ライフサイエンスコーパス: homoserine lactone

1 ble levels of 3-oxo-C6-HL (N-3-oxohexanoyl-l-homoserine lactone).

2 to its cognate substrate 3-oxo-C10 AHL (Acyl-Homoserine Lactone).

3 of TraR and its signal N-(3-oxo-octanoyl)-L-homoserine lactone.

4 ative transfer in response to exogenous acyl-homoserine lactone.

5 e (3-oxo-C12-HSL), and N-(3-oxotetradecanoyl)homoserine lactone.

6 -L-homoserine lactone and N-3-oxo-hexanoyl-L-homoserine lactone.

7 thentic N-butyrylvinylglycine to N-butyryl-L-homoserine lactone.

8 is composed of RhlR and the signal N-butyryl homoserine lactone.

9 low, even in the presence of added butanoyl-homoserine lactone.

10 rreversibly bound two molecules of 3-oxo-C12-homoserine lactone.

11 ation was suppressed by 200 microM 3-oxo-C12 homoserine lactone.

12 N-octanoyl-homoserine lactone and N-decanoyl-homoserine lactone.

13 te autoinducer ligand and not by N-butyryl-L-homoserine lactone.

14 esponse to its quormone, N-(3-oxooctanoyl)-L-homoserine lactone.

15 t acyl-homoserine lactone was N-hexadecanoyl-homoserine lactone.

16 the diffusible inducer N-(3-oxo-hexanoyl)-L-homoserine lactone.

17 ored by exogenous addition of N-hexadecanoyl-homoserine lactone.

18 irects the enzyme toward production of 3-oxo-homoserine lactones.

19 llei strain GB8 that was unable to make acyl-homoserine lactones.

20 AiiA, a lactonase enzyme that degrades acyl-homoserine lactones.

21 dodecanoyl) homoserine lactone and N-butyryl homoserine lactone].

22 tone autoinducer molecule [N-(3-oxohexanoyl) homoserine lactone].

23 sely related molecule paraquat) and the acyl-homoserine lactone 3-OC12-HSL significantly increased th

24 rast to its parent molecule 3-oxo-dodecanoyl homoserine lactone (3-oxo-C(12)-HSL), neither activation

25 dem mass spectrometry identified 3-oxo-C(14)-homoserine lactone (3-oxo-C(14)-HSL), C(16)-HSL, 3-oxo-C

26 ave determined that the AHL, 3-oxododecanoyl homoserine lactone (3-oxo-C12-(L)-HSL) can down-regulate

27 ially detectable QSSM, N-(3-oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) and 2-heptyl-3-hydrox

28 anoyl)homoserine lactone, N-(3-oxododecanoyl)homoserine lactone (3-oxo-C12-HSL), and N-(3-oxotetradec

29 of evidence establish that N-3-oxohexanoyl-L-homoserine lactone (3-oxo-C6-HL), the major AHL analog p

30 nI directs the synthesis of N-3-(oxohexanoyl)homoserine lactone (3-oxo-C6-HSL) and N-hexanoylhomoseri

31 to the agonistic analog N-(3-oxo-hexanoyl)-L-homoserine lactone (3-oxo-C6-HSL) exhibited similar indu

32 ne lactone (C6-HSL) and N-(3-oxo-hexanoyl)-l-homoserine lactone (3-oxo-C6-HSL) in Y. enterocolitica a

33 n was dependent on LuxR and 3-oxo-hexanoyl-l-homoserine lactone (3-oxo-C6-HSL).

34 serine lactone quormone N-(3-oxo-octanoyl)-L-homoserine lactone (3-oxo-C8-HSL).

35 serine lactone (acyl-HSL) N-3-oxo-octanoyl-L-homoserine lactone (3-oxo-C8-HSL).

36 inosa signal molecule, N-(3-oxododecanoyl)-l-homoserine lactone (3O, C(12)-HSL), is described.

