ライフサイエンスコーパス: homology region

1 s 114 to 176, directly centered on the major homology region.

2 ith PGC-1alpha via its activation function-2 homology region.

3 mouse and the corresponding human 11p14-p15 homology region.

4 tivated upon deletion of the entire calponin-homology region.

5 mosome 19 and the human chromosome 10q23-q26 homology region.

6 f the molecule located just after the yotiao homology region.

7 in and the C-terminal germinal center kinase homology region.

8 stinct domain lying adjacent to the TSC2 GAP homology region.

9 eside 18 cM proximal to the ACE locus in the homology region.

10 in or in the C-terminal section of the major homology region.

11 e to identify transcripts containing the tau homology region.

12 c protein synthesis initiation factor 2alpha homology region.

13 increase in vivo with truncation of the gRNA homology regions.

14 they appear outside previously noted kinase homology regions.

15 the C-terminal domains of the NF-kappaB Rel homology regions.

16 ished by their PER, AHR, ARNT, and SIM (PAS) homology regions.

17 for SV with breakpoints located in sequence homology regions.

18 ins another short conserved sequence, the En homology region 1 (eh1)/GEH motif, that is likely to pla

19 ology 3 (SH3) domain and a G protein-binding homology region 1 (HR1) domain.

20 ced apoptosis are clustered within the Bcl-2-homology regions 1 and 2 (BH1 and BH2 regions).

21 are Bcl-2 family members which contain Bcl-2 homology regions 1, 2, and 3 (BH1, BH2, and BH3), which

22 Each contains a Dock homology region-1 (DHR-1) domain that is required to loc

23 bility in a hinge region within the cytokine homology region 2 (CHR2) that is connected to rigid memb

24 use either the Dbl homology (DH) or the DOCK homology region 2 (DHR-2) catalytic domain.

25 rk oncogene product consist primarily of Src homology region 2 (SH2) and 3 (SH3) domains.

26 gene product are composed exclusively of Src homology region 2 (SH2) and SH3 domains.

27 Here, we report that Src homology region 2 (SH2) domain-containing phosphatase 1

28 we show that binding is mediated via the Src homology region 2 (SH2)-containing inositol phosphatase

29 embrane region, myristylation sites, and Src homology region 2 and 3 domains.

30 with similarity to mouse Whdc1 (WAS protein homology region 2 domain containing 1) and human JMY pro

31 n of inhibitory effectors (such as CD22, Src homology region 2 domain containing phosphatase 1, and S

32 A mutation within the Src homology region 2 domain of mutant p85 (Deltap85) preven

33 The role of tyrosine phosphatase Src homology region 2 domain-containing phosphatase (SHP)-1

34 lar importance, the key immune regulator src homology region 2 domain-containing phosphatase 1 (SHP-1

35 t study, we investigated the role of the Src homology region 2 domain-containing phosphatase 1 (SHP-1

36 Phosphatase Src homology region 2 domain-containing phosphatase 1 (SHP-1

37 Src homology region 2 domain-containing phosphatase 1 (SHP-1

38 ify the cytoplasmic tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1 (SHP-1

39 The tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1 (SHP-1

40 a selective increase in the activity of Src homology region 2 domain-containing phosphatase 1 (SHP-1

41 the tyrosine kinase Lyn, the phosphatase Src homology region 2 domain-containing phosphatase 1 (SHP1)

42 d that approximately 10- to 16-fold more Src homology region 2 domain-containing phosphatase 1 (SHP1)

43 Deficiency in Src homology region 2 domain-containing phosphatase 1/protei

44 activator of transcription 3 and induced Src homology region 2 domain-containing phosphatase 2 (SHP2)

45 everal tumor suppressor genes, including Src homology region 2 domain-containing phosphatase-1 (SHP-1

46 ctivation correlated with recruitment of Src homology region 2 domain-containing phosphatase-1 (SHP-1

47 ophilin (SPL), the tyrosine phosphatase, Src homology region 2 domain-containing phosphatase-1 (SHP-1

