ライフサイエンスコーパス: homoserine

1 to be a slow substrate-producing O-ureido-L-homoserine.

2 lactam 1 is reported starting from natural L-homoserine.

3 e formation of a syn substituted beta-phenyl homoserine.

4 in the presence and absence of N-decanoyl-l-homoserine.

5 of AHLs and their lactonolysis products acyl homoserines.

6 e isolation of the host signals and identify homoserine and asparagine, two free amino acids found in

7 e NaK channel with the unnatural amino acids homoserine and cysteine sulfonic acid.

8 ombinant TbHSK specifically phosphorylates L-homoserine and displays kinetic properties similar to ot

9 ween the product forming pathway (O-ureido-L-homoserine and free enzyme) and an inactivation pathway

10 undergoes slow hydrolysis to form O-ureido-L-homoserine and regenerated enzyme.

11 Acyl homoserines and their lactones are better substrates for

12 acid azidohomoalanine (AHA) using protected homoserine as a starting material.

13 this, a new strategy was developed utilizing homoserine as an aspartic acid precursor.

14 nium compound N,N,N-trimethyl homoserine (or homoserine betaine) and elucidated its biosynthetic path

15 ffold with conserved catalytic machinery and homoserine binding sites.

16 Aspartate kinase (AK) and homoserine dehydrogenase (HSD) function as key regulator

17 kinases (AKs) and dual-functional Asp kinase-homoserine dehydrogenases (AK-HSDHs).

18 istinguish isomers Leu from Ile and Thr from homoserine even when chromatographic resolution is incom

19 llowing transformation into procyclic forms, homoserine, homoserine lactone and certain acyl homoseri

20 Homoserine kinase (HSK) produces O-phospho-l-homoserine (HserP) used by cystathionine gamma-synthase

21 nssuccinylase catalyzes the succinylation of homoserine in several bacterial species, the first uniqu

22 hat tsetse endosymbionts possess part (up to homoserine in Wigglesworthia glossinidia) or all of the

23 nase family that includes galactokinase (G), homoserine kinase (H), mevalonate kinase (M), and phosph

24 des only the last two steps in this pathway: homoserine kinase (HSK) and threonine synthase.

25 Homoserine kinase (HSK) produces O-phospho-l-homoserine

26 SK36 in aerobic broth culture except for the homoserine kinase mutant.

27 entified genes encoding undecaprenol kinase, homoserine kinase, anaerobic ribonucleotide reductase, a

28 tylgalactosamine kinase, 7.4 x 10(-17) m for homoserine kinase, and 6.4 x 10(-18) m for hexokinase.

29 e enhancements produced by yeast hexokinase, homoserine kinase, and N-acetylgalactosamine kinase (obt

30 uX homologues and other GHMP (galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalon

31 dimensional structures of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalon

32 al strain revealed the presence of an N-acyl homoserine lactonase, an enzyme that hydrolyzes the este

33 rast to its parent molecule 3-oxo-dodecanoyl homoserine lactone (3-oxo-C(12)-HSL), neither activation

34 dem mass spectrometry identified 3-oxo-C(14)-homoserine lactone (3-oxo-C(14)-HSL), C(16)-HSL, 3-oxo-C

35 ave determined that the AHL, 3-oxododecanoyl homoserine lactone (3-oxo-C12-(L)-HSL) can down-regulate

36 anoyl)homoserine lactone, N-(3-oxododecanoyl)homoserine lactone (3-oxo-C12-HSL), and N-(3-oxotetradec

37 of evidence establish that N-3-oxohexanoyl-L-homoserine lactone (3-oxo-C6-HL), the major AHL analog p

38 nI directs the synthesis of N-3-(oxohexanoyl)homoserine lactone (3-oxo-C6-HSL) and N-hexanoylhomoseri

39 ne lactone (C6-HSL) and N-(3-oxo-hexanoyl)-l-homoserine lactone (3-oxo-C6-HSL) in Y. enterocolitica a

40 n was dependent on LuxR and 3-oxo-hexanoyl-l-homoserine lactone (3-oxo-C6-HSL).