37 k we report that the AHL N-(3-oxododecanoyl) homoserine lactone (3O-C(12)-HSL) from P. aeruginosa ind

38 nctions in concert with N-3-oxo-dodecanoyl-L-homoserine lactone (3O-C(12)-HSL) to coordinate the expr

39 patients and secretes N-(3-oxo-dodecanoyl)-S-homoserine lactone (3O-C12) to regulate bacterial gene e

40 ine lactones, such as N-(3-oxo-dodecanoyl)-l-homoserine lactone (3O-C12-HSL), that promote biofilm fo

41 onas aeruginosa utilizes the 3-oxododecanoyl homoserine lactone (3OC(12)-HSL) autoinducer as a signal

42 catalyses the synthesis of N-3-oxododecanoyl homoserine lactone (3OC12) and LasR is a transcription f

43 s aeruginosa produces N-(3-oxo-dodecanoyl)-L-homoserine lactone (3OC12), a crucial signaling molecule

44 rum-sensing molecules, N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL) and N-butanoyl-l-homoseri

45 N-(3-oxododecanoyl)-L-homoserine lactone (3OC12-HSL) is a key component of P.

46 The signaling molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) is thought to play a cent

47 t triggers the cascade is N-3-oxo-dodecanoyl homoserine lactone (3OC12-HSL), which interacts with two

48 ctone (3OHC12-HSL) and N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL).

49 heri quorum-sensing signal N-3-oxohexanoyl-l-homoserine lactone (3OC6-HSL) activates expression of th

50 its quorum-sensing signal, N-(3-oxohexanoyl) homoserine lactone (3OC6-HSL), LuxR binds to lux box DNA

51 inding the signaling molecule 3-oxo-hexanoyl-homoserine lactone (3OC6HSL), an acyl-HSL with a carbony

52 ing its cognate quorum signal, 3-oxohexanoyl-homoserine lactone (3OC6HSL).

53 the autoinducer N-((R)-3-hydroxybutanoyl)-L-homoserine lactone (3OH-C4 HSL) via the two-component re

54 differentially to N-(3-hydroxydodecanoyl)-l-homoserine lactone (3OHC12-HSL) and N-(3-oxododecanoyl)-

55 rough these studies, we found that 3-oxo-C12 homoserine lactone, a cell-cell signalling molecule prod

56 protein, catalyzes synthesis of the acylated homoserine lactone (acyl-HSL) N-3-oxo-octanoyl-L-homoser

57 element and increased production of the acyl-homoserine lactone (acyl-HSL) quormone.

58 nistic pathogen Pseudomonas aeruginosa, acyl-homoserine lactone (acyl-HSL) quorum sensing (QS) regula

59 Acyl-homoserine lactone (acyl-HSL) quorum sensing is common t

60 Many Proteobacteria use N-acyl-homoserine lactone (acyl-HSL) quorum sensing to control

61 Acyl-homoserine lactone (acyl-HSL) quorum-sensing signaling i

62 rine bacterium Vibrio fischeri uses two acyl-homoserine lactone (acyl-HSL) quorum-sensing systems.

63 Burkholderia mallei has two acyl-homoserine lactone (acyl-HSL) signal generator-receptor

64 Acyl-homoserine lactone (acyl-HSL) signaling is thought to me

65 a are capable of quorum sensing using N-acyl-homoserine lactone (acyl-HSL) signaling molecules that a

66 monas aeruginosa possesses two complete acyl-homoserine lactone (acyl-HSL) signaling systems.

67 pathogen Pseudomonas aeruginosa has two acyl-homoserine lactone (acyl-HSL) signalling systems, LasR-I

68 respond to the LasI- and RhlI-generated acyl-homoserine lactone (acyl-HSL) signals 3OC12-HSL and C4-H

69 sensing systems that produce and detect acyl-homoserine lactone (acyl-HSL) signals.

70 BtaI2 is an acyl-homoserine lactone (acyl-HSL) synthase that produces two

71 Many bacteria use acyl-homoserine lactone (acyl-HSL) synthases to generate fatt

72 Bacterial quorum sensing using acyl-homoserine lactones (acyl-HSLs) as cell-density dependen

73 s in quorum-sensing systems that employ acyl-homoserine lactones (acyl-HSLs) as signal molecules.

