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3 omologous to those of bacterial and archaeal homotetrameric alcohol dehydrogenases (ADHs) and also to
5 esence of secretable and functionally active homotetrameric alpha- and beta-tryptases in transfected
7 herichia coli MgsA is described, revealing a homotetrameric arrangement for the protein that distingu
10 rate that Kir 2.2 channels are formed by the homotetrameric association of Kir 2.2 subunits and do no
12 t differences between D. radiodurans SSB and homotetrameric bacterial SSB proteins may confer a selec
13 ly showed that Escherichia coli (Eco) SSB, a homotetrameric bacterial SSB, undergoes not only rapid s
14 biochemical analyses, we identified a single homotetrameric bifunctional ammonia-lyase (PTAL) among e
17 dimeric by gel filtration chromatography and homotetrameric by dynamic light scattering and to contai
19 n two adjacent hERG1 subunits, and, hence, a homotetrameric channel has four identical RPR binding si
22 e of the complex shows the drug bound in the homotetrameric channel, threaded between the side chains
26 in tobacco mesophyll protoplasts: KAT2 forms homotetrameric channels active at the plasma membrane, w
27 gion, preventing surface expression of Kv1.1 homotetrameric channels and of heteromeric Kv1 channels
28 eases surface expression of functional Kv1.1 homotetrameric channels and support a model whereby a DT
29 mutation is permissive for the expression of homotetrameric channels that are nonselective for cation
30 e compared this pH-dependence with that from homotetrameric channels with four copies of the mutation
31 However, L18A/L25A channels failed to form homotetrameric channels, as assessed by Co-IP, suggestin
34 ess at least two distinct PEPC enzyme-forms, homotetrameric Class-1 and heteromeric Class-2, that dif
36 at RECQ1 can form what appears to be a flat, homotetrameric complex and propose that RECQ1 tetramers
37 l muscle (RyR1) receptor isoforms, RyR3 is a homotetrameric complex comprising two main components, a
38 mass of 270 kDa, compatible with its being a homotetrameric complex of the approximately 64-kDa subun
40 tracellular superoxide dismutase (SOD3) is a homotetrameric copper- and zinc-containing glycoprotein
41 nformational ensembles of the D2 -symmetric, homotetrameric copper-sensitive operon repressor (CsoR)
46 +)-dependent enzyme, GCYH-IB is a bimodular, homotetrameric enzyme activated by a variety of divalent
47 of ATP binds at the subunit interface of the homotetrameric enzyme and that the majority of the ATP-e
49 a reduction in the overall dimensions of the homotetrameric enzyme following substrate binding and ox
56 yl-acyl carrier protein (ACP) reductase is a homotetrameric enzyme that catalyzes the last reductive
58 ate dehydrogenase from Escherichia coli is a homotetrameric enzyme which is allosterically regulated
59 manganese superoxide dismutase (MnSOD) is a homotetrameric enzyme which protects mitochondria agains
67 The kinetic mechanism of transfer of the homotetrameric Escherichia coli SSB protein between ssDN
68 or DrSSB that strongly resemble those of the homotetrameric Escherichia coli SSB, further supporting
69 ned the kinetic mechanism for binding of the homotetrameric Escherichia coliSSB protein to single-str
70 We demonstrate our approach on the yeast homotetrameric FBP1 complex, the rate-limiting enzyme in
71 dehydrogenase (IVD) is an intramitochondrial homotetrameric flavoenzyme that catalyzes the conversion
72 ort chain acyl-CoA dehydrogenase (SCAD) is a homotetrameric flavoenzyme that catalyzes the first intr
74 ition, it has not been demonstrated that the homotetrameric form of these proteins is essential for t
77 similar to the distal (B/D) subunits in the homotetrameric GluA2 alpha-amino-3-hydroxy-5-methyl-4-is
80 hese studies to investigate formation of the homotetrameric hemoglobin H, whose formation in vivo is
81 onding enzyme from Saccharomyces uvarum, the homotetrameric holoenzyme assembly has approximate 222 s
82 on equilibrium analysis indicates an alpha 4 homotetrameric holoenzyme structure (4 x 38,861 Da).
88 .0 A resolution, which establishes PKD2 as a homotetrameric ion channel and provides insight into pot
90 s with high affinity to membranes expressing homotetrameric K(v)1.3 channels, and high affinity diTC
95 ulations to dissect the various roles of the homotetrameric kinesin-5, KLP61F, in astral, centrosome-
98 y of tRNA(Met)i The crystal structure of the homotetrameric m1A58 tRNA Mtase from Mycobacterium tuber
99 heart of the H+ conductance mechanism in the homotetrameric M2 H+ channel from influenza A is a set o
103 removed by the product of the SOD2 gene, the homotetrameric manganese superoxide dismutase (MnSOD).
