ライフサイエンスコーパス: homeotic

1 sophila developmental protein female sterile homeotic.

2 r the trithorax group gene absent, small, or homeotic 1-like (Ash1l) at this developmental transition

3 levels of the Jak/STAT effectors Zinc finger homeotic-1 (Zfh-1) and Chronologically inappropriate mor

4 ding protein-5 (RbBP5), and the absent small homeotic-2-like protein (Ash2L).

5 n identity in plants is controlled by floral homeotic A/B/C/D/E-class genes.

6 iation, deletion of the 6th pharyngeal arch, homeotic aberration and loss of rostral vertebrae, and r

7 Floral homeotic and flower development mutants of Primula, incl

8 z cofactor interaction motifs led to loss of homeotic and gain of segmentation potential.

9 Homeotic and sex-determining genes control a wide range

10 n to regulate genes of the segment polarity, homeotic, and pair-rule classes.

11 with coactivators Fs(1)h [female sterile (1) homeotic] and Enok/Br140 during embryogenesis.

12 The floral homeotic APETALA3 (AP3) and PISTILLATA (PI) genes encode

13 The floral homeotic APETALA3 (AP3) gene in Arabidopsis thaliana enc

14 LFY-dependent activation of the homeotic APETALA3 (AP3) gene requires the activity of UN

15 ws homeotic changes characteristic of floral homeotic B class mutants.

16 pes resemble the Arabidopsis and Antirrhinum homeotic B-function mutants apetala3/deficiens (ap3/def)

17 idopsis thaliana, a core eudicot, the floral homeotic C-class gene AGAMOUS (AG) has a dual role speci

18 One common molecular interpretation of such homeotic cell identity transformations is that a regulat

19 poppy (Eschscholzia californica) that shows homeotic changes characteristic of floral homeotic B cla

20 These localized homeotic changes were associated with opposing miR172/Q

21 sepaloid and show ectopic expression of the homeotic class-A gene AP1.

22 In D. virilis, the homeotic cluster is split between Ubx and abd-A, and so

23 that in addition to encoding Hox genes, the homeotic clusters contain key noncoding RNA genes that p

24 ation and divergence of the tandemly arrayed homeotic clusters have been studied in considerable deta

25 criptional and epigenetic changes within the homeotic clusters of mouse embryonic stem cells.

26 nt that is a direct target of labial and the homeotic cofactors homothorax and extradenticle.

27 We found that at least seven different Homeotic complex (HOM-C) arrangements exist among Drosop

28 ryo by establishing fields in which specific Homeotic complex (Hom-C) proteins can function.

29 uch as Drosophila have demonstrated that the homeotic complex (Hox) genes impart segmental identity d

30 Homeotic control of neuronal identity programs has impli

31 lity to orf293, a mitochondrial gene causing homeotic conversion of anthers into petals.

32 ate a bristle identity program, resulting in homeotic conversion of bristles to spikelets.

33 C. hirsuta lfy mutants showed a complete homeotic conversion of flowers to leafy shoots, mimickin

34 fects in paleas and lodicules, including the homeotic conversion of lodicules into carpels.

35 (STM) induces carpel formation and promotes homeotic conversion of ovules to carpels when ectopicall

36 rning the B- and C-functions, leading to the homeotic conversion of sepals into petals, carpels, or s

37 internode elongation (IscLFY1) or by causing homeotic conversion of shoots into flowers (IscLFY2).

38 (TPL) and that PLT1/2 are necessary for the homeotic conversion of shoots to roots in tpl-1 mutants.

39 by virus-induced gene silencing resulted in homeotic conversion of stamens and carpels into sepaloid

40 tion of the endogenous auxin gradient led to homeotic conversions of florets and phyllaries in the ca

41 identity, and loss of B function results in homeotic conversions of petals into sepals and stamens i

42 A-function genes) in hua-pep mutants reduced homeotic conversions, rescuing ovule identity while prom

43 ion in TM6 function resulted in flowers with homeotic defects primarily in stamens.

44 led to reduced eyespot size in the expected homeotic direction, but neither additional eyespots nor

45 la trithorax group protein absent, small, or homeotic discs 1 (ASH1) is involved in maintaining activ

46 found that trithorax (TRX), absent small or homeotic discs 1 (ASH1), and Compass member SET1 histone

47 f the Drosophila trxG gene absent, small, or homeotic discs 2 (ash2) is a component of a 500-kD compl

48 ng protein-5), and the Ash2L (absent, small, homeotic discs-2-like) oncoprotein.

