ライフサイエンスコーパス: homeotic gene

1 hat drive parasegment-specific expression of homeotic genes.

2 1 and other suites of genes including floral homeotic genes.

3 eins and contain many neurally expressed and homeotic genes.

4 by the B, C and SEPALLATA classes of floral homeotic genes.

5 Pho and Pho-like act redundantly to repress homeotic genes.

6 ability to repress homothorax, a hallmark of homeotic genes.

7 n potential but retain the ability to act as homeotic genes.

8 ibutions to the organs are controlled by the homeotic genes.

9 oles by functional divergence from classical homeotic genes.

10 ed by spatially restricted expression of Hox/homeotic genes.

11 fd, Scr, and the Antennapedia homeobox-class homeotic genes.

12 e long term transcriptional silencing of the homeotic genes.

13 nant suppressors of Polycomb, a repressor of homeotic genes.

14 ype by blocking the ectopic transcription of homeotic genes.

15 AFY is a direct upstream regulator of floral homeotic genes.

16 units that act as positive regulators of the homeotic genes.

17 equired for transcriptional silencing of the homeotic genes.

18 Group protein required for silencing of the homeotic genes.

19 er floral meristem identity genes and floral homeotic genes.

20 maintenance of transcriptional repression of homeotic genes.

21 oup (PcG), is a transcriptional repressor of homeotic genes.

22 c) gene product, Esc, a putative silencer of homeotic genes.

23 hora of flowering-time regulatory and floral homeotic genes.

24 d result in alterations in the expression of homeotic genes.

25 rs required for proper spatial expression of homeotic genes.

26 r extra sex combs), a long-term repressor of homeotic genes.

27 activating the expression of multiple floral homeotic genes.

28 expression domain of another class of floral homeotic genes.

29 numerous functions in Arabidopsis beyond the homeotic genes.

30 the neighboring abdominal-A and Abdominal-B homeotic genes.

31 by maintaining transcriptional silencing of homeotic genes.

32 maintain stable and heritable repression of homeotic genes.

33 nt developmental regulatory genes, including homeotic genes.

34 The protein encoded by paired-box homeotic gene 3 (PAX3) is a key regulator of the microph

35 cDNA map to chromosome 2 near the paired box homeotic gene 3 (PAX3) locus, a region syngenic to mouse

36 ivator of transcription 3 (STAT3)-paired box homeotic gene 3 (PAX3)-signaling pathway, which is upreg

37 Duplication of a floral homeotic gene 51.7 million years (Myr) ago, followed by

38 scription factors encoded by four classes of homeotic genes, A, B, C and E, act in a combinatorial ma

39 l glial-specific element is dependent on the homeotic gene abdominal-A.

40 ied a 725 bp fragment, called MCP725, in the homeotic gene Abdominal-B, that accurately maintains pos

41 and haltere cells, contesting the view that homeotic genes act as binary switches.

42 genes, which are required so that states of homeotic gene activity are inherited through cell divisi

43 To understand how homeotic genes affect morphogenesis and differentiation,

44 iana, cis-regulatory sequences of the floral homeotic gene AGAMOUS (AG) are located in the second int

45 in maintaining the repression of the flower homeotic gene AGAMOUS (AG) during vegetative development

46 The homeotic gene AGAMOUS (AG) has dual roles in specifying

47 The Arabidopsis homeotic gene AGAMOUS (AG) is necessary for the specific

48 In Arabidopsis, the homeotic gene AGAMOUS (AG) terminates meristem activity

49 of transcriptional repression of the floral homeotic gene AGAMOUS (AG), we identified two mutations

50 PTAG2, homologous to the Arabidopsis floral homeotic gene AGAMOUS (AG).

51 (ATX1) control the expression of the flower homeotic gene AGAMOUS (AG).

52 to prevent ectopic expression of the floral homeotic gene AGAMOUS in flowers.

