ライフサイエンスコーパス: homologous chromosome

1 a the sister chromatid but failed to use the homologous chromosome.

2 a new region of the same chromosome or a non-homologous chromosome.

3 s Vbeta14Dbeta1Jbeta1.4 rearrangement on the homologous chromosome.

4 1 stimulated bias for strand invasion of the homologous chromosome.

5 form single-stranded DNA, which can invade a homologous chromosome.

6 nd could accompany gene conversions with the homologous chromosome.

7 bly of the synaptonemal complex (SC) between homologous chromosomes.

8 estry across a genome segment among a set of homologous chromosomes.

9 oofread and stabilize the pre-DSB pairing of homologous chromosomes.

10 otic prophase with defective synapsis of the homologous chromosomes.

11 be related to the exchange of parts between homologous chromosomes.

12 ic paralog of Rad51, mediates the pairing of homologous chromosomes.

13 genetic diversity and ensures segregation of homologous chromosomes.

14 it requires programmed recombination between homologous chromosomes.

15 genetic complementation of mutant alleles on homologous chromosomes.

16 over following mitotic recombination between homologous chromosomes.

17 ganization factors, and the biorientation of homologous chromosomes.

18 east one crossover (CO) between each pair of homologous chromosomes.

19 n, which promotes pairing and segregation of homologous chromosomes.

20 ves the segregation of replicated recombined homologous chromosomes.

21 has several structural polymorphisms between homologous chromosomes.

22 nto DNA and promotes strand exchange between homologous chromosomes.

23 s in these species are controlled by loci on homologous chromosomes.

24 , rather than copy number in each of the two homologous chromosomes.

25 generated, initiating recombination between homologous chromosomes.

26 f homology contained in sister chromatids or homologous chromosomes.

27 quences and those that act to align and pair homologous chromosomes.

28 zed recombination between highly polymorphic homologous chromosomes.

29 may primarily regulate recombination between homologous chromosomes.

30 e two radiations are in similar positions on homologous chromosomes.

31 se, and may be influenced by the presence of homologous chromosomes.

32 changes that ensure accurate segregation of homologous chromosomes.

33 on, are knocked in at identical locations on homologous chromosomes.

34 ize is required for pairing to occur between homologous chromosomes.

35 of the acentrosomal spindles that segregate homologous chromosomes.

36 or represent different overlapping events on homologous chromosomes.

37 C), a proteinaceous structure formed between homologous chromosomes.

38 des a transient but tight connection between homologous chromosomes.

39 essful meiosis, crossovers must form between homologous chromosomes.

40 t MutSgamma-independent associations between homologous chromosomes.

41 re double-strand breaks for synapsis between homologous chromosomes.

42 contacts form between maternal and paternal homologous chromosomes, a phenomenon known as somatic ho

43 Differential methylation of the homologous chromosomes, a well-known mechanism leading t

44 sis is the synapsis of maternal and paternal homologous chromosomes, accompanied by exchange of genet

45 that DSBs stimulate gene conversion between homologous chromosomes (allelic conversion) by >30-fold

46 c prophase I and mediates adhesion of paired homologous chromosomes along their entire lengths.

47 ations between bona fide nuclease targets on homologous chromosomes, an undesired collateral effect t

48 elies on the formation of crossovers between homologous chromosomes and a series of precisely control

49 mplified by improper pairing and synapsis of homologous chromosomes and altered processing of recombi

50 crossover recombination is essential to link homologous chromosomes and drive faithful chromosome seg

51 tic crossovers facilitate the segregation of homologous chromosomes and increase genetic diversity.

52 f such meiosis-specific events as pairing of homologous chromosomes and initiation of recombination.

53 Contact involves short segments of homologous chromosomes and is centered on a DSB in activ

54 ved from yeast to mammals, assembles between homologous chromosomes and is essential for accurate chr

55 mbination is required for the segregation of homologous chromosomes and is essential for fertility.

56 repair which ensures the proper synapsis of homologous chromosomes and normal meiotic progression.

