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1 sophila developmental protein female sterile homeotic.
2 r the trithorax group gene absent, small, or homeotic 1-like (Ash1l) at this developmental transition
3 levels of the Jak/STAT effectors Zinc finger homeotic-1 (Zfh-1) and Chronologically inappropriate mor
6 iation, deletion of the 6th pharyngeal arch, homeotic aberration and loss of rostral vertebrae, and r
16 pes resemble the Arabidopsis and Antirrhinum homeotic B-function mutants apetala3/deficiens (ap3/def)
17 idopsis thaliana, a core eudicot, the floral homeotic C-class gene AGAMOUS (AG) has a dual role speci
18 One common molecular interpretation of such homeotic cell identity transformations is that a regulat
19 poppy (Eschscholzia californica) that shows homeotic changes characteristic of floral homeotic B cla
22 that in addition to encoding Hox genes, the homeotic clusters contain key noncoding RNA genes that p
23 ation and divergence of the tandemly arrayed homeotic clusters have been studied in considerable deta
28 uch as Drosophila have demonstrated that the homeotic complex (Hox) genes impart segmental identity d
32 C. hirsuta lfy mutants showed a complete homeotic conversion of flowers to leafy shoots, mimickin
33 (STM) induces carpel formation and promotes homeotic conversion of ovules to carpels when ectopicall
34 rning the B- and C-functions, leading to the homeotic conversion of sepals into petals, carpels, or s
35 internode elongation (IscLFY1) or by causing homeotic conversion of shoots into flowers (IscLFY2).
36 (TPL) and that PLT1/2 are necessary for the homeotic conversion of shoots to roots in tpl-1 mutants.
37 by virus-induced gene silencing resulted in homeotic conversion of stamens and carpels into sepaloid
38 identity, and loss of B function results in homeotic conversions of petals into sepals and stamens i
40 led to reduced eyespot size in the expected homeotic direction, but neither additional eyespots nor
41 la trithorax group protein absent, small, or homeotic discs 1 (ASH1) is involved in maintaining activ
42 found that trithorax (TRX), absent small or homeotic discs 1 (ASH1), and Compass member SET1 histone
43 f the Drosophila trxG gene absent, small, or homeotic discs 2 (ash2) is a component of a 500-kD compl
45 ndings provide a molecular definition of the homeotic domains, and implicate precisely positioned H3K
49 hila BET protein encoded by female sterile 1 homeotic [fs(1)h] causes loss of fine, terminal dendriti
50 m identity, while GhLFY has evolved a novel, homeotic function during the evolution of head-like infl
53 ivator of transcription 3 (STAT3)-paired box homeotic gene 3 (PAX3)-signaling pathway, which is upreg
56 iana, cis-regulatory sequences of the floral homeotic gene AGAMOUS (AG) are located in the second int
57 in maintaining the repression of the flower homeotic gene AGAMOUS (AG) during vegetative development
60 of transcriptional repression of the floral homeotic gene AGAMOUS (AG), we identified two mutations
64 s provide the first evidence for a noncoding homeotic gene and raise the possibility that other such
65 PSC is specified early in the embryo by the homeotic gene Antennapedia (Antp) and expresses the sign
69 The Hox gene fushi tarazu (ftz) arose as a homeotic gene but functions as a pair-rule segmentation
70 We have examined chromatin at Drosophila homeotic gene clusters by measuring, at high resolution,
74 related to rice Karma, in the intron of the homeotic gene DEFICIENS, is common to all mantled clones
75 H3 lysine 27 (H3K27) mutations have the same homeotic gene expression and developmental defects as mu
76 n to play a major role in controlling floral homeotic gene expression and thus is an excellent candid
79 ure, Drosophila ptip is required to activate homeotic gene expression in response to the derepression
82 dies of dosage compensation, imprinting, and homeotic gene expression suggest that individual lincRNA
83 tral stem cell niche nor from reduced floral homeotic gene expression, but rather indicate a specific
86 eiohomeotic-like (Phol)] redundantly control homeotic gene expression, the regulatory contributions o
92 ectasia-mutated locus that is encoded by the homeotic gene multisex combs (mxc) as novel HLB componen
93 For example, Caudal, a key regulator of the homeotic gene network, preferentially activates transcri
97 orted for mutations in labial, an endodermal homeotic gene required for copper cell specification, an
98 complex expression pattern of the Drosophila homeotic gene Sex combs reduced (Scr) is directed by an
101 s likely mediated through suppression of the homeotic gene teashirt (tsh) and is independent of homot
104 -acetylgalactosaminyltransferase; paired box homeotic gene transcription factor 3; and melanoma antig
105 ipts of three TREs located in the Drosophila homeotic gene Ultrabithorax (Ubx) mediate transcription
106 major Polycomb response element (PRE) of the homeotic gene Ultrabithorax (Ubx), and efficient PRE rec
109 base-pair with the messenger RNA of a floral homeotic gene, APETALA2, regulates APETALA2 expression p
110 on the function of the APETALA1 (AP1) floral homeotic gene, since mutations in AP1 reduce LFY-depende
114 maintain the stable epigenetic repression of homeotic genes and other important developmental and cel
115 ired for maintaining the silent state of the homeotic genes and other important developmental regulat
117 n a screen for transcriptional activators of homeotic genes and subsequently shown to play a global r
118 complex has been linked to the silencing of homeotic genes and the inactivation of the X chromosome.
