in which C1q and HMGB1 can coopera

127 Collectively, these findings define a homeostatic mechanism in which Th2 cytokines promote, an

128 ture that correlates with a constellation of homeostatic mechanisms in both health and illness.

129 nd current studies, aging may affect calcium homeostatic mechanisms in central and peripheral autonom

130 Ca(2+) homeostatic mechanisms in hippocampal neurons also were

131 Homeostatic mechanisms in mammals respond to hormones an

132 Intracellular pH provides information on homeostatic mechanisms in neurons and glial cells.

133 ter receptor and is thought to contribute to homeostatic mechanisms in neurons.

134 dies, our work reveals an important role for homeostatic mechanisms in regulating functional connecti

135 rt gene expression and induction of specific homeostatic mechanisms in response to maternal undernutr

136 derstood, little is known about the apparent homeostatic mechanisms in these other yeasts and fungi.

137 esults provide a greater understanding of Zn-homeostatic mechanisms in wheat, demonstrating an expand

138 Two homeostatic mechanisms included a cascade structure, one

139 ebrain circuit that modulates stress-related homeostatic mechanisms, including the hypothalamic-pitui

140 The integrated stress response (ISR) is a homeostatic mechanism induced by endoplasmic reticulum (

141 How multiple cellular and synaptic homeostatic mechanisms interact in a neuronal circuit is

142 Immune response regulation includes homeostatic mechanisms intrinsic to the activation and d

143 Therefore, a homeostatic mechanism, intrinsic to the STN, balances co

144 bone mineral phenotype through compensatory homeostatic mechanisms involving Cyp24a1 We found that C

145 s will be useful for obtaining insights into homeostatic mechanisms involving liver cell compartments

146 lecular basis for the abrogation of this key homeostatic mechanism is poorly understood.

147 This homeostatic mechanism is significantly reduced in striat

148 and perfect adaptation seen when the calcium homeostatic mechanism is subjected to extreme disturbanc

149 The most known and studied homeostatic mechanism is the control of iron uptake in t

150 ent of sensory maps, a unique consequence of homeostatic mechanisms is the precise shaping of neurona

151 s at least partially activated by a reactive homeostatic mechanism, it is likely also regulated by th

152 channels can be compensated; in others, the homeostatic mechanism itself causes pathological loss of

153 istic synaptic plasticity rules coupled with homeostatic mechanisms lead to the formation of neuronal

154 rafficking, and degradation; failure of this homeostatic mechanism likely contributes to neurodegener

155 tracellular adenosine levels is an important homeostatic mechanism, loss of which contributes to the

156 In severe hypoxia, homeostatic mechanisms maintain function of the brainste

157 It has been postulated that homeostatic mechanisms maintain stable circuit function

158 up the burden of supporting transmission and homeostatic mechanisms maintained overall synaptic stren

159 However, the homeostatic mechanism maintaining the acid-secreting "co

160 e studies suggest that P-gp provides a local homeostatic mechanism, maintaining CSF T4 levels.

161 increases quadratically over time and that a homeostatic mechanism maintains a constant density of mi

162 ressive potency of MDSC, and that a feedback homeostatic mechanism maintains a steady-state level of

163 When homeostatic mechanisms malfunction, the volume and conce

164 It is thought that homeostatic mechanisms match intrinsic excitability to t

165 bservations suggest that altered [Ca(2+)](i) homeostatic mechanisms may underlie some aspects of the

166 Our results demonstrate that the host homeostatic mechanism mediated by Gal-9/Tim-3 interactio

167 ain function and architecture through robust homeostatic mechanisms mediated by self-renewing cells c

168 tudy effects of cyclic nucleotides on energy homeostatic mechanisms, mice were generated by targeted

169 This suggests that homeostatic mechanisms might be acting to preserve the p

170 conclusions did not change upon addition of homeostatic mechanisms, multiplicative STDP rules or wea

171 results show that interpretation of afferent homeostatic mechanisms must incorporate properties that

172 ng the molecular understanding of such metal homeostatic mechanisms, natural variation of metal toler

173 insights into the developmental networks and homeostatic mechanisms necessary for the transformation

174 PMs in the vasculature may represent a novel homeostatic mechanism of relevance to vascular health an

175 esh-mediated signalling pathway is a central homeostatic mechanism of the insect gut.

