ライフサイエンスコーパス: homology

1 e same architecture on the basis of sequence homology.

2 rily significant plant species based on gene homology.

3 large transcriptomic databases by transitive homology.

4 gene model based on known protein or domain homology.

5 amine-abelson murine leukemia viral oncogene homology 1 (ABL1)-mediated VE dysfunction and fluid extr

6 ing filament growth together with the formin homology 1 (FH1) domain.

7 f the IcsA passenger domain to both the WASP homology 1 (WH1) domain and the GTPase binding domain (G

8 The conserved formin homology 1 and 2 (FH1-FH2) domains of DAAM catalyze acti

9 the dimeric Ku protein complex via its Bcl-2 homology 1 and 3 (BH1 and BH3) domains, which are requir

10 mapped Cdc12 mechanoregulation to its formin homology 1 domain, which facilitates delivery of new act

11 rosine-dependent binding modules such as Src homology 2 (SH2) and phosphotyrosine-binding (PTB) domai

12 ates lysine-63 ubiquitination within the Src homology 2 (SH2) domain of STAT3, which is an essential

13 The binding of Src-homology 2 (SH2) domains to phosphotyrosine (pY) sites i

14 int mutations of Lyn catalytic domain or Src homology 2 (SH2) or SH3 domains or of the cysteine resid

15 tin-binding Wiskott-Aldrich syndrome protein homology 2 (WH2) domain that is absent in Tmods.

16 tin-binding Wiskott-Aldrich syndrome protein Homology 2 (WH2) domain, massively promoted the formatio

17 Formins have a conserved formin homology 2 domain, which nucleates and associates with t

18 The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotein of

19 In addition, DJ-1 reduced Src homology 2 domain-containing phosphatase 2 phosphatase a

20 The 66-kDa Src homology 2 domain-containing protein (p66Shc) is a maste

21 lfenic acid state, we visualize oxidized Src homology 2 domain-containing protein-tyrosine phosphatas

22 d shared binding partners, including the Src homology 2 domain-containing protein-tyrosine phosphatas

23 roline-rich domain and an actin-binding WASP-Homology 2 domain.

24 It's signals are mediated by SHIP (Src homology 2-containing inositol 5' phosphatase), in parti

25 Shc homology 2-containing inositol 5' phosphatase-2 (SHIP2)

26 A) and CagA-signaling molecules (phospho-Src homology-2 domain-containing phosphatase [p-SHP2] and ph

27 (fused in sarcoma) to a multivalent poly-Src homology 3 (SH3) domain protein that phase-separates whe

28 ar interaction between GK and the nearby Src homology 3 (SH3) domain, leading to a closed conformatio

29 has been shown to interact with several Src homology 3 (SH3) domain-containing proteins.

30 CB is expressed with or without a src homology 3 (SH3) domain.

31 all contain MyTH4-FERM domains (myosin tail homology 4-band 4.1, ezrin, radixin, moesin; MF) in thei

32 Despite low sequence homology (48.2%-77.3% similarity), all orthologs (Paf, A

33 rotein filaments efficiently locate sequence homology across genomic DNA remains unclear.

34 Despite sequence homology across the PAR isoforms, discovery of PAR2 anta

35 Despite high sequence homology among different deer species, a fallow deer-spe

36 entity of S. spontaneum with a high level of homology among its eight sub-genomes.

37 site, the sequence of which had only modest homology among p38 isoforms.

38 enaturation, biochemical assays and sequence homology analysis all strongly support defects in nucleo

39 l model of the complex was built via partial homology and by using constraints based on cross-linking

40 Proteins of the Src homology and collagen (Shc) family are typically involve

41 Genomes extracted from metagenomes using homology and compositional approaches revealed diverse m

42 eading: it binds paxillin via the pleckstrin homology and F0 domains to activate Rac1, and it directl

43 Structural homology and geometry optimization calculations enabled

44 vitro to confirm immunogenicity, absence of homology and global population coverage.