120 dentifying the genes regulated by the floral homeotic genes APETALA3 (AP3) and PISTILLATA (PI) is cru
121 We find that the transcript levels of floral homeotic genes APETALA3 (AP3), PISTILLATA (PI), and AGAM
122 analyses revealed that all classes of floral homeotic genes are down-regulated in mtnam mutants.
124 pression and activation of the expression of homeotic genes are maintained by proteins encoded by the
126 A, we further demonstrated that these floral homeotic genes are transcriptionally repressed by RGA ac
129 te that GA promotes the expression of floral homeotic genes by antagonizing the effects of DELLA prot
131 show, unexpectedly, that Psip1/p75 regulates homeotic genes by recruiting not only MLL complexes, but
137 istral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem c
138 b group (PcG) genes are required to maintain homeotic genes in a silenced state during development in
142 RE function, does not cause misexpression of homeotic genes or reporter genes in imaginal disks.
144 to study the function of orthologs of floral homeotic genes such as DEFICIENS (DEF) in non-model syst
146 ) in Drosophila melanogaster is a cluster of homeotic genes that determine body segment identity.
148 al repression to maintain cellular memory of homeotic genes turned out to be a highly conserved and s
149 addition, we describe the expression of the homeotic genes Ultrabithorax, abdominal-A, and Abdominal
151 scription factors encoded by four classes of homeotic genes, A, B, C and E, act in a combinatorial ma
152 e is not due to disruption of whorl-specific homeotic genes, AP3 or PISTILLATA, responsible for petal
154 owth as well as regulate the human engrailed homeotic genes, important regulators of brain developmen
156 ty is determined by specific combinations of homeotic genes, originate from a group of undifferentiat
157 ible function in the concerted repression of homeotic genes, probably through histone H3 lysine-27 tr
158 have examined the expression patterns of two homeotic genes, Ultrabithorax and abdominal-A (collectiv
159 hat determine segment-specific expression of homeotic genes, which are not masked by transcriptional
160 cent progress in our understanding of floral homeotic genes, with an emphasis on how their region-spe
174 rtant in development and cancer (for example homeotic genes; N=683 total genes) to explore the relati
176 We found that nearly all of the Drosophila homeotic (Hox) gene promoters, which lack TATA-box eleme
177 ween the anterior expression boundary of the homeotic (Hox) gene Ultrabithorax (Ubx) and the location
183 the GDPCs by the coordinated actions of the homeotic (Hox) genes, abdominal-A, Abdominal-B, and caud
184 ation within this enhancer that identified a homeotic (Hox) response element that is a direct target
185 ry improbable that any sensory fibers of the homeotic leg project to normal leg projection areas in t
187 methyltransferase Ash1l [(absent, small, or homeotic)-like (Drosophila)] develop epidermal hyperplas
190 protein associates directly with the master homeotic locus AGAMOUS, inducing its expression by regul
193 nome-wide in vivo DNA binding data show that homeotic MADS domain proteins recognize partly distinct
194 s revealed SOC1 repression by several floral homeotic MADS domain proteins, and we show that, mechani
195 les were isolated for each of the two floral homeotic MADS-box genes, MtPISTILATA and MtAGAMOUS.
196 and mass spectrometry that five major floral homeotic MADS-domain proteins (AP1, AP3, PI, AG, and SEP
200 s and one PI homolog in wild-type and floral homeotic mutant lines reveal complex patterns that sugge
201 protein accumulation and induces a classical homeotic mutant phenotype: the transformation of haltere
202 ion profiles of inflorescences of the floral homeotic mutants apetala1, apetala2, apetala3, pistillat
203 can be gained from careful investigation of homeotic mutants outside the core eudicot model species.
209 te a significant overlap in dosage-sensitive homeotic phenotypes and co-repression of a similar set o
210 Trithorax mimic (E(z)(Trm)) causes dominant homeotic phenotypes similar to those caused by mutations
212 immunoprecipitation, we show that the floral homeotic PISTILLATA (PI) protein, required for petal and
213 Results revealed that RA does not cause homeotic posteriorization in Oikopleura as it does in ve
214 vidence suggests that the lack of RA-induced homeotic posteriorization is a shared derived feature of
215 nuclear localization of beta-catenin but not homeotic posteriorization of the epithelium by Cdx2.
