ライフサイエンスコーパス: homocysteine

1 ability in swordfish (glutathione, cysteine, homocysteine).

2 re, high-sensitivity C-reactive protein, and homocysteine.

3 olism and the liver responses to ethanol and homocysteine.

4 that mTOR senses low folate rather than high homocysteine.

5 w diets along with water containing 0.18% DL-homocysteine.

6 an additional gene for sulfur insertion into homocysteine.

7 precursor for the cardiovascular risk factor homocysteine.

8 y lithium, or by elevation of the metabolite homocysteine.

9 H catalyzed the hydrolysis of SAH to produce homocysteine.

10 vention studies using betaine to lower blood homocysteine.

11 thiols made up of glutathione, cysteine, and homocysteine.

12 , S-methyl-5'-thioadenosine, methionine, and homocysteine.

13 rily related to the metabolism of folate and homocysteine.

14 the synthesis of many metabolites, including homocysteine.

15 H) from cystine and H2S from cysteine and/or homocysteine.

16 e-carbon units to regenerate methionine from homocysteine.

17 ide (H2S), from the amino acids cysteine and homocysteine.

18 ompared with 56 pmol/L), and 17% lower serum homocysteine (14.2 compared with 17.1 mumol/L).

19 0.6 mm Hg for each 1-SD unit increase in log homocysteine; 95% CI: -0.8, 1.9 mm Hg) but was positivel

20 tamins is confined to participants with high homocysteine (above the median, 11 micromol/L) and that,

21 TLS of the cyanylated cysteine or cyanylated homocysteine absorptions indicates that they do not enga

22 The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and f

23 mplex with its cofactor product S-adenosyl-l-homocysteine (AdoHcy) at 2.8 A resolution and identify a

24 ses; however, it is not known whether excess homocysteine alters retinal vasculature.

25 inding sites for a zinc ion and substrates L-homocysteine and 5-methyl-tetrahydrofolate-glutamate3.

26 thase (CBS), resulting in an accumulation of homocysteine and a concomitant decrease of cystathionine

27 Cysteine is a metabolic product of homocysteine and a precursor of the antioxidant glutathi

28 mine, resulting in formation of S-adenosyl-l-homocysteine and alpha-N-methylated proteins.

29 Plasma homocysteine and body composition were measured, and tol

30 We demonstrate elevated levels of homocysteine and concomitantly reduced levels of vitamin

31 on of homocysteine from serine, and rates of homocysteine and cystathionine production were assessed.

32 ocysteine remethylation or the appearance of homocysteine and cystathionine.

33 ctive was to assess the associations between homocysteine and cysteine and CRC incidence in postmenop

34 Associations between homocysteine and cysteine and incident CRC in the Women'

35 Extracellular levels of homocysteine and cysteine are comparable with other repo

36 Homocysteine and cysteine were measured by HPLC with pos

37 The associations with both homocysteine and cysteine were significant for localized

38 molecular bases for the cellular toxicity of homocysteine and demonstrate that it induces the formati

39 We hypothesize that homocysteine and H2S regulate CBS and CSE expressions in

40 methylmalonic aciduria, and elevated plasma homocysteine and harbored the mutations c.1667_1668delAG

41 n of S-adenosylhomocysteine to adenosine and homocysteine and is important in cell growth and the reg

42 (HC) has been implicated in AVNFH, levels of homocysteine and its associated pathway metabolites have

43 uria have markedly elevated plasma levels of homocysteine and methionine and reduced concentrations o

44 however, SAM is converted to the neurotoxin homocysteine and must be excreted or drawn back into the

45 Accumulation of homocysteine and S-adenosylhomocysteine, genome-wide DNA

46 ine (AdoMet) to glycine to form S-adenosyl-l-homocysteine and sarcosine.