74 antibiotics, as well as a suite of six acyl-homoserine lactones (acyl-HSLs) that includes four 3-hyd

75 (QS) as the common signaling molecule N-acyl-homoserine lactone (AHL) at concentrations 100-fold lowe

76 Gram-negative bacteria use acyl-homoserine lactone (AHL) autoinducers, which are detecte

77 example of membrane-bound receptors for acyl-homoserine lactone (AHL) autoinducers.

78 In Erwinia carotovora subspecies, N-acyl homoserine lactone (AHL) controls the expression of vari

79 oxo-dodecanoyl-L-homoserine lactone, an acyl-homoserine lactone (AHL) intercellular signaling molecul

80 N-acyl homoserine lactone (AHL) is required by Erwinia carotovo

81 N-Acyl-l-homoserine lactone (AHL) mediated quorum-sensing regulat

82 Acyl-homoserine lactone (AHL) quorum sensing controls gene ex

83 interactions with their plant hosts via acyl-homoserine lactone (AHL) quorum sensing, pectin metaboli

84 vosphingobium genus that produces the N-acyl-homoserine lactone (AHL) quorum-sensing (QS) signals.

85 N-acyl-homoserine lactone (AHL) quorum-sensing molecules produc

86 ation based on chemical gradients of an acyl-homoserine lactone (AHL) signal that is synthesized by '

87 Although each system generates an acyl-homoserine lactone (AHL) signal, the protein sequences o

88 on in the presence of their cognate acylated homoserine lactone (AHL) signal.

89 g affinity is modulated by diffusible N-acyl homoserine lactone (AHL) signalling molecules.

90 olves at least half a dozen different N-acyl homoserine lactone (AHL) signals and perhaps an equal nu

91 strain M2 was found to produce distinct acyl-homoserine lactone (AHL) signals based on the use of an

92 of lasRI/rhlRI or the production of N-acyl-L-homoserine lactone (AHL) signals.

93 we report the crystal structure of the acyl-homoserine lactone (AHL) synthase LasI that produces 3-o

94 R-type proteins, LasR and RhlR, and two acyl homoserine lactone (AHL) synthases, LasI and RhlI.

95 -sensing signaling molecules of the N-acyl-l-homoserine lactone (AHL) type but they can detect AHLs p

96 sender cells synthesize an inducer, an acyl-homoserine lactone (AHL), which freely diffuses to spati

97 fects of non-thermal plasma exposure on acyl homoserine lactone (AHL)-dependent quorum sensing (QS).

98 a LuxR homologue that is inactivated by acyl-homoserine lactone (AHL).

99 nities, the exchange of signals such as acyl-homoserine lactones (AHL) enables communication within a

100 pe enzymes catalyze the biosynthesis of acyl-homoserine lactones (AHL) signals using S-adenosyl-l-met

101 biological and chemical properties with acyl-homoserine lactones (AHL), suggesting some AHLs might ac

102 ynthesis and perception of diffusible N-acyl-homoserine lactones (AHL).

103 bacteria produce a specific set of N-acyl-L-homoserine-lactone (AHL) signaling molecules for the pur

104 ter bond of the homoserine lactone of N-acyl homoserine lactone (AHLs).

105 LuxR-type transcription factors detect acyl homoserine lactones (AHLs) and are typically used by bac

106 Acyl homoserine lactones (AHLs) are a major class of quorum s

107 tive of bacterial quorum sensing, where acyl homoserine lactones (AHLs) are both produced and sensed

108 quorum sensing in bacteria that use N-acyl-l-homoserine lactones (AHLs) as intercellular signaling mo

109 Quorum sensing (QS) using N-acyl homoserine lactones (AHLs) as signal molecules is a comm

110 mber of Gram-negative bacteria employ N-acyl homoserine lactones (AHLs) as signaling molecules in quo

111 ignal exchange, such as the exchange of acyl-homoserine lactones (AHLs) by Gram-negative bacteria.