53 alysis of a LEAFY-responsive enhancer in the homeotic gene AGAMOUS indicates that direct interaction

54 regulatory mechanism ensures that the floral homeotic gene AGAMOUS is only expressed in the center of

55 ts resemble those of mutations in the floral homeotic gene AGAMOUS.

56 is a key regulator of the Arabidopsis floral homeotic gene AGAMOUS.

57 pate in PcG-mediated silencing of the flower homeotic genes AGAMOUS, PISTILLATA, and APETALA3.

58 AP3, PI, and another homeotic gene, AGAMOUS (AG), are further required for SU

59 necessary for stable repression of a floral homeotic gene and encodes a protein with homology to the

60 s provide the first evidence for a noncoding homeotic gene and raise the possibility that other such

61 PcG proteins regulate expression of homeotic genes and are essential for axial body patterni

62 ulation of expression and/or function of two homeotic genes and document a new role of ct in the cont

63 maintain the stable epigenetic repression of homeotic genes and other important developmental and cel

64 ired for maintaining the silent state of the homeotic genes and other important developmental regulat

65 equired to maintain stable repression of the homeotic genes and others throughout development.

66 n a screen for transcriptional activators of homeotic genes and subsequently shown to play a global r

67 complex has been linked to the silencing of homeotic genes and the inactivation of the X chromosome.

68 rable intraspecific diversity at this floral homeotic gene, and the McDonald-Kreitman test suggests t

69 PSC is specified early in the embryo by the homeotic gene Antennapedia (Antp) and expresses the sign

70 rior constriction and for maintenance of the homeotic gene Antennapedia in the visceral mesoderm.

71 -hb stripe is critical for activation of the homeotic gene Antennapedia, but does not affect a gradie

72 s behavior of the Scx allele of the flanking homeotic gene, Antennapedia.

73 Thus, unlike other floral homeotic genes, AP2 is active during both reproductive a

74 e is not due to disruption of whorl-specific homeotic genes, AP3 or PISTILLATA, responsible for petal

75 The floral homeotic gene APETALA1 (AP1) specifies floral meristem i

76 The regulation of the floral homeotic gene APETALA2 (AP2) by miR172 is crucial for no

77 er of a gene family that includes the floral homeotic gene APETALA2 (AP2).

78 In Arabidopsis, two floral homeotic genes APETALA2 (AP2) and AGAMOUS (AG) specify t

79 base-pair with the messenger RNA of a floral homeotic gene, APETALA2, regulates APETALA2 expression p

80 ecified by antagonistic action of two floral homeotic genes, APETALA2 (AP2) and AGAMOUS (AG).

81 The floral homeotic gene APETALA3 (AP3) is required for stamen and

82 FIL to up-regulate expression of the floral homeotic gene APETALA3.

83 dentifying the genes regulated by the floral homeotic genes APETALA3 (AP3) and PISTILLATA (PI) is cru

84 We find that the transcript levels of floral homeotic genes APETALA3 (AP3), PISTILLATA (PI), and AGAM

85 er from each other in the involvement of two homeotic genes, APETALA3 (AP3) and PISTILLATA (PI).

86 e combinatorial activities of several floral homeotic genes, APETALA3, PISTILLATA, AGAMOUS (AG), SEPA

87 analyses revealed that all classes of floral homeotic genes are down-regulated in mtnam mutants.

88 The homeotic genes are essential to the patterning of the an

89 ing the course of flower development, floral homeotic genes are expressed in defined concentric regio

90 Homeotic genes are known to be involved in patterning mo

91 pression and activation of the expression of homeotic genes are maintained by proteins encoded by the

92 Despite this fact, several plant homeotic genes are negatively regulated by plant genes s

93 A, we further demonstrated that these floral homeotic genes are transcriptionally repressed by RGA ac

94 structurally and functionally related flower homeotic genes are under different control.

95 ftz evolved from an ancestral homeotic gene as a result of changes in both regulation

96 xpression of the abdominal-A and Abdominal-B homeotic genes at the Drosophila bithorax complex.