47 CBS condenses homocysteine and serine to cystathionine that is then co

48 Moreover, the decrease in homocysteine and the normalization of cysteine in PEGyla

49 Folate, homocysteine and vitamin B12 levels of children at birth

50 Folate, homocysteine and vitamin B12 levels of children at birth

51 Neonatal cord blood folate, homocysteine and vitamin B12 levels were measured, and M

52 lonic H2S synthesis, a 40% increase in serum homocysteine, and a phenotype similar to wild-type mice

53 acellular levels of free reduced cysteamine, homocysteine, and cysteine from OHSCs within 25 s in a 2

54 Concentrations of cysteamine, homocysteine, and cysteine in the extracellular space of

55 ne, C-reactive protein, D-dimer, fibrinogen, homocysteine, and growth differentiation factor-15 level

56 lipoprotein (HDL) cholesterol, higher total homocysteine, and higher body mass index (BMI)] and grea

57 a concentrations of folate, cobalamin, total homocysteine, and methylmalonic acid with cognitive perf

58 t of serum and red blood cell folate, plasma homocysteine, and MTHFR 677C>T genotype and colonic tiss

59 four thiols (mercaptoacetic acid, cysteine, homocysteine, and N-acetyl-cysteine) were detected in th

60 n transsulfuration pathway thiols, including homocysteine, and serum ADMA and SDMA concentrations at

61 : cysteine, dihydrolipoic acid, glutathione, homocysteine, and thioredoxin, and in the presence of cy

62 rations of omega-3 (omega-3) fatty acids and homocysteine are associated with the development of brai

63 ng evidence suggests that abnormal levels of homocysteine are associated with vascular dysfunctions,

64 High plasma concentrations of homocysteine are assumed to be associated with a high ri

65 uiv each of 5'-deoxyadenosine and S-adenosyl-homocysteine are produced for each methylation reaction

66 , possible deficiency on the basis of rising homocysteine as a metabolic indicator in persons >/=4 y

67 r adults by examining the increase in plasma homocysteine as the primary determinant.We provided caps

68 participants) using rs1801133 and additional homocysteine-associated SNPs as instruments.

69 idues 351-1600) in complex with S-adenosyl-l-homocysteine at 2.62A resolution.

70 oncentrations of 1-carbon metabolites (e.g., homocysteine) before flight.

71 roteins (MA1821 and MA1822) are essential to homocysteine biosynthesis in a background lacking an add

72 Likewise, allocation to B vitamins lowered homocysteine by 26% in the global cognition trials but a

73 ent with betaine produced a rapid decline of homocysteine by 50% to 70% in all 4 patients and, over 9

74 rotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cy

75 aMTH1-SAM (co-factor), and PaMTH1-S-adenosyl homocysteine (by-product) co-complexes refined to 2.0, 1

76 sed blood pressure is relevant because blood homocysteine can be effectively lowered by safe and inex

77 = 324), we measured plasma concentrations of homocysteine, choline, and betaine and genotyped them fo

78 inhibiting H3K27M peptide and a S-adenosyl-l-homocysteine cofactor.

79 od folate status and prevent the increase in homocysteine concentration that otherwise occurs in late

80 OLS regression, a 1-SD unit increase in log homocysteine concentration was associated with an increa

81 In the MR analysis of ICBP data, homocysteine concentration was not associated with SBP (

82 The association of homocysteine concentration with SBP and DBP was assessed

83 HFR) C677T (rs1801133) was used as proxy for homocysteine concentration.

84 2919 participants aged >/=65 y with elevated homocysteine concentrations (12-50 mumol/L).

85 to identify genetic variants associated with homocysteine concentrations and risk of CAD.

86 Elevated plasma homocysteine concentrations are a risk factor for osteop

87 Allocation to B vitamins lowered homocysteine concentrations by 28% in the cognitive-doma

88 uence of rs1801198 on holotranscobalamin and homocysteine concentrations in European-descent subjects

89 udy suggests that both vitamin B12 and total homocysteine concentrations may be related to accelerate

90 od bone mass, maternal phosphorus intake and homocysteine concentrations most-strongly predicted chil

91 d bone mass, whereas carbohydrate intake and homocysteine concentrations were associated with lower c

92 BC folate, serum vitamin B-12, and/or plasma homocysteine concentrations.

93 e chain lengths was only partly inhibited by homocysteine, consistent with multisite binding.