104 otein from influenza A virus is a 97-residue homotetrameric membrane protein that functions as a prot
105 Isovaleryl-CoA dehydrogenase (IVD) is a homotetrameric mitochondrial flavoenzyme which catalyzes
106 -CoA dehydrogenase (IVD), a nucleus-encoded, homotetrameric, mitochondrial flavoenzyme that catalyzes
107 al analyses of drug binding to the bacterial homotetrameric model CaV channel CaVAb, which is inhibit
110 Kinesin-5 (also called Eg5 or kif11) is a homotetrameric motor protein that functions by modulatin
114 quaternary structure, a potato small subunit homotetrameric mutant, TG-15, was subjected to iteration
117 ent, an intrinsic RNA kinase activity, and a homotetrameric or homodimeric quaternary structure, that
118 s are the largest known ion channels, with a homotetrameric organization and approximately 5,000 resi
119 5 motors, which display a conserved, bipolar homotetrameric organization consisting of two motor dime
121 The influenza A virus M2 protein (A/M2) is a homotetrameric pH-activated proton transporter/channel t
122 His-37 from symmetry-related monomers of the homotetrameric pore converge to form a coordination site
124 at the MGAT2 enzyme primarily functions as a homotetrameric protein and as a tetrameric protein.
126 to cobalt and nickel regulator) is a 40-kDa homotetrameric protein and metalloregulator that control
127 igand interaction between biotin (B) and the homotetrameric protein complex streptavidin (S(4)) in th
128 In the crystal structure each subunit of the homotetrameric protein contains one substrate-binding si
131 of the transmembrane-spanning region of the homotetrameric protein in the presence and absence of th
132 transthyretin (TTR), a human beta-sheet-rich homotetrameric protein that must undergo rate-limiting t
133 67 dihydrofolate reductase (DHFR) is a novel homotetrameric protein that possesses 222 symmetry and a
138 This is the case of transthyretin (TTR), a homotetrameric protein whose dissociation into its monom
143 chondrial ssDNA-binding protein (mtSSB) is a homotetrameric protein, involved in mtDNA replication an
144 of symmetry at the dimer interfaces in this homotetrameric protein, suggesting that the quaternary s
148 and that selective pressure may have caused homotetrameric proteins to evolve to assemble by a singl
152 wild-type and Lys --> Gln or Glu site mutant homotetrameric rabbit cytosolic SHMTs identified lysine
154 4-isoxazole propionic acid (AMPA)-sensitive, homotetrameric, rat GluA2 receptor at 3.6 A resolution i
156 -contraction coupling involves activation of homotetrameric ryanodine receptor ion channels (RyR1s),
159 in the last transmembrane region (S6) of the homotetrameric Shaker K+ channel creates metal binding s
161 tein is the adduct of the G26C mutant of the homotetrameric SSB from Escherichia coli and a diethylam
162 many of the same reactions catalyzed by the homotetrameric SSB of bacteria, but its origin, subunit
163 ing properties of these two highly conserved homotetrameric SSB proteins, and these differences might
166 results extend our previous observations on homotetrameric SSBs to homodimeric SSBs, indicating that
167 DrSSB that are analogous to those mapped in homotetrameric SSBs, although there are distinct contact
168 nylated Cp*Ir moiety (Cp* = C5Me5(-)) within homotetrameric streptavidin (Sav) (referred to as Cp*Ir(
174 tes at each protein-protein interface in the homotetrameric structure with binding constants relative
175 Previous studies demonstrated a specialized homotetrameric structure with two pairs of catalytic dom
176 ristics of mammalian class 1 ALDHs include a homotetrameric structure, high expression in liver, sens
179 The building block structure consists of a homotetrameric subunit complex with three unique supramo
181 thods to dissect the domain structure of the homotetrameric T4 Pnk protein and to localize essential
183 The p53 tumor suppressor gene encodes a homotetrameric transcription factor which is activated i
184 Common to both viruses is the M2 protein, a homotetrameric transmembrane proton channel that acidifi
186 single subunit of the previously determined homotetrameric tRNA splicing endonuclease from Methanoco
188 scorpion toxin, Charybdotoxin (CTX), blocks homotetrameric, voltage-gated K(+) channels by binding n
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