ライフサイエンスコーパス: homologous recombination

1 the repair of DNA double-stranded breaks by homologous recombination.

2 vectors enables precise gene editing through homologous recombination.

3 but not N863A-induced nicks are repaired by homologous recombination.

4 SPO11-induced double-strand breaks (DSBs) by homologous recombination.

5 kinase II gene (CaMKII) was generated using homologous recombination.

6 nd invasion reaction that takes place during homologous recombination.

7 ents into host chromosomes without requiring homologous recombination.

8 DNA ends into single-stranded substrates for homologous recombination.

9 hanism that is distinct from BRCA2-dependent homologous recombination.

10 eading to pathway selection between NHEJ and homologous recombination.

11 d mediator proteins during various stages in homologous recombination.

12 unction together in DNA end resection during homologous recombination.

13 or of BRCA2, a key mediator of DNA repair by homologous recombination.

14 enabling BRCA1 recruitment and DNA repair by homologous recombination.

15 nation and DNA double strand break repair by homologous recombination.

16 reviews describing various issues related to homologous recombination.

17 -mediated end joining rather than nonallelic homologous recombination.

18 n budding yeast, which is a model system for homologous recombination.

19 y generating intronic insertions via in vivo homologous recombination.

20 icient non-homologous end joining as well as homologous recombination.

21 before the stop codon of the MYF5 gene using homologous recombination.

22 ication stress and DNA damage, and defective homologous recombination.

23 or the repair of double-strand DNA-breaks by homologous recombination.

24 hen introns spread to empty target sites via homologous recombination.

25 s the crucial first step in their repair via homologous recombination.

26 nuclease complexes that process DNA ends for homologous recombination.

27 and promoting double strand break repair by homologous recombination.

28 e RecA strand exchange protein and a role in homologous recombination.

29 ing during repair of double strand breaks by homologous recombination.

30 ic cells, BRCA2 is needed for RAD51-mediated homologous recombination.

31 ion that provided a template for non-allelic homologous recombination.

32 est explained by gene conversion followed by homologous recombination.

33 nd can integrate it into their chromosome by homologous recombination.

34 a specific tau knock-out (KO) fly line using homologous recombination.

35 fork repair and crossover suppression during homologous recombination.

36 nscriptional silencing and repair of DSBs by homologous recombination.

37 ll as DNA double-strand break repair through homologous recombination.

38 predominantly of CNVs mediated by nonallelic homologous recombination.

39 differs from the process in G2 that leads to homologous recombination.

40 ntire gene cluster in mouse germline through homologous recombination.

41 epaired through nonhomologous end joining or homologous recombination.

42 sses repair by nonhomologous end-joining and homologous recombination.

43 rotein RAD51 facilitates the central step in homologous recombination, a process fundamentally import

44 As SSAPs can promote homologous recombination among DNA substrates with an im

45 sults identify a late role of BRCA1-BARD1 in homologous recombination, an attribute of the tumour sup

46 e mechanism is independent of Rad51-directed homologous recombination and avoids the creation of doub

47 xis that mediates sister chromatid cohesion, homologous recombination and chromosome synapsis.

48 pacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensi

49 strand displacement is a key reaction in DNA homologous recombination and DNA mismatch repair and is

50 NA joint formation and impaired mediation of homologous recombination and DNA repair in cells.

51 2 major DSB repair mechanisms, BRCA-mediated homologous recombination and DNA-dependent protein kinas

52 paired by 2 major mechanisms: BRCA-dependent homologous recombination and DNA-dependent protein kinas

53 t kinase Cdk1 is essential for DSB repair by homologous recombination and for DNA damage signaling.

54 enerated insertions in this gene by directed homologous recombination and found that the cah1 mutant

55 s is associated with repeats and non-allelic homologous recombination and furthermore that young repe

56 uency with respect to the inferred events of homologous recombination and horizontal gene transfer wi

57 atures of BRCA2 is crucial for understanding homologous recombination and how patient-derived mutatio

58 Trp53 (-/-);Brca2 (-/-) cells have defective homologous recombination and increased sensitivity to bo

59 utagenesis, in contrast to the components of homologous recombination and NHEJ, which have no effect.