41 patients and secretes N-(3-oxo-dodecanoyl)-S-homoserine lactone (3O-C12) to regulate bacterial gene e

42 ine lactones, such as N-(3-oxo-dodecanoyl)-l-homoserine lactone (3O-C12-HSL), that promote biofilm fo

43 onas aeruginosa utilizes the 3-oxododecanoyl homoserine lactone (3OC(12)-HSL) autoinducer as a signal

44 catalyses the synthesis of N-3-oxododecanoyl homoserine lactone (3OC12) and LasR is a transcription f

45 s aeruginosa produces N-(3-oxo-dodecanoyl)-L-homoserine lactone (3OC12), a crucial signaling molecule

46 rum-sensing molecules, N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL) and N-butanoyl-l-homoseri

47 N-(3-oxododecanoyl)-L-homoserine lactone (3OC12-HSL) is a key component of P.

48 The signaling molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) is thought to play a cent

49 t triggers the cascade is N-3-oxo-dodecanoyl homoserine lactone (3OC12-HSL), which interacts with two

50 ctone (3OHC12-HSL) and N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL).

51 heri quorum-sensing signal N-3-oxohexanoyl-l-homoserine lactone (3OC6-HSL) activates expression of th

52 its quorum-sensing signal, N-(3-oxohexanoyl) homoserine lactone (3OC6-HSL), LuxR binds to lux box DNA

53 inding the signaling molecule 3-oxo-hexanoyl-homoserine lactone (3OC6HSL), an acyl-HSL with a carbony

54 ing its cognate quorum signal, 3-oxohexanoyl-homoserine lactone (3OC6HSL).

55 the autoinducer N-((R)-3-hydroxybutanoyl)-L-homoserine lactone (3OH-C4 HSL) via the two-component re

56 differentially to N-(3-hydroxydodecanoyl)-l-homoserine lactone (3OHC12-HSL) and N-(3-oxododecanoyl)-

57 element and increased production of the acyl-homoserine lactone (acyl-HSL) quormone.

58 nistic pathogen Pseudomonas aeruginosa, acyl-homoserine lactone (acyl-HSL) quorum sensing (QS) regula

59 Many Proteobacteria use N-acyl-homoserine lactone (acyl-HSL) quorum sensing to control

60 Acyl-homoserine lactone (acyl-HSL) quorum-sensing signaling i

61 rine bacterium Vibrio fischeri uses two acyl-homoserine lactone (acyl-HSL) quorum-sensing systems.

62 Burkholderia mallei has two acyl-homoserine lactone (acyl-HSL) signal generator-receptor

63 Acyl-homoserine lactone (acyl-HSL) signaling is thought to me

64 a are capable of quorum sensing using N-acyl-homoserine lactone (acyl-HSL) signaling molecules that a

65 monas aeruginosa possesses two complete acyl-homoserine lactone (acyl-HSL) signaling systems.

66 pathogen Pseudomonas aeruginosa has two acyl-homoserine lactone (acyl-HSL) signalling systems, LasR-I

67 respond to the LasI- and RhlI-generated acyl-homoserine lactone (acyl-HSL) signals 3OC12-HSL and C4-H

68 sensing systems that produce and detect acyl-homoserine lactone (acyl-HSL) signals.

69 BtaI2 is an acyl-homoserine lactone (acyl-HSL) synthase that produces two

70 Many bacteria use acyl-homoserine lactone (acyl-HSL) synthases to generate fatt

71 (QS) as the common signaling molecule N-acyl-homoserine lactone (AHL) at concentrations 100-fold lowe

72 Gram-negative bacteria use acyl-homoserine lactone (AHL) autoinducers, which are detecte

73 example of membrane-bound receptors for acyl-homoserine lactone (AHL) autoinducers.

