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5 he p140 catalytic subunit (POLG) and the p55 homodimeric accessory subunit (POLG2), which enhances bi
6 le catalytic subunit, encoded by Polg, and a homodimeric accessory subunit encoded by the Polg2 gene.
8 ukaryotic nonmuscle cells, regulation of the homodimeric actin cross-linking protein alpha-actinin-4
10 ds on our recently reported structure of the homodimeric alpha-crystallin domain (ACD) and C-terminal
12 are believed to have evolved from an extinct homodimeric ancestor through a process of gene duplicati
13 ty and observed that GrxD can form FeS-bound homodimeric and BolA containing heterodimeric complexes.
16 ellular roles of GrxD as a component of both homodimeric and heterodimeric complexes to ultimately un
17 a database that contains clusters of similar homodimeric and heterodimeric interfaces observed in mul
24 these channels in the TMEM16 family share a homodimeric architecture facilitated by their cytoplasmi
28 re reveals an alpha/beta helix-grip fold and homodimeric assembly, verified in vivo by coimmunoprecip
29 ylase) complex, could adopt a salt-dependent homodimeric association with its target epigenomic loci.
32 d-facing crystal structures of the bacterial homodimeric ATP-binding cassette transporters MsbA from
35 membrane-spanning heterodimer, MalF-MalG; a homodimeric ATPase, MalK2; and a periplasmic maltose rec
37 cence resonance energy transfer (FRET), that homodimeric bacterial SSB from Thermus thermophilus (Tth
38 y can be applied to the engineering of other homodimeric bacteriophytochromes, which will further exp
39 xB), which we have termed mod2B, composed of homodimeric beta subunits that contain amino acid sequen
41 ure of the BEN-DNA target complex, revealing homodimeric binding of the BEN domain and extensive nucl
42 e molecules allows the direct observation of homodimeric boronic acids and their heterodimeric comple
45 ans contains genes for two SSB homologs: the homodimeric, canonical Ssb, encoded by the gene ssb, and
48 , we report the 3D NMR solution structure of homodimeric CC MBS in which amino acids 932-967 form a c
49 rystal structures of IgV domains that form a homodimeric CEACAM6 complex, monomeric CEACAM8, and a he
51 ons, recent studies have indicated that this homodimeric chaperone can also assume a variety of asymm
52 et of type III secretion (TTS) autoinhibited homodimeric chaperones adopt a molten globule-like state
54 ded by the kif3c-like (kif3cl) gene, and the homodimeric ciliary kinesin, kif17, are dispensable for
56 issect the action at the pathway entrance in homodimeric Clostridium tetani H(+)-PPase upon ligand bi
57 he bivalent carbohydrate-binding property of homodimeric CNL is essential for its activity, providing
59 t to design a set of orthogonal antiparallel homodimeric coiled coils using a computational approach.
62 otein-coupled receptor, forms a constitutive homodimeric complex that is stable even in the presence
63 PSAJ: complex crystal structure suggested a homodimeric complex with considerably fewer sequence-spe
64 with benzodiazepine binding across the CCK1R homodimeric complex, resulting in their ability to inhib
65 logous metazoan dynein light chains, forming homodimeric composite substrate binding sites that engag
66 omistic representations of each receptor, in homodimeric configurations with either transmembrane hel
67 ons suggest that the mutations stabilize the homodimeric conformation, positioning the cytosolic kina
69 h motor domain was characterized by studying homodimeric constructs, and a global fit to the data res
71 protein functions in the same pathway as its homodimeric counterparts (mitoNEET and NAF-1), and could
72 ct asymmetrical backbone motions, unlike its homodimeric counterparts that face the cytosolic side of
74 r phosphagen kinases of known structure (the homodimeric creatine kinase (CK) and the monomeric argin
78 a functionally replaced the requirement of a homodimeric cytokine receptor to promote the activation
79 he extracellular membrane proximal domain of homodimeric cytokine receptors as a key regulator of int
80 prolactin receptor as an archetype model of homodimeric cytokine receptors to address the role of th
81 d that JAK2-V617F requires interactions with homodimeric cytokine receptors to elicit its transformin
82 the interleukin-17 family form six different homodimeric cytokines (IL-17A-F) and the heterodimeric I
83 report the solution quaternary structure of homodimeric CzrA bound to a palindromic 28-bp czr operat
85 within R1A was responsible for R1A-RARalpha homodimeric DNA binding and interaction with wild-type R
87 t a mode of interaction where the N-terminal homodimeric domain of Rtt106 intercalates between the tw
88 nd in vitro, and mutations in the N-terminal homodimeric domain of Rtt106 that affect formation of Rt
89 w that the editing endonucleases do not form homodimeric domains, and may therefore function as inter
90 dynein intermediate chain (IC) bound to two homodimeric dynein light chains Tctex1 and LC8, there is
93 f an E1p-E2p didomain subcomplex involving a homodimeric E1p, and the results may be applicable to a
96 hymidylate synthase from Escherichia coli, a homodimeric enzyme known to be half-the-sites reactive.
