ライフサイエンスコーパス: homotetramer

1 human ABCG2 likely exists and functions as a homotetramer.

2 ons at this residue destabilize the R67 DHFR homotetramer.

3 active site pore traverses the length of the homotetramer.

4 and then two homodimers associate to form a homotetramer.

5 catalytic domain of E. coli RNase E forms a homotetramer.

6 Full-length AbrB is shown to exist as a homotetramer.

7 ommunication between the active sites in the homotetramer.

8 ently bound to Lys318 of two subunits of the homotetramer.

9 rometry and gel electrophoresis that it is a homotetramer.

10 The active form of the enzyme is a homotetramer.

11 ates that the native form of the enzyme is a homotetramer.

12 eoprotein (NP) and self-associates to form a homotetramer.

13 tudied the folding and stability of the DCoH homotetramer.

14 Thus, the enzyme is a homotetramer.

15 heterologous assembly of BcgI, TstI forms a homotetramer.

16 ut interacts with DNA in our structures as a homotetramer.

17 le caveolin-3 nonamers bind to a single RyR1 homotetramer.

18 g revealed that 66Y likely stabilized the NA homotetramer.

19 (M1 and M3) from another subunit within the homotetramer.

20 similar to the Escherichia coli SSB (EcoSSB) homotetramer.

21 d less than that seen for the unactivated SS homotetramer.

22 n the crystal structures of murine and human homotetramers.

23 and heterotetramers, with a predominance of homotetramers.

24 heteromers by attenuating formation of GluR2 homotetramers.

25 and 1:3 stoichiometries, in addition to the homotetramers.

26 d in Escherichia coli and purified as intact homotetramers.

27 ma membrane doubles the contribution of PIP2 homotetramers.

28 sufficient to maintain ATP regulation in R2 homotetramers.

29 ncentrations that specifically blocked SKCa2 homotetramers.

30 yrase regulate the formation of fully active homotetramers.

31 uired for cell surface localization of GIRK4 homotetramers.

32 are themselves capable of forming functional homotetramers.

33 the same extent as that observed for mutant homotetramers.

34 ring analysis that PlaB forms homodimers and homotetramers.

35 t channels preferentially self-assemble into homotetramers.

36 m and the transition from ExbB homodimers to homotetramers.

37 with viral proteins NP and L or formation of homotetramers.

38 lpha-subunit rather than antagonism to Kv1.2 homotetramers.

39 no acid hydroxylase superfamily, exists as a homotetramer (236 kDa on size exclusion chromatography).

40 KAP is a homotetramer (38.2 kDa per subunit) and, as purified, co

41 The enzyme is a homotetramer (42.06 kDa per subunit) and, as purified, c

42 ls of TRPC1 increased the formation of TRPC5 homotetramer, a highly Ca(2+)-permeable channel, and sti

43 B binds to the sinIR DNA target element as a homotetramer, affording a 4:1 protein:DNA stoichiometry.

44 The homotetramer (ALDH1 or ALDH2) is a dimer of dimers (A-B

45 pparent destabilization of the purified PEPC homotetramer, all were compromised catalytically in vivo

46 psilon A)]) with recombinant (C1)4 and (C2)4 homotetramers along with competition binding assays with

47 Apo-SiRHP forms a homotetramer, also dependent on its N terminus, that is

48 ng showed that the protein was purified as a homotetramer, although nonspecific oligomerization occur

49 thyroxin-binding sites in TTR stabilizes the homotetramer and attenuates TTR amyloidosis.

50 PpCMLE is a homotetramer and belongs to the fumarase class II superf

51 LpdA is a homotetramer and co-purifies with one molecule of tightl

52 lodysplastic syndromes, at the DNMT3A.DNMT3A homotetramer and DNMT3A.DNMT3L heterotetramer interfaces

53 The NA TMD formed a homotetramer and efficiently trafficked to the plasma me

54 The C. trachomatis FabI (CtFabI) is a homotetramer and exhibited typical FabI kinetics, and it

55 The M(2) ion channel is a homotetramer and has a 24-residue N-terminal extracellul

56 C-MS, we confirm that AbrB is assembled as a homotetramer and not as a homohexamer as previously sugg

57 5F11-scFv-streptavidin (5F11-scFv-SA) was a homotetramer and showed comparable avidity to 5F11 IgM a

58 This structure confirms that MspJI acts as a homotetramer and that the modified cytosine is flipped f

59 molecular mass of 235 kD corresponding to a homotetramer and the C-terminus was critical for this ol

60 ation analysis suggested that RPA1 exists as homotetramers and homodimers in solution, while RPA2 and

61 e activity and consisted of cross-linked A3G homotetramers and homodimers.

