ライフサイエンスコーパス: homology domain

1 t of the CCM3 focal adhesion targeting (FAT) homology domain.

2 tein that contains a Cyclin A (CycA)-binding homology domain.

3 obular domain that has been termed the ICP27 homology domain.

4 th the DH domain but not with the pleckstrin homology domain.

5 a Dbl homology (DH) domain and a pleckstrin homology domain.

6 from its neighboring diffuse B-cell lymphoma homology domain.

7 AP is actively targeted in rods by its SNARE homology domain.

8 PR binding to the cytosolic C-terminal NudT9-homology domain.

9 ough a domain located within its myosin-tail homology domain.

10 e site for binding to BubR1's conserved Mad3 homology domain.

11 lysine endopeptidase activity via a NlpC/P60 homology domain.

12 and the regulator of the G protein signaling homology domain.

13 adixin-moesin (FERM) domain and a pleckstrin homology domain.

14 al myristolyation and the co-factor C (TBCC) homology domain.

15 have increased DNA binding through the runt homology domain.

16 usion regulator, Fus2p, which contains a Dbl-homology domain.

17 These effects are mediated by the DAB homology domain.

18 on domain, which binds to GABA(B2), and a H1 homology domain.

19 the N-terminal part of Kindlin-3 pleckstrin homology domain.

20 acceptor site (Tyr-438) within the plekstrin homology domain.

21 a C-terminal focal adhesion targeting (FAT) homology domain.

22 nd encode for proteins sharing a common MAGE homology domain.

23 (TPR) region capped by a cryptic pleckstrin homology domain.

24 the N-terminal beta-N-acetylglucosaminidase homology domain.

25 e assembly of proteins containing prohibitin homology domains.

26 with p115 RhoGEF involving their pleckstrin homology domains.

27 m2, which associate with the PM via plextrin homology domains.

28 )) through interaction with their pleckstrin-homology domains.

29 igomerize through self-interacting T1 and H1 homology domains.

30 directly to ROCK2 through its PH (Pleckstrin Homology) domain.

31 to membranes through an N-terminal PX (phox homology) domain.

32 ger domain and a pair of BAH (bromo adjacent homology) domains.

33 Here, we show that the calponin homology domain 1 (CH1), within the filamin A (FLNa) act

34 We found that Eps15-homology domain 1 (EHD1), a protein that associates with

35 is a multidomain protein containing a Munc13 homology domain 1 (MHD1).

36 o acid substitution in the cytokine receptor homology domain 1 of LEPR.

37 le alpha/Armadillo/Toll-Interleukin receptor homology domain 1 protein (SARM1) in Wallerian-like dege

38 al structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from t

39 VASP [vasodilator-stimulated phosphoprotein] homology domain 1) binding domains of Lpd and the host V

40 s, mediated by amino-terminal immunoglobulin homology domain 1, contribute to maintenance of the vasc

41 s fiber-associated protein, LIM and calponin-homology domains 1 (LIMCH1), which regulates NM-II activ

42 is composed of amino-terminal immunoglobulin homology domains 1 and 2 (IgD1 and IgD2).

43 prouty-related protein with an EVH [Ena/Vasp homology] domain 1) and NF1 (neurofibromatosis 1) genes

44 with the C-terminal extension of the formin homology domain 2 (FH2) domain of Fmn2, called FSI.

45 differential binding partners of the formin-homology domain 2 (FH2) of mDia1, mDia2, and mDia3, whic

46 y identified class of actin nucleators, WASp homology domain 2 (WH2) nucleators, use tandem repeats o

47 n cooperates with profilin and Spire, a WASP homology domain 2 (WH2) repeat protein, to stimulate ass

48 protein kinase A (PKA) pathway activates Src homology domain 2 containing protein tyrosine phosphatas

49 protein tyrosine phosphatase (SHP) 2 and Src homology domain 2-containing inositol phosphatase 1 (SHI

50 SIRP-alpha and downstream activation of Src homology domain 2-containing phosphatase-1.

51 We observed that ICAM-1 interacts with Src homology domain 2-containing phosphatase-2 (SHP-2), and

52 nding to DCIR induced phosphorylation of Src homology domain 2-containing protein tyrosine phosphatas

