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1 ble levels of 3-oxo-C6-HL (N-3-oxohexanoyl-l-homoserine lactone).
2 to its cognate substrate 3-oxo-C10 AHL (Acyl-Homoserine Lactone).
3 of TraR and its signal N-(3-oxo-octanoyl)-L-homoserine lactone.
4 ative transfer in response to exogenous acyl-homoserine lactone.
5 e (3-oxo-C12-HSL), and N-(3-oxotetradecanoyl)homoserine lactone.
6 -L-homoserine lactone and N-3-oxo-hexanoyl-L-homoserine lactone.
7 thentic N-butyrylvinylglycine to N-butyryl-L-homoserine lactone.
8 is composed of RhlR and the signal N-butyryl homoserine lactone.
9 low, even in the presence of added butanoyl-homoserine lactone.
10 rreversibly bound two molecules of 3-oxo-C12-homoserine lactone.
11 ation was suppressed by 200 microM 3-oxo-C12 homoserine lactone.
12 N-octanoyl-homoserine lactone and N-decanoyl-homoserine lactone.
13 te autoinducer ligand and not by N-butyryl-L-homoserine lactone.
14 esponse to its quormone, N-(3-oxooctanoyl)-L-homoserine lactone.
15 t acyl-homoserine lactone was N-hexadecanoyl-homoserine lactone.
16 the diffusible inducer N-(3-oxo-hexanoyl)-L-homoserine lactone.
17 ored by exogenous addition of N-hexadecanoyl-homoserine lactone.
18 irects the enzyme toward production of 3-oxo-homoserine lactones.
19 llei strain GB8 that was unable to make acyl-homoserine lactones.
20 AiiA, a lactonase enzyme that degrades acyl-homoserine lactones.
21 dodecanoyl) homoserine lactone and N-butyryl homoserine lactone].
22 tone autoinducer molecule [N-(3-oxohexanoyl) homoserine lactone].
23 sely related molecule paraquat) and the acyl-homoserine lactone 3-OC12-HSL significantly increased th
24 rast to its parent molecule 3-oxo-dodecanoyl homoserine lactone (3-oxo-C(12)-HSL), neither activation
25 dem mass spectrometry identified 3-oxo-C(14)-homoserine lactone (3-oxo-C(14)-HSL), C(16)-HSL, 3-oxo-C
26 ave determined that the AHL, 3-oxododecanoyl homoserine lactone (3-oxo-C12-(L)-HSL) can down-regulate
27 ially detectable QSSM, N-(3-oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) and 2-heptyl-3-hydrox
28 anoyl)homoserine lactone, N-(3-oxododecanoyl)homoserine lactone (3-oxo-C12-HSL), and N-(3-oxotetradec
29 of evidence establish that N-3-oxohexanoyl-L-homoserine lactone (3-oxo-C6-HL), the major AHL analog p
30 nI directs the synthesis of N-3-(oxohexanoyl)homoserine lactone (3-oxo-C6-HSL) and N-hexanoylhomoseri
31 to the agonistic analog N-(3-oxo-hexanoyl)-L-homoserine lactone (3-oxo-C6-HSL) exhibited similar indu
32 ne lactone (C6-HSL) and N-(3-oxo-hexanoyl)-l-homoserine lactone (3-oxo-C6-HSL) in Y. enterocolitica a
37 k we report that the AHL N-(3-oxododecanoyl) homoserine lactone (3O-C(12)-HSL) from P. aeruginosa ind
38 nctions in concert with N-3-oxo-dodecanoyl-L-homoserine lactone (3O-C(12)-HSL) to coordinate the expr
39 patients and secretes N-(3-oxo-dodecanoyl)-S-homoserine lactone (3O-C12) to regulate bacterial gene e
40 ine lactones, such as N-(3-oxo-dodecanoyl)-l-homoserine lactone (3O-C12-HSL), that promote biofilm fo
41 onas aeruginosa utilizes the 3-oxododecanoyl homoserine lactone (3OC(12)-HSL) autoinducer as a signal
42 catalyses the synthesis of N-3-oxododecanoyl homoserine lactone (3OC12) and LasR is a transcription f
43 s aeruginosa produces N-(3-oxo-dodecanoyl)-L-homoserine lactone (3OC12), a crucial signaling molecule
44 rum-sensing molecules, N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL) and N-butanoyl-l-homoseri
46 The signaling molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) is thought to play a cent
47 t triggers the cascade is N-3-oxo-dodecanoyl homoserine lactone (3OC12-HSL), which interacts with two
49 heri quorum-sensing signal N-3-oxohexanoyl-l-homoserine lactone (3OC6-HSL) activates expression of th
50 its quorum-sensing signal, N-(3-oxohexanoyl) homoserine lactone (3OC6-HSL), LuxR binds to lux box DNA
51 inding the signaling molecule 3-oxo-hexanoyl-homoserine lactone (3OC6HSL), an acyl-HSL with a carbony
53 the autoinducer N-((R)-3-hydroxybutanoyl)-L-homoserine lactone (3OH-C4 HSL) via the two-component re
54 differentially to N-(3-hydroxydodecanoyl)-l-homoserine lactone (3OHC12-HSL) and N-(3-oxododecanoyl)-
55 rough these studies, we found that 3-oxo-C12 homoserine lactone, a cell-cell signalling molecule prod
56 protein, catalyzes synthesis of the acylated homoserine lactone (acyl-HSL) N-3-oxo-octanoyl-L-homoser
58 nistic pathogen Pseudomonas aeruginosa, acyl-homoserine lactone (acyl-HSL) quorum sensing (QS) regula
62 rine bacterium Vibrio fischeri uses two acyl-homoserine lactone (acyl-HSL) quorum-sensing systems.
