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1 other (heterophilic) but not to themselves (homophilic).
2 hism level tend to be positively correlated (homophilic).
3 gage in trans interactions that are strictly homophilic.
4 be used to establish specificity, including homophilic adhesion and synaptic refinement, but the ran
6 propose that Fas2-mediated intermicrovillar homophilic adhesion complexes help stabilize the brush b
8 least some of which exhibit isoform-specific homophilic adhesion in heterologous cells and are expres
11 equirements: intercalating growth depends on homophilic adhesion mediated by extracellular Ig domains
13 ry-induced protein 1 (Ninjurin1, Ninj1) is a homophilic adhesion molecule and involved in nerve regen
14 In the current work, we demonstrate that the homophilic adhesion molecule sidekick-1 (sdk-1) is up-re
15 noglobulin superfamily member 11 (IgSF11), a homophilic adhesion molecule that preferentially express
17 us in vitro studies have suggested a role as homophilic adhesion molecules in brain neurons, but the
18 rinsic pro-thrombotic activity mediated by 2 homophilic adhesion molecules, CD84 and CD150 (SLAM [sig
21 ct tracing to show that Cadherin-8 (Cdh8), a homophilic adhesion protein encoded by a gene associated
25 ic adhesion is not substantially weaker than homophilic adhesion, and the measured differences in adh
26 cessary and sufficient to mediate and target homophilic adhesion, and the QLVILA sequence is critical
27 fects Cad11-mediated cell migration, but not homophilic adhesion, as deletion of Amot binding motif o
28 eterologous cells showed that Cntn2 mediates homophilic adhesion, but does not bind detectably to Sdk
29 potential mechanisms of activity, including homophilic adhesion, homophilic repulsion and heterophil
30 ellular complexes, linked by Celsr1-mediated homophilic adhesion, that coordinate polarity non-autono
35 ether, these data suggest that CadN mediates homophilic adhesive interactions between R7 growth cones
37 ructures are formed by the clustering of the homophilic adhesive protein VE-cadherin, which recruits
38 us reports, demonstrate that the SLAM family homophilic affinities span at least three orders of magn
40 stems; for example, an olfactory gene set is homophilic and an immune system gene set is heterophilic
42 sly been shown that small differences in the homophilic and heterophilic binding affinities of differ
45 ate how graded differences between different homophilic and heterophilic cadherin dimerizaton affinit
46 s neurite outgrowth and neuronal survival in homophilic and heterophilic interactions and enhances ne
47 to drive the beneficial functions of L1 via homophilic and heterophilic interactions are functionall
48 ontains characteristic repeats that regulate homophilic and heterophilic interactions during adhesion
49 ts likely arises as a result of the numerous homophilic and heterophilic interactions that CEACAM1 ca
50 ng and adult nervous system are triggered by homophilic and heterophilic interactions that stimulate
51 functions of CAMs are brought about through homophilic and heterophilic interactions with other cell
52 nt of the binding affinities associated with homophilic and heterophilic interactions within the nect
55 e activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both
56 c activation molecule (SLAM) family includes homophilic and heterophilic receptors that regulate both
57 se cell surface receptors thought to provide homophilic and heterophilic recognition specificity for
59 n-coupled receptors (GPCRs) proposed to form homophilic and/or mixed oligomers on the basis of previo
61 othelial cells is uniquely determined by the homophilic assembly of vascular endothelial cadherin (VE
66 mAb-binding properties to EC4-5 and partial homophilic binding activity but did not restore full cel
69 surface-expressed CEACAM1 facilitates trans-homophilic binding and downstream effector signaling.
70 -helix domains in other proteins demonstrate homophilic binding and inhibit function; therefore, we t
72 majority of Dscam isoforms mediate specific homophilic binding and second by revealing the essence o
73 and rely on a high degree of specificity in homophilic binding as well as heterophilic interactions.
