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1 against high lethal dose challenges against homologous A/PR/8/34 and A/Aichi/2/68 viruses and protec
3 such as sleep and circadian rhythm, that are homologous across species will facilitate the implementa
4 Integrins alphaMbeta2 and alphaXbeta2 are homologous adhesive receptors that are expressed on many
8 errets, inducing antibodies that neutralized homologous and heterologous H5 viruses with different de
9 f arabinose, SLT16 (pCZ1) expressed both the homologous and heterologous O-antigens, whereas in the a
10 hese data suggest durable protection against homologous and heterologous Pf parasites can be achieved
11 activity, and earlier virus clearance after homologous and heterosubtypic [A/Philippines/2/82 (H3N2)
12 ic, and fibril amyloid-beta (Abeta) by three homologous antibodies (solanezumab, crenezumab, and thei
14 were protected against rechallenge with the homologous as well as a distinct isolate with only minut
18 D researchers are increasingly incorporating homologous biological measures to assess markers of risk
20 and a co-crystal structure of L-45 with the homologous Brd PfGCN5 from Plasmodium falciparum rationa
21 using a set of domains that are structurally homologous but evolved with widely varying sequence iden
22 ory GTPases, but is atypical in having a non-homologous, C-terminal domain of approximately 20 kDa an
23 (Cav1 and Cav2) and sodium channels possess homologous CaM-binding motifs, known as IQ motifs in the
24 imulated sterilizing immunity against lethal homologous challenge and complete protection against het
25 owed immunogenicity and protection against a homologous challenge that was better than that conferred
26 nized mice does not impair protection from a homologous challenge; however, it does significantly imp
27 ent, we quantified the mobility of a pair of homologous chromosomal loci in the interphase nuclei of
29 f large single-stranded DNA fragments of the homologous chromosome pairs allows for the independent s
31 Schizosaccharomyces pombe meiotic prophase, homologous chromosomes are co-aligned by linear elements
33 l complex (SC), which forms between pairs of homologous chromosomes during meiosis from yeast to huma
34 absent in oocytes during meiotic resumption, homologous chromosomes failed to segregate accurately du
35 EPSPS gene to pericentromeric regions of two homologous chromosomes in glyphosate sensitive A tubercu
36 ucing organisms, crossover formation between homologous chromosomes is necessary for proper chromosom
38 conserved proteinaceous structure that holds homologous chromosomes together and is required for the
41 -protein ring complex (RC) localized between homologous chromosomes, promotes chromosome congression
42 luster positions are indeed conserved within homologous coding sequences across diverse eukaryotic, b
43 conserved at specific positions in a set of homologous coding sequences, for example to tune transla
48 Gain-of-function CXCR4 mutations that affect homologous desensitization of the receptor have been rep
49 correlated with increased expression of the homologous DNA recombination enzyme RAD51 and tumors ove
50 , knockdown of FEN1 significantly attenuated homologous DNA repair efficiency and enhanced cytotoxic
52 aced by the heterocyclization (Cy) domain, a homologous domain that performs two consecutive reaction
54 long single-stranded (ss) RNAs with cognate homologous double-stranded (ds) DNA in vitro Using magne
55 x, is responsible for pairing the ssDNA with homologous double-stranded DNA (dsDNA), which serves as
56 We thus now propose that, in somatic cells, homologous dsDNA-dsDNA interactions between a small numb
58 motes the two major DSB repair pathways, non-homologous end joining (NHEJ) and homologous recombinati
60 to arise from a moderate attenuation of non-homologous end joining (NHEJ) repair, the role of DEK in
63 to enhanced phosphorylation of DNA-PK, a non-homologous end joining repair protein, in Hec-108 cells.