60 53BP1, two key factors in DNA DSB repair by homologous recombination and non-homologous end joining,

61 XRCC2 and XRCC4, two genes that take part in homologous recombination and non-homologous end joining,

62 n of Ubp7 with DNA damage repair pathways of homologous recombination and nucleotide excision repair.

63 d FASTKD3 homozygous knock-out cell lines by homologous recombination and observed that the absence o

64 s to repair DSBs through several pathways of homologous recombination and other nonhomologous end-joi

65 ignificance: Dual targeting of MYC-regulated homologous recombination and PARP-mediated DNA repair yi

66 Homologous recombination and repair factors are known to

67 imicking constitutive acetylation stimulates homologous recombination and robustly suppresses the DNA

68 influence of class I HDACs on DSB repair by homologous recombination and the possible clinical impli

69 nts feeding into intimate homolog pairing by homologous recombination and/or synaptonemal complex for

70 slippage, unequal sister chromatid exchange, homologous recombination, and aberrant double-strand bre

71 or DNA damage checkpoints, cells reliant on homologous recombination, and cells with increased repli

72 cription, long-range DNA interactions during homologous recombination, and replication origin timing

73 iciency of both homologous and the other non-homologous recombination, as well as increases sensitivi

74 SWIB5 in influencing mtDNA architecture and homologous recombination at specific intermediate-sized

75 or delivery of a homologous donor to achieve homologous recombination at the HBB gene in haematopoiet

76 y for targeting haematopoietic stem cells by homologous recombination at the HBB locus to advance the

77 elial homoeostasis, yet remains deficient in homologous recombination-based DSB repair.

78 s of patients in combination with subsequent homologous recombination-based gene correction provides

79 e inability of post-mitotic cells to support homologous recombination-based gene editing will be pres

80 n of DNA double-strand break (DSB) repair by homologous recombination because of downregulation of RA

81 ntity at the junction, suggesting nonallelic homologous recombination between defensin7 and defensin6

82 the MAT locus on chromosome III, followed by homologous recombination between the cut MAT locus and o

83 Precisely modified alleles are generated by homologous recombination between the host genome and dsD

84 The analysis also revealed contributions of homologous recombination (BRC-1/BRCA1), the MUS-81, EXO-

85 uppressing sister chromatid exchanges during homologous recombination but its GQ unfolding activity a

86 he repair of mitotic double-strand breaks by homologous recombination, but its relationship to 5' end

87 ted from other systems, the role of BRCA2 in homologous recombination, but not in stalled replication

88 ion-induced rearrangement (MIR) stems from a homologous recombination byproduct, where a broken DNA e

89 sical non-homologous end joining (cNHEJ) and homologous recombination compete for the repair of doubl

90 ve chromatin, read by the human TONSL-MMS22L homologous recombination complex.

91 r, this inhibition attenuates early steps in homologous recombination, consistent with p97-driven Ku

92 ne or somatic BRCA mutations), patients with homologous recombination deficiencies (BRCA mutant or BR

93 These tumors have equivalent homologous recombination deficiency scores to sporadic t

94 were classified into one of three predefined homologous recombination deficiency subgroups on the bas

95 classified into one of the three predefined homologous recombination deficiency subgroups: BRCA muta

96 1 arrest axis as an unanticipated outcome of homologous recombination deficiency, which triggers cell

97 ors have activity in ovarian carcinomas with homologous recombination deficiency.

98 of heterozygosity (LOH) might also represent homologous recombination deficiency.

99 plays an important function by facilitating homologous recombination-dependent processes, such as re

100 When DSBs are repaired by homologous recombination, DNA ends can undergo extensive

101 of cNHEJ that promotes error-free repair by homologous recombination during cell cycle phases when s

102 unclear why cNHEJ does not always outcompete homologous recombination during the S and G2 phases.