57 th particular regard to the juxtaposition of homologous chromosomes and potential nonallelic, ectopic

58 The pairing of homologous chromosomes and the intimate synapsis of the

59 s a prerequisite for the pairing of parental homologous chromosomes and the reductional division, whi

60 xchange of genetic material between parental homologous chromosomes, and ensures faithful chromosome

61 of chiasmata, the physical linkages between homologous chromosomes, and loss of the tight associatio

62 ombination (HR) between sister chromatids or homologous chromosomes, approximately 2% of all DSBs giv

63 ns- or interallele CSR), suggesting that the homologous chromosomes are aligned during CSR.

64 Schizosaccharomyces pombe meiotic prophase, homologous chromosomes are co-aligned by linear elements

65 monstrate that individual telomere tracts on homologous chromosomes are coordinately regulated throug

66 intermediates, in which sister chromatids or homologous chromosomes are covalently linked by four-way

67 Recombination and pairing of homologous chromosomes are critical for bivalent formati

68 uniparental disomy (UPD), in which a pair of homologous chromosomes are derived from a single parent,

69 s) that physically link sister chromatids or homologous chromosomes are formed as intermediates durin

70 Crossovers formed by recombination between homologous chromosomes are important for proper homolog

71 Homologous chromosomes are paired in somatic cells of Dr

72 In this system, homologous chromosomes are positioned off-center on the

73 eres move together to the same pole, and the homologous chromosomes are pulled apart.

74 Crossover recombination events between homologous chromosomes are required to form chiasmata, t

75 During meiosis I (MI), the paired homologous chromosomes are separated.

76 Despite the conservation of genes within homologous chromosome arms across species, the karyotype

77 ollowing this centromere depolarization were homologous chromosome arms connected, as observed by the

78 tion involves the remodeling of each pair of homologous chromosomes around the site of crossover into

79 recombination, the broken chromosome uses a homologous chromosome as a repair template.

80 nduced and preferentially repaired using the homologous chromosome as a template.

81 We propose the heterospecific pairing of homologous chromosomes as a preexisting condition of asy

82 netics, employ both NHEJ and HR, and can use homologous chromosomes as an HR template.

83 e of replication near paused RNA polII using homologous chromosomes as template leads to LOH.

84 During meiosis, homologous chromosomes associate to form the synaptonema

85 he synaptonemal complex (SC), which mediates homologous chromosome association before crossover forma

86 d reads overwhelmingly derived from only one homologous chromosome at any given location.

87 Nuclear reorganization and juxtaposition of homologous chromosomes at late leptotene/early zygotene

88 or monopolar spindles and nondisjunction of homologous chromosomes at meiosis I.

89 lent polyploids, simultaneous pairings among homologous chromosomes at meiosis result in a unique cyt

90 t induces contact between allelic regions of homologous chromosomes at sites of DSBs in human somatic

91 Proper separation of homologous chromosomes at the first meiotic division req

92 on, is essential for accurate segregation of homologous chromosomes at the first meiotic division, re

93 ique aspect of meiosis is the segregation of homologous chromosomes at the meiosis I division.

94 ique aspect of meiosis is the segregation of homologous chromosomes at the meiosis I division.

95 ata, to accomplish successful segregation of homologous chromosomes at the meiosis I division.

96 In budding yeast meiosis, homologous chromosomes become linked by chiasmata and th

97 fic structure that assembles between aligned homologous chromosomes, both constrains and is altered b

98 cation as well as pairing and segregation of homologous chromosomes, but the double-strand breaks (DS

99 synapsis, recombination, and segregation of homologous chromosomes, but the molecular organization o

100 the exchange of genetic information between homologous chromosomes by recombination.

101 g yeast which promotes recombination between homologous chromosomes by suppressing double-strand brea

102 Allelic differences between the two homologous chromosomes can affect the propensity of inhe

103 ic variation, sequence polymorphisms between homologous chromosomes can feedback onto the recombinati

104 In Drosophila, somatic pairing of homologous chromosomes can lead to transvection, by whic

105 species, where genomic polymorphisms between homologous chromosomes commonly result in unpaired DNA d

106 study, we report the unexpected finding that homologous chromosomes contact each other at the sites o

107 is displaced from kinetochores, consistently homologous chromosomes do not segregate, and polar body

108 Segregation of homologous chromosomes during meiosis depends on linkage

109 l complex (SC), which forms between pairs of homologous chromosomes during meiosis from yeast to huma

110 ecific adaptations enable the segregation of homologous chromosomes during meiosis I to reduce ploidy

111 modifications that ensure the segregation of homologous chromosomes during meiosis I.