49 ndings provide a molecular definition of the homeotic domains, and implicate precisely positioned H3K

50 In general, the homeotic effects of interference with the function of Ho

51 ol of seed size, acting downstream of floral homeotic factors.

52 protein in the epidermal growth factor-like homeotic family.

53 th, loss of apical dominance, sterility, and homeotic floral transformations.

54 hila BET protein encoded by female sterile 1 homeotic [fs(1)h] causes loss of fine, terminal dendriti

55 m identity, while GhLFY has evolved a novel, homeotic function during the evolution of head-like infl

56 within the anterior gt domain, demonstrating homeotic function in this domain.

57 The protein encoded by paired-box homeotic gene 3 (PAX3) is a key regulator of the microph

58 ivator of transcription 3 (STAT3)-paired box homeotic gene 3 (PAX3)-signaling pathway, which is upreg

59 Duplication of a floral homeotic gene 51.7 million years (Myr) ago, followed by

60 l glial-specific element is dependent on the homeotic gene abdominal-A.

61 The role of the floral homeotic gene AGAMOUS (AG) and its close homologues in d

62 iana, cis-regulatory sequences of the floral homeotic gene AGAMOUS (AG) are located in the second int

63 in maintaining the repression of the flower homeotic gene AGAMOUS (AG) during vegetative development

64 The Arabidopsis homeotic gene AGAMOUS (AG) is necessary for the specific

65 In Arabidopsis, the homeotic gene AGAMOUS (AG) terminates meristem activity

66 of transcriptional repression of the floral homeotic gene AGAMOUS (AG), we identified two mutations

67 (ATX1) control the expression of the flower homeotic gene AGAMOUS (AG).

68 to prevent ectopic expression of the floral homeotic gene AGAMOUS in flowers.

69 ts resemble those of mutations in the floral homeotic gene AGAMOUS.

70 s provide the first evidence for a noncoding homeotic gene and raise the possibility that other such

71 PSC is specified early in the embryo by the homeotic gene Antennapedia (Antp) and expresses the sign

72 The floral homeotic gene APETALA1 (AP1) specifies floral meristem i

73 The regulation of the floral homeotic gene APETALA2 (AP2) by miR172 is crucial for no

74 FIL to up-regulate expression of the floral homeotic gene APETALA3.

75 The Hox gene fushi tarazu (ftz) arose as a homeotic gene but functions as a pair-rule segmentation

76 We have examined chromatin at Drosophila homeotic gene clusters by measuring, at high resolution,

77 Homeotic gene clusters display conspicuous peaks of hist

78 At this homeotic gene complex, many different classes of cis-reg

79 hown to contribute to gene regulation in the homeotic gene complexes from fly to mouse.

80 related to rice Karma, in the intron of the homeotic gene DEFICIENS, is common to all mantled clones

81 H3 lysine 27 (H3K27) mutations have the same homeotic gene expression and developmental defects as mu

82 n to play a major role in controlling floral homeotic gene expression and thus is an excellent candid

83 n primordia within a whorl and boundaries of homeotic gene expression between whorls.

84 ) was identified as a co-activator of floral homeotic gene expression in Arabidopsis.

85 ure, Drosophila ptip is required to activate homeotic gene expression in response to the derepression

86 anscriptional cosuppressor to repress floral homeotic gene expression in the floral meristem.

87 Changes in homeotic gene expression patterns or in the functions of

88 dies of dosage compensation, imprinting, and homeotic gene expression suggest that individual lincRNA

89 tral stem cell niche nor from reduced floral homeotic gene expression, but rather indicate a specific

90 UTX function has been linked to homeotic gene expression, embryonic development, and cel

91 They are required for proper homeotic gene expression, in part through methylation of

92 eiohomeotic-like (Phol)] redundantly control homeotic gene expression, the regulatory contributions o

93 rate regulatory network in control of floral homeotic gene expression.

94 anscriptional co-factor in regulating floral homeotic gene expression.

95 functions in Drosophila, where they control homeotic gene expression.

96 terference with N. benthamiana normal floral homeotic gene function in perianth organs.