53 equence of FGFRL1 consists of a putative Src homology domain-2 (SH2)-binding motif adjacent to a hist

54 ing both heme oxygenase-1 (HO-1) and the Src homology domain-2 containing tyrosine phosphatase-1 micr

55 kinase with Ig and endothelial growth factor homology domains-2 (TIE2) receptor, protein kinase B, an

56 Select BCL-2 homology domain 3 (BH3) helices activate BAX directly by

57 achinery in early survivor cells using BCL-2 Homology Domain 3 (BH3) mimetic agents such as ABT-737,

58 e role of the proapoptotic B-cell lymphoma 2 homology domain 3 (BH3)-only protein BH3 interacting-dom

59 ecently identified that in response to Bcl-2 homology domain 3 (BH3)-only proteins and mitochondrial

60 We identify the endosome-based Eps15 homology domain 3 (EHD3) pathway as essential for cardia

61 ine rich, the hypothesis that it targets Src homology domain 3 (SH3) domains was tested, but mutation

62 tment of IRSp53 effector proteins to its Src homology domain 3 by promoting 14-3-3 binding in the vic

63 tic agents, such as fludarabine and the BCL2 homology domain 3 mimetic ABT-737.

64 studied the therapeutic potential of a BCL-2 homology domain 3 mimetic inhibitor, ABT-737.

65 bition of Bcl-xL by the small molecule Bcl-2 homology domain 3 mimetic, A-1331852, or Bcl-xL-specific

66 that adaptor protein containing a pleckstrin-homology domain, a phosphotyrosine-binding domain, and a

67 h the N-terminal actin depolymerizing factor homology domain (ADFH) domain of mAbp1.

68 rom that of other CDPKs; it has a pleckstrin homology domain adjacent to the kinase domain and two ca

69 the LR11 Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor (GGA)-binding m

70 inositide recognition through its pleckstrin homology domain all result in failure to build the later

71 Although the PX (phox homology) domain alone binds PI3P, we theorized that the

72 Gef3p contains a putative DH homology domain and a BAR/IMD-like domain.

73 t both a conserved surface on the pleckstrin homology domain and an intact TPR region are required fo

74 hanistically, AMOTL2 binds to AKT pleckstrin homology domain and interrupts AKT's membrane localizati

75 Pleckstrin homology domain and leucine rich repeat protein phosphat

76 In this study, we identified pleckstrin homology domain and leucine-rich repeat protein phosphat

77 nd that BCAP has a functional N-terminal TIR homology domain and links TLR signaling to activation of

78 of ANTI-SILENCING 1 (ASI1), a bromo-adjacent homology domain and RNA recognition motif-containing pro

79 d in and adjacent to both the N-terminal Rel homology domain and the C-terminal transactivation domai

80 ractions between the diffuse B-cell lymphoma homology domain and the pleckstrin homology domain of Cb

81 y, epsin binds Dvl2 via its epsin N-terminal homology domain and ubiquitin-interacting motifs and pro

82 e RNA binding protein owing to two central K-homology domains and a C-terminal arginine-glycine-glyci

83 ear motifs through its MATH (meprin and TRAF homology) domain and forms higher-order oligomers throug

84 cue, we demonstrate that both the GEF (CDC25 homology domain) and RA2 domains of PLC are required for

85 domains, a GTPase-like domain, a pleckstrin homology domain, and an ArfGAP domain, and exists as a c

86 similar to PLCdelta1, it lacks a pleckstrin homology domain, and it remains unclear how PLCzeta targ

87 mbrane topology of their conserved reticulon homology domain, and scaffolding, arising from the abili

88 ding to basic residues in the Akt pleckstrin homology domain, aPKCs lack this domain.