74 In Erwinia carotovora subspecies, N-acyl homoserine lactone (AHL) controls the expression of vari

75 oxo-dodecanoyl-L-homoserine lactone, an acyl-homoserine lactone (AHL) intercellular signaling molecul

76 N-acyl homoserine lactone (AHL) is required by Erwinia carotovo

77 N-Acyl-l-homoserine lactone (AHL) mediated quorum-sensing regulat

78 Acyl-homoserine lactone (AHL) quorum sensing controls gene ex

79 interactions with their plant hosts via acyl-homoserine lactone (AHL) quorum sensing, pectin metaboli

80 vosphingobium genus that produces the N-acyl-homoserine lactone (AHL) quorum-sensing (QS) signals.

81 N-acyl-homoserine lactone (AHL) quorum-sensing molecules produc

82 ation based on chemical gradients of an acyl-homoserine lactone (AHL) signal that is synthesized by '

83 Although each system generates an acyl-homoserine lactone (AHL) signal, the protein sequences o

84 on in the presence of their cognate acylated homoserine lactone (AHL) signal.

85 g affinity is modulated by diffusible N-acyl homoserine lactone (AHL) signalling molecules.

86 olves at least half a dozen different N-acyl homoserine lactone (AHL) signals and perhaps an equal nu

87 strain M2 was found to produce distinct acyl-homoserine lactone (AHL) signals based on the use of an

88 of lasRI/rhlRI or the production of N-acyl-L-homoserine lactone (AHL) signals.

89 -sensing signaling molecules of the N-acyl-l-homoserine lactone (AHL) type but they can detect AHLs p

90 sender cells synthesize an inducer, an acyl-homoserine lactone (AHL), which freely diffuses to spati

91 fects of non-thermal plasma exposure on acyl homoserine lactone (AHL)-dependent quorum sensing (QS).

92 a LuxR homologue that is inactivated by acyl-homoserine lactone (AHL).

93 ter bond of the homoserine lactone of N-acyl homoserine lactone (AHLs).

94 CviI synthesizes the autoinducer C(10)-homoserine lactone (C(10)-HSL), and CviR is a cytoplasmi

95 The bacterial molecule N-3-oxo-dodecanoyl-l-homoserine lactone (C12) has critical roles in both inte

96 owed that the bacterial N-(3-oxo-dodecanoyl) homoserine lactone (C12) selectively impairs the regulat

97 ing molecules, including N-(3-oxododecanoyl)-homoserine lactone (C12), for intercellular communicatio

98 g- and short-chain AHLs, N-3-(oxododecanoyl)-homoserine lactone (C12-HSL) and N-butyryl homoserine la

99 RhlI catalyses the synthesis of N-butanoyl homoserine lactone (C4) and RhlR is a transcription fact

100 )-homoserine lactone (C12-HSL) and N-butyryl homoserine lactone (C4-HSL), on cell viability and mucus

101 oserine lactone (3OC12-HSL) and N-butanoyl-l-homoserine lactone (C4-HSL), to control production of ex

102 ion by a large excess of exogenous N-butyryl homoserine lactone (C4-HSL).

103 the diet, reduce the levels of N-hexanoyl-l-homoserine lactone (C6-HSL) and N-(3-oxo-hexanoyl)-l-hom

104 oli and a candidate autoinducer N-octanoyl-L-homoserine lactone (C8-HSL) has been calculated in solut

105 SUPB145, was restored by 1 microM N-octanoyl homoserine lactone (C8-HSL).

106 ate group onto the gamma-carbon, affording L-homoserine lactone (HSL) and 5'-methylthioadenosine (MTA

107 nsing system consisting of TraR and its acyl-homoserine lactone (HSL) ligand.

108 g systems that produce and detect fatty acyl-homoserine lactone (HSL) signals.