45 e the synaptic joints either locate sequence homology and progress to a post-synaptic joint, or disso

46 earched for in fossils to address rhizophore homology and the conservation of auxin-related developme

47 nt-specific gene containing a bromo-adjacent homology and transcriptional elongation factor S-II doma

48 r profilins correlated with overall sequence homology, and 2 immunodominant epitope regions of Phl p

49 genes as a cluster with its shared biology, homology, and physical linkage was pivotal to later stud

50 nophyly and demosponge-hexactinellid spicule homology, and supports the primitive, stem-silicean inte

51 tion and topological analysis via persistent homology as the main tools.

52 When homology at the matched end is </=150 bp, efficient repa

53 ded previous Euclidian distance ONF (32%) or homology-based (22-62%) methods.

54 class, in order to distinguish them from the homology-based annotations in the remainder of the SCOPe

55 s prediction in both sequence and structural homology-based approach will be considered as 'high-conf

56 In first step, sequence homology-based genetic analysis of a set of 50 coding SN

57 Here, a homology-based model of CaV1.2 identified protein interf

58 nts (CCDs), can share significant structural homologies between different plants, they are prone to e

59 Structural and functional homologies between the Zika and Dengue viruses' envelope

60 A comprehensive in silico analysis assessed homologies between virus- and allergen-derived proteins.

61 These hallmarks, along with the lack of homology between breakpoint joins and the randomness of

62 Thus, sequence homology between T cell epitopes of 2 self-proteins and

63 This result demonstrates some structural homology between the metallic glass and its high tempera

64 tigenic regions correlated with the sequence homology between the MVA- and DNA Gag-encoded immunogens

65 mediated gene editing requires long-sequence homology between the target gene and repair template, bu

66 HREADER does not depend directly on sequence homology between the target protein and entries in the f

67 Homology between two distant protein families can be det

68 llustrate the close similarity, and possible homology, between hippocampal and DD/DL circuitry.

69 reported pathways dependent on the Fes/CIP4 homology Bin-Amphiphysin-Rvs167 (F-BAR) protein Cdc15 an

70 are quite diverse and share little sequence homology, but all contain a CXXC catalytic active site m

71 In ssDNA exonuclease mutants, one arm of homology can be reduced to as little as 40 bp while stil

72 putative orthology groups as homology or non-homology clusters by considering all sequences in a clus

73 ten employed for quality control of putative homology clusters.

74 D) of N-WASP and no binding to the verprolin homology/cofilin/acidic (VCA) region.

75 ons, it is still widely assumed that genetic homology conveys similar specificities.

76 re we consider a kinetic system, inspired by homology dependent pairing between double stranded DNA i

77 Cells use homology-dependent DNA repair to mend chromosome breaks

78 Cas9, are used for precise genome editing by homology-dependent repair (HDR).

79 of the ensuing DNA double-stranded break by homology-dependent repair (HDR).

80 NA end resection, an essential early step in homology-dependent repair of DNA double-strand breaks (D

81 ale for these observations, we study the Dbl-homology (DH) and Pleckstrin-homology (PH) domains of Bc

82 Sequence homology diagrams were constructed to compare experiment

83 d that Wwox-deficient cells exhibit enhanced homology directed repair (HDR) and decreased non-homolog

84 bility to induce targeted gene insertion via homology directed repair.

85 tors enables site-specific gene insertion by homology-directed genome editing.

86 protein delivery with AAV donor vectors for homology-directed genome editing.

87 Bs) are repaired through two major pathways, homology-directed recombination (HDR) and non-homologous

88 ith indel mutation frequencies of 40-50% and homology-directed repair (HDR) frequencies of 10-20%.

89 Precise genome editing via homology-directed repair (HDR) in targeted cells, partic

90 -efficiency precise genome editing (PGE) via homology-directed repair (HDR) pathways.

91 iated genome editing in Xenopus oocytes with homology-directed repair (HDR) that provides efficient n

92 RAD51 promotes homology-directed repair (HDR), replication fork reversa

93 tic modification of the human genome through homology-directed repair (HDR).

94 ogrammable nucleases and donor templates for homology-directed repair (HDR).

95 ient-derived primary corneal keratocytes via homology-directed repair (HDR).

96 edited cells, typically resulted in <0.1-4% homology-directed repair (HDR).