94 ocysteine (SAH), S-adenosylmethionine (SAM), homocysteine, cysteine, and dimethylglycine were also as

95 We also speculate that homocysteine, cysteine, or a related ligand could be inv

96 serum ADMA and SDMA (LC-MS/MS), and thiols (homocysteine, cysteine, taurine, glutamylcysteine, total

97 ecular weight thiols (glutathione, cysteine, homocysteine, cysteinylglycine, and beta-mercaptoethanol

98 kin-6, C-reactive protein, fibrinogen, total homocysteine, D-dimer, factor VIII, plasmin-antiplasmin

99 CDO and CSAD expression were proportional to homocysteine elevation, indicating a possible threshold

100 The generated homocysteine enabled the Hg(2+) to be removed from a hai

101 Overall, the effect of a 25% reduction in homocysteine equated to 0.02 y (95% CI: -0.10, 0.13 y) o

102 ation, apolipoprotein E e4 status, and total homocysteine, folate, and creatinine did not attenuate t

103 from homocysteine or utilize cysteine and/or homocysteine for synthesis of H2S, a signaling molecule.

104 y, we use metallized nanopores modified with homocysteine for the detection of insulin.

105 The latter donates its methyl group to homocysteine, forming methionine, which is then used for

106 cysteine remethylation, the remethylation of homocysteine from serine, and rates of homocysteine and

107 The transsulfuration pathway, through which homocysteine from the methionine cycle provides sulfur f

108 Cysteine, homocysteine, glutathione, quercetin, albumin and tannic

109 .46 (1.05, 2.04) for the highest quartile of homocysteine (>9.85 mumol/L) compared with the lowest qu

110 Increasing levels of homocysteine had no effect on PHT mTOR signalling, sugge

111 dings do not corroborate the hypothesis that homocysteine has a causal role in blood pressure, especi

112 been shown to influence homocysteine levels; homocysteine has been implicated as a cataractogenic str

113 Although Homocysteine (HC) has been implicated in AVNFH, levels o

114 Here we hypothesize that homocysteine (Hcy) alters retinal endothelial cell barri

115 tifies the disulfide bridge between proximal homocysteine (Hcy) and Cys as conferring much greater st

116 ective reactivity toward cysteine (Cys) over homocysteine (Hcy) and glutathione (GSH) under stoichiom

117 elevated levels of the amino acid metabolite homocysteine (Hcy) are at high risk of developing AD.

118 Homocysteine (Hcy) can induce endoplasmic reticulum (ER)

119 nation of relative H2S and cysteine (Cys) or homocysteine (Hcy) concentrations, two important metabol

120 Furthermore, homocysteine (Hcy) inhibited proliferation, adhesion, an

121 High level of homocysteine (Hcy) is a recognized risk factor for devel

122 High level of homocysteine (Hcy) is an AD risk factor and associates w

123 Elevated level of homocysteine (Hcy) is considered a risk factor for neuro

124 cy mice, Aza treatment normalized the plasma homocysteine (Hcy) level and BP.

125 Plasma homocysteine (Hcy) levels are positively correlated with

126 hase (CBS) deficiency, a genetic disorder in homocysteine (Hcy) metabolism in humans, elevates plasma

127 ded by genes at 5q14 and 21q22.3 function in homocysteine (Hcy) metabolism, and index SNPs for each h

128 Accumulation of the homocysteine (Hcy) precursor S-adenosylhomocysteine (Ado

129 showed reduced levels of enzymes catalyzing homocysteine (Hcy) production and recycling, together wi

130 Biothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) play crucial r

131 Biothiols, such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), play a key ro

132 In addition, structures are presented for homocysteine (Hcy), D-Cys, thiosulfate, and azide bound

133 for specific detection of cysteine (Cys) and homocysteine (Hcy).