103 As a result, depletion of USP21 decreases homologous recombination efficiency, causes an increase

104 g approach we show that increasing levels of homologous recombination enhance the efficiency with whi

105 Crossovers generated by homologous recombination ensure proper chromosome segreg

106 DNA double-strand break repair by homologous recombination entails nucleolytic resection o

107 y of t-loops within individual molecules and homologous recombination events between different DNAs a

108 (22q11.2DS) is caused by meiotic non-allelic homologous recombination events between flanking low cop

109 ozygosity is maximal at the centromeres, and homologous recombination events result in homozygosity t

110 ction can be used to recover relatively rare homologous recombination events.

111 merous solo-LTR form, thought to result from homologous recombination events.

112 reversed fork formation and describe how the homologous recombination factors BRCA1, BRCA2, and RAD51

113 versal and illuminate a complex interplay of homologous recombination factors in fork remodeling and

114 review and discuss the individual stages of homologous recombination, focusing on common pathways in

115 sed cell death under circumstances requiring homologous recombination for DNA repair.

116 pon additional deletion of TOP1, implicating homologous recombination for the repair of Top1-induced

117 s1 plays critical roles during DNA repair by homologous recombination, from end resection to Holliday

118 cked germline or somatic events in canonical homologous recombination genes-BRCA1, BRCA2, or PALB2.

119 lignment scores, suggesting that non-allelic homologous recombination has played a significant role i

120 In vivo homologous recombination holds the potential for optimal

121 r of the DNA damage response, which promotes homologous recombination (HR) and antagonizes 53BP1-depe

122 reases S-phase-specific DNA damage repair by homologous recombination (HR) and checkpoint recovery in

123 ir (MMR), non-homologous end joining (NHEJ), homologous recombination (HR) and interstrand crosslink

124 Moreover, functional assays showed impaired homologous recombination (HR) and nonhomologous end-join

125 We found that the functions of BRCA1 in homologous recombination (HR) and replication fork prote

126 1 variants or mutants in two HDR mechanisms, homologous recombination (HR) and single strand annealin

127 ling and stability.BRCA2 is involved in both homologous recombination (HR) and the protection of stal

128 Double-strand breaks repaired by homologous recombination (HR) are first resected to form

129 We show that human Nek1 regulates homologous recombination (HR) by phosphorylating Rad54 a

130 (MMR), nucleotide excision repair (NER), and homologous recombination (HR) capacity contributed to ac

131 ed or high-risk prostate cancer.Tumours with homologous recombination (HR) defects become sensitive t

132 Emerging data demonstrate homologous recombination (HR) defects in castration-resi

133 therapy agents, and promotes the survival of homologous recombination (HR) deficient cells, it repres

134 BRCA1- and BRCA2-mutated cells, which are homologous recombination (HR) deficient, are hypersensit

135 BRCA1 and BRCA2 are involved in homologous recombination (HR) DNA repair and are germ-li

136 RAD51 is the central protein in homologous recombination (HR) DNA repair and represents

137 herapies in the clinic.Germline mutations in homologous recombination (HR) DNA repair genes are linke

138 ve that bi-allelic pathogenic alterations in homologous recombination (HR) DNA repair-related genes a

139 e maintenance and cancer suppression require homologous recombination (HR) DNA repair.

140 Herpesvirus genomes readily undergo homologous recombination (HR) during productive replicat

141 ) protein has recently been shown to inhibit homologous recombination (HR) events.

142 Mutations in homologous recombination (HR) genes BRCA1 and BRCA2 pred

143 lso demonstrate gene-targeted integration by homologous recombination (HR) in all three of the homoeo

144 equent recruitment of RIF1, which suppresses homologous recombination (HR) in G1 cells.