89 ntified two regions on its double-pleckstrin homology domain architecture that mediated histone bindi

90 the membrane-bound O-acyltransferase (MBOAT) homology domain are segregated on opposite sides of the

91 iated by its 2 amino-terminal immunoglobulin homology domains, are essential for concentrating PECAM-

92 ne kinase family with immunoglobulin and EGF homology domains, are receptor tyrosine kinases found pr

93 , we identified the lipid-binding pleckstrin homology domain as being responsible for the differentia

94 pulldown analyses identified Akt1 pleckstrin homology domain as the interactive domain.

95 for its GEF activity, whereas the pleckstrin homology domain assists in the PX-mediated activity.

96 calization of mTORC2 via the Sin1 pleckstrin homology domain at the plasma membrane is PI3K and growt

97 cochleas in mice lacking the critical Bcl-2 homology domain (BH-3) inducers of p53- and p63-mediated

98 Noxa is a Bcl-2-homology domain (BH3)-only protein reported to be a proa

99 ports that Pob3 and Rtt106 double pleckstrin homology domains bind histones H3-H4, we also find that

100 e FAK-FERM (band 4.1, ezrin, radixin, moesin homology) domain bound directly to GATA4 and enhanced it

101 on promotes ASK1 activity via its pleckstrin homology domain but also facilitates ASK1 autoinhibition

102 ngement is not the F-BAR domain or the micro-homology domain, but rather is an uncharacterized 90 ami

103 cent region of the cyclic nucleotide-binding homology domain, can fully account for the differential

104 e C-terminal region of p130Cas or Cas family homology domain (CCHD) has been reported to adopt a stru

105 The C-terminal homology domain (CHD) of Af4 was sufficient to confer th

106 ter anaphase and is mediated by the calponin homology domain (CHD) of Iqg1, but the regulatory mechan

107 Hec1/Ndc80 also contains a calponin homology domain (CHD) that increases its affinity for mi

108 hannels contains a cyclic-nucleotide-binding homology domain (CNBHD) and C-linker that couples the CN

109 region contains a cyclic nucleotide-binding homology domain (CNBHD), which is connected to the pore

110 The structure of an Eps15/RFcho1 mu-homology domain complex reveals a spacing-dependent DPF

111 We identified PRDI-BF1 and RIZ homology domain containing 8 (PRDM8) as a highly conserv

112 PLEKHA7 (pleckstrin homology domain containing family A member 7) has been f

113 The Src homology domain containing phosphatase 2 (SHP2) and the

114 Herein, we show that Pleckstrin homology domain containing protein family member 1 (PLEK

115 een we identified the fly homologue of Eps15 homology domain containing protein-binding protein 1 (dE

116 growth factor receptor pathway substrate 15)-homology domain containing proteins (EHDs) comprise a fa

117 The Eps15-homology domain-containing (EHD) protein family comprise

118 Members of the four-member C-terminal EPS15-Homology Domain-containing (EHD) protein family play cru

119 others, which function together with EPS-15 homology domain-containing (EHD) proteins in non-T cell

120 Eps15 homology domain-containing 2 (EHD2) belongs to the EHD-c

121 inhibit Rac1 and activate a RhoA-ROCK-Formin homology domain-containing 3 (FHOD3) pathway and generat

122 this study, we provide evidence that the Src-homology domain-containing adaptor Nck1 negatively regul

123 s (LNPs) encapsulating osteogenic pleckstrin homology domain-containing family O member 1 (Plekho1) s

124 ophage leads to activation of the pleckstrin homology domain-containing guanine-nucleotide exchange f

125 Among them, the formin homology domain-containing protein (FHOD) family of form

126 Here, we identify a pleckstrin homology domain-containing protein (PHLDB3)-encoding gen

127 tations in PRDM12 (encoding PRDI-BF1 and RIZ homology domain-containing protein 12) in subjects with

128 We previously linked the C-terminal Eps15 homology domain-containing protein 3 (EHD3) with endosom

129 with coiled-coil, Ank repeat, and pleckstrin homology domain-containing protein ACAP2 as an Rab35 eff

130 We show that Pleckstrin homology domain-containing protein family member 1 (PLEK

131 nhsl1b encodes a WAVE-homology domain-containing protein related to human Nanc

132 ol of PI-4P specifically recruits pleckstrin homology domain-containing proteins involved in lipid tr