109 Interestingly, exogenously added C(4)-homoserine lactone (HSL), but not 3-oxo-C(12)-HSL, resto

110 mutants, which do not respond to 3-oxo-C(12)-homoserine lactone (HSL)-mediated QS, exhibit reduced vi

111 monas aeruginosa secrete N-(3-oxododecanoyl)-homoserine lactone (HSL-C12) as a quorum-sensing molecul

112 onstrate that the QSSM N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) from P. aeruginosa blocks pro

113 sing (QS) signal molecule 3-oxo-dodecanoyl-L-homoserine lactone (OdDHL) is produced by the opportunis

114 s on the production of a N-(3-oxohexanoyl)-L-homoserine lactone (OHHL) quorum sensing (QS) signal.

115 nsing (QS) signal molecule, 3-oxo-hexanoyl-l-homoserine lactone (OHHL), and (ii) the intracellular 'a

116 ing signalling molecule, N-(3-oxohexanoyl)-L-homoserine lactone (OHHL).

117 the signalling molecule, N-(3-oxohexanoyl)-l-homoserine lactone (OHHL).

118 the quorum-sensing signal N-3-oxooctanoyl- l-homoserine lactone (OOHL) and a C-terminal domain that b

119 raR requires the pheromone N-3-oxooctanoyl-L-homoserine lactone (OOHL) for biological activity, and i

120 ires its cognate autoinducer N-3-oxooctanoyl-homoserine lactone (OOHL) for resistance of proteolysis

121 he presence of the autoinducer 3-oxooctanoyl-homoserine lactone (OOHL).

122 the autoinducer pheromone N-3-oxooctanoyl-l-homoserine lactone (OOHL).

123 N-3-oxo-tetradecanoyl-l-homoserine lactone (oxo-C14-HSL) primed plants for enhan

124 The yenI(+) EHEC produces oxo-C6-homoserine lactone (oxo-C6-HSL) and had a significant re

125 signal synthase, which produces p-coumaroyl-homoserine lactone (pC-HSL) and RpaR, which is a pC-HSL-

126 ynthesized quorum-sensing signal p-coumaroyl-homoserine lactone (pC-HSL).

127 sely related molecule paraquat) and the acyl-homoserine lactone 3-OC12-HSL significantly increased th

128 nts from A. tumefaciens (i.e. 3-oxooctanyl-l-homoserine lactone [OOHL]) synthesized by the TraI prote

129 sformation into procyclic forms, homoserine, homoserine lactone and certain acyl homoserine lactones

130 with a 12-carbon chain length, e.g. C12-acyl homoserine lactone and dodecanol also affected C. albica

131 t PAO-MW1 alongside plasma treated N-butyryl-homoserine lactone and n-(3-oxo-dodecanoyl)-homoserine l

132 the predominant AHLs were N-3-oxooctanoyl-L-homoserine lactone and N-3-oxo-hexanoyl-L-homoserine lac

133 produces the signaling molecules N-octanoyl-homoserine lactone and N-decanoyl-homoserine lactone.

134 cited against a lactam mimetic of the N-acyl homoserine lactone and represents the only reported mono

135 em is RhlI and RhlR, which generate butanoyl-homoserine lactone and respond to butanoyl-homoserine la

136 t is measured for hydrolysis of N-hexanoyl-l-homoserine lactone and the corresponding thiolactone by

137 of the ring-opened product of N-hexanoyl- l-homoserine lactone are determined at 0.95 and 1.4 A reso

138 to quorum sensing inhibitor (QSI) - a N-acyl homoserine lactone autoinducer antagonist - and then dos

139 es that bind in place of the native acylated homoserine lactone autoinducer, provided that they stabi

140 x reactions to some irritants including acyl-homoserine lactone bacterial quorum-sensing molecules, w

141 ous virulence factors, by N-3-oxododecanolyl homoserine lactone binding to the quorum sensing recepto

142 e catalyzes the hydrolysis of N-hexanoyl-(S)-homoserine lactone but not the (R) enantiomer.

143 al signals, most of which belong to the acyl-homoserine lactone class.