112 y, we characterized the production of N-acyl homoserine lactones (AHLs) by two commonly used S. melil

113 sensing systems are those that use acylated homoserine lactones (AHLs) for communication.

114 ent manner by auto-inducers, like the N-acyl homoserine lactones (AHLs) in numerous Gram-negative bac

115 We reported that SdiA senses acyl homoserine lactones (AHLs) in the bovine rumen to activa

116 are responsible for the production of N-acyl homoserine lactones (AHLs) in two S. meliloti strains, R

117 Profiles of N-acyl-homoserine lactones (AHLs) isolated from the wild type a

118 phiphilic inducer molecules such as N-acyl-L-homoserine lactones (AHLs) or isopropyl-beta-D-thio-gala

119 uxR homolog, SdiA, which can detect the acyl-homoserine lactones (AHLs) produced by other bacteria an

120 C harbors SdiA, a regulator that senses acyl-homoserine lactones (AHLs) produced by other bacteria.

121 reviously demonstrated that EHEC senses acyl-homoserine lactones (AHLs) produced by the microbiota in

122 cteria produce and utilize diffusible N-acyl-homoserine lactones (AHLs) to regulate the expression of

123 Enzymes capable of hydrolyzing N-acyl- l-homoserine lactones (AHLs) used in some bacterial quorum

124 oserine, homoserine lactone and certain acyl homoserine lactones (AHLs) were found to substitute for

125 Here, we propose a mechanism for how N-acyl-homoserine lactones (AHLs), a group of QS molecules, inf

126 ensing-associated signaling molecules N-acyl homoserine lactones (AHLs), such as butanoyl and hexanoy

127 cell-cell communication via exchange of acyl homoserine lactones (AHLs).

128 lular signal molecules, such as the N-acyl-l-homoserine lactones (AHLs).

129 onella is a LuxR homolog that detects N-acyl homoserine lactones (AHLs).

130 actor(s) that is not lipopolysaccharide, C12 homoserine lactone, alginate, CIF, or exotoxin A, S, T,

131 used to identify bacteria that produce acyl-homoserine lactones, although the specificities of these

132 ned biochar sorption of N-3-oxo-dodecanoyl-L-homoserine lactone, an acyl-homoserine lactone (AHL) int

133 sformation into procyclic forms, homoserine, homoserine lactone and certain acyl homoserine lactones

134 with a 12-carbon chain length, e.g. C12-acyl homoserine lactone and dodecanol also affected C. albica

135 t PAO-MW1 alongside plasma treated N-butyryl-homoserine lactone and n-(3-oxo-dodecanoyl)-homoserine l

136 the predominant AHLs were N-3-oxooctanoyl-L-homoserine lactone and N-3-oxo-hexanoyl-L-homoserine lac

137 exogenous autoinducers [N-(3-oxododecanoyl) homoserine lactone and N-butyryl homoserine lactone].

138 . aeruginosa autoinducers, N-3-oxododecanoyl-homoserine lactone and N-butyryl-homoserine lactone, can

139 produces the signaling molecules N-octanoyl-homoserine lactone and N-decanoyl-homoserine lactone.

140 cited against a lactam mimetic of the N-acyl homoserine lactone and represents the only reported mono

141 em is RhlI and RhlR, which generate butanoyl-homoserine lactone and respond to butanoyl-homoserine la

142 t is measured for hydrolysis of N-hexanoyl-l-homoserine lactone and the corresponding thiolactone by

143 ed library of synthetic, non-native N-acyl l-homoserine lactones and identified compounds that can dr

144 focused collections of non-native N-acylated homoserine lactones and the systematic evaluation of the

145 odecanoyl)-L-homoserine lactone, N-butyryl-L-homoserine lactone, and the Pseudomonas quinolone signal

146 xy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone, and the redox mediator pyocyanin bin

147 its cell-to-cell signal, N-(3-oxododecanoyl) homoserine lactone, and the rhl system is composed of Rh

148 ds, including expensive N-alkyl amino acids, homoserine lactones, and Agl lactams, and to achieve the

149 of the ring-opened product of N-hexanoyl- l-homoserine lactone are determined at 0.95 and 1.4 A reso

150 mall diffusible molecules, specifically acyl-homoserine lactones, are produced by P. aeruginosa to pr

151 Many proteobacteria use acyl-homoserine lactones as quorum-sensing signals.

152 rum-sensing systems, ain and lux, using acyl homoserine lactones as signaling molecules.