62 ortant structural differences between sqKv1A homotetramers and native squid channels are likely to ex

63 We tested whether purified KLP61F homotetramers and Ncd homodimers can generate a force ba

64 nd 15 (four homodimers, six homotrimers, six homotetramers and one homopentamer) had solution small-a

65 te of subunit exchange between wild-type TTR homotetramers and wild-type TTR homotetramers tagged wit

66 rs could combine to form either two types of homotetramers and/or one heterotetramer composed of both

67 protein exists in solution as a heat-stable homotetramer, and enzymatic assays reveal that the expre

68 f only 1 mol of phosphate per mole of enzyme homotetramer, and glycogen synthase kinase-3 incorporate

69 uine butyrylcholinesterase (BChE), a 364 kDa homotetramer, and the complexes were studied by (1)H NMR

70 XR is unique in that it self-associates into homotetramers, and that these tetramers dissociate rapid

71 The assembly process of the hemoglobin H homotetramer apparently follows a scenario similar to th

72 vities of the resurrected L(K41R.T51K.S302N) homotetramer are compared with its heterotetrameric form

73 ugh the evidence to date suggests that GIRK1 homotetramers are not functional.

74 ers in each of the expression systems with a homotetramer as a predominant form.

75 etic data reveal the dissociation of the p73 homotetramers as the rate-limiting step for heterotetram

76 entrifugation, where the active enzyme was a homotetramer at 4 degrees C but dissociated into inactiv

77 lytic portion of beta-tryptase to the active homotetramer at acid pH requires heparin.

78 we found that this peptide assembles into a homotetramer at neutral pH in contrast to the native mol

79 and incorporate subunits from labeled WT TTR homotetramers at a rate equivalent to that exhibited by

80 rates of two ligands, beta-glucuronidase (a homotetramer bearing multiple Man-6-P moieties) and IGF-

81 in the ESI mass spectrum corresponds to the homotetramer beta*4, alongside homodimeric species and m

82 SSB homotetramers bind ssDNA in several modes that differ in

83 nge (DeltaC(p,obs)) for Escherichia coli SSB homotetramer binding to single-stranded (ss) DNA.

84 cells shows that MAT-3 predominantly forms a homotetramer but also a trimer and a dimer.

85 We show that nestin forms homodimers and homotetramers but does not form IF by itself in vitro.

86 The E. coli enzyme is a homotetramer, but in a quaternary state between the cano

87 o note that both of these proteins behave as homotetramers, but one behaves as a more compact molecul

88 the subunit exchange reaction of p53 family homotetramers by nanoflow electrospray mass spectrometry

89 gion of contact between subunits within RyR1 homotetramer Ca2+ release channels.

90 ompetition with the other pathways, in which homotetramers can be formed either by the association of

91 Mutant homotetramers carry little or no K+ current despite norm

92 In oligodendrocytes, KIR4.1 appears as a homotetramer channel, in astrocytes as homo- and heterot

93 Comprised of a homotetramer complex, its function primarily is to slide

94 T4 Pnk is a homotetramer composed of a C-terminal phosphatase domain

95 In solution, the enzyme (EC ) exists as a homotetramer composed of non-covalently linked subunits

96 yntaxin 1A H3, four molecules associate as a homotetramer composed of two pairs of parallel helices t

97 rotein of human metapneumovirus (HMPV) forms homotetramers composed of a stable oligomerization domai

98 oltage-dependent potassium channels (Kv) are homotetramers composed of four voltage sensors and one p

99 The enzyme is a homotetramer comprising two obligate dimers and four pyr

100 complex, indicating that the crystallin was homotetramer consisting of 38-kDa subunits.

101 The structure of EmoB is a homotetramer consisting of four alpha/beta-single-domain

102 C-terminal region of Abeta assemble to form homotetramers consisting of two hydrogen-bonded dimers.

103 The enzyme is a homotetramer, consisting of an alpha/beta single domain

104 The subunit of the DAHPS(Tm) homotetramer consists of an N-terminal ferredoxin-like (

105 contain four identical subunits which form a homotetramer containing a single active site pore access

106 the E. coli enzyme, A. aeolicus KDO8PS is a homotetramer containing four distinct active sites at th

107 Because the lac repressor homotetramer contains two DNA binding modules, it bridge

108 well as an experimental SAXS profile of the homotetramer D-xylose isomerase.