65 a are capable of quorum sensing using N-acyl-homoserine lactone (acyl-HSL) signaling molecules that a
67 pathogen Pseudomonas aeruginosa has two acyl-homoserine lactone (acyl-HSL) signalling systems, LasR-I
68 respond to the LasI- and RhlI-generated acyl-homoserine lactone (acyl-HSL) signals 3OC12-HSL and C4-H
73 s in quorum-sensing systems that employ acyl-homoserine lactones (acyl-HSLs) as signal molecules.
74 antibiotics, as well as a suite of six acyl-homoserine lactones (acyl-HSLs) that includes four 3-hyd
75 (QS) as the common signaling molecule N-acyl-homoserine lactone (AHL) at concentrations 100-fold lowe
78 In Erwinia carotovora subspecies, N-acyl homoserine lactone (AHL) controls the expression of vari
79 oxo-dodecanoyl-L-homoserine lactone, an acyl-homoserine lactone (AHL) intercellular signaling molecul
83 interactions with their plant hosts via acyl-homoserine lactone (AHL) quorum sensing, pectin metaboli
84 vosphingobium genus that produces the N-acyl-homoserine lactone (AHL) quorum-sensing (QS) signals.
86 ation based on chemical gradients of an acyl-homoserine lactone (AHL) signal that is synthesized by '
90 olves at least half a dozen different N-acyl homoserine lactone (AHL) signals and perhaps an equal nu
91 strain M2 was found to produce distinct acyl-homoserine lactone (AHL) signals based on the use of an
93 we report the crystal structure of the acyl-homoserine lactone (AHL) synthase LasI that produces 3-o
95 -sensing signaling molecules of the N-acyl-l-homoserine lactone (AHL) type but they can detect AHLs p
96 sender cells synthesize an inducer, an acyl-homoserine lactone (AHL), which freely diffuses to spati
97 fects of non-thermal plasma exposure on acyl homoserine lactone (AHL)-dependent quorum sensing (QS).
99 nities, the exchange of signals such as acyl-homoserine lactones (AHL) enables communication within a
100 pe enzymes catalyze the biosynthesis of acyl-homoserine lactones (AHL) signals using S-adenosyl-l-met
101 biological and chemical properties with acyl-homoserine lactones (AHL), suggesting some AHLs might ac
103 bacteria produce a specific set of N-acyl-L-homoserine-lactone (AHL) signaling molecules for the pur
105 LuxR-type transcription factors detect acyl homoserine lactones (AHLs) and are typically used by bac
107 tive of bacterial quorum sensing, where acyl homoserine lactones (AHLs) are both produced and sensed
108 quorum sensing in bacteria that use N-acyl-l-homoserine lactones (AHLs) as intercellular signaling mo
110 mber of Gram-negative bacteria employ N-acyl homoserine lactones (AHLs) as signaling molecules in quo
111 ignal exchange, such as the exchange of acyl-homoserine lactones (AHLs) by Gram-negative bacteria.