153 systems (Sin, Tra, and Mel) that use N-acyl homoserine lactones as their quorum-sensing signal molec

154 C3193 produce 3-oxo-C8-HL (N-3-oxooctanoyl-l-homoserine lactone) as the major AHL analog as well as l

155 to quorum sensing inhibitor (QSI) - a N-acyl homoserine lactone autoinducer antagonist - and then dos

156 ctivator LuxR in the presence of an acylated homoserine lactone autoinducer molecule [N-(3-oxohexanoy

157 es that bind in place of the native acylated homoserine lactone autoinducer, provided that they stabi

158 x reactions to some irritants including acyl-homoserine lactone bacterial quorum-sensing molecules, w

159 Many bacteria are capable of acyl-homoserine lactone-based or peptide-based intraspecies q

160 Our analysis revealed that acyl-homoserine lactone-based quorum sensing controls the exp

161 wn to be positively regulated by an N-acyl-L-homoserine lactone-based quorum sensing system, but oper

162 ous virulence factors, by N-3-oxododecanolyl homoserine lactone binding to the quorum sensing recepto

163 ly formed product from N-(3-oxododecanoyl)-L-homoserine lactone; both the N-acylhomoserine and its no

164 e catalyzes the hydrolysis of N-hexanoyl-(S)-homoserine lactone but not the (R) enantiomer.

165 requires the quorum-sensing signal butanoyl-homoserine lactone, but other factors are also required

166 CviI synthesizes the autoinducer C(10)-homoserine lactone (C(10)-HSL), and CviR is a cytoplasmi

167 y the observation that synthetic palmitoleyl homoserine lactone (C(16:1)-HL), one of the previously i

168 long with its cognate autoinducer, N-butyryl homoserine lactone (C(4)-HSL), regulates gene expression

169 ctones (AHLs), such as butanoyl and hexanoyl homoserine lactones (C(4)- and C(6)-HSLs), as well as N-

170 -homoserine lactone (C8-HSL), and N-decanoyl-homoserine lactone (C10-HSL).

171 The bacterial molecule N-3-oxo-dodecanoyl-l-homoserine lactone (C12) has critical roles in both inte

172 owed that the bacterial N-(3-oxo-dodecanoyl) homoserine lactone (C12) selectively impairs the regulat

173 ing molecules, including N-(3-oxododecanoyl)-homoserine lactone (C12), for intercellular communicatio

174 g- and short-chain AHLs, N-3-(oxododecanoyl)-homoserine lactone (C12-HSL) and N-butyryl homoserine la

175 RhlI catalyses the synthesis of N-butanoyl homoserine lactone (C4) and RhlR is a transcription fact

176 xoproducts but retained wild-type N-butanoyl homoserine lactone (C4-HSL) levels.

177 phase, epithelial cell contact, and butanoyl homoserine lactone (C4-HSL), a quorum sensing signaling

178 )-homoserine lactone (C12-HSL) and N-butyryl homoserine lactone (C4-HSL), on cell viability and mucus

179 oserine lactone (3OC12-HSL) and N-butanoyl-l-homoserine lactone (C4-HSL), to control production of ex

180 ion by a large excess of exogenous N-butyryl homoserine lactone (C4-HSL).