144 Exposure of this strain to exogenous N-acyl-homoserine lactone counteracts this adhesion phenotype.

145 We show that two other homoserine lactone derivatives are also capable of actin

146 n density by utilizing members of the N-acyl homoserine lactone family as inducers and a transcriptio

147 the esaR gene and responds to exogenous acyl-homoserine lactone for derepression.

148 on factor, QscR, bound to N-3-oxo-dodecanoyl-homoserine lactone from the opportunistic human pathogen

149 three-dimensional structure of the N-acyl-l-homoserine lactone hydrolase (AHL lactonase) from Bacill

150 tivator A (AiiA) is a metal-dependent N-acyl homoserine lactone hydrolase that displays broad substra

151 The N-acyl- l-homoserine lactone hydrolases (AHL lactonases) have attr

152 des the quorum-sensing receptor for N-acyl-l-homoserine lactone in Escherichia coli.

153 Furthermore, N-(3-oxo-dodecanoyl)homoserine lactone induced distension of mitochondria an

154 icient in the synthesis of a diffusible acyl-homoserine lactone inducer remain repressed for EPS synt

155 Although acyl-homoserine lactone levels in cultures of this strain are

156 The acyl-homoserine lactone molecular species (AHLs) produced by

157 , in the presence of 1-100 nM exogenous acyl-homoserine lactone molecules has been quantified.

158 enzyme that hydrolyzes the ester bond of the homoserine lactone of N-acyl homoserine lactone (AHLs).

159 anding of the effects of N-(3-oxo-dodecanoyl)homoserine lactone on host cells and its role in persist

160 n secretion profile and increased N-butanoyl homoserine lactone production and influenced several quo

161 rkholderia thailandensis contains three acyl-homoserine lactone quorum sensing circuits and has two a

162 in, which appears to bind and sequester some homoserine lactone quorum signals, resulting in the inab

163 aeruginosa utilizes two interconnected acyl-homoserine lactone quorum-sensing (acyl-HSL QS) systems,

164 The acyl-homoserine lactone quorum-sensing (QS) systems of these

165 thelium and is activated in response to acyl-homoserine lactone quorum-sensing molecules secreted by

166 yet another subtle regulatory layer for acyl-homoserine lactone quorum-sensing signal-responsive tran

167 c bacterium Pseudomonas aeruginosa uses acyl-homoserine lactone quorum-sensing signals to coordinate

168 Vibrio fischeri possesses two acyl-homoserine lactone quorum-sensing systems, ain and lux,

169 xy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone reporter assays, showing that Fap fib

170 the cps cluster are significantly more acyl-homoserine lactone responsive than genes located towards

171 ion of the lasI mutant with 3-oxo-dodecanoyl homoserine lactone restores pel transcription to the wil

172 The LasI-generated 3-oxododecanoyl-homoserine lactone serves as a signal molecule for QscR.

173 QscR uses the LasI-generated acyl-homoserine lactone signal and controls a specific regulo

174 I and LasR, which generate a 3-oxododecanoyl-homoserine lactone signal and respond to that signal, re

175 transcriptional regulator that responds to a homoserine lactone signal to activate expression of acut

176 In such a system, binding of an acyl-homoserine lactone signal to its cognate transcriptional

177 ng signals for many Proteobacteria, and acyl-homoserine lactone signaling is known to control coopera

178 nd the glyoxylate bypass are induced by acyl-homoserine lactone signaling.

179 P. aeruginosa uses at least two N-acyl l-homoserine lactone signals and three homologous LuxR-typ

180 any Gram-negative bacteria involves acylated homoserine lactone signals that are perceived through bi

181 Along with their cognate acyl-homoserine lactone signals, the quorum sensing regulator

182 converse bidirectionally by exchanging acyl-homoserine lactone signals.

183 LasI is an acyl-homoserine lactone synthase that produces a quorum-sensi

184 to discovering inhibitors of LuxI-type acyl-homoserine lactone synthases.