109 tion in non-alpha chains plays a key role in homotetramer, dimer, and monomer formation, which in tur

110 of bacterial SSB family members function as homotetramers, dimeric SSB proteins were recently discov

111 Homotetramers dominated in Nonidet P-40, and dimers and

112 BK channels are homotetramers (encoded by Slo1) that possess a unique tr

113 Unlike the SS enzyme, however, the LS302N homotetramer enzyme is neither activated by the effector

114 tion of a population of AGPase small subunit homotetramer enzymes with enhanced affinity toward ATP a

115 Inversely, the GIRK2 homotetramers exhibit low Ibasal and strong activation b

116 We show that the T119M homotetramer exhibits kinetic stabilization and therefor

117 IVD protein rapidly and stably forms mature homotetramer following import, whereas Type III mutant p

118 vious evidence that peripherin/rds mice form homotetramers for outer segment targeting.

119 The structure of OsGAPDH showed a homotetramer form with each monomer comprising three dom

120 GIRK4 homotetramers form channels with unusual single channel

121 a(112Thr,116Ile) chains showed homodimer and homotetramer formation like gamma-globin chains which co

122 on of betaB1DeltaN56 increased, resulting in homotetramer formation, and heteromolecular association

123 modeling predictions for ASL heterotetramer/homotetramer formation.

124 herichia coli RNase E protein functions as a homotetramer formed by Zn linkage of dimers within a reg

125 The E487K homotetramers had 8% specific activity of the Glu487 enz

126 tose-1,6-bisphosphate aldolase (EC 4.1.2.13) homotetramer has been destabilized by site-directed muta

127 data reveal that the C10S/V30M and V30M TTR homotetramers have identical amyloidogenicity and stabil

128 The map shows that the protein is a homotetramer, having a low-density region on the 4-fold

129 man gamma2 tetramers as well as human gamma4 homotetramers (hemoglobin Bart's).

130 tor (RXR) can regulate transcription through homotetramers, homodimers, and heterodimers with other n

131 s30 and Tyr166 from adjacent subunits in the homotetramer human manganese superoxide dismutase (Mn-SO

132 The enzyme is a homotetramer in its functional state, and the symmetry o

133 2-6His shows that it associates as a 196-kDa homotetramer in vitro, a result that is significant in l

134 KDO8P synthase is a homotetramer in which each monomer has the fold of a (be

135 cture of the apoenzyme form of LmFBPase is a homotetramer in which the dimer of dimers adopts a plana

136 Structural studies revealed a homotetramer in which the quaternary arrangement of subu

137 Rabbit muscle aldolase is a homotetramer in which the subunits have a classical alph

138 ctions in purine biosynthesis, is normally a homotetramer in which three subunits contribute to each

139 cinate lyase (ASL) of Bacillus subtilis is a homotetramer in which three subunits contribute to each

140 ansport protein (GLUT1) forms homodimers and homotetramers in detergent micelles and in cell membrane

141 Structures of GluA2 homotetramers in distinct functional states, together wi

142 We also show that GIRK subunits may form homotetramers in expression systems, although the eviden

143 ABCD1 and its homolog ABCD2 exist mainly as homotetramers in the peroxisomal membrane.

144 ) currents generated by N-type alpha-subunit homotetramers inactivate rapidly because an N-terminal b

145 in three human TTR single amino acid variant homotetramers including two familial amyloidotic polyneu

146 amyloid by acid-mediated dissociation of the homotetramer into monomers.

147 Each subunit of the homotetramer is characterized by a five-stranded anti-pa

148 etin is not amyloidogenic because the native homotetramer is kinetically stable under physiologic con

149 We show that the DCoH1 homotetramer is kinetically trapped, meaning once it for

150 Each subunit of the homotetramer is made up of three distinct domains with o

151 This suggests that the formation of homotetramers is a common feature of NAP-1 fold histone

152 KIF11 encodes EG5, a homotetramer kinesin motor.

153 In solution, native CelF exists as a homotetramer (M(w), approximately 200,000) composed of n

154 esidues, but exhibits neither the functional homotetramer nor the homodimer that distinguish all SDRs

155 trophoresis to provide evidence that it is a homotetramer of 110-kDa subunits.