176 ollicle an ideal system with which to define homeostatic mechanisms of an adult stem cell population.

177 Compared with homeostatic mechanisms of feeding, much less is known ab

178 ntrations would be predicted to disrupt many homeostatic mechanisms of growth, development, and metab

179 Unlike other essential metals, cell-level homeostatic mechanisms of Mn have not been identified.

180 stem cells and promote their escape from the homeostatic mechanisms of proliferation control.

181 survival signals and thus may contribute to homeostatic mechanisms of tonic signaling.

182 parse coding models, such as those employing homeostatic mechanisms on neural firing rates, can exhib

183 This could be consistent with a defect in a homeostatic mechanism operating at the root-to-shoot tra

184 Loss of hCLCA2 may allow escape from pHi homeostatic mechanisms, permitting the higher intracellu

185 networks in most type I strains, that other homeostatic mechanisms predominate in type II strains, a

186 While several homeostatic mechanisms prevent oxygen-dependent killing

187 tor networks in conjunction with appropriate homeostatic mechanisms provide a robust, biologically pl

188 As a further indication of failed homeostatic mechanisms, R2KO mice displayed indices of c

189 sequence of imbalances in what are intrinsic homeostatic mechanisms, rather than a result of external

190 waves in ChAT knock-out regions suggest that homeostatic mechanisms regulate retinal output during de

191 Homeostatic mechanisms regulate synaptic function to mai

192 entry and progression, providing a critical homeostatic mechanism regulating cellular proliferation.

193 d, as part of a conserved post-translational homeostatic mechanism regulating lymphocyte numbers or a

194 we report that Pum2 is indeed central to the homeostatic mechanism regulating membrane excitability i

195 This study sought to examine normal homeostatic mechanisms regulating adaptive immunity to R

196 the underlying molecular components of these homeostatic mechanisms remain poorly understood.

197 role of peripheral circadian clocks in these homeostatic mechanisms remains unknown.

198 The homeostatic mechanism reproduces experimentally observed

199 e paracortical T-cell zone (TZ) that impairs homeostatic mechanisms required for T-cell survival.

200 Accurate encoding is recovered when a homeostatic mechanism scales the excitatory synapses to

201 Homeostatic mechanisms stabilize neural circuit function

202 olism and storage, whereas scarcity triggers homeostatic mechanisms, such as the mobilization of inte

203 ess limitless self-renewal, may hijack these homeostatic mechanisms, take refuge within the sanctuary

204 A homeostatic mechanism, termed the actin-scavenger system

205 ffects of the mutations are mitigated by the homeostatic mechanism that acts on expression of other G

206 f synaptic plasticity may constitute a novel homeostatic mechanism that can prevent the runaway synap

207 emonstrate that WRP anchoring to WAVE-1 is a homeostatic mechanism that contributes to neuronal devel

208 We propose that PS flip is part of a homeostatic mechanism that controls sterol loading and l

209 el modulator, Rem2 may function as part of a homeostatic mechanism that controls synapse number.