97 cterize a singly ligated state ("lig1") of a homodimeric enzyme that is otherwise obscured by rapid e
98 yotic topo II, a type II topoisomerase, is a homodimeric enzyme that solves topological entanglement
101 es along the reaction pathway of a bacterial homodimeric enzyme, fluoroacetate dehalogenase (FAcD).
105 I topoisomerases are essential ATP-dependent homodimeric enzymes required for transcription, replicat
107 outstanding questions, we expressed chimeric homodimeric enzymes, enhanced GFP (EGFP)-PDE6C-A and EGF
109 topoisomerases (Top2alpha and Top2beta) are homodimeric enzymes; they are essential for altering DNA
111 hepsin cascade that is initiated through the homodimeric EPOR complex and is required for the surviva
112 tability and oligomerization dynamics of the homodimeric Escherichia coli beta and the homotrimeric S
115 ee-dimensional structure of MtmOIV, a 56 kDa homodimeric FAD- and NADPH-dependent monooxygenase, whic
118 nprecedented asymmetric structure within the homodimeric Fc polypeptide, enable completely selective
119 Mammalian nitric oxide synthase (NOS) is a homodimeric flavo-hemoprotein that catalyzes the oxidati
120 cenone atropodiastereomeric pairs, including homodimeric flavomannin A (1) and the previously unrepor
121 ppear to conform to the same winged helical, homodimeric fold, that collectively "sense" a wide array
122 unctionally important state as a symmetrical homodimeric form of SecR decorated by monomeric Atr1a, i
124 ow the LXRalpha ligand binding domain in its homodimeric form, an arrangement previously thought to b
128 (Single-GATA) while a monomeric GATA1 and a homodimeric GATA1 bivalently bind to two GATA motifs in
129 nge (weakly associating proteins), such as a homodimeric GB1 variant, and with K(d) values in the nan
130 While there has been growing interest in the homodimeric gene products of CISD1 (mitoNEET) and CISD2
132 Stanniocalcin-1 (STC1) is a disulfide-bound homodimeric glycoprotein, first identified as a hypocalc
134 monomeric hCMG complex and suggest that the homodimeric hCtf4 acts as a platform linking polymerase
135 strate that the hCtf4-CMG complex contains a homodimeric hCtf4 and a monomeric hCMG complex and sugge
136 munoglobulin new antigen receptor (IgNAR), a homodimeric heavy chain-only antibody, as a major part o
138 resent a comprehensive geometric analysis of homodimeric helices that demonstrates the existence of a
140 tin interactions are established through the homodimeric hinge domain of Smchd1 and, intriguingly, th
141 sses in microorganisms, and each comprises a homodimeric histidine kinase receptor and a cytoplasmic
150 ral and quantitative differences between the homodimeric interactions of the three mouse PERIOD homol
153 ly important regions of TNSALP (active site, homodimeric interface, crown domain, calcium site, ...).
154 the P2 subdomain was mainly involved in the homodimeric interface, whereas a large gap between the P
156 dicated considerable differences between the homodimeric interfaces of AUX/IAA and ARF PB1 domains.
157 ansition and exchanges partners in localized homodimeric interfaces to form an ExbD(2)-TonB heterotri
161 motor proteins; however, the function of the homodimeric Kif17 motor in cilia is poorly understood, w
162 s significantly slower than ADP release from homodimeric KIF3AA and KIF3BB, which reach 80-90 s(-1) T
166 microtubule dynamics in vitro, an engineered homodimeric KIF3CC was incorporated into a dynamic micro
167 unctional differences, the heterodimeric and homodimeric kinesin-14s share a common evolutionary stru
170 tructures of aglycosylated heterodimeric and homodimeric "knob" and "hole" Fc fragments derived from
175 We demonstrate that HbI functions like a homodimeric mechanical device, such as pliers or scissor
179 arsenic repressor (ArsR) family of bacterial homodimeric metal-sensing proteins and has emerged as a
181 complex molybdenum cofactor (Moco)-dependent homodimeric metalloenzyme that is vitally important for
182 itis elegans CPS-6, a homolog of EndoG, is a homodimeric Mg(2+)-dependent nuclease, binding preferent
186 an meprin beta is a 145-kDa disulfide-linked homodimeric multidomain type-I membrane metallopeptidase
187 es throughout the catalytic cycle of LmrA, a homodimeric multidrug ABC transporter from L. lactis.
191 ix containing the R1500P mutation folds into homodimeric (mutant/mutant) and heterodimeric [mutant/wi
194 gene duplication and fusion from a classical homodimeric nitroreductase such that the monomeric prote
195 different from the arrangements observed in homodimeric non-NMDA receptors and reveals the molecular
197 radical cofactor, Mn(III)(2)-Y(*), in their homodimeric NrdF (beta2) subunit to initiate reduction o
198 reening strategies to therapeutically target homodimeric oncogenic proteins considered undruggable.