97 Homology-directed repair and non-homologous end joining

98 RISPR-Cas9-based targeting accuracy and high homology-directed repair efficiency by activating an end

99 paced palindromic repeats/CRISPR-associated) homology-directed repair gene-editing.

100 etermine that LbCpf1 significantly increases homology-directed repair in zebrafish, improving current

101 Thus, it is considered that noncanonical homology-directed repair regulates the SNGD-mediated gen

102 ingle-stranded oligodeoxynucleotide-mediated homology-directed repair revealed that insulin signaling

103 trategy combining CRISPR-Cas9 technology and homology-directed repair to allow for the selection of h

104 The combination of homology-directed repair-dependent and NHEJ-dependent ge

105 target gene using CRISPR/Cas9 technology and homology-directed repair.

106 c insertions and deletions, or dependence on homology-directed repair.

107 The potential mechanism of ALT is homology-directed telomere synthesis, but molecular mech

108 e C-terminal region of p130Cas or Cas family homology domain (CCHD) has been reported to adopt a stru

109 The C-terminal homology domain (CHD) of Af4 was sufficient to confer th

110 sing the endocytic protein epsin1 N-terminal homology domain (ENTH), previously thought to drive fiss

111 hese adaptors bind cargo via a C-terminal mu-homology domain (muHD); however, few cargoes exhibiting

112 y direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinositol 3,4,5-tri

113 d sensor, phospholipase C delta 1 pleckstrin homology domain (PLC delta1-PH), is completely inhibited

114 sexta Fkh (MsFkh) interacted with Relish-Rel-homology domain (RHD) but not with Dorsal-RHD.

115 ain and the regulator of G protein signaling homology domain (RHD) is highly correlated with establis

116 wn activity of RUNX1 required an intact runt homology domain (RHD), a domain where most leukemia-asso

117 Although the TNF homology domain (THD) of human (h)4-1BBL forms non-coval

118 We observed that ICAM-1 interacts with Src homology domain 2-containing phosphatase-2 (SHP-2), and

119 ine rich, the hypothesis that it targets Src homology domain 3 (SH3) domains was tested, but mutation

120 t both a conserved surface on the pleckstrin homology domain and an intact TPR region are required fo

121 hanistically, AMOTL2 binds to AKT pleckstrin homology domain and interrupts AKT's membrane localizati

122 In this study, we identified pleckstrin homology domain and leucine-rich repeat protein phosphat

123 on promotes ASK1 activity via its pleckstrin homology domain but also facilitates ASK1 autoinhibition

124 The Src homology domain containing phosphatase 2 (SHP2) and the

125 growth factor receptor pathway substrate 15)-homology domain containing proteins (EHDs) comprise a fa

126 uct containing the juxta-membrane and kinase homology domain harbored an exclusive binding site for G

127 ns increased kinase activity, and pleckstrin homology domain mutants exhibited enhanced phospholipid

128 YOD1 binds to the C-terminal TRAF homology domain of TRAF6 that also serves as the interac

129 interaction of the adhesion of a pleckstrin homology domain with phosphatidylinositol 4,5-bisphospha

130 impaired inhibition by the TGEF2 pleckstrin-homology domain, resulting in dramatically increased TGE

131 Along with an N-terminal pleckstrin homology domain, the central domain affects neurite outg

132 ffects a highly conserved residue in the DBL homology domain, which is required for the interaction a

133 others, which function together with EPS-15 homology domain-containing (EHD) proteins in non-T cell

134 Among them, the formin homology domain-containing protein (FHOD) family of form

135 with coiled-coil, Ank repeat, and pleckstrin homology domain-containing protein ACAP2 as an Rab35 eff

136 rough a C-terminal KASH (Klarsicht/Anc1/Syne homology) domain (Figure 1A) [1-4].

137 sing the N-terminal to C-terminal pleckstrin homology domains (PHn-PHc), are auto-inhibited.

138 lsolin in the linker region between gelsolin homology domains G3 and G4, which, in the absence of cal

139 ne kinase family with immunoglobulin and EGF homology domains, are receptor tyrosine kinases found pr

140 GEF (Sec7) and membrane-binding (pleckstrin homology) domains, revealing that it has a constitutivel

141 In the presence of homology donors, these lesions facilitate high-efficienc

142 we introduce the element-specific persistent homology (ESPH) method.