112 g sites required for accurate segregation of homologous chromosomes during meiosis in C. elegans.

113 Pairing and synapsis of homologous chromosomes during meiosis is crucial for pro

114 In most eukaryotes, segregation of homologous chromosomes during meiosis is dependent on cr

115 Faithful segregation of homologous chromosomes during meiosis requires pairing,

116 n loxP sites located at allelic positions on homologous chromosomes during meiosis.

117 c1 are essential for strand exchange between homologous chromosomes during meiosis.

118 a polymer that spans 100 nm between paired homologous chromosomes during meiosis.

119 are important for the correct segregation of homologous chromosomes during meiosis.

120 tion facilitates the accurate segregation of homologous chromosomes during meiosis.

121 enables correct synapsis and segregation of homologous chromosomes during meiosis.

122 st organisms for the faithful segregation of homologous chromosomes during meiotic cell division.

123 The faithful alignment of homologous chromosomes during meiotic prophase requires

124 synaptonemal complex (SC) that forms between homologous chromosomes during meiotic prophase.

125 t assembles at the interface between aligned homologous chromosomes during meiotic prophase.

126 id1 proteins are required for the pairing of homologous chromosomes during meiotic recombination.

127 , mediating the stable pairing (synapsis) of homologous chromosomes during prophase I.

128 nserved protein assembly that holds together homologous chromosomes during prophase of the first meio

129 nformation and allow balanced segregation of homologous chromosomes during the first division of meio

130 w that size differences between telomeres on homologous chromosome ends are greater for atm tert than

131 During meiotic prophase, homologous chromosomes engage in a complex series of int

132 t meiotic division, crossovers (COs) between homologous chromosomes ensure their correct segregation.

133 Crossovers (COs) between homologous chromosomes ensure their faithful segregation

134 Meiotic recombination between homologous chromosomes ensures their proper segregation

135 Recombination between homologous chromosomes facilitates accurate meiotic chro

136 Crossing-over between homologous chromosomes facilitates their accurate segreg

137 absent in oocytes during meiotic resumption, homologous chromosomes failed to segregate accurately du

138 s display meiotic arrest in which pairing of homologous chromosomes fails.

139 apture and next-generation sequencing of the homologous chromosome for ten 16p13.11-deletion patients

140 Two homologous chromosomes for each of the 10 sorghum chromo

141 We have previously shown that homologous chromosomes have a tendency to associate duri

142 in meiosis I, where bivalents consisting of homologous chromosomes held together by chiasmata biorie

143 sis, recombination events that occur between homologous chromosomes help prepare the chromosome pairs

144 ombination using the sister chromatid or the homologous chromosome (homolog) as a template.

145 ic prophase I is a complex process involving homologous chromosome (homolog) pairing, synapsis, and r

146 ation of healthy gametes requires pairing of homologous chromosomes (homologs) as a prerequisite for

147 During meiosis, paired homologous chromosomes (homologs) become linked via the

148 How homologous chromosomes (homologs) find their partner, pa

149 lanced distribution of chromosomes, pairs of homologous chromosomes (homologs) must recognize each ot

150 id organisms to produce haploid gametes: (1) homologous chromosomes (homologs) pair and undergo cross

151 sed into crossovers, ensuring segregation of homologous chromosomes (homologs).

152 Genes on the remaining homologous chromosome, however, are not recurrently muta

153 proper pairing, synapsis, and segregation of homologous chromosomes; however, it is dispensable for t

154 construct from its site of insertion to its homologous chromosome in a faithful, site-specific manne

155 the sister chromatid in mitotic cells or the homologous chromosome in meiotic cells, as a template fo

156 The use of the homologous chromosome in mitotic gene conversion is thou

157 rmining which alleles lie on each of the two homologous chromosomes in a diploid individual.