145 We describe a method to multiplex homologous recombination (HR) in human hematopoietic ste

146 DNA double-strand break (DSB) repair by homologous recombination (HR) involves resection of the

147 Homologous recombination (HR) is a central process to en

148 Homologous recombination (HR) is a crucial pathway for d

149 Homologous recombination (HR) is a DNA double-strand bre

150 Homologous recombination (HR) is a major mechanism to re

151 Homologous recombination (HR) is a template-driven repai

152 Homologous recombination (HR) is one of the major DNA do

153 ense BRCA1 or BRCA2 variants known to impair homologous recombination (HR) on the basis of this signa

154 breaks (DSBs) are mainly repaired either by homologous recombination (HR) or by nonhomologous end-jo

155 RAD52 is a member of the homologous recombination (HR) pathway that is important

156 nd repair of DNA double-strand breaks by the homologous recombination (HR) pathway.

157 her the non-homologous end joining (NHEJ) or homologous recombination (HR) pathway.

158 ical non-homologous end joining (C-NHEJ), or homologous recombination (HR) pathways.

159 Current models of bacterial homologous recombination (HR) posit that extensive resec

160 RAD52 is a homologous recombination (HR) protein that is conserved

161 Induction of homologous recombination (HR) repair genes was reduced w

162 strate that Sirt1 interacts and deacetylates homologous recombination (HR) repair machinery proteins,

163 s in Drosophila cells revealed that faithful homologous recombination (HR) repair of heterochromatic

164 Homologous recombination (HR) repair of programmed meiot

165 roficiency for DNA repair via the error-free homologous recombination (HR) repair pathway.

166 ta signaling in FA HSPCs results in elevated homologous recombination (HR) repair with a concomitant

167 We show that TOPBP1 acts in homologous recombination (HR) repair, impacts olaparib r

168 80 complex, whereas TRADD is dispensable for homologous recombination (HR) repair.

169 to exogenous DNA damage, and have defects in homologous recombination (HR) repair.

170 peutics especially for tumors with deficient homologous recombination (HR) repair.

171 f the budding yeast Shu complex in promoting homologous recombination (HR) upon replication fork dama

172 that DNA double-strand break (DSB) repair by homologous recombination (HR) was compromised.

173 ed DNA facilitates DSB repair via error-free homologous recombination (HR) while stymieing repair by

174 at embryonic stem cells could be modified by homologous recombination (HR) with engineered template D

175 tants are defective for DNA damage repair by homologous recombination (HR), and have altered HR prote

176 RAD51D is a key player in DNA repair by homologous recombination (HR), and RAD51D truncating var

177 (DSBs) are known to be powerful inducers of homologous recombination (HR), but single-strand breaks

178 thways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), is regulated by the cell

179 ajor pathways known to mend DNA DSBs, namely homologous recombination (HR), nonhomologous end-joining

180 Homologous recombination (HR), the error-free pathway fo

181 repair of DNA double-strand breaks (DSBs) by homologous recombination (HR), the molecular mechanism u

182 ion forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA do

183 ication forks are most commonly repaired via homologous recombination (HR), which begins with 5' end

184 in DNA double-strand break (DSB) repair via homologous recombination (HR), which is important for tu

185 Homologous recombination (HR)-mediated DNA double-strand

186 sample-specific BRCA scores, which indicates homologous recombination (HR)-mediated DNA repair pathwa

187 eins BRCA1 and BRCA2 play essential roles in homologous recombination (HR)-mediated DNA repair, which

188 ethyltransferase PRMT5 as a key regulator of homologous recombination (HR)-mediated double-strand bre

189 ential regulator of DSB repair that promotes homologous recombination (HR)-mediated repair and, to a

190 COs are produced by homologous recombination (HR)-mediated repair of program

191 d by DNA damage tolerance (DDT) pathways and homologous recombination (HR).

192 stress by stimulating DNA end resection and homologous recombination (HR).

193 In yeast, DNA breaks are usually repaired by homologous recombination (HR).

194 onse (DDR) and is required for DSB repair by homologous recombination (HR).

195 eracting protein that promotes DNA repair by homologous recombination (HR).

196 e hypothesized DEK plays additional roles in homologous recombination (HR).

197 xperience DNA damage that requires repair by homologous recombination (HR).

198 plex initiates double-strand break repair by homologous recombination (HR).

199 cells again attempt replication and activate homologous recombination (HR).

200 that generates the 3' ssDNA intermediate for homologous recombination (HR).