74 e in cell proliferation caused by E-cadherin homophilic binding at the cell surface, independent of o
75 dherin (EC) domains mediate isoform-specific homophilic binding between cells, conferring cell recogn
76 as unaffected by mutations that disrupt Ncad homophilic binding but was inhibited by a mutation in Pc
77 xtinction of SHP-1 expression or blockade of homophilic binding by CEACAM1 using a Fab that specifica
79 Here we report the direct measurement of homophilic binding forces by the serine-aspartate repeat
85 ety of axon pathways, and suggest that L1-L1 homophilic binding is important in the production of X-l
90 this surface disulfide bond did not inhibit homophilic binding of the purified beta3-Ig domain in fr
95 using a Fab that specifically recognizes the homophilic binding region of human CEACAM1 increases the
98 receptor Dscam is an exceptional example of homophilic binding specificity involved in a number of i
99 that epitope I, but not epitope II, confers homophilic binding specificity of full-length Dscam rece
101 bers of neuronal transmembrane proteins with homophilic binding specificity, individual members of wh
104 Pmu wedge peptides demonstrated PTP-specific homophilic binding, and LAR wedge peptide-coated beads p
105 that LAR wedge domain peptides would exhibit homophilic binding, bind to LAR, and inhibit LAR functio
106 These ectodomains show isoform-specific homophilic binding, leading to speculation that Dscam pr
118 rmining the crystal structure of the PECAM-1 homophilic-binding domain, which is composed of amino-te
119 tion 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an A
120 ature and orientation of the PECAM-1-PECAM-1 homophilic-binding interface, we undertook studies aimed
121 te importantly in the formation of the trans homophilic-binding interface, with a total buried interf
122 how that the beta3 subunit can mediate trans homophilic-binding via its Ig domain and that the beta3-
124 stion, we have selectively formed E-cadherin homophilic bonds at the cell surface of isolated epithel
125 -cell adhesion via specific Zn(2+)-dependent homophilic bonds between beta-sheet-rich G5-E domains on
131 with C3 close to the thioester bond, induced homophilic C3 complexes, and promoted formation of an ov
133 han CD166(-/-) cells, suggesting that HSC-OB homophilic CD166 interactions are critical for HSC engra
137 afadin, thus directing the broadly expressed homophilic cell adhesion molecule Cdh2 toward mediating
142 oteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic r
146 wth in cerebellar granule neurons (CGNs) via homophilic cell adhesion, fyn kinase, and contactin.
147 that beta1-C121W cannot participate in trans-homophilic cell adhesion, lead to the hypothesis that SC
150 t gonad formation in Drosophila requires the homophilic cell-adhesion molecule Drosophila E-cadherin
151 tested whether mammalian teneurins also are homophilic cell-adhesion molecules, in addition to bindi
152 urins in Drosophila were suggested to act as homophilic cell-adhesion molecules, whereas our findings
154 .beta-catenin.alpha-catenin complex mediates homophilic cell-cell adhesion and mechanically couples t
156 monstrate the rescue of E-cadherin-dependent homophilic cell-cell adhesion by ectopic expression of f
160 molecule, N-cadherin, which mediates strong homophilic cell-cell adhesion via linkage to the actin c
161 protein complexes, ablates calcium-dependent homophilic cell-cell adhesion, stimulates ubiquitination
163 sence of the shed extracellular fragments of homophilic cell-cell CAMs in serum and tumor tissue of c
170 bulin variable domain revealed an orthogonal homophilic dimer with high similarity to the recently re
173 over, IGPR-1 chimera, which mimics the trans-homophilic dimerization of IGPR-1, induced a sustained p
174 helial adherens junctions and, through trans-homophilic dimerization, regulates endothelial cell-cell
175 so suggest that, like NTB-A, all SLAM family homophilic dimers adopt a highly kinked organization spa
176 ree recent papers show that isoform-specific homophilic Dscam interactions cause dendritic branches o
177 tissues by connecting adjacent cells through homophilic E-cadherin interactions and are linked to the
179 may be a kind of "functional kin." Finally, homophilic genotypes exhibit significantly higher measur
180 ermolecular beta-sheet are essential for the homophilic interaction and that the residues at the hydr
181 uantitatively equivalent block, suggesting a homophilic interaction between CD99 on the neutrophil an
187 s identify a pivotal function of VE-cadherin homophilic interaction in modulating endothelial barrier
188 hematical simulations suggest that the apCAM homophilic interaction is mediated by two distinct bonds
189 mbrane receptor for soluble basigin and this homophilic interaction is not dependent upon glycosylati
191 n is a specific up-regulation and subsequent homophilic interaction mediated by the cell surface glyc
192 Coordinated dimerization of IGPR-1 and its homophilic interaction modulates its adhesive function a
199 remodeling of the neural network, but their homophilic interaction that mediates adhesion is not wel
202 n revealed at least two independent types of homophilic interaction which, taken together, suggest th
204 exhibited a faster, more substantial loss of homophilic interactions (tau = 0.86 +/- 0.02 s(-1)), sug
205 ions revealed a sudden, but partial, loss of homophilic interactions (tau = 1.17 +/- 0.06 s(-1)) upon
206 explain stronger heterophilic versus weaker homophilic interactions among these family members and a
207 development of cortical layers, due to their homophilic interactions and their restricted spatiotempo
208 D147 cyclophilin-independent activity, CD147 homophilic interactions are thought to underlie its acti
209 ietic niche and highlight how CD166-mediated homophilic interactions between both cell types may be c
210 ural cell adhesion molecule, N-CAM, mediates homophilic interactions between cells has been variously
211 hows that the basis for specificity involves homophilic interactions between extracellular domains.