158 During early meiosis, homologous chromosomes in atrad51c-1 fail to undergo syn

159 romatin bridges between the telomeres of non-homologous chromosomes in Atrecq4A at metaphase I, in so

160 te to the pairing and close juxtaposition of homologous chromosomes in budding yeast.

161 r SNP allele compositions in each of the two homologous chromosomes in CNV regions using real data.

162 nisms use purely inbred lines, where the two homologous chromosomes in each individual are identical.

163 otic and early somatic chromosome pairing of homologous chromosomes in flies that are mutant for vari

164 EPSPS gene to pericentromeric regions of two homologous chromosomes in glyphosate sensitive A tubercu

165 sually distinguish the maternal and paternal homologous chromosomes in mammalian and insect systems.

166 meric complex, ensure the proper synapsis of homologous chromosomes in meiosis by acting in concert w

167 els indicate that the kinetochores of paired homologous chromosomes in MI or sister chromatids in MII

168 2B of wild emmer accessions substituted for homologous chromosomes in tetraploid and hexaploid backg

169 es pombe has a residual ability to segregate homologous chromosomes in the absence of meiotic recombi

170 regation involves pairing and segregation of homologous chromosomes in the first division and segrega

171 Thus, an interruption of BIR involving fully homologous chromosomes in yeast triggers a switch to MMB

172 rogram of recombination and synapsis between homologous chromosomes, including loading of recombinati

173 otype structure and heterozygosities between homologous chromosomes, including the identification of

174 rrecombination between sister chromatids and homologous chromosomes, indicating an anti-recombination

175 mbly of the synaptonemal complex (SC) brings homologous chromosomes into close apposition along their

176 ent in strictly asexual organisms results in homologous chromosomes irreversibly accumulating mutatio

177 dedicated protein machinery ensures that the homologous chromosome is favored over the nearby sister

178 The pairing of homologous chromosomes is a critical aspect of meiotic p

179 Correct pairing of homologous chromosomes is controlled by the Ph1 locus.

180 dination of V rearrangements between loci on homologous chromosomes is critical for Ig and TCR alleli

181 Pairing of homologous chromosomes is facilitated by telomere-led ch

182 Crossing over between homologous chromosomes is initiated in meiotic prophase

183 ei's speculation that full-length pairing of homologous chromosomes is mediated by the extension of t

184 ucing organisms, crossover formation between homologous chromosomes is necessary for proper chromosom

185 Recombination between homologous chromosomes is required for the faithful meio

186 During meiosis, the arrangement of homologous chromosomes is tightly regulated by the synap

187 duction of a site-specific crossover between homologous chromosomes, is driven by a preferential inhe

188 This bivalent, a linked pair of homologous chromosomes, is essential for proper chromoso

189 which provides a physical connection between homologous chromosomes, is essential in most species for

190 cialized, proteinaceous structure connecting homologous chromosomes, is stabilized in cis on chromoso

191 Homologous chromosomes must pair and establish stable co

192 During meiosis, segregation of homologous chromosomes necessitates the coordination of

193 ks occurs primarily by recombination between homologous chromosomes, not sister chromatids.

194 ation and sequencing to show that alleles on homologous chromosomes occupy distinct territories, and

195 During meiosis, reciprocal exchange between homologous chromosomes occurs as a result of crossovers

196 Nondisjunction of homologous chromosomes occurs in mei-38 mutants primaril

197 re into chiasmata, which hold and orient the homologous chromosomes on the meiotic spindle to ensure

198 on from a homologous template, typically the homologous chromosome or sister chromatid.

199 including selection for efficient pairing of homologous chromosomes or for recombination of deleterio

200 ), in which an individual contains a pair of homologous chromosomes originating from only one parent,

201 s from diploid precursors requires that each homologous chromosome pair be properly segregated to pro

202 rental disomy describes the inheritance of a homologous chromosome pair from only one parent.