185 reased amounts of rhamnolipids and N-butyryl homoserine lactone were detected in the biofilm effluent

186 hat recognizes the naturally-occuring N-acyl homoserine lactone with high affinity.

187 C3193 produce 3-oxo-C8-HL (N-3-oxooctanoyl-l-homoserine lactone) as the major AHL analog as well as l

188 ble levels of 3-oxo-C6-HL (N-3-oxohexanoyl-l-homoserine lactone).

189 to its cognate substrate 3-oxo-C10 AHL (Acyl-Homoserine Lactone).

190 actor(s) that is not lipopolysaccharide, C12 homoserine lactone, alginate, CIF, or exotoxin A, S, T,

191 ned biochar sorption of N-3-oxo-dodecanoyl-L-homoserine lactone, an acyl-homoserine lactone (AHL) int

192 odecanoyl)-L-homoserine lactone, N-butyryl-L-homoserine lactone, and the Pseudomonas quinolone signal

193 xy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone, and the redox mediator pyocyanin bin

194 its cell-to-cell signal, N-(3-oxododecanoyl) homoserine lactone, and the rhl system is composed of Rh

195 -homoserine lactone and n-(3-oxo-dodecanoyl)-homoserine lactone, exhibited marked attenuation of viru

196 AHLs synthesized via YenI: N-(3-oxodecanoyl)homoserine lactone, N-(3-oxododecanoyl)homoserine lacton

197 cell-to-cell signals, N-(3-oxododecanoyl)-L-homoserine lactone, N-butyryl-L-homoserine lactone, and

198 gulated by the quorum-sensing signal, N-acyl homoserine lactone, plant signals, an assortment of tran

199 l-homoserine lactone and respond to butanoyl-homoserine lactone, respectively.

200 d the bacterial signaling molecule 3-oxo-C12-homoserine lactone, showing the necessity for cholinergi

201 Compound 12b, 3-oxo-12-phenyldodecanoyl-L-homoserine lactone, was identified as a lead compound wi

202 n of the AinS-generated pheromone N-octanoyl homoserine lactone, which may account for the previously

203 Our analysis revealed that acyl-homoserine lactone-based quorum sensing controls the exp

204 wn to be positively regulated by an N-acyl-L-homoserine lactone-based quorum sensing system, but oper

205 on of mRFP1 with ahlI, which exhibits N-acyl homoserine lactone-dependent transcriptional activity, a

206 n 11.2 kDa antiactivator, modulates the acyl-homoserine lactone-mediated autoinduction of Ti plasmid

207 ent recently published reports indicate that homoserine lactone-mediated quorum sensing regulates the

208 Many Proteobacteria use acyl-homoserine lactone-mediated quorum-sensing (QS) to activ

209 we provide evidence that N-(3-oxo-dodecanoyl)homoserine lactone-mediated signaling does not require t

210 n is the founding member of a family of acyl-homoserine lactone-responsive quorum-sensing transcripti

211 of TraR and its signal N-(3-oxo-octanoyl)-L-homoserine lactone.

212 ative transfer in response to exogenous acyl-homoserine lactone.

213 e (3-oxo-C12-HSL), and N-(3-oxotetradecanoyl)homoserine lactone.

214 -L-homoserine lactone and N-3-oxo-hexanoyl-L-homoserine lactone.

215 thentic N-butyrylvinylglycine to N-butyryl-L-homoserine lactone.

216 is composed of RhlR and the signal N-butyryl homoserine lactone.

217 low, even in the presence of added butanoyl-homoserine lactone.

218 rreversibly bound two molecules of 3-oxo-C12-homoserine lactone.

219 ation was suppressed by 200 microM 3-oxo-C12 homoserine lactone.

220 N-octanoyl-homoserine lactone and N-decanoyl-homoserine lactone.

221 te autoinducer ligand and not by N-butyryl-L-homoserine lactone.