97 The Hox gene fushi tarazu (ftz) arose as a homeotic gene but functions as a pair-rule segmentation

98 f was first identified in several Drosophila homeotic genes but also in fushi tarazu, a gene found in

99 te that GA promotes the expression of floral homeotic genes by antagonizing the effects of DELLA prot

100 Cellular memory is maintained at homeotic genes by cis-regulatory elements whose mechanis

101 show, unexpectedly, that Psip1/p75 regulates homeotic genes by recruiting not only MLL complexes, but

102 We have examined chromatin at Drosophila homeotic gene clusters by measuring, at high resolution,

103 Homeotic gene clusters display conspicuous peaks of hist

104 At this homeotic gene complex, many different classes of cis-reg

105 hown to contribute to gene regulation in the homeotic gene complexes from fly to mouse.

106 Homeotic genes contain cis-regulatory trithorax response

107 Ptx2, or Otlx2), is a member of a family of homeotic genes containing a short motif shared with seve

108 tionchus mutants suggest that alterations in homeotic gene control of anteroposterior patterning is i

109 Although homeotic genes control organ identity in both animals an

110 The homeotic genes controlling segment identity in Drosophil

111 related to rice Karma, in the intron of the homeotic gene DEFICIENS, is common to all mantled clones

112 ila second chromosome that interact with the homeotic gene Deformed (Dfd).

113 nes whose dosage affects the function of the homeotic gene Deformed.

114 oral expression of the Antennapedia-bithorax homeotic genes determining the fruit fly's body pattern.

115 We propose that cnn provides an example of homeotic genes directly regulating the accumulation of e

116 tional repressors that maintain silencing of homeotic genes during development.

117 ntial for maintaining the silencing state of homeotic genes during development.

118 appears to be a key mechanism in regulating homeotic genes during development; recent advances indic

119 romatin structure, the expression pattern of homeotic genes during Drosophila development.

120 enes that maintain the expression pattern of homeotic genes during Drosophila development.

121 The Hox/homeotic genes encode transcription factors that generat

122 ity is controlled by combinatorial action of homeotic genes expressed in different territories within

123 odes multiple GAF isoforms, are required for homeotic gene expression and are essential for Drosophil

124 H3 lysine 27 (H3K27) mutations have the same homeotic gene expression and developmental defects as mu

125 n to play a major role in controlling floral homeotic gene expression and thus is an excellent candid

126 Spatial boundaries of homeotic gene expression are initiated and maintained by

127 n primordia within a whorl and boundaries of homeotic gene expression between whorls.

128 G proteins maintain differential patterns of homeotic gene expression during development in Drosophil

129 ins are responsible for stable repression of homeotic gene expression during Drosophila melanogaster

130 ts of this study suggest that Eed-restricted homeotic gene expression during embryogenesis reflects t

131 alf of the protein and is thought to repress homeotic gene expression during mouse embryogenesis.

132 Thus an originally Artemia-like pattern of homeotic gene expression has apparently been modified in

133 ) was identified as a co-activator of floral homeotic gene expression in Arabidopsis.

134 s that have long been known as regulators of homeotic gene expression in Drosophila.

135 ure, Drosophila ptip is required to activate homeotic gene expression in response to the derepression

136 anscriptional cosuppressor to repress floral homeotic gene expression in the floral meristem.

137 Proper regulation of homeotic gene expression is critical for pattern formati

138 Regulation of homeotic gene expression is critical for proper developm

139 Changes in homeotic gene expression patterns or in the functions of

140 dies of dosage compensation, imprinting, and homeotic gene expression suggest that individual lincRNA

141 additional role of WUS in regulating floral homeotic gene expression supports the hypothesis that fl

142 ster are required to maintain the pattern of homeotic gene expression that is established early in em

143 ophila Polycomb group proteins that regulate homeotic gene expression through alteration of chromatin

144 eflecting underlying mechanisms for coupling homeotic gene expression to morphogenesis.