203 substitution strains (CSS) that each carry a homologous chromosome pair from the A/J inbred strain on

204 Genetic analysis with a homologous chromosome pair indicated nonrandom chromatid

205 of structural changes between members of the homologous chromosome pair.

206 As a prelude to haploidization, homologous chromosomes pair and recombine to undergo seg

207 During meiosis, homologous chromosomes pair and recombine via repair of

208 During zygotene, as homologous chromosomes pair and synapse, a synaptonemal

209 In meiosis I, homologous chromosomes pair and then attach to the spind

210 During meiosis homologous chromosomes pair and undergo reciprocal genet

211 The mechanism by which homologous chromosomes pair during meiosis, as a prelude

212 first and most complex stage of meiosis when homologous chromosomes pair to exchange genetic informat

213 Homologous chromosome pairing and synapsis are prerequis

214 ed recombination intermediates or defects in homologous chromosome pairing and synapsis independent o

215 with abnormal chromosome dynamics, affecting homologous chromosome pairing and synapsis.

216 DSB repair catalyzed solely by HOP2 supports homologous chromosome pairing and synapsis.

217 Homologous chromosome pairing is a prerequisite to estab

218 In meiotic prophase I, homologous chromosome pairing is promoted through chromo

219 The contribution of the bouquet structure to homologous chromosome pairing is uncertain.

220 InDrosophila, homologous chromosome pairing leads to "transvection," i

221 ive and one inactive centromere are present, homologous chromosome pairing reduces the frequency of i

222 king the Ph1 locus, a locus ensuring correct homologous chromosome pairing, and discover that bouquet

223 er regulate X chromosome fate by controlling homologous chromosome pairing, counting, and mutually ex

224 those observed in Cdk2 KO mice including non-homologous chromosome pairing, unrepaired double-strand

225 hich is essential for proper SC assembly and homologous chromosome pairing.

226 chromosomal interactions are dispensable for homologous chromosome pairing.

227 ring meiotic prophase, is thought to promote homologous chromosome pairing.

228 mal complex (SC) and its role in maintaining homologous chromosome pairings, the critical roles of th

229 Homologous chromosome pairs (bivalents) undergo restruct

230 f large single-stranded DNA fragments of the homologous chromosome pairs allows for the independent s

231 formation of at least one chiasma/CO between homologous chromosome pairs is essential for accurate ch

232 pairs and likely plays the same role for all homologous chromosome pairs.

233 rophase, incomplete and aberrant synapsis of homologous chromosomes, persistence of strand exchange p

234 For this program, crossovers between homologous chromosomes play an essential mechanical role

235 ysical breakage and rejoining of DNA between homologous chromosomes, plays a central role in mediatin

236 o model genomes having more than two sets of homologous chromosomes (polyploidy).

237 H is mitotic crossover recombination between homologous chromosomes, potentially initiated by a doubl

238 -protein ring complex (RC) localized between homologous chromosomes, promotes chromosome congression

239 tility require meiotic recombination between homologous chromosomes rather than the equally available

240 ecombination in that DSBs are repaired using homologous chromosomes, rather than sister chromatids.

241 nged arrest in prophase of meiosis I between homologous chromosome recombination and ovulation.

242 During meiosis, homologous chromosomes recombine and become closely appo

243 In Drosophila, homologous chromosomes remain paired in somatic tissues,

244 eriencing a double-strand break (DSB) on one homologous chromosome repair the break by RAD51-mediated

245 s in meiosis, when cross-overs (COs) between homologous chromosomes secure an exchange of their genet

246 In Drosophila males, homologous chromosomes segregate by an unusual process i

247 In meiosis I, homologous chromosomes segregate, while sister chromatid

248 vers (COs) are crucial for ensuring accurate homologous chromosome segregation during meiosis I.

249 However, we also found that random homologous chromosome segregation during ploidy reductio

250 s cyclin CLB3 in meiosis I, thereby ensuring homologous chromosome segregation.

251 genes are expressed from only one of the two homologous chromosomes, selected at random in each cell.