112 y, we characterized the production of N-acyl homoserine lactones (AHLs) by two commonly used S. melil
114 ent manner by auto-inducers, like the N-acyl homoserine lactones (AHLs) in numerous Gram-negative bac
116 are responsible for the production of N-acyl homoserine lactones (AHLs) in two S. meliloti strains, R
118 phiphilic inducer molecules such as N-acyl-L-homoserine lactones (AHLs) or isopropyl-beta-D-thio-gala
119 uxR homolog, SdiA, which can detect the acyl-homoserine lactones (AHLs) produced by other bacteria an
120 C harbors SdiA, a regulator that senses acyl-homoserine lactones (AHLs) produced by other bacteria.
121 reviously demonstrated that EHEC senses acyl-homoserine lactones (AHLs) produced by the microbiota in
122 cteria produce and utilize diffusible N-acyl-homoserine lactones (AHLs) to regulate the expression of
123 Enzymes capable of hydrolyzing N-acyl- l-homoserine lactones (AHLs) used in some bacterial quorum
124 oserine, homoserine lactone and certain acyl homoserine lactones (AHLs) were found to substitute for
125 Here, we propose a mechanism for how N-acyl-homoserine lactones (AHLs), a group of QS molecules, inf
126 ensing-associated signaling molecules N-acyl homoserine lactones (AHLs), such as butanoyl and hexanoy
130 actor(s) that is not lipopolysaccharide, C12 homoserine lactone, alginate, CIF, or exotoxin A, S, T,
131 used to identify bacteria that produce acyl-homoserine lactones, although the specificities of these
132 ned biochar sorption of N-3-oxo-dodecanoyl-L-homoserine lactone, an acyl-homoserine lactone (AHL) int
133 sformation into procyclic forms, homoserine, homoserine lactone and certain acyl homoserine lactones
134 with a 12-carbon chain length, e.g. C12-acyl homoserine lactone and dodecanol also affected C. albica
135 t PAO-MW1 alongside plasma treated N-butyryl-homoserine lactone and n-(3-oxo-dodecanoyl)-homoserine l
136 the predominant AHLs were N-3-oxooctanoyl-L-homoserine lactone and N-3-oxo-hexanoyl-L-homoserine lac
137 exogenous autoinducers [N-(3-oxododecanoyl) homoserine lactone and N-butyryl homoserine lactone].
138 . aeruginosa autoinducers, N-3-oxododecanoyl-homoserine lactone and N-butyryl-homoserine lactone, can
139 produces the signaling molecules N-octanoyl-homoserine lactone and N-decanoyl-homoserine lactone.
140 cited against a lactam mimetic of the N-acyl homoserine lactone and represents the only reported mono
141 em is RhlI and RhlR, which generate butanoyl-homoserine lactone and respond to butanoyl-homoserine la
142 t is measured for hydrolysis of N-hexanoyl-l-homoserine lactone and the corresponding thiolactone by
143 ed library of synthetic, non-native N-acyl l-homoserine lactones and identified compounds that can dr
144 focused collections of non-native N-acylated homoserine lactones and the systematic evaluation of the
145 odecanoyl)-L-homoserine lactone, N-butyryl-L-homoserine lactone, and the Pseudomonas quinolone signal
146 xy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone, and the redox mediator pyocyanin bin
147 its cell-to-cell signal, N-(3-oxododecanoyl) homoserine lactone, and the rhl system is composed of Rh
148 ds, including expensive N-alkyl amino acids, homoserine lactones, and Agl lactams, and to achieve the
149 of the ring-opened product of N-hexanoyl- l-homoserine lactone are determined at 0.95 and 1.4 A reso
150 mall diffusible molecules, specifically acyl-homoserine lactones, are produced by P. aeruginosa to pr
153 systems (Sin, Tra, and Mel) that use N-acyl homoserine lactones as their quorum-sensing signal molec
154 C3193 produce 3-oxo-C8-HL (N-3-oxooctanoyl-l-homoserine lactone) as the major AHL analog as well as l
155 to quorum sensing inhibitor (QSI) - a N-acyl homoserine lactone autoinducer antagonist - and then dos
156 ctivator LuxR in the presence of an acylated homoserine lactone autoinducer molecule [N-(3-oxohexanoy
157 es that bind in place of the native acylated homoserine lactone autoinducer, provided that they stabi
158 x reactions to some irritants including acyl-homoserine lactone bacterial quorum-sensing molecules, w
161 wn to be positively regulated by an N-acyl-L-homoserine lactone-based quorum sensing system, but oper
162 ous virulence factors, by N-3-oxododecanolyl homoserine lactone binding to the quorum sensing recepto
163 ly formed product from N-(3-oxododecanoyl)-L-homoserine lactone; both the N-acylhomoserine and its no
165 requires the quorum-sensing signal butanoyl-homoserine lactone, but other factors are also required