143 mics regulated by Ror2, which influenced Ras Homology Family Member A (RhoA) and Rho-Associated Coile

144 tly, we created a model of protein structure homology for each allele and identified their key struct

145 fication of natural LHE proteins by sequence homology from genomic and metagenomic sequence databases

146 ish between true-positive and false-positive homology groups.

147 constructs for MuGENT require large arms of homology (>2000 bp) surrounding each genome edit, which

148 Homology has been proposed between glomus cells, which a

149 h 3,761 are novel with little or no sequence homology in any existing databases.

150 We find that a 600 bp homology in both arms leads to high-level genome knockin

151 rganisms and then subsequently identified by homology in human.

152 interpretated as further evidence of serial homology in paired fins, that could have arisen by dupli

153 analogous folds where little or no sequence homology information is.

154 Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1

155 Behavioral homology is often assumed to involve similarity in under

156 proteins, while element specific persistent homology is proposed to retain essential biological info

157 No homology is required between the donors, and the interve

158 The K-homology (KH) domain is a nucleic acid-binding domain pr

159 MIR is stimulated by increasing homology length and spatial proximity of the donors and

160 essential for both checkpoint activation and homology-mediated repair; however, the precise mechanism

161 tion of Kgp and RgpB, we derived a plausible homology model and mechanism of Kgp-regulating zymogenic

162 that validate the newly developed structural homology model of CNT membrane architecture for human CN

163 we identified small molecule ligands using a homology model of GPR171 to virtually screen a library o

164 On the basis of a homology model of the 35-amino acid NTR of MYO1C(35) (NT

165 cture of the T4CP holocomplex by combining a homology model of the ATPase domain of DotL.

166 making it difficult to generate an accurate homology model of the protein.

167 A receptor homology model was built and docking studies were perfor

168 Using a homology model, four residues (N251, A263, I299, and F38

169 using unbound, and 12% (2/17) when using the homology-modeled backbones to generate the complexes.

170 s of deduced amino acid sequence, phylogeny, homology modeling and docking simulation.

171 Homology modeling and in silico analysis of the GmSACPD-

172 Using homology modeling and phylogenetic analyses, we present

173 rmance of the constrained de novo method for homology modeling and rigid-body docking and present the

174 Activity profiling, complex isolation, and homology modeling data revealed unique interactions of R

175 Using homology modeling followed by docking, we identified key

176 Here, using homology modeling in combination with mutagenesis and el

177 Mechanistically, homology modeling indicated that the beta3-alpha3 loop d

178 Homology modeling is a powerful tool for predicting a pr

179 of evolutionary and biochemical analyses and homology modeling of the Galpha and RGS proteins to addr

180 Structural homology modeling predicts that this protease adopts a f

181 Homology modeling suggested that the Glu-221 side chain

182 Here, homology modeling supported the alternating access trans

183 veloped a structural model of Hsp21 based on homology modeling, cryo-EM, cross-linking mass spectrome

184 electrophysiological analysis, together with homology modeling, demonstrates that W583 is part of the

185 an interdisciplinary approach that included homology modeling, MD simulations, and biophysical and b

186 Using template-based structural homology modeling, we now show that the ectodomain of HA

187 into these kinetic differences acquired via homology modeling.

188 r homologs related to oxidative stress by 3D-homology modelling and orthologous group comparisons.

189 Protein homology modelling suggests that four amino acid substit

190 Via homology modelling we predicted and confirmed an integra

191 aid of previously determined structures and homology modelling, we derive a pseudo-atomic structure

192 Furthermore, using homology models and biochemical verifications, we show t

193 Several CFTR homology models have been developed using bacterial ABC

194 on chemokine receptor crystal structures and homology models illustrates the possibilities and challe

195 plar antagonists from two chemical series to homology models of both human and mouse Free Fatty Acid

196 Specifically, we built homology models of the three antibody-gp120 complexes, e

197 Wnt-Frizzled CRD interactions, we generated homology models of Wnt-Frizzled CRD interactions and dev

198 ered molecular dynamics (SMD) simulations on homology models offered insight into the process of cohe

199 ap still primarily rely on fitting atomic or homology models to the density map.