181 the diet, reduce the levels of N-hexanoyl-l-homoserine lactone (C6-HSL) and N-(3-oxo-hexanoyl)-l-hom

182 rly effective alkanoyl acyl-HSL N-hexanoyl-L-homoserine lactone (C6-HSL) required the continued prese

183 type B. thailandensis synthesizes N-hexanoyl-homoserine lactone (C6-HSL), N-octanoyl-homoserine lacto

184 oli and a candidate autoinducer N-octanoyl-L-homoserine lactone (C8-HSL) has been calculated in solut

185 noyl-homoserine lactone (C6-HSL), N-octanoyl-homoserine lactone (C8-HSL), and N-decanoyl-homoserine l

186 SUPB145, was restored by 1 microM N-octanoyl homoserine lactone (C8-HSL).

187 ododecanoyl-homoserine lactone and N-butyryl-homoserine lactone, can both enter eukaryotic cells and

188 al signals, most of which belong to the acyl-homoserine lactone class.

189 Exposure of this strain to exogenous N-acyl-homoserine lactone counteracts this adhesion phenotype.

190 on of mRFP1 with ahlI, which exhibits N-acyl homoserine lactone-dependent transcriptional activity, a

191 We show that two other homoserine lactone derivatives are also capable of actin

192 -homoserine lactone and n-(3-oxo-dodecanoyl)-homoserine lactone, exhibited marked attenuation of viru

193 n density by utilizing members of the N-acyl homoserine lactone family as inducers and a transcriptio

194 the esaR gene and responds to exogenous acyl-homoserine lactone for derepression.

195 on factor, QscR, bound to N-3-oxo-dodecanoyl-homoserine lactone from the opportunistic human pathogen

196 ate group onto the gamma-carbon, affording L-homoserine lactone (HSL) and 5'-methylthioadenosine (MTA

197 nsing system consisting of TraR and its acyl-homoserine lactone (HSL) ligand.

198 g systems that produce and detect fatty acyl-homoserine lactone (HSL) signals.

199 Interestingly, exogenously added C(4)-homoserine lactone (HSL), but not 3-oxo-C(12)-HSL, resto

200 mutants, which do not respond to 3-oxo-C(12)-homoserine lactone (HSL)-mediated QS, exhibit reduced vi

201 monas aeruginosa secrete N-(3-oxododecanoyl)-homoserine lactone (HSL-C12) as a quorum-sensing molecul

202 Acyl-homoserine lactones (HSLs) serve as quorum-sensing signa

203 tor QscR responds to a variety of fatty acyl-homoserine lactones (HSLs), including N-3-oxododecanoyl-

204 three-dimensional structure of the N-acyl-l-homoserine lactone hydrolase (AHL lactonase) from Bacill

205 tivator A (AiiA) is a metal-dependent N-acyl homoserine lactone hydrolase that displays broad substra

206 The N-acyl- l-homoserine lactone hydrolases (AHL lactonases) have attr

207 des the quorum-sensing receptor for N-acyl-l-homoserine lactone in Escherichia coli.

208 the EsaR protein binds N-(3-oxo-hexanoyl)-L-homoserine lactone, in a 1:1 protein:ligand ratio, and t

209 Furthermore, N-(3-oxo-dodecanoyl)homoserine lactone induced distension of mitochondria an

210 icient in the synthesis of a diffusible acyl-homoserine lactone inducer remain repressed for EPS synt

211 oof of concept, we characterize a set of Lux homoserine-lactone-inducible genetic devices with differ

212 ydra to specifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterpart

213 Signaling via acyl-homoserine lactones is the paradigm for QS in Proteobact

214 Although acyl-homoserine lactone levels in cultures of this strain are

215 n 11.2 kDa antiactivator, modulates the acyl-homoserine lactone-mediated autoinduction of Ti plasmid

216 ent recently published reports indicate that homoserine lactone-mediated quorum sensing regulates the

217 Many Proteobacteria use acyl-homoserine lactone-mediated quorum-sensing (QS) to activ

218 we provide evidence that N-(3-oxo-dodecanoyl)homoserine lactone-mediated signaling does not require t

219 These findings suggest that N-(3-oxo-acyl)homoserine lactones might be recognized by receptors of

220 The acyl-homoserine lactone molecular species (AHLs) produced by

221 , in the presence of 1-100 nM exogenous acyl-homoserine lactone molecules has been quantified.