156 eptomyces lividans KcsA potassium channel, a homotetramer of 17.6 kDa subunits, was found to contain

157 manganese superoxide dismutase (MnSOD) is a homotetramer of 22 kDa subunits, a dimer of dimers conta

158 of human Mn superoxide dismutase (hMnSOD), a homotetramer of 22 kDa, reveals a functional role for th

159 The tumor suppressor p53 is a homotetramer of 4 x 393 residues.

160 Cardiac ryanodine receptor (RyR2) is a homotetramer of 560 kDa polypeptides regulated by calmod

161 The native enzyme was a homotetramer of 58-kDa subunits and exhibited a pI of 4.

162 The enzyme is a homotetramer of about 50 kDa subunits and is not subject

163 AqpZ is a homotetramer of four water-conducting channels that faci

164 residues in each of the four subunits of the homotetramer of human MnSOD was replaced with 3-fluoroty

165 report that the rat BCKD kinase exists as a homotetramer of M(r) = 185,000, based on results of gel

166 c GABA(B(1,2)) receptors that associate with homotetramers of auxiliary KCTD8, -12, -12b, or -16 (nam

167 nsing and pore-forming domains, but they are homotetramers of four identical subunits, rather than ps

168 e among bacterial SSBs, which typically form homotetramers of single-OB domain subunits.

169 nin is a monomeric protein that forms stable homotetramers on addition of BLA to the protein.

170 se allosteric interactions that exist in the homotetramer phosphofructokinase from Bacillus stearothe

171 The crystal conformation of the homotetramer points to the fact that, in the absence of

172 This homotetramer possesses a single active site pore and exa

173 high-resolution crystal structure shows the homotetramer possesses exact 222 symmetry.

174 The LS302N homotetramer possesses very little enzyme activity at a

175 This enzyme is a homotetramer possessing 222 symmetry, and a single activ

176 e 78 amino acids long, which assemble into a homotetramer possessing 222 symmetry.

177 nomers (78 amino acids long) assemble into a homotetramer possessing 222 symmetry.

178 R67 DHFR is a homotetramer possessing a single active site pore.

179 The active form of the protein is a homotetramer possessing D(2) symmetry and a single activ

180 Thus, beta-tryptase homotetramers probably account for active enzyme detecte

181 GAC activation requires the formation of homotetramers, promoted by anionic allosteric activators

182 glucose to concanavalin A (ConA), a 106 KDa homotetramer protein, in free solution using picomoles o

183 cture of the full-length AMPA receptor GluA2 homotetramer, provide unique insights into the mechanism

184 We demonstrate herein that TTR homotetramers reassemble by an unusual monomer-dimer-tri

185 etal muscle Ca(2+) release channel (RyR1), a homotetramer, regulates the release of Ca(2+) from the s

186 er (Solanum tuberosum) AGPase (small subunit homotetramer) reported previously by others revealed tha

187 tion conditions for a group of eight protein homotetramers, representing a broad sample of protein st

188 w, in single molecule assays, that kinesin-5 homotetramers require the nonmotor C terminus for crossl

189 y kinetics of (35)S label incorporation into homotetramers showed a lag period corresponding to the t

190 contains a single Mis18 isoform that forms a homotetramer, showing tetrameric Mis18 is conserved from

191 During export in Escherichia coli, SecB, a homotetramer structurally organized as a dimer of dimers

192 The Lys 30 --> Nle variant forms a stable homotetramer (T(m) = 60 degrees C).

193 6/Lys 30 --> Nle variant forms a very stable homotetramer (T(m) = 80 degrees C).

194 ild-type TTR homotetramers and wild-type TTR homotetramers tagged with an N-terminal acidic flag tag

195 Purified ssA-TIBF is a homotetramer that binds one substrate molecule and conta

196 ed DNA binding protein (SSB) is an essential homotetramer that binds ssDNA and recruits multiple prot

197 hat hKif15 is a plus-end-directed processive homotetramer that can step against loads of up to 3.5 pN

198 Dihydrodipicolinate reductase (DHPR) is a homotetramer that catalyzes reduction of dihydrodipicoli

199 Transthyretin (TTR) is a homotetramer that circulates in both blood and cerebrosp

200 The M2 protein is a homotetramer that contains four 19-residue transmembrane

201 The M2 protein is a homotetramer that contains in its aqueous pore a histidi

202 KLP61F is a bipolar homotetramer that cross-links spindle microtubules [4].

203 R67 DHFR is a homotetramer that exhibits numerous characteristics of a

204 hermophilus phosphofructokinase (BsPFK) is a homotetramer that is allosterically inhibited by phospho

205 The dimers form a functional homotetramer that is fashioned through contacts between

206 ring mass spectrometry revealed AmpR to be a homotetramer that is stabilized by DNA containing the T-

207 stal structure data reveals this enzyme is a homotetramer that possesses a single active site pore.

208 pha3 chain the novel long chains assemble to homotetramers that are incorporated into mixed microfibr

209 embrane (TM) helix, which associates to form homotetramers that bind the anti-influenza drug amantadi

210 ceptor potential (TRP) channel subunits form homotetramers that function in sensory transduction.