133 PIP3 recruits pleckstrin homology domain-containing proteins to the membrane to a

134 Biology, Lu et al. (2015) identify two Eps15-homology-domain-containing proteins as critical effector

135 ntain a C-terminal cyclic nucleotide-binding homology domain coupled to the pore of the channel by a

136 llular domain of VEGFRs consists of seven Ig homology domains; domains 1-3 (D1-3) are responsible for

137 lular receptor domain (ECD) consists of 7 Ig-homology domains; domains 2 and 3 (D23) represent the li

138 rminal domain and the cytohesin-3 pleckstrin homology domain, each tagged with enhanced green fluores

139 to the hypothesis that the C-terminal Eps15 homology domain (EHD) ATPase proteins are involved in th

140 n of the "pinchase" EHD1, a C-terminal Eps15 homology domain (EHD) ATPase, also induced hypertubulati

141 nserved membrane-remodeling C-terminal Eps15 Homology Domain (EHD) protein Past1 is required for the

142 cell lines to investigate the role of Eps15 Homology Domain (EHD) proteins at the neck of caveolae.

143 The C-terminal Eps15 homology domain (EHD)-containing proteins have been impl

144 The epsin N-terminal homology domain (ENTH) is a major player in clathrin-med

145 sing the endocytic protein epsin1 N-terminal homology domain (ENTH), previously thought to drive fiss

146 the basic helix-loop-helix PAS (Per-Arnt-Sim homology domain) family known to mediate the toxic and c

147 rough a C-terminal KASH (Klarsicht/Anc1/Syne homology) domain (Figure 1A) [1-4].

148 of a long helical stalk with the pleckstrin homology domain flexibly attached on its opposing end.

149 ion on four serine acceptor sites in the Rel homology domain for the expression of an array of NF-kap

150 lsolin in the linker region between gelsolin homology domains G3 and G4, which, in the absence of cal

151 uct containing the juxta-membrane and kinase homology domain harbored an exclusive binding site for G

152 ver direct interaction between CCM2 harmonin homology domain (HHD) and the N terminus of MEKK3, and d

153 h phospholipid binding in related pleckstrin homology domains, however, suggests that ISPs do not ret

154 to the PX domain, a region in the pleckstrin homology domain (Ile-306-Ala-310) aids in the PX-mediate

155 In place of the pleckstrin homology domain in dynamin, however, Drp1 contains an un

156 absence of a recognized G protein signaling homology domain in Rgnef, no proximal linkage to G prote

157 merization domains, but also included a phox-homology domain in the converter region.

158 gin-Cullin E3 ligase complex via a ubiquitin-homology domain in the Ela1 protein.

159 of yeast Sac1, containing the conserved Sac1 homology domain, in complex with Vps74, a phosphatidylin

160 ith an N-terminal F0 domain and a pleckstrin homology domain inserted in the F2 domain.

161 dynamics simulations of the epsin N-terminal homology domain interacting with a lipid bilayer and dem

162 assessed the prognostic impact of pleckstrin homology domain-interacting protein (PHIP) copy number a

163 e, we show that the activation of Pleckstrin homology domain-interacting protein (PHIP), promotes mel

164 -associated regulator of G-protein signaling homology domain-interacting protein), a component of the

165 Moreover, we found that the Sti Citron-Nik1 homology domain interacts with RhoA regardless of its st

166 al interactions that tether the two calponin homology domains into a closed ABD conformation.

167 mitochondria, and the C-terminal pleckstrin homology domain is associated with the plasma membrane.

168 We show that the mu-homology domain is dispensable for COPI function in the

169 epends on its last 145 residues, and the DBL-homology domain is important for its function in cytokin

170 demonstrate that the Arg C-terminal calponin homology domain is necessary and sufficient to increase

171 The SUN (Sad1-UNC-84 homology) domain is conserved in a number of nuclear env

172 KinG is a calponin homology domain kinesin that directly interacts with the

173 -homocysteine mixed disulfide bonds within K-homology domains known to interact with mRNA.