48 We found that the abrogation of Src homology region 2 domain-containing phosphatase-1 (SHP-1

49 tein kinase A-mediated activation of the Src homology region 2 domain-containing phosphatase-1 (SHP-1

50 We show that Src homology region 2 domain-containing phosphatase-1 (SHP-1

51 e revealed that the tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1 (SHP-1

52 ietic protein tyrosine phosphatase (PTP) Src homology region 2 domain-containing phosphatase-1 (Shp-1

53 These results indicate that the Lyn-CD22-Src homology region 2 domain-containing phosphatase-1 inhibi

54 lation of its ITIM motifs and subsequent Src homology region 2 domain-containing phosphatase-1 recrui

55 ibitor, as well as the novel DPC protein Src homology region 2 domain-containing phosphatase-1, was a

56 naling pathways because of activation of Src homology region 2 domain-containing phosphatase-1, which

57 Indeed, Src homology region 2 domain-containing phosphatase-2 has a

58 ppresses tyrosine phosphorylation of the Src homology region 2 domain-containing phosphatase-2/protei

59 encoding a dominant negative isoform of Src homology region 2 domain-containing tyrosine phosphatase

60 We fused the inter-Src homology region 2 of the regulatory p85alpha subunit of

61 activity originating from its DHR2 (for DOCK homology region 2) domain.

62 The dimerization domain (nervy homology region 2) of ETO is responsible for the reduced

63 within the protein tyrosine phosphatase Src homology region 2, phosphatase 2 (SHP2) are responsible

64 ent of the protein tyrosine phosphatase, Src homology region 2-containing protein tyrosine phosphatas

65 Recently, the tyrosine phosphatase Src homology region 2-containing protein tyrosine phosphatas

66 Src homology region 2-containing protein tyrosine phosphatas

67 type protein tyrosine phosphatase SHP-2 (src homology region 2-domain phosphatase-2), cause NS, accou

68 nine amino acid region similar to the Bcl-2 homology region 3 (BH3) domain but does not contain a BH

69 also contains a region similar to the Bcl-2 homology region 3 (BH3) domain that allows Mule to speci

70 ach with a hydrophobic pocket in which Bcl-2 homology region 3 (BH3) helices bind.

71 ntaining a conserved region designated Bcl-2 homology region 3 (BH3) were sufficient for specific bin

72 The src homology region 3 (SH3) domain-bearing protein Bem1p and

73 of Nef with this motif is similar to the Src homology region 3 (SH3) ligand domain found in many cell

74 g studies on peptides derived from the Bcl-2 homology region 3 of proapoptotic family members indicat

75 s, in which the BH3-domain-containing (Bcl-2 homology region 3) protein EGL-1 binds the cell-death in

76 three unique domains including a myosin tail homology region 4 (MyTH4), a talin-like domain, and a ca

77 o zinc fingers contained in C-terminal Nervy homology region 4 (NHR4) of ETO.

78 n internal region overlapping with the G box-homology region (a putative G protein-interacting site).

79 It has a DD homology region, a box-B-like ring finger, and a zinc fi

80 sed of three domains: an amino-terminal SacI homology region, a central inositol 5'-phosphatase homol

81 inal domain of N-WASP containing a verprolin-homology region, a cofilin-homology sequence, and an aci

82 mology domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal

83 s of four highly conserved sites in this FHA homology region abolishes the KI domain's interaction wi

84 Deletion of either alpha-homology region (amino acids 29-55 or 226-267) from the

85 step involved in RNA release, while the Rif homology region, amino acids 455 to 521, interacts with

86 ORF1 encoded a retrovirus-like major homology region and a Cys/His box motif, also present in

87 l assembly into particles; both the CA major homology region and the adjacent C-terminal CA sequences

88 and its donor template share a 108-base-pair homology region and the donor carries different densitie

89 of TSP-1 has been mapped to the procollagen homology region and the type 1 repeats (TSR) using synth

90 erin beta3 contains two putative Ran-binding homology regions and bound to Ran-GTP in a solution-bind

91 of targeting DNA encompassing both flanking homology regions and the marker into hDNA.