211 ro, recombinant AIRE can form homodimers and homotetramers that were also detected in thymic protein

212 recombinant cav-3 nonamers and purified RyR1 homotetramers that would imply that at least one of the

213 ull-length ACAT1 converted the enzyme from a homotetramer to a homodimer.

214 lies on kinesin-5 motors that act as bipolar homotetramers to crosslink microtubules.

215 Unlike the other ACADs, which are soluble homotetramers, VLCAD is a homodimer associated with the

216 The subunit size of the native homotetramer was determined to be 34,000 Da.

217 A model for the DNMT3A homotetramer was developed via computational interface s

218 ng pattern of Gbetagamma attachment to GIRK4 homotetramers was consistent with the binding of one, tw

219 Putative homotetramers were also observed.

220 Homotetramers were identified for the type III IP3R; how

221 ified for the type III IP3R; however, type I homotetramers were undetectable.

222 These GIRK4 complexes, most likely GIRK4 homotetramers, were previously not seen because of their

223 Both form enzymatically active homotetramers when overexpressed in Escherichia coli.

224 us with the TPP enzymes having arisen from a homotetramer which subsequently diverged into an alpha(2

225 absence of ligand, RXR self-associates into homotetramers which are transcriptionally silent, and th

226 behavior similar to that of the E. coli SSB homotetramer, which also shows binding mode transitions,

227 quitously expressed enzyme, functioning as a homotetramer, which catalyzed the rate-limiting step in

228 ramer of immature proteoid roots into a p107 homotetramer while significantly increasing the enzyme's

229 omodimers or heterodimers, but it also forms homotetramers whose function is poorly defined.

230 The AQP1 water channel protein is a homotetramer with 28 kDa subunits containing six transme

231 It forms a symmetric homotetramer with a central pore which functions as the

232 MAO-N exists as a homotetramer with a large channel at its centre and shar

233 FOR is a homotetramer with a mass of 280 kDa and contains approxi

234 This enzyme is a homotetramer with a molecular mass of 108 kDa.

235 This enzyme is a homotetramer with a monomer molecular mass of 42 kDa.

236 Short chain acyl-CoA dehydrogenase is a homotetramer with a subunit mass of 43 kDa and crystalli

237 The membrane-associated enzyme is a homotetramer with a subunit molecular mass of 49,500 Da.

238 ole in excitation-contraction coupling, is a homotetramer with a subunit molecular mass of 565 kDa.

239 Thus, CorA appears to be a homotetramer with a TM segment of one monomer physically

240 the principal ion observed corresponds to a homotetramer with an average molecular mass of 86,844 Da

241 -C6H4)-OCH2CH2NH2 PLL was discovered to be a homotetramer with an intersubunit disulfide bridge.

242 ped protomers assemble into a C(4)-symmetric homotetramer with an open central core and a surface con

243 gral membrane protein whose active form is a homotetramer with each polypeptide chain containing 96-a

244 The enzyme from S. typhi is a homotetramer with each subunit containing 339 amino acid

245 SSB functions as a homotetramer with each subunit possessing a DNA binding

246 cal characterization indicates TtHGXPRT as a homotetramer with excellent activity and stability acros

247 chia coli phosphofructokinase 1 (EcPFK) is a homotetramer with four active and four allosteric sites.

248 ctokinase from Escherichia coli (EcPFK) is a homotetramer with four active sites and four allosteric

249 ctokinase from Escherichia coli (EcPFK) is a homotetramer with four active sites, which bind the subs

250 exchange rates in rabbit muscle aldolase, a homotetramer with M(r) = 157,000.

251 enzyme for treatment of hyperuricemia, is a homotetramer with multiple surface lysines, limiting con

252 The asymmetric unit contains a homotetramer with substrate/product bound in two monomer

253 IscA exists as an (alpha1alpha2)2 homotetramer with the (alpha1alpha2) dimer comprising th

254 The enzyme forms a 222 homotetramer with the PLP cofactor bound via a Schiff-ba

255 RyRs form homotetramers with a mushroom-like shape, consisting of

256 Voltage-gated potassium (Kv) channels are homotetramers with each subunit constructed from six tra

257 bipolar mitotic spindle in eukaryotes, forms homotetramers with two pairs of motor domains positioned

258 It is a homotetramer, with each monomer consisting of a transmem

259 SOR forms a homotetramer, with each subunit adopting an immunoglobul

260 The enzyme forms a homotetramer, with the dinucleotide binding at the monom

261 RmlA is a homotetramer, with the monomer consisting of three funct

262 of bacterial SSB family members function as homotetramers, with each monomer contributing a single O