174 Here we show that the pleckstrin homology domain leucine-rich repeat protein phosphatase

175 he hydrophobic motif phosphatase, pleckstrin homology domain leucine-rich repeat protein phosphatase

176 he recent discovery of the PHLPP (pleckstrin homology domain leucine-rich repeat protein phosphatase)

177 regulatory factor 1 (NHERF1) and pleckstrin-homology domain leucine-rich repeat protein phosphatases

178 dephosphorylation of Akt through pleckstrin homology domain leucine-rich repeats protein phosphatase

179 e phospholipid binding profile of pleckstrin homology domain localizing mutations.

180 phosphate [PtdIns(4,5)P(2)] via a pleckstrin homology domain located in the myo1c tail, which is impo

181 9 including the mannose 6-phosphate receptor homology domain mediates the association with Hrd3 in vi

182 These behaviors require a pleckstrin homology-domain membrane tether and a WD40 clustering do

183 interesting challenge given that their motor homology domain (MHD) cannot bind ATP.

184 st the core and N terminus of the Vik1 motor homology domain (MHD).

185 PARP13 features a divergent PARP homology domain missing a PARP consensus sequence motif;

186 ibit actin binding by latching both calponin homology domains more tightly.

187 The mu-homology domain (muHD) of FCHO2 binds directly to DPF se

188 hese adaptors bind cargo via a C-terminal mu-homology domain (muHD); however, few cargoes exhibiting

189 ns increased kinase activity, and pleckstrin homology domain mutants exhibited enhanced phospholipid

190 Numerous proteins possess Nudix homology domains (NHDs) that have no known function.

191 hat contained a deletion of all of the Bcl-2 homology domains, none of which impacted anti-CIS capabi

192 re of the C-linker/cyclic nucleotide-binding homology domain of a mosquito ERG channel at 2.5-A resol

193 interacted specifically with the pleckstrin homology domain of BchC1.

194 In vitro, the pleckstrin homology domain of Cb binds phosphoinositides, specifica

195 ense mutation in the diffuse B-cell lymphoma homology domain of Cb, which carries the guanine nucleot

196 lymphoma homology domain and the pleckstrin homology domain of Cb.

197 ts active, GTP-bound state to the pleckstrin homology domain of Cb.

198 are comparable with those of the pleckstrin homology domain of cytohesin-3 (general receptor for pho

199 The pleckstrin homology domain of dynamin is essential for targeting to

200 Hook proteins, which resembles the calponin-homology domain of end-binding (EB) proteins but cannot

201 d that the Tudor domain of Esa1 and the EPcA homology domain of Epl1 play critical roles in Piccolo N

202 ol 4,5-bisphosphate, binds to the pleckstrin homology domain of GEP100.

203 ion to kinetochores depended on the calponin homology domain of HEC1 but not on Aurora B-dependent ph

204 gene consists of the Tec homology-pleckstrin homology domain of ITK and the kinase domain of SYK, and

205 Moreover, deletion of the pleckstrin homology domain of kindlin-1 also failed to rescue elect

206 This interaction involves the pleckstrin homology domain of kindlin-3 and blades 5-7 of RACK1.

207 rminal region of HDA6 and the bromo-adjacent homology domain of MET1 were responsible for the interac

208 s with multiple CESA proteins through the mu-homology domain of mu2, which is involved in specific in

209 In contrast, mutations in the calponin homology domain of Ndc80 abrogated kinetochore function

210 tivation of the mannose 6-phosphate receptor homology domain of OS9 had no effect on its action on NK

211 tional analysis revealed that the pleckstrin homology domain of P-Rex1 is required.

212 Herein, we show that the pleckstrin homology domain of p63RhoGEF is not involved in its PM t

213 d the effects of K-to-Q mutations in the REL homology domain of p65 on the response to IL-1beta in 29

214 The crystal structure of the PARP homology domain of PARP13 shows obstruction of the canon

215 5 interacts specifically with the pleckstrin homology domain of PDK1 and impairs formation of a PDK1/

216 s, such as the PI(4,5)P2-specific pleckstrin homology domain of phospholipase Cdelta1 (PHPLCdelta1),

217 oop motif located on the surface of the RecA homology domain of RAD51.