92 gy region, a central inositol 5'-phosphatase homology region, and a carboxyl-terminal proline-rich re

93 n SH3 domain, a Cdc42-binding region, a Ralt homology region, and a proline-rich region.

94 cell cycle-dependent element/cell cycle gene homology region, and p53-binding sites.

95 ticular, hydrophobic residues near the major homology region are partially buried in HTLV-I CA, which

96 ecisely when conserved residues in the major homology region are required during assembly, these stud

97 Highly conserved residues in the major homology region are required for assembly of retroviruse

98 The 149 amino acids derived from the KLC homology region are required for colocalization of the t

99 proteins, defined by the presence of 'formin homology' regions, are important for a number of actin-d

100 pairs into delta-rec, primers derived from a homology region between human and mouse led to the detec

101 The three functionally important Bcl-2 homology regions (BH1, BH2 and BH3) are in close spatial

102 nding on RetGC1 requires not only the kinase homology region but also directly involves the dimerizat

103 ed the 55-amino acid carboxyl-terminal TALIN homology region but not the leucine zipper domain.

104 irst indication that regions outside the Rel Homology Region can participate in the control of bindin

105 cts the complex to promoter cell cycle genes homology region (CHR) elements.

106 The cell cycle genes homology region (CHR) has been identified as a DNA eleme

107 that IL-6/IL-Ralpha and the cytokine-binding homology region (CHR) of gp130 (D2D3) form a stable trim

108 ent elements (CDEs), and one cell cycle gene homology region (CHR), typically found in G2-M-expressed

109 amino acids 1-450, including the coiled-coil homology region) completely abolished the formation of o

110 in subfamily a, 8E) and WHDC1L1 (WAS protein homology region containing 1-like 1) and have further ch

111 at contains FADD/Mort1 death effector domain homology regions, designated FLAME-1.

112 In particular, the major homology region does not contribute to defining particle

113 d PI(3,4,5)P(3), was fused to the photolyase homology region domain of CRY2, and the CRY2-binding dom

114 d linear donors with extremely short (50 bp) homology regions drive transgene integration into 5-10%

115 an ancillary N-terminal domain, the Extended Homology Region (EHR), endow maf proteins with unique DN

116 inding is directed via CHR (cell cycle genes homology region) elements.

117 ement pathway in which incorporation of both homology regions from a single strand of targeting DNA i

118 more complete understanding of how the major homology region functions.

119 ccharomyces cerevisiae EF-3 (spanning the S5 homology region) has been cloned, expressed, and purifie

120 EpsC is periplasmic, containing a so-called homology region (HR) domain and a PDZ domain.

121 with gp130 domains 2 and 3 (cytokine-binding homology region), identified a variant, VI120EE, that wa

122 p interacts directly with Hsp82p via its p23 homology region in a nucleotide-dependent manner.

123 determined the solution structure of the RBD homology region in ALY by nuclear magnetic resonance met

124 has been assembled that extends from the XY homology region in Xq21.3 to proximal Xq24, approximatel

125 irected mutagenesis of the BH1, BH2, and BH3 homology regions in Bax to determine the ability of wild

126 ealing, cloned junctions map to four of five homology regions in subtelomeric DNA.

127 le Forkhead-binding elements within two high homology regions in the Itgb3 promoter.

128 We show that the photolyase-homology region interacts with the C-terminal domain, in

129 Dephosphorylation of the NFAT homology region is critical for NFAT nuclear translocati

130 The homology region is likely to reside on human chromosome

131 f 6 amino acids at the C terminus of the Rel-homology region is necessary for nuclear localization.

132 This homology region is preceded by an N-terminal extension a

133 however, one region of Gag, termed the major homology region, is conserved among all retroviruses and

134 copies of highly conserved protein kinase C homology regions known as the C2A and C2B domains, acts

135 of the eukaryotic initiation factor 2-alpha homology region, mapping to the 34 aa within the sixth P

136 We propose that the C-terminal Mig6 homology region (MHR) (residues 802-990) participates in

137 eromultimers using a region containing major homology region (MHR) and zinc knuckle (CCHC) motifs, se

138 ransposons but which is similar to the major homology region (MHR) described for retrovirus CA.