134 Because of homocysteine (HCys) belonging to the thiol and amino gro

135 e conversion of S-methylmethionine (SMM) and homocysteine (HCys) to two equivalents of methionine.

136 eceptors that mediate oscillatory control of homocysteine homeostasis in mice.

137 ession of DNMT1, MMP9, TIMP1, and S-adenosyl homocysteine hydrolase (SAHH) and upregulated methylene

138 logs of the SAH hydrolase Ahcy (S-adenosyl-L-homocysteine hydrolase [SAHH[), CG9977/dAhcyL1 and Ahcy8

139 he accumulation of methylmalonic acid and/or homocysteine in blood and urine.

140 conclude that mild to moderate elevation of homocysteine in Cbs(+/-) mice is accompanied by progress

141 Severe elevation of homocysteine in cbs(-/-) mutant mice is accompanied by a

142 EG/SEG, supporting a possible causal role of homocysteine in EG/SEG.

143 lodiphosphate (GSPP) along with S-adenosyl-L-homocysteine in the cofactor binding site, resulting fro

144 IKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTa

145 lalanine, cyanylated cysteine, or cyanylated homocysteine incorporated at different positions within

146 001) in unsupplemented women, whereas plasma homocysteine increased (6.6 +/- 2.3 to 7.6 +/- 2.3 mumol

147 ri cannot utilize the other product of LuxS, homocysteine, indicating that phenotypes of luxS mutants

148 Diets containing ethanol or homocysteine induced hyperhomocysteinemia and glucose in

149 Here we show that homocysteine-induced ER protein (Herp), a protein highly

150 ave previously identified a link between the homocysteine-induced suppression of the selenoprotein gl

151 identified known ERAD factors such as Hrd1; homocysteine-inducible, endoplasmic reticulum stress-ind

152 base-promoted intramolecular cyclization of homocysteine into Dha formed a stable cystathionine (thi

153 ents of one-carbon metabolism, remethylating homocysteine into methionine and providing methyl groups

154 An understanding of whether homocysteine is a cause or a marker of increased blood p

155 Elevated plasma homocysteine is a risk factor for Alzheimer disease, but

156 Excess homocysteine is a risk factor for cardiovascular disease

157 High plasma homocysteine is associated with increased risk of CRC, w

158 Folate B12-dependent remethylation of homocysteine is important, but less is understood about

159 Homocysteine is metabolized to methionine by the action

160 Met metabolism changes, and increased plasma homocysteine is more apparent.

161 ternatively, by the transulfuration pathway, homocysteine is transformed to hydrogen sulphide (H2S),

162 ystathionine (R-S-(2-amino-2-carboxyethyl)-l-homocysteine) is a non-proteinogenic thioether containin

163 c acid, glutamine, glycine, histidine, total homocysteine, isoleucine, kynurenine, leucine, lysine, m

164 und to be associated with elevated levels of homocysteine, known as hyperhomocysteinemia.

165 5% CI, -5.1 to 4.0 mg/dL; P = .81), or serum homocysteine level (Delta, 0.004 mg/L; 95% CI, -0.12 to

166 OR = 1.50; 95% CI = 1.01-2.23) and elevated homocysteine levels (>15 micromol/L: OR = 2.24; 95% CI =

167 omisation the association among MTHFR C677T, homocysteine levels and WMH, approached, but did not rea

168 trials focusing on elderly subjets with high homocysteine levels are warranted to see if progression

169 In the placebo group, higher homocysteine levels at baseline are associated with fast

170 d Relevance: MTHFR polymorphism and elevated homocysteine levels contributed separately and jointly t

171 If these findings are confirmed, homocysteine levels may be a therapeutic target to reduc

172 t out another deleterious trait of disturbed homocysteine levels that could participate in the aetiol

173 possible pathway of MTHFR polymorphisms via homocysteine levels to cortical cataract.