145 tral stem cell niche nor from reduced floral homeotic gene expression, but rather indicate a specific

146 In addition to its role in floral homeotic gene expression, HUA ENHANCER2 is required for

147 They are required for proper homeotic gene expression, in part through methylation of

148 eiohomeotic-like (Phol)] redundantly control homeotic gene expression, the regulatory contributions o

149 functions in Drosophila, where they control homeotic gene expression.

150 econd, later role in the induction of floral homeotic gene expression.

151 itionally, we show that NURF is required for homeotic gene expression.

152 is also involved in the regulation of floral homeotic gene expression.

153 rithorax (trx), which encodes a regulator of homeotic gene expression.

154 e of long-term transcriptional repression of homeotic gene expression.

155 structures by transcriptional repression of homeotic gene expression.

156 imaginal discs depends on stable patterns of homeotic gene expression.

157 rate regulatory network in control of floral homeotic gene expression.

158 anscriptional co-factor in regulating floral homeotic gene expression.

159 of the hepatocyte nuclear factor 3/forkhead homeotic gene family, as a nuclear hormone receptor (NR)

160 nuclear factor-3 (HNF-3) and the Drosophila homeotic gene fork head proteins are prototypes of an ex

161 The products of the HOM/Hox homeotic genes form a set of evolutionarily conserved tr

162 t Sindbis virus, we were able to investigate homeotic gene function in non-model arthropod species.

163 terference with N. benthamiana normal floral homeotic gene function in perianth organs.

164 f2cb, or that it is related to the selector (homeotic) gene function of mef2ca.

165 nt with the hypothesis that ancestral insect homeotic gene functions have been modified considerably

166 The homeotic genes have long been thought to play an importa

167 The homeotic gene HOXA5 has been shown to play an important

168 istral (Mira) activates transcription of the homeotic genes Hoxa6 and Hoxa7 in mouse embryonic stem c

169 owth as well as regulate the human engrailed homeotic genes, important regulators of brain developmen

170 h mutant protein can influence regulation of homeotic genes in a manner distinct from the intact prot

171 b group (PcG) genes are required to maintain homeotic genes in a silenced state during development in

172 The patterned expression of floral homeotic genes in Arabidopsis depends on the earlier act

173 on factors that activate overlapping sets of homeotic genes in Arabidopsis flowers.

174 comb group (PcG) chromatin proteins regulate homeotic genes in both animals and plants.

175 Polycomb group proteins (PcG) repress homeotic genes in cells where these genes must remain in

176 or maintenance of the repressed state of the homeotic genes in Drosophila.

177 PcG proteins regulate homeotic genes in flies and vertebrates, but little is k

178 provide different levels of trx function at homeotic genes in imaginal cells.

179 In order to test the roles of the floral homeotic genes in regulating these patterns of cell prol

180 Homeotic genes in the Antennapedia Complex of Drosophila

181 ntenance of master regulatory genes, such as homeotic genes, in an appropriate 'on' or 'off' state fo

182 The APETALA3 floral homeotic gene is required for petal and stamen developme

183 The Arabidopsis APETALA3 (AP3) floral homeotic gene is required for specifying petal and stame

184 nts of the homologues of the Drosophila head homeotic genes labial (lab), proboscipedia (pb), and Def

185 embryonic expression of Deformed and another homeotic gene, labial.