216 hese "degen-YPWMs" showed varying degrees of homeotic potential when expressed in Drosophila, suggest
217 ll identity gene WUSCHEL (WUS) by the floral homeotic protein AGAMOUS (AG) is a key part of this proc
219 nction but also identify a new regulation of homeotic protein-mediated transcriptional regulation in
220 Unlike the other highly characterized floral homeotic proteins containing MADS domains, AP2 has two D
221 The results also suggest that AG and other homeotic proteins with which it interacts (SEPALLATA3, A
222 many transcription factors including floral homeotic proteins, by which floral organ identity is det
225 thway of spleen development and reveal how a homeotic regulator employs different molecular mechanism
226 Among these, the class B and class C floral homeotic regulators are of central importance as they sp
228 localization of A, B, C and SEPALLATA floral homeotic RNAs suggest that HUA ENHANCER2 is required for
230 ration and tubulogenesis in the ASP and that homeotic selector gene function is necessary for the tem
231 on in plants, we studied the function of the homeotic selector genes APETALA3 (AP3) and PISTILLATA (P
233 We have sequenced the region containing the homeotic selector genes required for proper development
235 ass inflorescence development, which invokes homeotic shifts in multiple distinct meristem identities
236 Increased doses of Cdx proteins result in homeotic shifts in vertebral types along most of the ver
238 They had brachycephaly, small rib cages, and homeotic skeletal transformations with incomplete penetr
240 ate homologue of the Drosophila melanogaster homeotic transcription factor Spalt, has previously been
243 work defines the molecular basis of ACS as a homeotic transformation (mandible to maxilla) in humans.
245 w structures in Ednra(-/-) embryos undergo a homeotic transformation into maxillary-like structures s
246 ed a novel molecule, DAC-2-25, that causes a homeotic transformation of body column into tentacle zon
251 Furthermore, overexpression of tsh induces a homeotic transformation of the fly head into thoracic st
253 tion in each of the three insects results in homeotic transformation of the labial appendages to legs
254 Following knockdown of miR-196, we observe a homeotic transformation of the last cervical vertebrae t
255 ss of multiple bone structures and posterior homeotic transformation of the last thoracic vertebra.
256 he upper jaw, whereas Dlx5/6(-/-) results in homeotic transformation of the lower jaw into upper jaw.
257 tral gene expression, the result of which is homeotic transformation of the mandible into a maxilla-l
258 uctures while depletion of homothorax led to homeotic transformation of the proximal maxilla and labi
262 thylation (the Bad Karma epiallele) predicts homeotic transformation, parthenocarpy and marked loss o
263 e find that heightened stx activity leads to homeotic transformation, reduced Pc activity, and de-rep
264 true evolutionary reversal but an innovative homeotic transformation, where, in this case, all petals
267 ncing by Polycomb protein complexes leads to homeotic transformations and altered developmental-phase
271 ws that vitamin A deficiency causes anterior homeotic transformations extending from the cervical to
272 sed on a striking floral phenotype, in which homeotic transformations from sepals to carpels are foun
273 ges of the number of trunk vertebrae require homeotic transformations from trunk into sacral vertebra
275 ramatically at 26 degrees C, and we identify homeotic transformations in a subset of embryos grown at
276 were first identified in genetic screens for homeotic transformations in Drosophila melanogaster.
278 d this defect in Wnt signalling manifests as homeotic transformations in the vertebrae of Tert(-/-) m
280 on mutation in Tomato AP3 (TAP3) resulted in homeotic transformations of both petals and stamens, whe
281 oss of paralogous function leads to anterior homeotic transformations of colinear regions throughout
282 esults from other species, we did not obtain homeotic transformations of embryonic appendages in resp
283 of B-class gene function results in extreme homeotic transformations of petal and stamen identities.
285 are viable and fertile but exhibit posterior homeotic transformations of the axial vertebrae in a dos
286 1 mutant mice displayed dramatic synergistic homeotic transformations of the reproductive tracts, wit
288 rning, because mutating this region leads to homeotic transformations similar to those observed with
289 regulatory interactions but also results in homeotic transformations typical of Hox gene misregulati
291 genes via highly conserved sites, leading to homeotic transformations when ectopically expressed.
292 ormation and their depletion has resulted in homeotic transformations with neuron loss and miswiring.
293 esence of a dominant phenotype consisting of homeotic transformations, similar to those observed in m
294 ior organ and therefore it is reminiscent of homeotic transformations, which can occur in transgenic
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