64 critical role in ICL repair was seen for non-homologous end-joining (cku-80) or base excision repair
65 II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes
66 that combined inactivation of the XRCC4 non-homologous end-joining (NHEJ) DNA repair gene and p53 ef
67 lele-specific gene disruption induced by non-homologous end-joining (NHEJ) DNA repair offers a potent
69 logy directed repair (HDR) and decreased non-homologous end-joining (NHEJ) repair, suggesting that Ww
72 nstrate the importance of TDP2-dependent non-homologous end-joining in protecting both gene transcrip
74 the proximity of the break were due to a non-homologous end-joining pathway, while larger deletions w
75 mycoredoxin cluster, we also characterized a homologous enzyme of Corynebacterium glutamicum (NCgl233
77 e 11p13, is an intergenic region between Ets homologous factor (EHF) and Apaf-1 interacting protein (
78 titative O-Man glycoproteomics to identify a homologous family of four putative protein O-mannosyltra
83 validated by qRT-PCR, and compared with the homologous genes from S. japonica, a species in the same
85 to those obtained following coinfection with homologous, genetically tagged, pH1N1 viruses as a contr
88 erologous A/H3N2, for example, was 84.0% for homologous H3N2 seroconverters versus 11.4% for nonseroc
89 rcing a conformation more similar to that of homologous (i.e., non-seam) contacts by which it regular
90 n be explained by a combination of a lack of homologous immunity, frequent reinfections, weak competi
91 any pathogens is driven by type-specific or "homologous" immunity, which promotes the spread of varia
94 tural studies reveal that Hi1a comprises two homologous inhibitor cystine knot domains separated by a
95 nemically with long dsDNA via periodic short homologous interactions, e.g. mediated by RNA/DNA triple
97 memory, but rodent studies on the putatively homologous lateral entorhinal cortex suggest that it als
98 , but nearly all were constructed by merging homologous loci into single "consensus" sequences, gener
99 ed as the ability of one locus to affect its homologous locus in trans Although it was first discover
100 ete multiple voltage plateaus observed for a homologous macrocyclic dimer and an acyclic derivative o
102 ism by which these specialized cells utilize homologous members of a core cardiac transcription facto
103 ammation (targeting chemoattractant receptor-homologous molecules expressed on TH2 lymphocytes, PDE4,
105 ted subjects after in vitro stimulation with homologous (NF54) or heterologous (7G8) PfSPZ were highl
106 homologous TEMPO oxoammonium salts and three homologous nitroxide radicals have been prepared and cha
110 roles in other meiotic processes, including homologous pairing, recombination, and chromosome segreg
112 netic and physiological studies suggest that homologous peroxidases are already present in mycetozoan
114 signaling proteins (Sts-1 and Sts-2) are two homologous phosphatases that negatively regulate signali
115 olymers was significantly lower than that in homologous polymers, suggesting that each protein compon
117 dent cytolysins (CDCs) represent a family of homologous pore-forming proteins secreted by many Gram-p
118 corresponds to the natural amino acid at the homologous position in STAT6, does not change the specif
120 asurements of CCAAT/enhancer-binding protein homologous protein (chop) and immunoglobulin heavy chain
121 changes correlated with an increase in C/EBP homologous protein (CHOP) expression and the activation
122 the absence of ARC increased levels of C/EBP homologous protein (CHOP) in wild type isolated islets s
123 Ablation of CCAAT-enhancer-binding protein homologous protein (CHOP), the major ER stress-associate
124 complex, including Reticulocyte binding-like Homologous protein 5 (PfRH5) and the RH5-interacting pro
125 G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sha
127 activating transcription factor 4 and C/EBP homologous protein up-regulation, associated with caspas
128 nd is essential for embryonic development, a homologous protein, Ctr2, has been proposed to function
129 nstructions of TCPM mutants in which the non-homologous proteins are individually deleted, we propose
130 35 of Ebola virus and to known structures of homologous proteins in the measles, mumps, and Nipah vir
132 the type of amino acid, its conservation in homologous proteins, and its tendency of being exposed t
135 analysis of genotype patterns revealed that homologous reassortment was random while heterologous re
137 Moreover, functional assays showed impaired homologous recombination (HR) and nonhomologous end-join
138 We found that the functions of BRCA1 in homologous recombination (HR) and replication fork prote