167 y the observation that synthetic palmitoleyl homoserine lactone (C(16:1)-HL), one of the previously i
168 long with its cognate autoinducer, N-butyryl homoserine lactone (C(4)-HSL), regulates gene expression
169 ctones (AHLs), such as butanoyl and hexanoyl homoserine lactones (C(4)- and C(6)-HSLs), as well as N-
171 The bacterial molecule N-3-oxo-dodecanoyl-l-homoserine lactone (C12) has critical roles in both inte
172 owed that the bacterial N-(3-oxo-dodecanoyl) homoserine lactone (C12) selectively impairs the regulat
173 ing molecules, including N-(3-oxododecanoyl)-homoserine lactone (C12), for intercellular communicatio
174 g- and short-chain AHLs, N-3-(oxododecanoyl)-homoserine lactone (C12-HSL) and N-butyryl homoserine la
175 RhlI catalyses the synthesis of N-butanoyl homoserine lactone (C4) and RhlR is a transcription fact
177 phase, epithelial cell contact, and butanoyl homoserine lactone (C4-HSL), a quorum sensing signaling
178 )-homoserine lactone (C12-HSL) and N-butyryl homoserine lactone (C4-HSL), on cell viability and mucus
179 oserine lactone (3OC12-HSL) and N-butanoyl-l-homoserine lactone (C4-HSL), to control production of ex
181 the diet, reduce the levels of N-hexanoyl-l-homoserine lactone (C6-HSL) and N-(3-oxo-hexanoyl)-l-hom
182 rly effective alkanoyl acyl-HSL N-hexanoyl-L-homoserine lactone (C6-HSL) required the continued prese
183 type B. thailandensis synthesizes N-hexanoyl-homoserine lactone (C6-HSL), N-octanoyl-homoserine lacto
184 oli and a candidate autoinducer N-octanoyl-L-homoserine lactone (C8-HSL) has been calculated in solut
185 noyl-homoserine lactone (C6-HSL), N-octanoyl-homoserine lactone (C8-HSL), and N-decanoyl-homoserine l
187 ododecanoyl-homoserine lactone and N-butyryl-homoserine lactone, can both enter eukaryotic cells and
189 Exposure of this strain to exogenous N-acyl-homoserine lactone counteracts this adhesion phenotype.
190 on of mRFP1 with ahlI, which exhibits N-acyl homoserine lactone-dependent transcriptional activity, a
192 -homoserine lactone and n-(3-oxo-dodecanoyl)-homoserine lactone, exhibited marked attenuation of viru
193 n density by utilizing members of the N-acyl homoserine lactone family as inducers and a transcriptio
195 on factor, QscR, bound to N-3-oxo-dodecanoyl-homoserine lactone from the opportunistic human pathogen
196 ate group onto the gamma-carbon, affording L-homoserine lactone (HSL) and 5'-methylthioadenosine (MTA
200 mutants, which do not respond to 3-oxo-C(12)-homoserine lactone (HSL)-mediated QS, exhibit reduced vi
201 monas aeruginosa secrete N-(3-oxododecanoyl)-homoserine lactone (HSL-C12) as a quorum-sensing molecul
203 tor QscR responds to a variety of fatty acyl-homoserine lactones (HSLs), including N-3-oxododecanoyl-
204 three-dimensional structure of the N-acyl-l-homoserine lactone hydrolase (AHL lactonase) from Bacill
205 tivator A (AiiA) is a metal-dependent N-acyl homoserine lactone hydrolase that displays broad substra
208 the EsaR protein binds N-(3-oxo-hexanoyl)-L-homoserine lactone, in a 1:1 protein:ligand ratio, and t
210 icient in the synthesis of a diffusible acyl-homoserine lactone inducer remain repressed for EPS synt
211 oof of concept, we characterize a set of Lux homoserine-lactone-inducible genetic devices with differ
212 ydra to specifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterpart
215 n 11.2 kDa antiactivator, modulates the acyl-homoserine lactone-mediated autoinduction of Ti plasmid
216 ent recently published reports indicate that homoserine lactone-mediated quorum sensing regulates the
218 we provide evidence that N-(3-oxo-dodecanoyl)homoserine lactone-mediated signaling does not require t
219 These findings suggest that N-(3-oxo-acyl)homoserine lactones might be recognized by receptors of
222 ction of Pig and Car is controlled by N-acyl homoserine lactone (N-AHL) quorum sensing, with synthesi
223 AHLs synthesized via YenI: N-(3-oxodecanoyl)homoserine lactone, N-(3-oxododecanoyl)homoserine lacton
224 cell-to-cell signals, N-(3-oxododecanoyl)-L-homoserine lactone, N-butyryl-L-homoserine lactone, and
225 and rhlI genes, impairing the production of homoserine lactones necessary for quorum-sensing, an imp
226 onstrate that the QSSM N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) from P. aeruginosa blocks pro
227 sing (QS) signal molecule 3-oxo-dodecanoyl-L-homoserine lactone (OdDHL) is produced by the opportunis
228 enzyme that hydrolyzes the ester bond of the homoserine lactone of N-acyl homoserine lactone (AHLs).