222 ly formed product from N-(3-oxododecanoyl)-L-homoserine lactone; both the N-acylhomoserine and its no

223 bacteria produce a specific set of N-acyl-L-homoserine-lactone (AHL) signaling molecules for the pur

224 ession, resulting in increased N-(butyryl)-l-homoserine-lactone quorum sensing signal and decreased E

225 ene, which is co-transcribed with the N-acyl-homoserine-lactone synthase gene cinI, is required to fu

226 oof of concept, we characterize a set of Lux homoserine-lactone-inducible genetic devices with differ

227 eived through binding to LuxR-type, acylated-homoserine-lactone-responsive transcription factors.

228 s in quorum-sensing systems that employ acyl-homoserine lactones (acyl-HSLs) as signal molecules.

229 antibiotics, as well as a suite of six acyl-homoserine lactones (acyl-HSLs) that includes four 3-hyd

230 nities, the exchange of signals such as acyl-homoserine lactones (AHL) enables communication within a

231 pe enzymes catalyze the biosynthesis of acyl-homoserine lactones (AHL) signals using S-adenosyl-l-met

232 biological and chemical properties with acyl-homoserine lactones (AHL), suggesting some AHLs might ac

233 LuxR-type transcription factors detect acyl homoserine lactones (AHLs) and are typically used by bac

234 Acyl homoserine lactones (AHLs) are a major class of quorum s

235 tive of bacterial quorum sensing, where acyl homoserine lactones (AHLs) are both produced and sensed

236 quorum sensing in bacteria that use N-acyl-l-homoserine lactones (AHLs) as intercellular signaling mo

237 Quorum sensing (QS) using N-acyl homoserine lactones (AHLs) as signal molecules is a comm

238 mber of Gram-negative bacteria employ N-acyl homoserine lactones (AHLs) as signaling molecules in quo

239 ignal exchange, such as the exchange of acyl-homoserine lactones (AHLs) by Gram-negative bacteria.

240 sensing systems are those that use acylated homoserine lactones (AHLs) for communication.

241 ent manner by auto-inducers, like the N-acyl homoserine lactones (AHLs) in numerous Gram-negative bac

242 We reported that SdiA senses acyl homoserine lactones (AHLs) in the bovine rumen to activa

243 Profiles of N-acyl-homoserine lactones (AHLs) isolated from the wild type a

244 phiphilic inducer molecules such as N-acyl-L-homoserine lactones (AHLs) or isopropyl-beta-D-thio-gala

245 uxR homolog, SdiA, which can detect the acyl-homoserine lactones (AHLs) produced by other bacteria an

246 C harbors SdiA, a regulator that senses acyl-homoserine lactones (AHLs) produced by other bacteria.

247 reviously demonstrated that EHEC senses acyl-homoserine lactones (AHLs) produced by the microbiota in

248 cteria produce and utilize diffusible N-acyl-homoserine lactones (AHLs) to regulate the expression of

249 Enzymes capable of hydrolyzing N-acyl- l-homoserine lactones (AHLs) used in some bacterial quorum

250 oserine, homoserine lactone and certain acyl homoserine lactones (AHLs) were found to substitute for

251 Here, we propose a mechanism for how N-acyl-homoserine lactones (AHLs), a group of QS molecules, inf

252 ensing-associated signaling molecules N-acyl homoserine lactones (AHLs), such as butanoyl and hexanoy

253 cell-cell communication via exchange of acyl homoserine lactones (AHLs).

254 lular signal molecules, such as the N-acyl-l-homoserine lactones (AHLs).

255 onella is a LuxR homolog that detects N-acyl homoserine lactones (AHLs).

256 ctones (AHLs), such as butanoyl and hexanoyl homoserine lactones (C(4)- and C(6)-HSLs), as well as N-

257 Acyl-homoserine lactones (HSLs) serve as quorum-sensing signa

258 tor QscR responds to a variety of fatty acyl-homoserine lactones (HSLs), including N-3-oxododecanoyl-

259 ed library of synthetic, non-native N-acyl l-homoserine lactones and identified compounds that can dr

260 focused collections of non-native N-acylated homoserine lactones and the systematic evaluation of the

261 rum-sensing systems, ain and lux, using acyl homoserine lactones as signaling molecules.

