ライフサイエンスコーパス: homocysteine thiolactone

1 of the reaction of human serum albumin with homocysteine thiolactone.

2 es results in the formation of the thioester homocysteine thiolactone.

3 results in formation of a cyclic thioester, homocysteine thiolactone.

4 me, edits homocysteine by converting it into homocysteine thiolactone.

5 ves of methionine is as fast as formation of homocysteine thiolactone.

6 d carboxyl group forming a cyclic thioester, homocysteine thiolactone.

7 d carboxyl group forming a cyclic thioester, homocysteine thiolactone.

8 nce at 240 nm, a maximum in a UV spectrum of homocysteine-thiolactone.

9 Homocysteine thiolactone, a cyclic thioester, is synthes

10 Homocysteine-thiolactone, a cyclic thioester of homocyst

11 The thioester homocysteine-thiolactone, a reactive metabolite of homoc

12 ther thiol-containing compounds, including l-homocysteine thiolactone and DTT, induced VEGF expressio

13 The metabolic conversion of homocysteine to homocysteine thiolactone and the reactivity of the thiol

14 sitive assay for the determination of plasma homocysteine-thiolactone and demonstrate its utility wit

15 ted directly with D,L-homocysteine or with L-homocysteine thiolactone, and a dose response was establ

16 ned product of the non-natural N-hexanoyl- l-homocysteine thiolactone at 1.3 A resolution is also det

17 Using this assay, homocysteine-thiolactone concentrations in plasma from n

18 The assay involves separation of homocysteine-thiolactone from macromolecules by ultrafil

19 Homocysteine, cysteine, or homocysteine thiolactone have no effect on factor V acti

20 Homocysteine thiolactone (Hcy TL) is a metabolite of Hcy

21 ts in approximately 40% of survivors or with homocysteine thiolactone in combination with each of a s

22 A new assay for the determination of homocysteine-thiolactone in biological samples is descri

23 However, data on the levels of homocysteine-thiolactone in humans are limited, mostly d

24 ionine by methionine synthase), produce more homocysteine thiolactone, in addition to homocysteine, t

25 ation of rapid electrophoretic monitoring of homocysteine thiolactone-induced protein oligomerization

26 Substrate specificity studies suggest that homocysteine thiolactone is a likely natural substrate o

27 Homocysteine thiolactone is a metabolite of homocysteine

28 potentially harmful, the ability to detoxify homocysteine thiolactone is essential for biological int

29 Although homocysteine thiolactone is expected to acylate amino gr

30 Homocysteine thiolactone is formed in all cell types stu

31 The data support the conclusion that homocysteine-thiolactone is a ubiquitous metabolite whos

32 Further purification of plasma homocysteine-thiolactone is achieved by high-performance

33 Plasma homocysteine-thiolactone is first separated from macromo

34 Homocysteine-thiolactone is further purified and quantif

35 ins by homocysteine and its cyclic congener, homocysteine thiolactone, is emerging as an area of grea

36 29 of the 60 human plasma samples analyzed, homocysteine-thiolactone levels were below the detection

37 ne hydrolase is not involved because neither homocysteine thiolactone nor an S-adenosylhomocysteine h

38 ic dose (200 mM D,L-homocysteine or 100 mM L-homocysteine thiolactone) on incubation days 0, 1, and 2

39 In human serum incubated with homocysteine thiolactone, protein homocysteinylation was

40 duced by the addition of homoserine lactone, homocysteine thiolactone, pyruvate, Casamino Acids, or a

41 Homocysteine-thiolactone represented from 0 to 0.28%, on

42 The exceptions were compounds with a homocysteine thiolactone ring in place of the homoserine

43 Homocysteine thiolactone, selenohomocysteine lactone, an

44 By detoxifying homocysteine thiolactone, the thiolactonase/paraoxonase

45 ocess of neural tube closure with sufficient homocysteine thiolactone to induce NC and NT defects in

46 Neither cysteine nor homocysteine thiolactone treatment of factor V affected

47 opionitrile, [U-14C]phenylhydrazine, or [35S]homocysteine thiolactone was observed.

48 servations for the aminolysis of N-acetyl-dl-homocysteine thiolactone with n-butylamine in THF and CH