210 e modeling, that initiator dimerization is a homeostatic mechanism that dampens active monomer increa

211 that primarily regulates sleep timing and a homeostatic mechanism that detects and responds to sleep

212 type I metabotropic glutamate receptors is a homeostatic mechanism that detects synaptic crosstalk an

213 ion in T lymphocytes by ST3Gal-I comprises a homeostatic mechanism that eliminates CD8+ T cells by ap

214 N10-dependent degradation of WRI1 provides a homeostatic mechanism that favors lipid biosynthesis whe

215 over parameters, the auditory system uses a homeostatic mechanism that increases the robustness of i

216 results suggest that retinal neurons have a homeostatic mechanism that integrates energetic status o

217 tissue in the small intestine, is part of a homeostatic mechanism that is activated in response to t

218 We describe a homeostatic mechanism that limits NMDA receptor currents

219 These findings reveal a robust homeostatic mechanism that maintains physiological level

220 , our results show that Pum2 forms part of a homeostatic mechanism that matches membrane excitability

221 ve autophagy of Bcl10 is a pathway-intrinsic homeostatic mechanism that modulates TCR signaling to NF

222 in, and this response is likely an important homeostatic mechanism that prevents the overaccumulation

223 e for fast vesicle recycling as a functional homeostatic mechanism that prevents vesicle depletion an

224 Thus, Crb is part of a homeostatic mechanism that promotes Ex inhibition of Yki

225 Thus, we uncover a homeostatic mechanism that reciprocally regulates A-type

226 Here we report biological evidence for a homeostatic mechanism that reconciles the apparently opp

227 t that both Rbm3 and microRNAs are part of a homeostatic mechanism that regulates global levels of pr

228 ought that redox signaling might represent a homeostatic mechanism that regulates the function of syn

229 gulatory T cells and uncover a new intrinsic homeostatic mechanism that regulates the magnitude of im

230 Cell competition is a homeostatic mechanism that regulates the size attained b

231 MMIC may represent an important homeostatic mechanism that supports peripheral tolerance

232 Here we identify a homeostatic mechanism that transcriptionally tailors CD8

233 ver pathways in plants and some of the known homeostatic mechanisms that act during meiotic recombina

234 etween rapid forms of Hebbian plasticity and homeostatic mechanisms that adjust the threshold for pla

235 phasizing the important contributions of K(+)homeostatic mechanisms that are known to be reduced in H

236 vity caused by exposure to drugs may trigger homeostatic mechanisms that attempt to restore normal ne

237 To determine homeostatic mechanisms that balance this input-output/sy

238 in the liver and renal glutamine uptake, are homeostatic mechanisms that cause negative nitrogen bala

239 is involves the progressive dysregulation of homeostatic mechanisms that control growth.

240 constraining neoplastic progression through homeostatic mechanisms that control pancreatic regenerat

241 either inhibition or excitation would engage homeostatic mechanisms that converge to regulate NMDA re

242 as development and tissue repair, as well as homeostatic mechanisms that counteract ageing and neurod

243 Neurons are equipped with homeostatic mechanisms that counteract long-term perturb

244 The emergence of homeostatic mechanisms that enable maintenance of an int

245 carcinogenesis proceeds by misappropriating homeostatic mechanisms that govern tissue repair and ste

246 This is especially true of the homeostatic mechanisms that have evolved to maintain the

247 istance to influenza, suggesting that normal homeostatic mechanisms that limit basal tissue inflammat

248 esis by hypoxia is an important component of homeostatic mechanisms that link vascular oxygen supply

249 hese data suggest steady-state DA may enable homeostatic mechanisms that maintain motor network outpu

250 he osteoclast is an important element of the homeostatic mechanisms that maintain skeletal integrity

251 antigen-specific T memory (Tm) cells but the homeostatic mechanisms that maintain the size and divers

252 ols are maintained through poorly understood homeostatic mechanisms that may include signaling via cy

253 such O2-sensing cells have evolved as vital homeostatic mechanisms that monitor O2 supply and alter

254 radoxical effect may reflect a disruption of homeostatic mechanisms that normally act to reduce seizu

255 arallel pathways, generating a nested set of homeostatic mechanisms that operate over different tempo

256 Neurons may possess activity-dependent homeostatic mechanisms that permit them to globally alte

257 uced long-lasting alterations in [Ca(2+)](i) homeostatic mechanisms that persist for up to 1 year aft

258 Surprisingly, homeostatic mechanisms that regulate circuit output have

259 e is thought to be maintained by an array of homeostatic mechanisms that regulate neuronal and circui

260 lity to activate protein-synthesis-dependent homeostatic mechanisms that restore top-down excitatory

261 al for learning and memory, are dependent on homeostatic mechanisms that stabilize neural activity.