139 different interface that includes the major homology region (MHR) has been suggested as the function

140 are divergent except in the 20-residue major homology region (MHR) in the CTD.

141 The major homology region (MHR) is a highly conserved motif that i

142 The major homology region (MHR) is a highly conserved sequence in

143 s with amino acid substitutions in the major homology region (MHR) of CA.

144 The most conserved region of CA, the major homology region (MHR), has been implicated in both immat

145 arbors a conserved sequence motif, the major homology region (MHR), in the otherwise highly variable

146 A, approximately 20 amino acids of the major homology region (MHR), lies within the carboxy-terminal

147 ow that CA sequences N terminal to the major homology region (MHR), which form a distinct domain, are

148 s a stretch of 20 residues, called the major homology region (MHR), which is conserved across retrovi

149 ghly conserved structural element, the major homology region (MHR), within the carboxyterminal domain

150 highly conserved subdomain termed the major homology region (MHR).

151 highly variable Gag protein called the major homology region (MHR).

152 The major homology region (MHR, aa 285-304), a highly conserved se

153 helical 'ribs' spanning the N-terminal TRPM homology regions (MHRs), thus holding four subunits in a

154 i) Regions containing zinc knuckle and major homology region motifs, characteristic of retroviral Gag

155 terestingly, capsid proteins of mature major homology region mutant particles could be cysteine cross

156 In at least one major homology region mutant, Ty3 protein concentrated in foci

157 ion of the fusion protein includes the nervy homology region (NHR) 3 domain, which shares homology wi

158 volutionarily conserved domains termed nervy homology regions (NHR) 1-4.

159 ll-length N protein containing the Toll-IL-1 homology region, nucleotide binding site, and LRR, is mo

160 The N gene, a member of the Toll-IL-1 homology region-nucleotide binding site-leucine-rich rep

161 o N gene, a member of the Toll-interleukin 1 homology region/nucleotide binding site/leucine-rich rep

162 that the conserved BH3, but not BH1 or BH2, homology region of Bax is necessary for its interaction

163 kyrin domain for its binding site on the Rel-homology region of CSL, enabling docking of the ankyrin

164 he presence of a 93-bp exon in the PI kinase homology region of DNA-PKcs that was not present in the

165 ried out by regions within the conserved Rel-homology region of Dorsal.

166 nst 23 amino acids, representing the highest homology region of eubacterial transducers.

167 in a 10-codon segment overlapping the major homology region of Fv1; this segment is known to be invo

168 fusion protein that contains only the TALIN homology region of HIP1 fused to PDGFbetaR is incapable

169 possible three-dimensional structure for the homology region of IF3chl has been modeled using the X-r

170 that required the predicted integrin-binding homology region of ImaA.

171 maturity-onset diabetes of the young (MODY2) homology region of mouse chromosome 11 (logarithm of odd

172 ith PKR did not require the C-terminal DNA-J homology region of P58IPK but was dependent on the prese

173 1, whereas 149 residues derived from the KLC homology region of PAT1 are important for binding to Us1

174 he three flexibly linked segments of the rel homology region of Rel/NF-kappaB proteins (the nuclear l

175 neither the p53-binding region nor the Bcl-2 homology region of T antigen was sufficient to prevent c

176 Mutants with mutations in the J-domain homology region of TAg are defective for altering p130 a

177 We further demonstrate that the J-domain homology region of TAg confers a growth advantage to wil

178 hybrid assay that the entire Tetrahymena p80 homology region of TEP1 is required for its interaction

179 Expression of a CP2 mutant lacking the Elf-1-homology region of the DNA-binding domain inhibited IL-4

180 the conserved Enhancer of Polycomb A (EPcA) homology region of the Epl1 component and the N-terminal

181 folded state HJ rapidly migrates over entire homology region of the HJ in one hop.