200 The updated homology models will be useful for virtual screening and

201 docking large toxin peptides to ion channel homology models, as exemplified by the alpha-GID:alpha4b

202 dent, required interactions between the U2AF-homology motif (UHM) and the alpha6 helix of U2AF35, and

203 Despite serial homology of all silk glands, the expression profiles of

204 This finding supports the homology of gills in cyclostomes and gnathostomes, and a

205 patibility of capsids from AAV serotypes and homology of recognition sites of AAV Nab located on diff

206 We propose that the shared evolutionary homology of teeth and the neurosensory system, and the a

207 Here we test the homology of these organs through comparisons with the ar

208 d for filtering putative orthology groups as homology or non-homology clusters by considering all seq

209 The clusters exhibited little gene homology or promoter element similarity, and largely ove

210 Pleckstrin homology (PH) domains mediate protein-membrane interacti

211 e study the Dbl-homology (DH) and Pleckstrin-homology (PH) domains of Bcr-Abl p210, which constitute

212 rotein tyrosine phosphatase (VE-PTP) and Src homology phosphatase 2 (SHP2), both of which are implica

213 Crystal structures of the SNX5 phox-homology (PX) domain in complex with IncE define the pre

214 tein kinase A-mediated activation of the Src homology region 2 domain-containing phosphatase-1 (SHP-1

215 everal tumor suppressor genes, including Src homology region 2 domain-containing phosphatase-1 (SHP-1

216 encoding a dominant negative isoform of Src homology region 2 domain-containing tyrosine phosphatase

217 and its donor template share a 108-base-pair homology region and the donor carries different densitie

218 that required the predicted integrin-binding homology region of ImaA.

219 helical 'ribs' spanning the N-terminal TRPM homology regions (MHRs), thus holding four subunits in a

220 for SV with breakpoints located in sequence homology regions.

221 In this study, based on homology search and phylogenetic analysis, we identified

222 pathway perhaps by contributing to the RecA homology search before ternary complex formation.

223 The low sensitivity on short read homology search can lead to inaccurate domain compositio

224 Homology search is still a significant step in functiona

225 -model species and metagenomic data, profile homology search is widely adopted in integrated pipeline

226 is a need for better methods to improve the homology search performance for short reads.

227 3' single-strand tails that participate in a homology search, ultimately forming double Holliday junc

228 homologous region on DNA, which is called a homology search.

229 the state-of-the-art methodology of profile homology search.

230 e phenomena may play in the RecA-facilitated homology search.

231 Homology searches with the structural subunits of known

232 lassified into four groups based on sequence homology (SEPT2, SEPT3, SEPT6, and SEPT7 groups).

233 Properdin, which lacks the structural homology shared by other complement pattern recognition

234 Thus, homology shorter than an apparent minimum efficient proc

235 cell wall polysaccharide (SCWP) via S-layer homology (SLH) domains.

236 Importantly, we identified K-Homology Splicing Regulatory Protein (KHSRP) as a negati

237 In this study, we have identified that K-homology splicing regulatory protein (KSRP), an ARE-BP,

238 particularly for targets that have no close homology templates.

239 ified tractable model, we identify different homology testing stages that naturally occur in the syst

240 mes share approximately 50% protein sequence homology, the membrane topology of VKOR is still in deba

241 Despite their large homology, the phosphate-specific OprP and the diphosphat

242 Despite high homology, the two integrins bind iC3b at multiple distin

243 ough the RSKs have a high degree of sequence homology, their functional differences in cancer are of

244 Despite functional similarity and structural homology, they exhibit low sequence identity.

245 egion in the rabies virus glycoprotein, with homologies to snake toxins, has the ability to alter beh

246 Simple BLAST searches may reveal homology to a known toxin, when in fact the protein may

247 whereas the C-terminal domain bears closest homology to a subdomain of 6-phosphofructokinase, an imp

248 y understood lysosomal membrane protein with homology to amino acid transporters.

249 17) now show that, in addition to using this homology to attach to ciliated cells, it activates human

250 and found that ImaA has a region with remote homology to bacterial integrin-binding proteins.

251 contain a C-terminal domain with significant homology to carnitine O-acyltransferase (cAT).