97 The homeotic gene HOXA5 has been shown to play an important

98 ectasia-mutated locus that is encoded by the homeotic gene multisex combs (mxc) as novel HLB componen

99 For example, Caudal, a key regulator of the homeotic gene network, preferentially activates transcri

100 ution of distinct functions for these floral homeotic gene products.

101 exes, and discuss their multifaceted role in homeotic gene regulation.

102 orted for mutations in labial, an endodermal homeotic gene required for copper cell specification, an

103 complex expression pattern of the Drosophila homeotic gene Sex combs reduced (Scr) is directed by an

104 In addition to loss of homeotic gene silencing, some PcG mutants also have smal

105 e complexes 1 and 2 (PRC1 and PRC2) maintain homeotic gene silencing.

106 s likely mediated through suppression of the homeotic gene teashirt (tsh) and is independent of homot

107 ociated chromatin marks in the regulation of homeotic gene transcription during development.

108 tosaminyl-transferase), and Pax3 (paired-box homeotic gene transcription factor 3).

109 -acetylgalactosaminyltransferase; paired box homeotic gene transcription factor 3; and melanoma antig

110 ipts of three TREs located in the Drosophila homeotic gene Ultrabithorax (Ubx) mediate transcription

111 major Polycomb response element (PRE) of the homeotic gene Ultrabithorax (Ubx), and efficient PRE rec

112 ences in the maintenance element (ME) of the homeotic gene Ultrabithorax.

113 base-pair with the messenger RNA of a floral homeotic gene, APETALA2, regulates APETALA2 expression p

114 f2cb, or that it is related to the selector (homeotic) gene function of mef2ca.

115 pate in PcG-mediated silencing of the flower homeotic genes AGAMOUS, PISTILLATA, and APETALA3.

116 PcG proteins regulate expression of homeotic genes and are essential for axial body patterni

117 maintain the stable epigenetic repression of homeotic genes and other important developmental and cel

118 ired for maintaining the silent state of the homeotic genes and other important developmental regulat

119 equired to maintain stable repression of the homeotic genes and others throughout development.

120 n a screen for transcriptional activators of homeotic genes and subsequently shown to play a global r

121 complex has been linked to the silencing of homeotic genes and the inactivation of the X chromosome.

122 In Arabidopsis, two floral homeotic genes APETALA2 (AP2) and AGAMOUS (AG) specify t

123 dentifying the genes regulated by the floral homeotic genes APETALA3 (AP3) and PISTILLATA (PI) is cru

124 We find that the transcript levels of floral homeotic genes APETALA3 (AP3), PISTILLATA (PI), and AGAM

125 analyses revealed that all classes of floral homeotic genes are down-regulated in mtnam mutants.

126 The homeotic genes are essential to the patterning of the an

127 pression and activation of the expression of homeotic genes are maintained by proteins encoded by the

128 Despite this fact, several plant homeotic genes are negatively regulated by plant genes s

129 A, we further demonstrated that these floral homeotic genes are transcriptionally repressed by RGA ac

130 structurally and functionally related flower homeotic genes are under different control.

131 te that GA promotes the expression of floral homeotic genes by antagonizing the effects of DELLA prot

132 Cellular memory is maintained at homeotic genes by cis-regulatory elements whose mechanis

133 show, unexpectedly, that Psip1/p75 regulates homeotic genes by recruiting not only MLL complexes, but

134 Homeotic genes contain cis-regulatory trithorax response

135 Although homeotic genes control organ identity in both animals an

136 tional repressors that maintain silencing of homeotic genes during development.

137 ntial for maintaining the silencing state of homeotic genes during development.

138 istral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem c

139 comb group (PcG) chromatin proteins regulate homeotic genes in both animals and plants.

140 PcG proteins regulate homeotic genes in flies and vertebrates, but little is k

141 nd short days, whereas HvCEN affected floral homeotic genes only under LDs.

142 The products of B class floral homeotic genes specify petal and stamen identity, and lo

143 to study the function of orthologs of floral homeotic genes such as DEFICIENS (DEF) in non-model syst

144 ) in Drosophila melanogaster is a cluster of homeotic genes that determine body segment identity.

145 n of CYP71 resulted in ectopic activation of homeotic genes that regulate meristem development.