213 o a growing body of evidence suggesting that homophilic interactions between surface proteins present
214 maintain neuronal networks, relying on trans homophilic interactions between their extracellular cadh
215 There is growing evidence that specific homophilic interactions between these proteins represent
217 Given the importance of PECAM-1-mediated homophilic interactions in mediating each of these cell
218 an IgCAM known to activate the EGFR through homophilic interactions in other systems, is transiently
219 ens up avenues for understanding the role of homophilic interactions in staphylococcal adhesion, and
220 etramerization in cis, coupled with strictly homophilic interactions in trans, predicts that the 22 g
222 ic in solution and, thus, suggest that CD147 homophilic interactions in vivo are mediated through oth
223 Our data support a model in which Dscam2 homophilic interactions mediate repulsion between neurit
225 a and SG neurons raises the possibility that homophilic interactions of RPTP-kappa contribute to esta
228 ious studies have shown that PECAM-1/PECAM-1 homophilic interactions play a key role in leukocyte tra
229 a Fab fragment from a CD5 mAb shown to block homophilic interactions provided evidence that the extra
231 tebrate neurons, engaging in highly specific homophilic interactions to mediate important roles in ma
232 ms comprise an Ig superfamily code that uses homophilic interactions to promote lamina-specific targe
235 s of zebrafish, where its mechanism involves homophilic interactions within the developing fiber trac
236 es biophysical evidence that apCAM undergoes homophilic interactions, and that magnetic tweezers-base
237 says revealed that all CadN isoforms mediate homophilic interactions, but the isoforms encoded by exo
239 Previous studies have shown that PECAM-1 homophilic interactions, mediated by amino-terminal immu
240 herins typically function via trans-cellular homophilic interactions, our results suggest presynaptic
241 es of clustered Pcdhs can engage in specific homophilic interactions, that cell surface delivery of P
242 oforms, and distinct Dscam1 isoforms mediate homophilic interactions, which in turn, result in repuls
257 This process may, in part, be dependent on homophilic intercellular interactions between FLRT molec
259 bind tightly to a groove within the PECAM-1 homophilic interface in an orientation that favors the f
260 Structural and chemical differences in the homophilic interfaces provide a mechanism to prevent the
261 ngulfment ligand or receptor that engages in homophilic intermolecular interaction at intercellular j
262 ssed at the cell surface which localise in a homophilic manner to cell-cell contacts expressing the f
264 ressed the regulatory mechanisms controlling homophilic Neuroglian-mediated cell adhesion by analyzin
265 es of cell-surface glycoproteins, which form homophilic or heterophilic interactions across the inter
266 identified perspective on the role of ORs in homophilic OSN axon adhesion and lead us to propose a ne
267 molecule 1 (CEACAM1) can engage in both cis-homophilic (parallel) oligomerization and trans-homophil
272 NK, T, and B cell Ag (NTB-A), a SLAM family homophilic receptor, in clone 2E2 compared with 2G1.
273 ediated by the cooperative engagement of the homophilic receptors Slamf1 (SLAM) and Slamf6 (Ly108) an
275 on sister neurites exhibit isoform-specific homophilic recognition and elicit repulsion between proc
276 in which specific isoforms of Dscam1 mediate homophilic recognition between processes of different ce
277 ealing the essence of the molecular basis of homophilic recognition by Dscams through high-resolution
279 g Pcdh isoforms encodes their diverse strict homophilic recognition specificities, which are required
283 se wiring strategies are established through homophilic repulsion between Dscam proteins expressed on
287 Drosophila Dscam1 and Dscam2, genes encoding homophilic repulsive proteins, act redundantly to ensure
289 adherin Flamingo functions as a short-range, homophilic signal, passing between specific R cell growt
292 uperfamily member IgSF9/Dasm1 as a candidate homophilic synaptic adhesion protein that regulates inhi
293 gh teneurins bind to each other in solution, homophilic teneurin-teneurin binding is unable to suppor
294 ucture of the RPTPmu ectodomain that forms a homophilic trans (antiparallel) dimer with an extended a
295 canonical head-to-tail interaction mode for homophilic trans dimers comprising primary intermolecula
296 ressed in individual neurons, they engage in homophilic trans-interactions as multimers and they are
298 with an extracellular ligand and/or GPR56 NT homophilic trans-trans associations) can remove this inh
299 re, we found that the GPR56 NT is capable of homophilic trans-trans interactions that enhance recepto
300 hesion mediated by type I cadherins involves homophilic "trans" interactions that are thought to be b
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