218 ppaB through direct interaction with the Rel homology domain of RelA.

219 previous report, the actin-binding calponin homology domain of Rng2p is not required for viability,

220 p and the nucleosome binding, Bromo-Adjacent-Homology domain of Sir3p.

221 Slm1, can be bypassed by fusing the plextrin homology domain of Slm1 alone onto Ypk1, demonstrating t

222 ransforming point mutation in the pleckstrin homology domain of the Akt1 oncoprotein.

223 Walker A motif, KNRXG motif and Lon protease homology domain of the Escherichia coli RadA protein are

224 substitution R145C within the conserved TNF-homology domain of the full-length protein.

225 f instances the mannose 6-phosphate receptor homology domain of the gamma subunit is required for opt

226 ted membrane translocation of the pleckstrin homology domain of the kinase Akt and thus augmented dow

227 is approximately 75 nm outside the calponin homology domain of the Ndc80 complex.

228 The prohibitin homology domain of the slit diaphragm protein podocin co

229 e present the structure of the C-terminal mu-homology domain of the yeast delta-COP subunit in comple

230 YOD1 binds to the C-terminal TRAF homology domain of TRAF6 that also serves as the interac

231 rin by interacting directly with the Epsin15 homology domains of Eps15 and intersectin-1.

232 Three-dimensional alignment of the PARP homology domains of PARP13, PARP12, and PARP15 illustrat

233 ding to the KASH (Klarsicht, ANC-1, and Syne homology) domain of nesprin 2, and the regions involved

234 The third and fourth KH (hnRNP K homology) domains of ZBP1 specifically recognize a bipar

235 ted X protein, BAX) cooperate with the BCL-2 homology domain only (BH3-only) subclass (e.g. BCL-2 int

236 patches when it was attached to a pleckstrin homology domain or a CAAX motif.

237 ith tandem phospholipase C-delta1 pleckstrin homology domains or by co-expression with wild-type Galp

238 ire Net1A catalytic activity, its pleckstrin homology domain, or its regulatory C terminus.

239 Two conserved histidine residues in the OSBP homology domain ORP4 are essential for binding phosphati

240 mong the Akt isoforms in both the pleckstrin homology domain (P domain) and regulatory domain (R doma

241 a protein from the src homology and collagen homology domain (p66Shc) and reduced the expression of s

242 ositol-4,5-bisphosphate using the pleckstrin-homology domain (PHD) and engage in rapid membrane fissi

243 -terminal tail that appends the conserved PL homology domain (PHD) and is important for function.

244 y direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinositol 3,4,5-tri

245 y direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinositol 3,4,5-tri

246 ses detect large movements of the pleckstrin homology domain (PHD) from a 'closed' conformation docke

247 sing the N-terminal to C-terminal pleckstrin homology domains (PHn-PHc), are auto-inhibited.

248 APPL1 (adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leuc

249 d sensor, phospholipase C delta 1 pleckstrin homology domain (PLC delta1-PH), is completely inhibited

250 gi PI-4P that was detected with a pleckstrin homology domain probe.

251 High expression of the formin homology domain protein 1 outlines the LC population.

252 lts indicate human LCs (SIRPalpha(+), formin homology domain protein 1(+), CD8alpha/alpha(+), CD34(-)

253 te meiotic spindle assembly are the calponin homology domain protein encoded by aspm-1, the katanin f

254 le alpha/Armadillo/Toll-Interleukin receptor homology domain protein) cell-autonomously suppresses Wa

255 le alpha/Armadillo/Toll-Interleukin receptor homology domain protein) gene, a key mediator of Walleri

256 d vesicular membranes decorated by the Eps15 homology domain protein, EHD1, is responsible for recept

257 he lipid-binding specificity of a pleckstrin homology domain protein.