252 a Chlamydomonas reinhardtii HAP2 that reveal homology to class II viral membrane fusion proteins.

253 We describe a pseudogene sharing homology to exons 2 through 5 of human CD59 present in t

254 Candidates are proteins with homology to FinO, a factor that promotes base pairing be

255 model bacterium Bacillus subtilis shows high homology to genes encoding fibronectin-binding proteins

256 Many of the genes share homology to human genes and demonstrate the diverse arra

257 guard cell-expressed, secreted protein with homology to Hyp-rich cell wall proteins.

258 oantigens with differential presentation and homology to infectious disease-derived peptides identifi

259 s, including the cell adhesion molecule with homology to L1 (Chl1).

260 cosylated, and secreted heme peroxidase with homology to mammalian peroxidases.

261 antibody generated against a peptide without homology to mammalian sequences labeled a nonglycosylate

262 unconventional kinetochores with no apparent homology to model organisms suggests that more than one

263 AmOmpA exhibits predicted structural homology to OmpA of A. phagocytophilum (ApOmpA), an adhe

264 We show that despite homology to only a few amino acids of msRNAP, and the ab

265 development is difficult due to the lack of homology to other proteins and high-resolution structure

266 Interestingly, NCgl2760 lacks any motifs or homology to other proteins of known function.

267 prokaryotic pLGIC with excellent structural homology to other relevant channels sensitive to general

268 e-helix (6-TM) domain, which has no sequence homology to the canonical tetrameric K(+) channels and l

269 he LRTOMT gene, which encodes a protein with homology to the catecholamine methyltransferase COMT tha

270 d that they all share a fragment of DNA with homology to the genome of Bacteroides vulgatus.

271 Despite close sequence homology to the protease cathepsin L, the silicateins se

272 r-membrane pore complex (TraC and TraG) with homology to type IV secretion-like systems.

273 ng common C-terminal PDZ and C2 domains with homology to vertebrate active zone proteins Piccolo and

274 Three of the newly identified CPGs displayed homology to vertebrate proteins.

275 breadth and potency, and sequence/structural homology were observed between selected macaque cross-re

276 Based on homologies with components of the M. xanthus T4aPM and a

277 moellendorffii whose encoded proteins share homology with BBI inhibitory loops.

278 They often shared sequence homology with co-expressed genes and contained potential

279 in its Zf-GRF domain, a region sharing high homology with DDR proteins Topoisomerase 3alpha (TOP3alp

280 Persistent homology with graph filtration on alpha-gamma correlatio

281 Lyme disease because of their close genetic homology with humans and demonstration of all three phas

282 A lack of homology with known proteins has hindered attempts to de

283 reviously that NaStEP, a stigma protein with homology with Kunitz-type protease inhibitors, is essent

284 YonO shares very distant homology with msRNAPs, but no homology with single-subun

285 has 5'-to-3' exonuclease activity and shares homology with nucleases from other members of the Herpes

286 ase and phytase activities, it showed little homology with other known low-Pi-responsive HAD superfam

287 helix, as a consequence of its low sequence homology with other Kv family members.

288 A1 domain, demonstrating striking structural homology with other sequentially diverse KA1 domains.

289 Based on structural homology with other spliceosome subunits, and recent fin

290 ophore is a unique and enigmatic organ whose homology with roots, shoots, or neither of the two remai

291 s very distant homology with msRNAPs, but no homology with single-subunit polymerases.

292 KIN shares homology with SNF1/AMPKalpha, and yeast complementation

293 L142 N-terminal domain indicated significant homology with some characterized sugar acetyltransferase

294 uman FHRs that share sequence and structural homology with the alternative pathway complement inhibit

295 B (TmrAB), which not only shares structural homology with the antigen translocation complex TAP, but

296 Due to its significant homology with the force-activated titin kinase, smMLCK i

297 sequences located on the B chromosome shows homology with the gene coding for the CAP-G subunit of c

298 Although StnA has no significant sequence homology with the reported alpha/beta-fold hydrolases, i

299 equires only approximately 35 nucleotides of homology with the targeted locus to introduce edits rang

300 ongus operon, whose predicted products share homology with transcriptional regulators.