146 al repression to maintain cellular memory of homeotic genes turned out to be a highly conserved and s

147 Homeotic genes were subsequently co-opted to suppress gr

148 scription factors encoded by four classes of homeotic genes, A, B, C and E, act in a combinatorial ma

149 e is not due to disruption of whorl-specific homeotic genes, AP3 or PISTILLATA, responsible for petal

150 ecified by antagonistic action of two floral homeotic genes, APETALA2 (AP2) and AGAMOUS (AG).

151 owth as well as regulate the human engrailed homeotic genes, important regulators of brain developmen

152 ATX1 functions as an activator of homeotic genes, like Trithorax in animal systems.

153 ty is determined by specific combinations of homeotic genes, originate from a group of undifferentiat

154 ible function in the concerted repression of homeotic genes, probably through histone H3 lysine-27 tr

155 have examined the expression patterns of two homeotic genes, Ultrabithorax and abdominal-A (collectiv

156 hat determine segment-specific expression of homeotic genes, which are not masked by transcriptional

157 er floral meristem identity genes and floral homeotic genes.

158 hora of flowering-time regulatory and floral homeotic genes.

159 activating the expression of multiple floral homeotic genes.

160 i-proliferative and repressive action of Hox homeotic genes.

161 expression domain of another class of floral homeotic genes.

162 numerous functions in Arabidopsis beyond the homeotic genes.

163 the neighboring abdominal-A and Abdominal-B homeotic genes.

164 hat drive parasegment-specific expression of homeotic genes.

165 by maintaining transcriptional silencing of homeotic genes.

166 maintain stable and heritable repression of homeotic genes.

167 nt developmental regulatory genes, including homeotic genes.

168 1 and other suites of genes including floral homeotic genes.

169 eins and contain many neurally expressed and homeotic genes.

170 rtant in development and cancer (for example homeotic genes; N=683 total genes) to explore the relati

171 leading to AML-like disease by altering the homeotic/hematopoietic gene-associated chromatin signatu

172 The conservation of Homeotic (Hox) gene clustering and colinearity in many m

173 We found that nearly all of the Drosophila homeotic (Hox) gene promoters, which lack TATA-box eleme

174 ween the anterior expression boundary of the homeotic (Hox) gene Ultrabithorax (Ubx) and the location

175 Homeotic (HOX) genes are dysregulated in multiple malign

176 The homeotic (Hox) genes are highly conserved in metazoans,

177 able, mitotically heritable silencing of the homeotic (HOX) genes during development.

178 or directing the transcription of just three homeotic (Hox) genes during embryonic development.

179 While recent studies have shown that homeotic (hox) genes establish segmental identity of fir

180 the GDPCs by the coordinated actions of the homeotic (Hox) genes, abdominal-A, Abdominal-B, and caud

181 ation within this enhancer that identified a homeotic (Hox) response element that is a direct target

182 methyltransferase Ash1l [(absent, small, or homeotic)-like (Drosophila)] develop epidermal hyperplas

183 identity promote sex determination through a homeotic-like mechanism.

184 In addition, Mohavea has undergone a homeotic-like transformation in stamen number relative t

185 ue differentiation states to facilitate both homeotic-like transformations and limit progenitor produ

186 ressive and irreversible, as observed at the homeotic loci in flies and mammals.

187 protein associates directly with the master homeotic locus AGAMOUS, inducing its expression by regul

188 and initial phenotypic characterization of a homeotic locus discovered in this screen.

189 In turn, the encoded floral homeotic MADS domain proteins appear to bind SOC1 regula

190 nome-wide in vivo DNA binding data show that homeotic MADS domain proteins recognize partly distinct

191 s revealed SOC1 repression by several floral homeotic MADS domain proteins, and we show that, mechani

192 les were isolated for each of the two floral homeotic MADS-box genes, MtPISTILATA and MtAGAMOUS.

193 and mass spectrometry that five major floral homeotic MADS-domain proteins (AP1, AP3, PI, AG, and SEP

194 Arabidopsis, ovule identity is determined by homeotic MADS-domain proteins that define the floral C-

195 are specified by the combinatorial action of homeotic master regulatory transcription factors.