201 PA exchanges during the multistep process of homologous recombination (HR).

202 rs (PARPi) is toxic to cells with defects in homologous recombination (HR).

203 hways, non-homologous end joining (NHEJ) and homologous recombination (HR).

204 histone variant that promotes DNA repair by homologous recombination (HR).

205 key regulator of cell-cycle checkpoints and homologous recombination (HR).

206 d by DNA damage, promotes ATR activation and homologous recombination (HR).

207 sets found a significant upregulation of the homologous-recombination (HR) pathway genes.

208 CA2 in maintaining genomic stability through homologous recombination (HRR).

209 tated FLT3 and JAK2 confers interchromosomal homologous recombination (iHR), a precedent for CN-LOH.

210 n mediator protein is critical for efficient homologous recombination in bacteriophage T4 and is the

211 We used homologous recombination in C57BL/6 NJ (B6N) and 129S1/S

212 ds, a ZFN-induced DSB was shown to stimulate homologous recombination in cells.

213 e generated using labor-intensive methods of homologous recombination in embryonic stem cells and are

214 Central to homologous recombination in eukaryotes is the RAD51 reco

215 Homologous recombination in ID8 remained intact in funct

216 ons for the BRC motifs of BRCA2 in promoting homologous recombination in meiotic and mitotic cells.

217 xon deletion or complete gene correction via homologous recombination in myogenic cells.

218 amily that influences mtDNA architecture and homologous recombination in plants and suggests a link b

219 the stabilization of transcripts involved in homologous recombination in response to DNA damage.

220 nd annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an

221 rocesses, but one of the most important is a homologous recombination, in which the repair of breaks

222 markably, these defects impair DNA repair by homologous recombination indicating that SPB integrity i

223 al abnormalities and decreased DNA repair by homologous recombination, indicating that BAP1 dosage is

224 Homologous recombination involving sister chromatids is

225 per genome per generation and the rate of IS homologous recombination is 4.5 x 10(-5) recombinations

226 A critical step in the homologous recombination is a search for a corresponding

227 homologs, spindle-A and spindle-B, revealing homologous recombination is active and actually impairs

228 Our understanding of homologous recombination is built upon more than a centu

229 Although homologous recombination is essential for chromosome pai

230 Homologous recombination is inhibited during the G1 phas

231 Finally, we demonstrate that homologous recombination is required for repairing lesio

232 n event 1 kb upstream of the DNA involved in homologous recombination is sufficient to transform C. j

233 A key facet of homologous recombination is the ability of recombination

234 This mechanism, combined with frequent homologous recombination, is likely responsible for the

235 parib increased DNA damage and downregulated homologous recombination, leading to subsequent downregu

236 f PIMMS2 function through gene disruption by homologous recombination leads to normal development of

237 DNA in the presence of DNA damage, favoring homologous recombination linked to sister-chromatid cohe

238 While recruitment of the homologous recombination machinery is well characterized

239 ways, such as non-homologous end joining and homologous recombination, may be important cellular mech

240 suggest that in addition to playing roles in homologous recombination-mediated DNA double-strand brea

241 The Smc5/6 complex is implicated in homologous recombination-mediated DNA repair during DNA

242 nucleotide depletion, which causes defective homologous recombination-mediated DNA repair, suggesting

243 ge response, ML364 also caused a decrease in homologous recombination-mediated DNA repair.

244 elic ATAD3A deletions mediated by nonallelic homologous recombination (NAHR) between ATAD3A and gene

245 redispose chromosomes to meiotic non-allelic homologous recombination (NAHR) events and thus lead to

246 Although nonallelic homologous recombination (NAHR) is known to be a major m

247 Homologous recombination occurs especially frequently ne

248 lighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks (DS

249 lts provide a mechanism for how MRN promotes homologous recombination on nucleosome-coated DNA.

250 Genetic defects in the homologous recombination pathway undermine genomic integ

251 r in yeast cells, and Rad52, a member of the homologous recombination pathway, emerged as an importan

252 ys support a role of SALL4 in inhibiting the homologous recombination pathway.