186 t transcriptional activation of other floral homeotic genes, LFY acts in both a direct and an indirec

187 ATX1 functions as an activator of homeotic genes, like Trithorax in animal systems.

188 estimates suggest that the different floral homeotic gene lineages began to diverge from one another

189 depends on the function of a limited set of homeotic genes, many of them members of the MADS-box gen

190 angiosperms is controlled in part by floral homeotic genes, many of which are members of the plant M

191 The Tribolium castaneum homeotic gene maxillopedia (mxp) is the ortholog of Dros

192 s in the function and expression patterns of homeotic genes may have played a major role in the evolu

193 ectasia-mutated locus that is encoded by the homeotic gene multisex combs (mxc) as novel HLB componen

194 rtant in development and cancer (for example homeotic genes; N=683 total genes) to explore the relati

195 For example, Caudal, a key regulator of the homeotic gene network, preferentially activates transcri

196 iation at the APETALA3 and PISTILLATA floral homeotic genes of Arabidopsis thaliana was analyzed to i

197 Homeotic genes of Drosophila melanogaster encode transcr

198 els of transcription of many genes including homeotic genes of the ANT-C and BX-C. trx encodes two pr

199 aining the transcriptional repression of the homeotic genes of the Antennapedia (ANT-C) and bithorax

200 es in Drosophila melanogaster, including the homeotic genes of the bithorax complex.

201 As with the homeotic genes of the BX-C, the transcription patterns o

202 The homeotic genes of the Drosophila bithorax complex are co

203 RE function, does not cause misexpression of homeotic genes or reporter genes in imaginal disks.

204 ty is determined by specific combinations of homeotic genes, originate from a group of undifferentiat

205 ible function in the concerted repression of homeotic genes, probably through histone H3 lysine-27 tr

206 -44 and its candidate receptor LIN-17, and a homeotic gene product EGL-5.

207 niou serves as a tissue-specific cofactor of homeotic gene products in visceral mesoderm patterning.

208 Here we demonstrate that the homeotic gene products Proboscipedia (Pb) and Sex combs

209 ution of distinct functions for these floral homeotic gene products.

210 exes, and discuss their multifaceted role in homeotic gene regulation.

211 f a chromatin-remodeling complex involved in homeotic gene regulation.

212 g that the function of osa is not limited to homeotic gene regulation.

213 n Drosophila melanogaster and is a target of homeotic gene regulation.

214 la brahma (brm) gene encodes an activator of homeotic genes related to the yeast chromatin remodeling

215 l distinct silencing complexes that maintain homeotic gene repression during development.

216 (PcG) genes are required for maintenance of homeotic gene repression during development.

217 me that other PcG proteins become engaged in homeotic gene repression.

218 orted for mutations in labial, an endodermal homeotic gene required for copper cell specification, an

219 f DNA sequence homology to a region-specific homeotic gene (SAL) in Drosophila.

220 complex expression pattern of the Drosophila homeotic gene Sex combs reduced (Scr) is directed by an

221 amined the expression of the ortholog of the homeotic gene Sex combs reduced (Scr) of Drosophila mela

222 in the Drosophila embryo is dependent on the homeotic gene Sex combs reduced (Scr).

223 WRS-85D expression is dependent on the homeotic gene Sex combs reduced (Scr).

224 la embryo is linked to the expression of the homeotic gene Sex combs reduced (Scr).

225 s, the identity of the labium depends on the homeotic genes Sex combs reduced (Scr) and proboscipedia

226 iated with loss-of-function mutations in the homeotic genes Sex combs reduced and Abdominal-B. kismet

227 on in the salivary duct is controlled by the homeotic gene, Sex combs reduced (Scr), and by another s

228 Porcellio scaber ortholog of the Drosophila homeotic gene, Sex combs reduced (Scr).

229 In addition to loss of homeotic gene silencing, some PcG mutants also have smal

230 e complexes 1 and 2 (PRC1 and PRC2) maintain homeotic gene silencing.

231 on the function of the APETALA1 (AP1) floral homeotic gene, since mutations in AP1 reduce LFY-depende

232 ers in the protein encoded by the Drosophila homeotic gene spalt and in the human transcription facto

233 cription factor homologous to the Drosophila homeotic gene Spalt.