174 lue Mountains Eye Study 2 cohort with normal homocysteine levels was 68.3 (8.1) years and 73.2 (8.5)

175 Serum homocysteine levels were assessed following standard met

176 t, the second survey serves as baseline when homocysteine levels were assessed, and 5-year incidence

177 Combined CT/TT genotypes and elevated homocysteine levels were associated with a 3-fold risk o

178 Increased total homocysteine levels were associated with faster rates of

179 eractions between MTHFR and child folate and homocysteine levels were observed for wheezing and asthm

180 ssociations of MTHFR polymorphisms and serum homocysteine levels with incident cortical cataract in a

181 Plasma lipid profile and homocysteine levels, blood pressure, oxidative stress, a

182 rials demonstrated that despite reduction in homocysteine levels, disease outcome remained unaffected

183 synthesis and significantly decreased serum homocysteine levels.

184 r blood glucose, serum cholesterol, or serum homocysteine levels.

185 and 73.2 (8.5) years for those with elevated homocysteine levels.

186 cortical cataract was partially mediated via homocysteine levels.

187 PEX included blood glucose, cholesterol, and homocysteine levels; blood pressure; and cardiac morbidi

188 ) polymorphisms have been shown to influence homocysteine levels; homocysteine has been implicated as

189 Homocysteine lowering by using B vitamins had no signifi

190 for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive agin

191 xaenoic acid) modify the treatment effect of homocysteine-lowering B vitamins on brain atrophy rates

192 sease (CAD) and the null associations in the homocysteine-lowering trials have prompted the need to i

193 Most homocysteine-lowering trials with folate and vitamins B6

194 high-sensitivity C-reactive protein <2 mg/L, homocysteine <10 micromol/L, N-terminal pro-brain natriu

195 tors VIII/IX/XI, fibrinogen, lipoprotein(a), homocysteine, lupus anticoagulant, anticardiolipin antib

196 Homocysteine may interact with both risk factors and pro

197 timing of expression of genes that regulate homocysteine metabolism and the liver responses to ethan

198 timing in expression of genes that regulate homocysteine metabolism compared with control mice.

199 vel mechanism for H2S-mediated regulation of homocysteine metabolism in cardiomyocytes, and a negativ

200 FA plays an established role in folate and homocysteine metabolism, but the means by which it suppr

201 a novel role in promoting H2S production and homocysteine metabolism, which may have therapeutic valu

202 Folate, choline, and betaine participate in homocysteine metabolism.

203 Here we report the binding of L-homocysteine, methionine, and several folate analogs.

204 in B-12 deficiency increases choline use for homocysteine methylation.

205 betaine (N,N,N-trimethylglycine) via betaine-homocysteine methyltransferase (BHMT), which is expresse

206 ent methylation pathway-catalyzed by betaine-homocysteine methyltransferase (BHMT)-for establishing a

207 also found expression of the enzyme betaine homocysteine methyltransferase in cortical neurons.

208 We studied C57Bl/6J Bhmt (betaine-homocysteine methyltransferase)-null mice at age 4, 12,

209 structures identify interactions between the homocysteine moiety and the 5'-alkylthiol binding site o

210 been described, the interactions between the homocysteine moiety of SAH and the 5'-alkylthiol binding

211 define severe MTHFR deficiency, methionine, homocysteine, MTHFR enzyme activity in fibroblasts, or m

212 Six thiols (mercaptoacetic acid, cysteine, homocysteine, N-acetyl-cysteine, mercaptoethane-sulfonat

213 erhomocysteinemia was defined as total serum homocysteine of 12 micromol/L or greater.

214 erhomocysteinemia was defined as total serum homocysteine of 12 mumol/L or greater.

215 However, effect of H2S or homocysteine on CBS and CSE expression, and cross-talk b

216 he aim was to assess the causal influence of homocysteine on systolic and diastolic blood pressure (S

217 orrectly oriented for an in-line attack by l-homocysteine on the N(5)-methyl.