139 1 variants or mutants in two HDR mechanisms, homologous recombination (HR) and single strand annealin
140 ling and stability.BRCA2 is involved in both homologous recombination (HR) and the protection of stal
141 herapies in the clinic.Germline mutations in homologous recombination (HR) DNA repair genes are linke
142 ve that bi-allelic pathogenic alterations in homologous recombination (HR) DNA repair-related genes a
144 lso demonstrate gene-targeted integration by homologous recombination (HR) in all three of the homoeo
149 ense BRCA1 or BRCA2 variants known to impair homologous recombination (HR) on the basis of this signa
150 breaks (DSBs) are mainly repaired either by homologous recombination (HR) or by nonhomologous end-jo
154 strate that Sirt1 interacts and deacetylates homologous recombination (HR) repair machinery proteins,
155 s in Drosophila cells revealed that faithful homologous recombination (HR) repair of heterochromatic
159 tants are defective for DNA damage repair by homologous recombination (HR), and have altered HR prote
160 RAD51D is a key player in DNA repair by homologous recombination (HR), and RAD51D truncating var
161 ajor pathways known to mend DNA DSBs, namely homologous recombination (HR), nonhomologous end-joining
162 repair of DNA double-strand breaks (DSBs) by homologous recombination (HR), the molecular mechanism u
163 ication forks are most commonly repaired via homologous recombination (HR), which begins with 5' end
164 eins BRCA1 and BRCA2 play essential roles in homologous recombination (HR)-mediated DNA repair, which
165 ethyltransferase PRMT5 as a key regulator of homologous recombination (HR)-mediated double-strand bre
173 tated FLT3 and JAK2 confers interchromosomal homologous recombination (iHR), a precedent for CN-LOH.
174 redispose chromosomes to meiotic non-allelic homologous recombination (NAHR) events and thus lead to
175 e mechanism is independent of Rad51-directed homologous recombination and avoids the creation of doub
176 paired by 2 major mechanisms: BRCA-dependent homologous recombination and DNA-dependent protein kinas
177 enerated insertions in this gene by directed homologous recombination and found that the cah1 mutant
178 s is associated with repeats and non-allelic homologous recombination and furthermore that young repe
179 Trp53 (-/-);Brca2 (-/-) cells have defective homologous recombination and increased sensitivity to bo
180 ignificance: Dual targeting of MYC-regulated homologous recombination and PARP-mediated DNA repair yi
182 SWIB5 in influencing mtDNA architecture and homologous recombination at specific intermediate-sized
183 1 arrest axis as an unanticipated outcome of homologous recombination deficiency, which triggers cell
185 As a result, depletion of USP21 decreases homologous recombination efficiency, causes an increase
186 g approach we show that increasing levels of homologous recombination enhance the efficiency with whi
188 versal and illuminate a complex interplay of homologous recombination factors in fork remodeling and
189 pon additional deletion of TOP1, implicating homologous recombination for the repair of Top1-induced
192 the stabilization of transcripts involved in homologous recombination in response to DNA damage.
193 nd annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an
194 markably, these defects impair DNA repair by homologous recombination indicating that SPB integrity i
199 f PIMMS2 function through gene disruption by homologous recombination leads to normal development of
203 uble-stand break repair via facilitating DNA homologous recombination processes and highlighted the g
207 plays a central role in DNA replication and homologous recombination repair, and is known to be invo
209 ocesses ranging from repairing DNA damage by homologous recombination to generation of genetic divers
211 sults identify a late role of BRCA1-BARD1 in homologous recombination, an attribute of the tumour sup
212 he repair of mitotic double-strand breaks by homologous recombination, but its relationship to 5' end
215 -way junctions are structures present during homologous recombination, repair of double stranded DNA
216 ch other and with other proteins involved in homologous recombination, such as DprA, thus placing the
230 ecombination is a search for a corresponding homologous region on DNA, which is called a homology sea
231 ngineering (CREATE), links each guide RNA to homologous repair cassettes that both edit loci and func
232 olymerase inhibition and that restoration of homologous repair function may be a mechanism of disease
234 conversion, non-reciprocal transfer from one homologous sequence to another, is a major force in evol