253 BRCA signature with prevalent defects in the homologous recombination pathway; (ii) dominant T>G muta

254 y the loss of both translesion synthesis and homologous recombination pathways.

255 th alternative nonhomologous end-joining and homologous recombination pathways.

256 llowing protocol takes advantage of a double homologous recombination phenomenon in the chloroplast,

257 Homologous recombination plays key roles in double-stran

258 igate the intermediates of the RecA-mediated homologous recombination process and find it to be highl

259 uble-stand break repair via facilitating DNA homologous recombination processes and highlighted the g

260 al replisome components, ATM and ATR, or the homologous recombination protein Rad51.

261 RAD51 is an indispensable homologous recombination protein, necessary for strand i

262 red for checkpoint activation and loading of homologous recombination proteins Rad52/51/55/57.

263 etic regulation (DNMT3A, ASLX3, TET1-3); and homologous recombination (RAD51C, BRCA2, POLD1).

264 aic gene editing in founder animals, and low homologous recombination rates.

265 vidence that Ape1 facilitates BRCA1-mediated homologous recombination repair (HR), while counteractin

266 L cells, and its loss or inhibition disrupts homologous recombination repair (HRR).

267 hat is dependent on Exo1- and Shu1-dependent homologous recombination repair (HRR).

268 ermore, reduced OFD1 impaired DSB repair via homologous recombination repair (HRR).

269 d sequence (block size of six, stratified by homologous recombination repair gene mutation status, pr

270 ced radiation-induced cell death and reduced homologous recombination repair of DNA double-strand bre

271 on synthesis (TLS), Fanconi anemia (FA), and homologous recombination repair pathways.

272 plays a central role in DNA replication and homologous recombination repair, and is known to be invo

273 ed in protecting stressed replication forks: homologous recombination repair, DNA inter-strand cross-

274 Owing to their function in homologous recombination repair, much research has focus

275 -way junctions are structures present during homologous recombination, repair of double stranded DNA

276 ions, a mutational signature associated with homologous-recombination-repair deficiency.

277 Homologous recombination repairs DNA double-strand break

278 that, if not repaired through RAD51-mediated homologous recombination, result in B lymphocyte death.

279 opological problem; a genetic crossover from homologous recombination results in dimerization of the

280 mental reprogramming, wound response, and/or homologous recombination should be used to boost the rec

281 ch other and with other proteins involved in homologous recombination, such as DprA, thus placing the

282 Recombineering, the use of endogenous homologous recombination systems to recombine DNA in viv

283 Because of its highly efficient homologous recombination, the moss Physcomitrella patens

284 rand breaks on the GFP-Pem1 reporter gene by homologous recombination, the persistent activation and

285 Besides its role in homologous recombination, the tumor suppressor BRCA2 pro

286 During T4 homologous recombination, the UvsX recombinase has to co

287 f recombinases executes the critical step in homologous recombination: the search for homologous DNA

288 satile system (named jStack) utilizing yeast homologous recombination to efficiently assemble DNA int

289 ocesses ranging from repairing DNA damage by homologous recombination to generation of genetic divers

290 xt level, demonstrating the efficient use of homologous recombination to make genetic tools for a ran

291 We used homologous recombination to precisely delete foraging, g

292 as recruitment of Rad51 (a key component of homologous recombination) to DSBs, homology-directed rep

293 ely combat the mutational meltdown, and that homologous recombination under paternal leakage might no

294 edited in a reliable, predictable manner via homologous recombination, whereas Cas9 primarily caused

295 d a mesenchymal phenotype, and deficiency in homologous recombination, which is in part associated wi

296 VSG switching occurs by frequent homologous recombination, which is thought to require lo

297 A key step of meiosis is homologous recombination, which promotes homologous pair

298 Collapsed forks can be rescued by homologous recombination, which restarts replication.

299 ansmission through releasing genomic DNA for homologous recombination while simultaneously reducing h

300 t planarian body upon systemic disruption of homologous recombination with RNA-interference of Rad51