182 nized in a region corresponding to the major homology region of the human immunodeficiency virus, a r

183 ne-rich repeats and intracellular Toll/IL-1R homology region of TLR5 as well as the adaptor protein M

184 his activation is mediated solely by the GCK homology region of TNIK.

185 nciples in order to form crystals of the Rel homology region of transcription factor NF-kappaB in com

186 The crystal structure of the homology regions of Idas in complex with Geminin showed

187 The three complete human LDL receptor homology regions of the LDL receptor-related protein (sL

188 34 residue fragment spanning the KH and QUA2 homology regions of the Quaking protein from Xenopus lae

189 DNA-binding domain (DBD) and C-terminal IRF homology regions of vIRF4.

190 native C-terminal CA cysteines or that major homology regions on neighbor capsid proteins are in clos

191 In addition to SP100 homology regions, one LYSP100 cDNA isoform contains a br

192 o acid 216, located between the PER-ARNT-SIM homology region (PAS) A and PAS B repeats.

193 These receptors consist of a photolyase homology region (PHR) carrying the oxidized flavin adeni

194 found that the second half of the photolyase homology region (PHR) of CRY is important for repression

195 a small domain extending from the photolyase homology region (PHR) of CRY1 regulates the specificity

196 g alpha-helical domain within the photolyase homology region (PHR) of CRY1, designated as CRY1-PHR(31

197 ly conserved, 22-amino acid segment, the PHO homology region (PHR), which is located within its centr

198 eceptors bind oxidized FAD in the photolyase homology region (PHR).

199 important, the recognition of eukaryote-wide homology regions provides extensive and detailed informa

200 in the N-terminal domain 1 of the Dorsal Rel homology region rather than at the Cactus binding site.

201 ll cycle-Dependent Elements-Cell cycle genes Homology Region) region of cyclin A promoter as a target

202 cates to the nucleus and binds to cell cycle homology region repressor elements within the cyclin A p

203 A forkhead-associated (FHA) homology region resides in this minimal KI domain.

204 dues within an 86-residue segment of the Rel homology region (RHR) of c-Rel are responsible for the c

205 ined the crystal structure of the entire Rel homology region (RHR) of human NFAT1 (NFATc2) bound to D

206 tween v-Rel and c-Rel located within the Rel homology region (RHR) of the family that might confer fu

207 ng bioinformatics tools, we identified a Rel homology region (RHR) within CSL that was used as a guid

208 c-Rel, and RelB, all have amino-terminal Rel-homology regions (RHRs).

209 sms (SNPs)) were selected from the segmental homology regions (SHRs) of 13 QTLs.

210 (PNA) within or adjacent to the probe-target homology region significantly enhances the yield of hybr

211 main upstream of the Dbl homology-pleckstrin homology region similar to mammalian RhoGEFs with RGS do

212 no acids 1-169), containing the immunophilin homology region, similarly reduced PDE4A5 activity and i

213 on gp130, now known as the cytokine binding homology region (site II contact surface), which fortuit

214 and glycosylation sites in each LDL receptor homology region (sLRP), all were shown to be competent f

215 lts show that binding-competent LDL receptor homology regions (sLRPs) can be produced in high yield i

216 All TRAF proteins share a C-terminal homology region termed the TRAF domain that is capable o

217 ce time was obtained for the design with the homology region that consists of only GC pairs.

218 ontains one or two copies of a 26 amino acid homology region that has been recently termed the WWP or

219 xy-terminal extensions beyond the photolyase-homology region that have been shown to mediate phototra

220 Within a 135-bp core homology region, the human HS12 enhancers are approximat

221 Alignment of IRS-1 and IRS-2 reveals two homology regions: the IH1(PH) contains a pleckstrin homo

222 cassettes and, in one approach, a dystrophin homology region to fully correct the mutation.

223 RT-PCR) using primers specific to peroxidase homology regions was used to survey for novel peroxidase

224 that the two Ig-like subdomains of each Rel-homology region, which are connected by a flexible linke

225 nase binds to a site overlapping a verprolin homology region, which has been shown to interact with a

226 ins; the third is similar to the discs-large homology region, which was first found in a Drosophila D