196 In plants, the homeotic MIKC MADS factors that regulate floral organ id

197 In addition, our homeotic mutant analysis shows that wing transformation

198 s and one PI homolog in wild-type and floral homeotic mutant lines reveal complex patterns that sugge

199 protein accumulation and induces a classical homeotic mutant phenotype: the transformation of haltere

200 ion profiles of inflorescences of the floral homeotic mutants apetala1, apetala2, apetala3, pistillat

201 can be gained from careful investigation of homeotic mutants outside the core eudicot model species.

202 We also show that in Medicago truncatula, a homeotic mutation in the co-transcriptional regulator ge

203 In addition to displaying a homeotic organ identity phenotype in all the four whorls

204 th through negative regulation of the floral homeotic pathway.

205 that bapx1 contributes to the moz-deficient homeotic pattern.

206 n changes in postmigratory CNC prefigure the homeotic phenotype in moz mutants.

207 The mutant also exhibits a homeotic phenotype, displaying abnormal leaf development

208 te a significant overlap in dosage-sensitive homeotic phenotypes and co-repression of a similar set o

209 Trithorax mimic (E(z)(Trm)) causes dominant homeotic phenotypes similar to those caused by mutations

210 least partially accounts for the moz mutant homeotic phenotypes.

211 immunoprecipitation, we show that the floral homeotic PISTILLATA (PI) protein, required for petal and

212 Results revealed that RA does not cause homeotic posteriorization in Oikopleura as it does in ve

213 vidence suggests that the lack of RA-induced homeotic posteriorization is a shared derived feature of

214 nuclear localization of beta-catenin but not homeotic posteriorization of the epithelium by Cdx2.

215 hese "degen-YPWMs" showed varying degrees of homeotic potential when expressed in Drosophila, suggest

216 ll identity gene WUSCHEL (WUS) by the floral homeotic protein AGAMOUS (AG) is a key part of this proc

217 ity contributes to functional differences of homeotic protein complexes.

218 nction but also identify a new regulation of homeotic protein-mediated transcriptional regulation in

219 Unlike the other highly characterized floral homeotic proteins containing MADS domains, AP2 has two D

220 The results also suggest that AG and other homeotic proteins with which it interacts (SEPALLATA3, A

221 many transcription factors including floral homeotic proteins, by which floral organ identity is det

222 can activate transcription independently of homeotic proteins.

223 nd miR-203 control expression of the stomach homeotic regulator Barx1.

224 thway of spleen development and reveal how a homeotic regulator employs different molecular mechanism

225 Among these, the class B and class C floral homeotic regulators are of central importance as they sp

226 y controlled and executed by four classes of homeotic regulators.

227 Homeotic selector (Hox) proteins often bind DNA cooperat

228 ration and tubulogenesis in the ASP and that homeotic selector gene function is necessary for the tem

229 on in plants, we studied the function of the homeotic selector genes APETALA3 (AP3) and PISTILLATA (P

230 regulate the correct segmental expression of homeotic selector genes.

231 erior Abd-B expression, a late developmental homeotic shift.

232 ass inflorescence development, which invokes homeotic shifts in multiple distinct meristem identities

233 Increased doses of Cdx proteins result in homeotic shifts in vertebral types along most of the ver

234 del could account, at least in part, for the homeotic shifts in vertebral types.

235 They had brachycephaly, small rib cages, and homeotic skeletal transformations with incomplete penetr

236 s leads to different physiologies focuses on homeotic supercoil control.

237 ate homologue of the Drosophila melanogaster homeotic transcription factor Spalt, has previously been

238 mir172 microRNA that targets APETALA2 floral homeotic transcription factors.

239 re determined by the combinational action of homeotic transcription factors.

240 work defines the molecular basis of ACS as a homeotic transformation (mandible to maxilla) in humans.

241 Pc protein, in vertebrate cells and induces homeotic transformation in Drosophila.

242 w structures in Ednra(-/-) embryos undergo a homeotic transformation into maxillary-like structures s

243 ed a novel molecule, DAC-2-25, that causes a homeotic transformation of body column into tentacle zon

244 rved target sites, and can induce a dramatic homeotic transformation of halteres into wings.

245 Embryonic loss of CDX2 triggers homeotic transformation of intestinal fate, whereas adul

246 These defects include homeotic transformation of lower jaw structures into upp

247 These include homeotic transformation of mandibular arch-derived struc

248 d D-function genes are reduced, resulting in homeotic transformation of ovules.