230 s on the production of a N-(3-oxohexanoyl)-L-homoserine lactone (OHHL) quorum sensing (QS) signal.
231 nsing (QS) signal molecule, 3-oxo-hexanoyl-l-homoserine lactone (OHHL), and (ii) the intracellular 'a
234 anding of the effects of N-(3-oxo-dodecanoyl)homoserine lactone on host cells and its role in persist
235 the quorum-sensing signal N-3-oxooctanoyl- l-homoserine lactone (OOHL) and a C-terminal domain that b
236 raR requires the pheromone N-3-oxooctanoyl-L-homoserine lactone (OOHL) for biological activity, and i
237 ires its cognate autoinducer N-3-oxooctanoyl-homoserine lactone (OOHL) for resistance of proteolysis
240 nts from A. tumefaciens (i.e. 3-oxooctanyl-l-homoserine lactone [OOHL]) synthesized by the TraI prote
243 signal synthase, which produces p-coumaroyl-homoserine lactone (pC-HSL) and RpaR, which is a pC-HSL-
245 gulated by the quorum-sensing signal, N-acyl homoserine lactone, plant signals, an assortment of tran
247 n secretion profile and increased N-butanoyl homoserine lactone production and influenced several quo
248 ssay to detect production of long-acyl-chain homoserine lactone production by Rhodobacter capsulatus
249 transcriptional activator TraR and its acyl-homoserine lactone quormone N-(3-oxo-octanoyl)-L-homoser
251 rkholderia thailandensis contains three acyl-homoserine lactone quorum sensing circuits and has two a
252 in, which appears to bind and sequester some homoserine lactone quorum signals, resulting in the inab
253 aeruginosa utilizes two interconnected acyl-homoserine lactone quorum-sensing (acyl-HSL QS) systems,
255 thelium and is activated in response to acyl-homoserine lactone quorum-sensing molecules secreted by
256 yet another subtle regulatory layer for acyl-homoserine lactone quorum-sensing signal-responsive tran
257 c bacterium Pseudomonas aeruginosa uses acyl-homoserine lactone quorum-sensing signals to coordinate
260 ession, resulting in increased N-(butyryl)-l-homoserine-lactone quorum sensing signal and decreased E
261 xy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone reporter assays, showing that Fap fib
263 the cps cluster are significantly more acyl-homoserine lactone responsive than genes located towards
264 n is the founding member of a family of acyl-homoserine lactone-responsive quorum-sensing transcripti
265 eived through binding to LuxR-type, acylated-homoserine-lactone-responsive transcription factors.
267 ion of the lasI mutant with 3-oxo-dodecanoyl homoserine lactone restores pel transcription to the wil
273 d the bacterial signaling molecule 3-oxo-C12-homoserine lactone, showing the necessity for cholinergi
275 I and LasR, which generate a 3-oxododecanoyl-homoserine lactone signal and respond to that signal, re
276 transcriptional regulator that responds to a homoserine lactone signal to activate expression of acut
278 ng signals for many Proteobacteria, and acyl-homoserine lactone signaling is known to control coopera
281 P. aeruginosa uses at least two N-acyl l-homoserine lactone signals and three homologous LuxR-typ
283 any Gram-negative bacteria involves acylated homoserine lactone signals that are perceived through bi
287 ene, which is co-transcribed with the N-acyl-homoserine-lactone synthase gene cinI, is required to fu
289 L were found to efficiently hydrolyze N-acyl homoserine lactones that mediate quorum sensing in many
290 ssion system, whereas in the absence of acyl homoserine lactones, the protein is expressed into insol
291 kers of the effects induced by N-(3-oxo-acyl)homoserine lactones, the secreted products of a number o
292 lactonase catalyzing the hydrolysis of acyl-homoserine lactones; these molecules are involved in Gra
293 es, with low efficiency, lactones other than homoserine lactones, thus preceding the detoxifying func
296 Compound 12b, 3-oxo-12-phenyldodecanoyl-L-homoserine lactone, was identified as a lead compound wi
297 reased amounts of rhamnolipids and N-butyryl homoserine lactone were detected in the biofilm effluent
298 n of the AinS-generated pheromone N-octanoyl homoserine lactone, which may account for the previously
300 ration assay, it is apparent that acylated l-homoserine lactones with an 11-13 C side chain containin
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