199 To date, studies have demonstrated that homodimeric p55 disease variants are deficient in the ab
200 c18 plasmids encode parS sites and two small homodimeric ParA-like (delta2) and ParB-like (omega2) pr
201 we report the biochemical properties of the homodimeric PFO of C. reinhardtii expressed in Escherich
203 nt a room-temperature neutron structure of a homodimeric PLP-dependent enzyme, aspartate aminotransfe
204 r (TGF)-beta1, -beta2, and -beta3 are 25-kDa homodimeric polypeptides that play crucial nonoverlappin
208 n this study, we used 14-3-3sigma as a model homodimeric protein and performed a systematic investiga
209 e C-terminal domains of both subunits of the homodimeric protein bind different ends of the intron RN
211 H(+)-Pyrophosphatase is a membrane-embedded homodimeric protein containing a single type of polypept
212 alysis of CYT-18 shows that both CTDs of the homodimeric protein extend outward from the catalytic do
213 tures (residues 37-61 in each monomer of the homodimeric protein molecule) was systematically varied.
216 at shock protein Hsp31 is a stress-inducible homodimeric protein that is involved in diauxic shift re
217 These studies have shown that Hsp90 is a homodimeric protein that requires ATP hydrolysis and a h
218 lecules that could disrupt the constitutive, homodimeric protein-protein interface within CK2beta.
221 otic CLC anion channels and transporters are homodimeric proteins composed of multiple alpha-helical
222 ymmetry in the absence of ligands in several homodimeric proteins that are either asymmetric function
227 se (TR) is a selenocysteine (Sec)-containing homodimeric pyridine nucleotide oxidoreductase which cat
228 The three-dimensional structure revealed a homodimeric quaternary organization, never reported befo
230 and Mossbauer spectroscopic features of the homodimeric QueE point to the presence of a single [4Fe-
232 2-angstrom resolution x-ray structure of the homodimeric reaction center-photosystem from the phototr
234 roliferative leukemia virus oncogene, MPL, a homodimeric receptor activated by thrombopoietin (THPO),
236 solution crystal structures of reconstructed homodimeric receptors in complex with hen-egg white lyso
237 her our data demonstrate that in addition to homodimeric receptors, some heterodimeric receptor compo
244 apicomplexan orthologue to be a functional, homodimeric serine palmitoyltransferase localized to the
245 e enzyme bound with NAD(+) and UDP reveals a homodimeric short-chain dehydrogenase/reductase (SDR), b
246 Two alternative HAMP structures in these homodimeric signaling proteins have been described: HAMP
247 eta1, -beta2, and -beta3, are small secreted homodimeric signaling proteins with essential roles in r
249 vious observations on homotetrameric SSBs to homodimeric SSBs, indicating that the dynamic features m
251 size that WipA can thereby transition from a homodimeric state to a heterodimeric state in which the
252 -angle X-ray scattering, we show that in the homodimeric state, the OH transitions between these two
254 family by having a heterodimeric rather than homodimeric structure and possessing a three amino acid
255 substrate, we found that each monomer of the homodimeric structure bound AdoMet in its active site.
256 rrhoeae and E. coli reveals a well-conserved homodimeric structure consisting of two oligosaccharide/
257 e binding two zinc ions, the domain adopts a homodimeric structure highly similar to those of a numbe
258 This study is the first to demonstrate the homodimeric structure of 5-HT2C receptors endogenously e
261 y also provide a rationale for the mandatory homodimeric structure of polyketide synthases, in contra
262 The latter exhibits a thioredoxin fold and a homodimeric structure with two intermolecular disulfide
263 The four independent subunits from the two homodimeric structures differ only slightly in the pepti
264 r, each crystal structure produced different homodimeric structures, suggesting flexibility in their
267 on was caused by charge reduction using PTR, homodimeric superoxide dismutase/CuZn (31.4 kDa) was sub
269 sted symmetric binding modes relative to the homodimeric target; however, none can fully explain SAR
270 studies in S. pneumoniae that an unannotated homodimeric TetR from S. agalactiae (PDB 3KKC) is the bo
271 the glycophorin A (GpA) model system, whose homodimeric TM helix interface has been characterized by
272 eption, UVR8 switches instantaneously from a homodimeric to monomeric configuration, which leads to i
273 n a reengineered single-chain version of the homodimeric transcription factor cAMP receptor protein.
275 transferrin (hTF) molecules to the specific homodimeric transferrin receptor (TFR) on the cell surfa
276 complex, biologically important system: the homodimeric transmembrane dimer from the alpha chain of
280 e of bound ethidium, revealing an asymmetric homodimeric two-domain molecule with an entirely helical
281 eeds to directly associate with a functional homodimeric type I cytokine receptor, suggesting that, a
288 , purified to homogeneity, and shown to be a homodimeric uridine phosphorylase, with similar specific
289 photon reception by the Arabidopsis thaliana homodimeric UV RESISTANCE LOCUS8 (UVR8) photoreceptor le
291 terial protein-disulfide isomerase DsbC is a homodimeric V-shaped enzyme that consists of a dimerizat
292 micromolar concentrations, Grp1 and ARNO are homodimeric whereas Cytohesin-1 and Grsp1 are monomeric.
298 IX (CA IX) is an extracellular transmembrane homodimeric zinc metalloenzyme that has been validated a
299 main revealed a novel zinc-ribbon fold and a homodimeric Zn3 structure that formed in the crystal lat
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