218 We show that binding of L-homocysteine or methionine results in conformational rea

219 Furthermore, each 2-fold increment in homocysteine or methylmalonic acid concentration was ass

220 HL1 cardiomyocytes with increasing doses of homocysteine or Na2S/GYY4137, a H2S donor, and measured

221 sulfur metabolism to cysteine synthesis from homocysteine or utilize cysteine and/or homocysteine for

222 the genetics of 1-carbon pathway metabolism, homocysteine, oxidative stress, endothelial dysfunction,

223 8), treatment with beta-blockers (P = 0.03), homocysteine (P = 0.02), and glutamylcysteine (P = 0.003

224 increased methylmalonic acid (P<0.01-0.04), homocysteine (P<0.01), cystathionine (P<0.01), and the d

225 nthase and gamma-cystathionase (CSE) and for homocysteine persulfide synthesis from homocystine by CS

226 ylation, promoted by the accumulation of the homocysteine precursor SAH, suppresses GPx-1 expression

227 he decreased S-adenosylmethionine/S-adenosyl homocysteine ratio (P<0.01).

228 Initially, homocysteine reacts with native catalase and/or redox-ac

229 omplex with aclacinomycin T and S-adenosyl-L-homocysteine refined to 1.9-A resolution revealed that t

230 o thymidylate biosynthesis at the expense of homocysteine remethylation during folate deficiency.

231 ate synthesis occurs in the nucleus, whereas homocysteine remethylation occurs in the cytosol.

232 plementation did not affect in vivo rates of homocysteine remethylation or the appearance of homocyst

233 indicated that the thymidylate synthesis and homocysteine remethylation pathways compete for a limiti

234 holine can be used as a source of methyl for homocysteine remethylation to methionine, but choline sy

235 erved in folate deficiency at the expense of homocysteine remethylation, but the mechanisms are unkno

236 In vivo fluxes of total homocysteine remethylation, the remethylation of homocys

237 switch from cystathionine to cysteine and/or homocysteine renders H2S synthesis by CSE responsive to

238 We investigated maternal folate and homocysteine responses and related effects in the newbor

239 Expression of homocysteine-responsive endoplasmic reticulum-resident u

240 Betaine-homocysteine S-methyltransferase (BHMT) activity is only

241 eterodimer partner [SHP]-null mice), betaine-homocysteine S-methyltransferase (Bhmt), or both genes (

242 t the design and synthesis of poly(S-alkyl-L-homocysteine)s, which were found to be a new class of re

243 sence of its methyl donor product S-adenosyl-homocysteine (SAH) and its ortholog scTrm10 from Sacchar

244 sibly reflected in high levels of S-adenosyl-homocysteine (SAH) and low levels of S-adenosyl-methioni

245 NTMT1 in complex with cofactor S-adenosyl-L-homocysteine (SAH) and six substrate peptides, respectiv

246 y/mass spectrometry (LC/MS)-based S-adenosyl homocysteine (SAH) detection assay for histone methyltra

247 The affinity of S-adenosyl-l-homocysteine (SAH) for SAM binding proteins was used to

248 Here, we describe a suite of S-adenosyl homocysteine (SAH) photoreactive probes and their applic

249 tive fluorescent biosensors for S-adenosyl-l-homocysteine (SAH) that provide a direct "mix and go" ac

250 m7)G0pppA1G2U3U4G5U6U7-3'), and S-adenosyl-l-homocysteine (SAH), the by-product of the methylation re

251 h is converted via methylation to S-adenosyl-homocysteine (SAH), which accumulates during aging.

252 cond SAM (SAM2) is converted to S-adenosyl-l-homocysteine (SAH).

253 uman tRNA3(Lys) and the product S-adenosyl-L-homocysteine show a dimer of heterodimers in which each

254 exhibited higher selectivity toward cysteine/homocysteine than toward other amino acids and thiol-con

255 arding the associations between plasma total homocysteine (tHcy) and B vitamin levels and age-related

256 linked hearing loss to elevated plasma total homocysteine (tHcy) and folate deficiency, and have show

257 ecrease of approximately 75% in plasma total homocysteine (tHcy) and normalization of cysteine concen

258 rong observational association between total homocysteine (tHcy) concentrations and risk of coronary

259 tCys, methionine and total homocysteine (tHcy) increased with age.