235 uperfamily of phosphotransferases that share homologous sequences and structural motifs and have many
236 roves structure prediction accuracy of other homologous sequences beyond the accuracy obtained by seq
238 In some cases, we also downloaded published, homologous sequences of the ITS region of fungi inspecte
239 oteins that do not have sufficient number of homologous sequences to derive reliable co-evolution pro
242 anism Caenorhabditis elegans produce various homologous series of l-ascarylose-derived glycolipids ca
243 -DPPH assay was developed for separating the homologous series of oligomeric proanthocyanidins and th
244 232 azaarene congeners distributed in eight homologous series, including alkylated derivatives and t
245 a novel role for RIPK1 and RIPK3, a pair of homologous serine/threonine kinases previously implicate
247 eading in water are reported for a series of homologous squaraine dyes with different substituents (s
251 million protein domains classified into 2737 homologous superfamilies, doubling the number of predict
253 Melibe leonina and Dendronotus iris exhibit homologous swimming behaviors, consisting of alternating
254 e viscosity profiles of ferropericlase using homologous temperature scaling and find that viscosity i
257 ever, since they are plentiful and extremely homologous, these PE/PPEs are very challenging to study,
258 SNPs were found within 39 transcripts highly homologous to 49 publically-searched rubber biosynthesis
259 span of genomic DNA in C. porcellus that is homologous to a portion of mammalian CD59 and show that
260 orting model-based behavior are structurally homologous to and overlapping with those thought to carr
262 f T-cell reactivity to Mtb epitopes that are homologous to bacteria in the microbiome in persons with
263 oraenol synthase is an oxidosqualene cyclase homologous to bacterial lanosterol synthases and distinc
264 calized at chromosome 2p23.1-p21 and is most homologous to CAPN13 (36% sequence identity), which is l
266 e (RING)-type E3s, thereby restricting it to homologous to E6AP C-terminus (HECT) and RING-in-between
267 entified MoGlo3 as an ArfGAP protein that is homologous to Glo3p of the budding yeast Saccharomyces c
268 ion of mutated mouse CRMP4 (S540Y), which is homologous to human CRMP4 (S541Y), in cultured hippocamp
270 gh light-inducible proteins (Hlips) that are homologous to light-harvesting antenna of plants and alg
271 e report that HRPU-2, an RNA-binding protein homologous to mammalian heterogeneous nuclear ribonucleo
272 G0 or G1 transgene in nephrocytes, fly cells homologous to mammalian podocytes, induced increased end
273 Imd is a receptor-proximal adaptor protein homologous to mammalian RIP1 that is regulated by proteo
274 hort form of membrane IgE (mIgES ), which is homologous to mouse mIgE, and the up-regulation of the l
278 mammalian replisome component C20orf43/RTF2 (homologous to S. pombe Rtf2) must be removed for fork re
279 ous system (CNS) from a neural plate that is homologous to that of vertebrates, allowing direct topol
280 stome ancestor possessed a molecular toolkit homologous to that which drives canonical MYD88-dependen
281 T-oligo, a guanine-rich oligonucleotide homologous to the 3'-telomeric overhang of telomeres, el
282 B is a mitochondrion-associated protein with homologous to the E6-AP Cterminus (HECT) E3 ubiquitin li
283 76C, S1176L, and G1178S), three of which are homologous to the gating mutations of cystic fibrosis tr
284 we show that an HD-Zip transcription factor homologous to the LATE MERISTEM IDENTITY1 (LMI1) gene of
285 in the Bengalese finch brain-a premotor area homologous to the mammalian premotor cortex-alters the s
286 ion of Teb2 and Teb3, which are structurally homologous to the RPA middle and small subunits, respect
287 ition reveals that corazonin, a neuropeptide homologous to the vertebrate gonadotropin-releasing horm
289 ural and genomic features of collagen IV are homologous to those of non-bilaterian animal phyla and B
292 d the frequency with which segments carrying homologous versus heterologous packaging signals were in
293 the H7 WIV completely protected mice against homologous viral challenge, and antibodies directed agai
295 tralising antibody seroresponses against the homologous Wa-strain were seen in 40 (85%, 72-94) of 47
296 tope by changing 3 amino acids so that it is homologous with a known H3 immunogenic epitope sequence
298 ex responsible for type IV pilus assembly is homologous with the type II protein secretion complex.
300 X chromosomes separate during meiosis I, and homologous X chromatids segregate to the functional sper
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