234 The products of B class floral homeotic genes specify petal and stamen identity, and lo

235 transcription factor LEAFY acts upstream of homeotic genes such as AGAMOUS to confer floral identity

236 to study the function of orthologs of floral homeotic genes such as DEFICIENS (DEF) in non-model syst

237 Homeotic genes, such as Scr, specify tissue identity by

238 t LEAFY acts as a direct activator of floral homeotic genes, supporting the hypothesis that the trans

239 s likely mediated through suppression of the homeotic gene teashirt (tsh) and is independent of homot

240 le mutants show more severe misexpression of homeotic genes than do the single mutants.

241 ) in Drosophila melanogaster is a cluster of homeotic genes that determine body segment identity.

242 The homeotic genes that determine floral organ identity in p

243 hma (brm) encodes an activator of Drosophila homeotic genes that functions as the ATPase subunit of a

244 dentity gene LEAFY has a role in controlling homeotic genes that is separable from its role in specif

245 n of CYP71 resulted in ectopic activation of homeotic genes that regulate meristem development.

246 developing embryo depends on two clusters of homeotic genes: the Antennapedia complex (ANT-C) and the

247 la trithorax (trx) gene is known to regulate homeotic genes through alternative RNA splicing.

248 r observation that LEAFY activates different homeotic genes through distinct mechanisms, we propose a

249 aintains the position-specific repression of homeotic genes throughout Drosophila development.

250 how Drosophila ftz evolved from an ancestral homeotic gene to obtain a novel function in segmentation

251 ential quantitative genetic contributions of homeotic genes to appendage morphology are discussed, no

252 ociated chromatin marks in the regulation of homeotic gene transcription during development.

253 tosaminyl-transferase), and Pax3 (paired-box homeotic gene transcription factor 3).

254 -acetylgalactosaminyltransferase; paired box homeotic gene transcription factor 3; and melanoma antig

255 Mutations in lawc affect homeotic gene transcription, causing ectopic expression

256 aintain the spatially restricted patterns of homeotic gene transcription.

257 al repression to maintain cellular memory of homeotic genes turned out to be a highly conserved and s

258 ipts of three TREs located in the Drosophila homeotic gene Ultrabithorax (Ubx) mediate transcription

259 major Polycomb response element (PRE) of the homeotic gene Ultrabithorax (Ubx), and efficient PRE rec

260 y a stretch of 5' untranslated mRNA from the homeotic gene Ultrabithorax (Ubx), which is inserted bet

261 (Kr), knirps (kni), and giant (gt), and the homeotic gene Ultrabithorax (Ubx).

262 s virus, we investigated the function of the homeotic gene Ultrabithorax in the development of butter

263 he expressivity of an amorphic allele of the homeotic gene Ultrabithorax, (Ubx1) was characterized af

264 rosophila transcription factor zeste and the homeotic gene Ultrabithorax.

265 ences in the maintenance element (ME) of the homeotic gene Ultrabithorax.

266 is because of the repressive effects of the homeotic genes Ultrabithorax (Ubx) and abdominal-A (abd-

267 s, changes in the expression patterns of the homeotic genes Ultrabithorax and abdominal-A have played

268 mediating transcriptional stimulation of the homeotic genes Ultrabithorax and labial, they are also r

269 process, Dpp stimulates transcription of the homeotic genes Ultrabithorax in the visceral mesoderm an

270 addition, we describe the expression of the homeotic genes Ultrabithorax, abdominal-A, and Abdominal

271 The segment-polarity gene Engrailed and the homeotic genes Ultrabithorax/Abdominal-A are expressed i

272 have examined the expression patterns of two homeotic genes, Ultrabithorax and abdominal-A (collectiv

273 Expression of floral induction and homeotic genes was derepressed in mutant embryos and see

274 Homeotic genes were subsequently co-opted to suppress gr

275 Homeotic genes, which act later to specify the identity

276 he flower, participates in the activation of homeotic genes, which are expressed in specific regions

277 hat determine segment-specific expression of homeotic genes, which are not masked by transcriptional

278 cent progress in our understanding of floral homeotic genes, with an emphasis on how their region-spe