222 ction of Pig and Car is controlled by N-acyl homoserine lactone (N-AHL) quorum sensing, with synthesi

223 AHLs synthesized via YenI: N-(3-oxodecanoyl)homoserine lactone, N-(3-oxododecanoyl)homoserine lacton

224 cell-to-cell signals, N-(3-oxododecanoyl)-L-homoserine lactone, N-butyryl-L-homoserine lactone, and

225 and rhlI genes, impairing the production of homoserine lactones necessary for quorum-sensing, an imp

226 onstrate that the QSSM N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) from P. aeruginosa blocks pro

227 sing (QS) signal molecule 3-oxo-dodecanoyl-L-homoserine lactone (OdDHL) is produced by the opportunis

228 enzyme that hydrolyzes the ester bond of the homoserine lactone of N-acyl homoserine lactone (AHLs).

229 In contrast, other acylated homoserine lactones of different chain lengths did not a

230 s on the production of a N-(3-oxohexanoyl)-L-homoserine lactone (OHHL) quorum sensing (QS) signal.

231 nsing (QS) signal molecule, 3-oxo-hexanoyl-l-homoserine lactone (OHHL), and (ii) the intracellular 'a

232 ing signalling molecule, N-(3-oxohexanoyl)-L-homoserine lactone (OHHL).

233 the signalling molecule, N-(3-oxohexanoyl)-l-homoserine lactone (OHHL).

234 anding of the effects of N-(3-oxo-dodecanoyl)homoserine lactone on host cells and its role in persist

235 the quorum-sensing signal N-3-oxooctanoyl- l-homoserine lactone (OOHL) and a C-terminal domain that b

236 raR requires the pheromone N-3-oxooctanoyl-L-homoserine lactone (OOHL) for biological activity, and i

237 ires its cognate autoinducer N-3-oxooctanoyl-homoserine lactone (OOHL) for resistance of proteolysis

238 he presence of the autoinducer 3-oxooctanoyl-homoserine lactone (OOHL).

239 the autoinducer pheromone N-3-oxooctanoyl-l-homoserine lactone (OOHL).

240 nts from A. tumefaciens (i.e. 3-oxooctanyl-l-homoserine lactone [OOHL]) synthesized by the TraI prote

241 N-3-oxo-tetradecanoyl-l-homoserine lactone (oxo-C14-HSL) primed plants for enhan

242 The yenI(+) EHEC produces oxo-C6-homoserine lactone (oxo-C6-HSL) and had a significant re

243 signal synthase, which produces p-coumaroyl-homoserine lactone (pC-HSL) and RpaR, which is a pC-HSL-

244 ynthesized quorum-sensing signal p-coumaroyl-homoserine lactone (pC-HSL).

245 gulated by the quorum-sensing signal, N-acyl homoserine lactone, plant signals, an assortment of tran

246 ssor of Pig and Car when levels of N-acyl- l-homoserine lactones, produced by SmaI, are low.

247 n secretion profile and increased N-butanoyl homoserine lactone production and influenced several quo

248 ssay to detect production of long-acyl-chain homoserine lactone production by Rhodobacter capsulatus

249 transcriptional activator TraR and its acyl-homoserine lactone quormone N-(3-oxo-octanoyl)-L-homoser

250 Acyl-homoserine lactone quorum sensing appears to be a system

251 rkholderia thailandensis contains three acyl-homoserine lactone quorum sensing circuits and has two a

252 in, which appears to bind and sequester some homoserine lactone quorum signals, resulting in the inab

253 aeruginosa utilizes two interconnected acyl-homoserine lactone quorum-sensing (acyl-HSL QS) systems,

254 The acyl-homoserine lactone quorum-sensing (QS) systems of these

255 thelium and is activated in response to acyl-homoserine lactone quorum-sensing molecules secreted by

256 yet another subtle regulatory layer for acyl-homoserine lactone quorum-sensing signal-responsive tran

257 c bacterium Pseudomonas aeruginosa uses acyl-homoserine lactone quorum-sensing signals to coordinate

258 Vibrio fischeri possesses two acyl-homoserine lactone quorum-sensing systems, ain and lux,

259 There are two interrelated acyl-homoserine lactone quorum-sensing-signaling systems in P

260 ession, resulting in increased N-(butyryl)-l-homoserine-lactone quorum sensing signal and decreased E

261 xy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone reporter assays, showing that Fap fib

262 l-homoserine lactone and respond to butanoyl-homoserine lactone, respectively.