260 Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor f

261 Elevated total plasma homocysteine (tHcy) is considered to be an independent c

262 In 148 stable RTRs, total serum homocysteine (tHcy) level, folate, serum albumin and cre

263 vious data suggest that elevated serum total homocysteine (tHcy) may be a risk factor for bone fractu

264 ntake is positively related and total plasma homocysteine (tHcy) negatively related to academic succe

265 choline, betaine, dimethylglycine, and total homocysteine (tHcy) were measured longitudinally at <12,

266 s of vitamin B-12, holotranscobalamin, total homocysteine (tHcy), and methylmalonic acid (MMA) were m

267 ancy with the use of plasma cobalamin, total homocysteine (tHcy), and methylmalonic acid (MMA).

268 measurement of serum cobalamin, plasma total homocysteine (tHcy), and plasma methylmalonic acid (MMA)

269 ined by combining vitamin B-12, plasma total homocysteine (tHcy), methylmalonic acid (MMA), and holot

270 c evidence of a relation between serum total homocysteine (tHcy), vitamin B-12, and folate and age-re

271 bolism characterized by elevated serum total homocysteine (tHcy).

272 In 2SLS regression, for the same increase in homocysteine, the coefficients were -1.8 mm Hg for SBP (

273 onine synthase (MS) catalyzes methylation of homocysteine, the last step in the biosynthesis of methi

274 s in body composition.On the basis of plasma homocysteine, the NOAEL of supplemented Met intake is 46

275 -methyl-tetrahydrofolate-glutamate3 to the l-homocysteine thiol.

276 servations for the aminolysis of N-acetyl-dl-homocysteine thiolactone with n-butylamine in THF and CH

277 -methyl-tetrahydrofolate-glutamate3 to the L-homocysteine thiolate to generate methionine.

278 elial cells (HRECs) were treated with excess homocysteine to analyze permeability.

279 CBS condenses serine and homocysteine to cystathionine with the help of three cof

280 enes into the unprecedented S-oxygenation of homocysteine to engender the corresponding sulfenic acid

281 onine cycle, in which folate and B12 convert homocysteine to methionine, which is in turn converted t

282 itamin B12 functions in the remethylation of homocysteine to methionine, which regenerates THF from 5

283 This enzyme catalyzes the remethylation of homocysteine to methionine, with betaine as the methyl d

284 the four DNA bases and the remethylation of homocysteine to methionine.

285 purine nucleotides and for remethylation of homocysteine to methionine.

286 and result in a hypothesis about the role of homocysteine-to-Cys interconversion and Asn biosynthesis

287 Conversely, in the homocysteine-treated cardiomyocytes, CBS and miR-133a we

288 Homocysteine-treated HRECs showed increased permeability

289 We found that homocysteine upregulates CSE but downregulates CBS where

290 rs, for instance by lowering elevated plasma homocysteine using B vitamins.

291 tion were assessed via questionnaires.Plasma homocysteine was elevated with the highest dose of suppl

292 The association with homocysteine was significant for proximal colon tumors (

293 folate, serum vitamin B-12, and plasma total homocysteine were determined.

294 cy because combined abnormalities of MMA and homocysteine were very frequent and the concentrations t

295 Serum homocysteine, when studied singly, has been reported to

296 following chain of events: B vitamins lower homocysteine, which directly leads to a decrease in GM a

297 R)-hydroxyproline and proline by cysteine or homocysteine, which reduces the preorganization and ther

298 Lowering homocysteine with combined vitamin B-12 and folic acid s

299 The association of genetically increased homocysteine with DBP was not consistent across differen

300 nt enzyme that catalyzes the condensation of homocysteine with serine or with cysteine to form cystat