258 , which lie between the motor and pleckstrin homology domains, reduced the instantaneous velocity of

259 Tuberin contains a RapGAP homology domain responsible for inactivation of Rheb, bu

260 impaired inhibition by the TGEF2 pleckstrin-homology domain, resulting in dramatically increased TGE

261 GEF (Sec7) and membrane-binding (pleckstrin homology) domains, revealing that it has a constitutivel

262 Both MsRel2A and MsRel2B contain only a Rel homology domain (RHD) and lack the ankyrin-repeat inhibi

263 sexta Fkh (MsFkh) interacted with Relish-Rel-homology domain (RHD) but not with Dorsal-RHD.

264 ain and the regulator of G protein signaling homology domain (RHD) is highly correlated with establis

265 LRR domain of LRRC25 interacted with the Rel Homology domain (RHD) of p65/RelA and promotes the degra

266 nforeseen structural similarity with the Rel homology domain (RHD) of the mammalian transcription fac

267 wn activity of RUNX1 required an intact runt homology domain (RHD), a domain where most leukemia-asso

268 Reticulon/DP1 proteins contain reticulon homology domains (RHDs) that have unusually long hydroph

269 The expression of the runt homology domain, RUNX1(41-214), in mouse hematopoietic c

270 r proteins and BSLs attach via their S-layer homology domains (SLH) to the secondary cell wall polysa

271 he envelope of B. anthracis requires S-layer homology domains (SLH) within S-layer proteins and S-lay

272 ent the first crystal structure of the ICP27 homology domain, solved to 1.9 A resolution.

273 talin-Hip1/R/Sla2 actin-tethering C-terminal homology domain, suggesting that clc1-Delta19-76 promote

274 nction in embryos and human cells via a TIKI homology domain that is conserved from bacteria to mamma

275 and -16 contain an additional C-terminal H2 homology domain that is not sequence-related to the H1 d

276 Vik1 contains a motor homology domain that retains microtubule binding propert

277 e canonical Dbl homology (DH) and pleckstrin homology domains that carry out the guanine nucleotide e

278 These propeptides flank the central VEGF homology domain, that contains the binding sites for VEG

279 Although the TNF homology domain (THD) of human (h)4-1BBL forms non-coval

280 n TNF ligands (scTNF) comprised of three TNF homology domain (THD) protomers that mimic tmTNF.

281 Along with an N-terminal pleckstrin homology domain, the central domain affects neurite outg

282 -783 in the beta1 tail, and that the Arg Src homology domain then engages this phosphorylated region

283 Vam6p binds through its clathrin heavy chain homology domain to a unique region of MCV LT adjacent to

284 ly "opens" CB2SH3+ and allows the pleckstrin homology domain to properly bind lipids depending on the

285 nstead requires a neighboring PH (Pleckstrin Homology) domain to achieve these functions.

286 n neurons, which initiate expression of Runt homology domain transcription factor RUNX1 and the nerve

287 y eps8 siRNA or overexpression of pleckstrin homology domain-truncated Eps8 (i.e. 261-p97(Eps8)) decr

288 In contrast, substitutions in the kinase homology domain, W708R and I734T, linked to Leber congen

289 that the RNA-binding protein PumHD (Pumilio homology domain), which has been widely used in native a

290 Fragments of CynA lacking the pleckstrin homology domain, which are normally found in the cytosol

291 its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FA

292 in containing a mannose-6-phosphate receptor homology domain, which is also found in yeast and mammal

293 ffects a highly conserved residue in the DBL homology domain, which is required for the interaction a

294 av activity through stabilization of the Dbl homology domain, which is responsible for exchange activ

295 ue to a lack of the lipid-binding pleckstrin homology domain, which is used for lipid-mediated regula

296 interacts with PI(4,5)P2 via its pleckstrin homology domain, which may guide its subcellular localiz

297 c motor domain and a Vik1/Cik1 partner motor homology domain whose interactions with microtubules are

298 interaction of the adhesion of a pleckstrin homology domain with phosphatidylinositol 4,5-bisphospha

299 (PM) via the interaction of their pleckstrin homology domains with phosphatidylinositol 4-phosphate (

300 nvolves the N-terminal subdomain of the Sac1 homology domain, within which mutations in the related S