262 Recent studies have helped define the homeostatic mechanisms that support the diverse pool of

263 Our data suggests that homeostatic mechanisms that support the naive T cell poo

264 TLRs also activate homeostatic mechanisms that suppress osteoclastogenesis

265 of leukocyte recruitment may represent local homeostatic mechanisms that tissues and organs may have

266 s in normal signal transduction pathways and homeostatic mechanisms that would trigger apoptosis in n

267 These results reveal a homeostatic mechanism through which activity regulates t

268 ymes ACAT1 and ACAT2 is, in part, a cellular homeostatic mechanism to avoid toxicity associated with

269 As a possible homeostatic mechanism to control persistent infection-in

270 that ABA-induced accumulation of miR159 is a homeostatic mechanism to direct MYB33 and MYB101 transcr

271 We propose that this regulation is part of a homeostatic mechanism to limit excessive inflammation an

272 r in nociceptive sensory neurons provides an homeostatic mechanism to prevent excessive ATP signaling

273 We hypothesized that fasting alters homeostatic mechanisms to eliminate excitatory responses

274 to be properly fine-tuned and controlled by homeostatic mechanisms to ensure proper network function

275 insic adaptive responses operating as global homeostatic mechanisms to maintain firing macro-stabilit

276 n the HSC fraction, suggesting the action of homeostatic mechanisms to maintain sufficient levels of

277 Thus, homeostatic mechanisms to preserve membrane compositions

278 marrow caused primarily by failure of normal homeostatic mechanisms to prevent the expansion of postg

279 ate how innate receptors engage multilayered homeostatic mechanisms to promote immunity and survival

280 t-specific synaptic modifications and global homeostatic mechanisms to provide stability to neural ne

281 be toxic, cells have developed sophisticated homeostatic mechanisms to regulate their levels and avoi

282 w they engage a neuron's or neural network's homeostatic mechanisms to self-correct.

283 cells and therefore organisms have developed homeostatic mechanisms to tightly regulate its acquisiti

284 e AMPK-PGC-1alpha signaling cascade, a known homeostatic mechanism, to increase prostate cancer cell

285 ise in sedentary cultures restores perturbed homeostatic mechanisms towards the normal physiological

286 Thus, a homeostatic mechanism used during activity reduction pro

287 citatory-inhibitory balance is maintained by homeostatic mechanisms, we examined the role of MeCP2 in

288 nd the host limits iron availability through homeostatic mechanisms, we hypothesized that B. anthraci

289 ed, and whether neurons develop compensatory homeostatic mechanisms were unknown and are the focus of

290 hloride transport systems highlights a novel homeostatic mechanism whereby ambient glutamate levels d

291 Autophagy is a fundamental cellular homeostatic mechanism, whereby cells autodigest parts of

292 in stable network function, neurones possess homeostatic mechanisms which integrate activity levels a

293 excitability through an activity-dependent, homeostatic mechanism, which could have major effects on

294 strategies it is important to understand the homeostatic mechanisms, which exist to maintain a balanc

295 gy metabolism through the control of several homeostatic mechanisms, which include autophagy and prot

296 We suggest that these specific homeostatic mechanisms, which match the number, strength

297 ponse (UPR), represents a conserved cellular homeostatic mechanism with important roles in normal dev

298 Homeostatic mechanisms within the cell respond by reduci

299 n of the proteasome results in disruption of homeostatic mechanisms within the cell that can lead to

300 These data establish that homeostatic mechanisms within the intact CNS act to stab