263 the cps cluster are significantly more acyl-homoserine lactone responsive than genes located towards

264 n is the founding member of a family of acyl-homoserine lactone-responsive quorum-sensing transcripti

265 eived through binding to LuxR-type, acylated-homoserine-lactone-responsive transcription factors.

266 Although the acyl-homoserine lactone responsiveness of both proteins is th

267 ion of the lasI mutant with 3-oxo-dodecanoyl homoserine lactone restores pel transcription to the wil

268 However, structures lacking the homoserine lactone ring, structures lacking the l-config

269 Because acyl-homoserine lactones serve as quorum-sensing molecules fo

270 Acyl-homoserine lactones serve as quorum-sensing signals for

271 Thus, long-chain acyl-homoserine lactones serve as quorum-sensing signals to e

272 The LasI-generated 3-oxododecanoyl-homoserine lactone serves as a signal molecule for QscR.

273 d the bacterial signaling molecule 3-oxo-C12-homoserine lactone, showing the necessity for cholinergi

274 QscR uses the LasI-generated acyl-homoserine lactone signal and controls a specific regulo

275 I and LasR, which generate a 3-oxododecanoyl-homoserine lactone signal and respond to that signal, re

276 transcriptional regulator that responds to a homoserine lactone signal to activate expression of acut

277 In such a system, binding of an acyl-homoserine lactone signal to its cognate transcriptional

278 ng signals for many Proteobacteria, and acyl-homoserine lactone signaling is known to control coopera

279 olone signal (PQS), which interacts with the homoserine lactone signaling pathway.

280 nd the glyoxylate bypass are induced by acyl-homoserine lactone signaling.

281 P. aeruginosa uses at least two N-acyl l-homoserine lactone signals and three homologous LuxR-typ

282 were not deficient in production of acylated homoserine lactone signals or catalase activity.

283 any Gram-negative bacteria involves acylated homoserine lactone signals that are perceived through bi

284 Along with their cognate acyl-homoserine lactone signals, the quorum sensing regulator

285 converse bidirectionally by exchanging acyl-homoserine lactone signals.

286 LasI is an acyl-homoserine lactone synthase that produces a quorum-sensi

287 ene, which is co-transcribed with the N-acyl-homoserine-lactone synthase gene cinI, is required to fu

288 to discovering inhibitors of LuxI-type acyl-homoserine lactone synthases.

289 L were found to efficiently hydrolyze N-acyl homoserine lactones that mediate quorum sensing in many

290 ssion system, whereas in the absence of acyl homoserine lactones, the protein is expressed into insol

291 kers of the effects induced by N-(3-oxo-acyl)homoserine lactones, the secreted products of a number o

292 lactonase catalyzing the hydrolysis of acyl-homoserine lactones; these molecules are involved in Gra

293 es, with low efficiency, lactones other than homoserine lactones, thus preceding the detoxifying func

294 t greatly influenced by addition of butanoyl-homoserine lactone to the biofilm growth medium.

295 The most abundant acyl-homoserine lactone was N-hexadecanoyl-homoserine lactone

296 Compound 12b, 3-oxo-12-phenyldodecanoyl-L-homoserine lactone, was identified as a lead compound wi

297 reased amounts of rhamnolipids and N-butyryl homoserine lactone were detected in the biofilm effluent

298 n of the AinS-generated pheromone N-octanoyl homoserine lactone, which may account for the previously

299 hat recognizes the naturally-occuring N-acyl homoserine lactone with high affinity.

300 ration assay, it is apparent that acylated l-homoserine lactones with an 11-13 C side chain containin