252 ther during the first meiotic division (when homologous chromosomes separate) and then segregate away

253 veral homologous repair templates, including homologous chromosomes, sister chromatids, and linked or

254 rescent reporters at equivalent positions on homologous chromosomes so that they would pair via the e

255 ithin this structure 'crosslink' the axes of homologous chromosomes, stabilizing their pairing.

256 that are differentially modified on the two homologous chromosomes such as imprinted domains and the

257 During meiosis, homologous chromosomes synapse and recombine at sites ma

258 heir disruption results in severe defects in homologous chromosome synapsis and an early-stage failur

259 Deletion of Hop2 in mice eliminates homologous chromosome synapsis and disrupts double-stran

260 d that Bsg KO spermatocytes displayed normal homologous chromosome synapsis and progression through m

261 Reduction of SYN3 caused defects in homologous chromosome synapsis and synaptonemal complex

262 p2-Mnd1 heterodimer, which are essential for homologous chromosome synapsis during meiosis.

263 trum of meiotic defects including incomplete homologous chromosome synapsis or persistent histone H2A

264 in the Brca2-/- rats is due to a failure of homologous chromosome synapsis.

265 olyploid somatic nucleus: multiple copies of homologous chromosomes tended to cluster, consistent wit

266 c recombination generates crossovers between homologous chromosomes that are essential for genome hap

267 nation establishes physical linkages between homologous chromosomes that are required for their prope

268 ta) to maintain physical connections between homologous chromosomes that ensure their proper segregat

269 In many eukaryotes, homologous chromosomes that fail to become linked by exc

270 These counterintuitive findings suggest that homologous chromosomes that have successfully engaged on

271 mata, which are physical connections between homologous chromosomes that provide the tension necessar

272 n examine how sequence polymorphisms between homologous chromosomes, that is, heterozygosity, can inf

273 NA region cannot be detected on the opposite homologous chromosome, then this lack of "sensing" activ

274 pread from their chromosome of origin to the homologous chromosome, thereby converting heterozygous m

275 Dmc1-mediated stable strand invasion between homologous chromosomes, thereby preserving genomic integ

276 ination between the polymorphic sequences of homologous chromosomes, thus contributing to gene conver

277 nd tails that undergo strand exchange with a homologous chromosome to form joint molecule (JM) interm

278 incenp mutation leads to a failure of paired homologous chromosomes to biorient, such that bivalents

279 , recombination is directed to occur between homologous chromosomes to create connections necessary f

280 a checkpoint that monitors synapsis between homologous chromosomes to ensure accurate meiotic segreg

281 telomeres in meiosis promotes the ability of homologous chromosomes to find one another in budding Sa

282 ocal exchange of genetic information between homologous chromosomes to generate new allelic combinati

283 assembly must occur between correctly paired homologous chromosomes to promote formation of chiasmata

284 hesins from chromosome arms is necessary for homologous chromosomes to segregate during meiosis I.

285 t on crossovers (COs), which enable pairs of homologous chromosomes to segregate to opposite poles at

286 conserved proteinaceous structure that holds homologous chromosomes together and is required for the

287 lated to occur only between aligned pairs of homologous chromosomes, ultimately ensuring proper chrom

288 During meiosis, homologous chromosomes undergo crossover recombination,

289 During meiosis, homologous chromosomes undergo crossover recombination,

290 During meiosis homologous chromosomes undergo crossover recombination.

291 During meiosis paired homologous chromosomes undergo recombination, which can

292 During meiosis, homologous chromosomes undergo synapsis and recombinatio

293 ng and generates crossovers (COs) to connect homologous chromosomes until their separation at anaphas

294 on the pericentromeric region on one pair of homologous chromosomes was detected.

295 ation timing between respective telomeres of homologous chromosomes was highly coordinated, but no su

296 so that there is at least one CO per pair of homologous chromosomes whereas the maximum number of COs

297 s is processed into crossovers (CRs) between homologous chromosomes, which promote their accurate seg

298 he sites of reciprocal recombination between homologous chromosomes, which suggests a possible 10-fol

299 ositions generally serves to loosely coalign homologous chromosomes, while crossover-bound recombinat

300 individual variation and differences between homologous chromosomes within the same individual (allel