249 Furthermore, overexpression of tsh induces a homeotic transformation of the fly head into thoracic st

250 This anterior homeotic transformation of the intestine was first appar

251 Following knockdown of miR-196, we observe a homeotic transformation of the last cervical vertebrae t

252 ss of multiple bone structures and posterior homeotic transformation of the last thoracic vertebra.

253 he upper jaw, whereas Dlx5/6(-/-) results in homeotic transformation of the lower jaw into upper jaw.

254 tral gene expression, the result of which is homeotic transformation of the mandible into a maxilla-l

255 ations in the Ultrabithorax (Ubx) gene cause homeotic transformation of the normally two-winged Droso

256 uctures while depletion of homothorax led to homeotic transformation of the proximal maxilla and labi

257 at cause cytoplasmic male sterility (CMS) by homeotic transformation of the stamens.

258 ct resulting in a maxillary phenotype (i.e., homeotic transformation).

259 Although homeotic transformation, observed in Cdx2-null embryos,

260 thylation (the Bad Karma epiallele) predicts homeotic transformation, parthenocarpy and marked loss o

261 f human tumors, targeted deletion results in homeotic transformation, proliferative defects, and prem

262 e find that heightened stx activity leads to homeotic transformation, reduced Pc activity, and de-rep

263 true evolutionary reversal but an innovative homeotic transformation, where, in this case, all petals

264 and unprecedented model of gastrointestinal homeotic transformation.

265 were observed in forewings as expected of a homeotic transformation.

266 ncing by Polycomb protein complexes leads to homeotic transformations and altered developmental-phase

267 mal pattern of Hox gene expression result in homeotic transformations and malformations.

268 We found that the homeotic transformations and shifts in Hox gene expressi

269 In addition, mild anterior homeotic transformations are seen in the third and fourt

270 lection against the production of incomplete homeotic transformations at the lumbo-sacral border in f

271 ws that vitamin A deficiency causes anterior homeotic transformations extending from the cervical to

272 sed on a striking floral phenotype, in which homeotic transformations from sepals to carpels are foun

273 ges of the number of trunk vertebrae require homeotic transformations from trunk into sacral vertebra

274 We hypothesize that such incomplete homeotic transformations impair flexibility of the lumbo

275 ramatically at 26 degrees C, and we identify homeotic transformations in a subset of embryos grown at

276 were first identified in genetic screens for homeotic transformations in Drosophila melanogaster.

277 ns affecting this expression pattern produce homeotic transformations in the abdomen.

278 d this defect in Wnt signalling manifests as homeotic transformations in the vertebrae of Tert(-/-) m

279 Ectopic Ubx leads to homeotic transformations of anterior appendages toward m

280 on mutation in Tomato AP3 (TAP3) resulted in homeotic transformations of both petals and stamens, whe

281 oss of paralogous function leads to anterior homeotic transformations of colinear regions throughout

282 esults from other species, we did not obtain homeotic transformations of embryonic appendages in resp

283 of B-class gene function results in extreme homeotic transformations of petal and stamen identities.

284 fic patterning defects, including pronounced homeotic transformations of the axial skeleton.

285 are viable and fertile but exhibit posterior homeotic transformations of the axial vertebrae in a dos

286 1 mutant mice displayed dramatic synergistic homeotic transformations of the reproductive tracts, wit

287 Our findings suggest that the homeotic transformations result from altered DNA binding

288 rning, because mutating this region leads to homeotic transformations similar to those observed with

289 regulatory interactions but also results in homeotic transformations typical of Hox gene misregulati

290 Homeotic transformations were observed in Lmo4-null embr

291 genes via highly conserved sites, leading to homeotic transformations when ectopically expressed.

292 ormation and their depletion has resulted in homeotic transformations with neuron loss and miswiring.

293 esence of a dominant phenotype consisting of homeotic transformations, similar to those observed in m

294 ior organ and therefore it is reminiscent of homeotic transformations, which can occur in transgenic

295 ults in noncleavage (nc) of MLL and MLL2 and homeotic transformations.

296 n by causing ectopic Hox gene expression and homeotic transformations.

297 despread ectopic expression of Hox genes and homeotic transformations.

298 ulated animals display specific and striking homeotic transformations.

299 DLK1 encodes an EGF-like homeotic transmembrane protein homologous to the notch/d

300 The homeotic YPWM motif independently degenerated multiple t