262 systems (Sin, Tra, and Mel) that use N-acyl homoserine lactones as their quorum-sensing signal molec

263 ydra to specifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterpart

264 Signaling via acyl-homoserine lactones is the paradigm for QS in Proteobact

265 These findings suggest that N-(3-oxo-acyl)homoserine lactones might be recognized by receptors of

266 and rhlI genes, impairing the production of homoserine lactones necessary for quorum-sensing, an imp

267 In contrast, other acylated homoserine lactones of different chain lengths did not a

268 Because acyl-homoserine lactones serve as quorum-sensing molecules fo

269 Acyl-homoserine lactones serve as quorum-sensing signals for

270 L were found to efficiently hydrolyze N-acyl homoserine lactones that mediate quorum sensing in many

271 ds, including expensive N-alkyl amino acids, homoserine lactones, and Agl lactams, and to achieve the

272 mall diffusible molecules, specifically acyl-homoserine lactones, are produced by P. aeruginosa to pr

273 ssor of Pig and Car when levels of N-acyl- l-homoserine lactones, produced by SmaI, are low.

274 ssion system, whereas in the absence of acyl homoserine lactones, the protein is expressed into insol

275 kers of the effects induced by N-(3-oxo-acyl)homoserine lactones, the secreted products of a number o

276 es, with low efficiency, lactones other than homoserine lactones, thus preceding the detoxifying func

277 irects the enzyme toward production of 3-oxo-homoserine lactones.

278 llei strain GB8 that was unable to make acyl-homoserine lactones.

279 AiiA, a lactonase enzyme that degrades acyl-homoserine lactones.

280 lactonase catalyzing the hydrolysis of acyl-homoserine lactones; these molecules are involved in Gra

281 cluding the GHMP kinase superfamily (galacto-homoserine-mevalonate-phosphomevalonate), but duplicatio

282 The galacto-, homoserine-, mevalonate-, phosphomevalonate-kinase (GHMP

283 force in beta(3)-peptides containing beta(3)-homoserine or beta(3)-homothreonine, and (4) demonstrate

284 quaternary ammonium compound N,N,N-trimethyl homoserine (or homoserine betaine) and elucidated its bi

285 ex with the ring-opened product N-hexanoyl-l-homoserine revealed binding interactions near the metal

286 enoic acid (fluoroallylglycine), (S)-beta(2)-homoserine, (S) and (R)-beta(3)-homocysteine, and (2R,3R

287 g a combination of an aromatic amino acid, a homoserine side chain, and a d-amino acid, a series of l

288 The conversion of homoserine to aspartic acid in the glycopeptide was succ

289 enzyme nucleophile, followed by transfer to homoserine to form O-succinylhomoserine.

290 r homoserine transsuccinylase (HTS, metA) or homoserine transacetylase (HTA; met2) for the biosynthes

291 Bacteria and yeast rely on either homoserine transsuccinylase (HTS, metA) or homoserine tr

292 rovide the first detailed description of the homoserine transsuccinylase active site and provide a fr

293 Homoserine transsuccinylase catalyzes the succinylation

294 eems to result from destabilization of MetA (homoserine transsuccinylase), the first enzyme in methio

295 he protein catalyzes the transacetylation of homoserine using acetyl-CoA.

296 hway leads to direct formation of O-ureido-L-homoserine via a reactive thiouronium intermediate.

297 ine is transferred to the terminal carbon of homoserine via its sulfhydryl group to form cystathionin

298 ne, methionine, cystathionine, cysteine, and homoserine were quantified by liquid chromatography-posi

299 Bacillus cereus metA protein in complex with homoserine, which provides the first view of a ligand bo

300 ccessfully prepared poly(L-phosphorylcholine homoserine) with controlled chain lengths and found thes