ライフサイエンスコーパス: homotrimer

1 active ecto-ATPase quaternary structure (the homotrimer).

2 rimers are identical in amino acid sequence (homotrimers).

3 density in all three active sites of the MIF homotrimer.

4 ant CERT proteins containing the UVB-induced homotrimer.

5 1, which assembles into a large, multidomain homotrimer.

6 tein and forms a target membrane-inserted E1 homotrimer.

7 fusion loop and refolds to form a stable E1 homotrimer.

8 ll inserts into target membranes and forms a homotrimer.

9 kDa, which is consistent with it being an S homotrimer.

10 ein and induces the formation of a stable E1 homotrimer.

11 MvINS exists as a homotrimer.

12 to proteolysis in the protease-resistant E1 homotrimer.

13 fic epitopes, and formation of the stable E1 homotrimer.

14 nactive monomer to the DNA-binding competent homotrimer.

15 s, resulting in the formation of a stable E1 homotrimer.

16 ated mass of 88 kDa, suggesting that it is a homotrimer.

17 -coil interface with the other chains in the homotrimer.

18 n, Ara h 1 was shown to form a highly stable homotrimer.

19 ses establish that purified AcpS exists as a homotrimer.

20 tion-specific epitope and formation of an E1 homotrimer.

21 the purified OASS is either a homodimer or a homotrimer.

22 igase I undergoes self-association to form a homotrimer.

23 or binding at the remaining two sites of the homotrimer.

24 me which bind equally to all subunits of the homotrimer.

25 0 ectodomain exists as an elongate, flexible homotrimer.

26 ng that its native conformation is that of a homotrimer.

27 te of unknown function between subunits of a homotrimer.

28 h target liposome membranes, and form the E1 homotrimer.

29 ng the lack of efficient formation of the E1 homotrimer.

30 artilages and consists of a disulfide-linked homotrimer.

31 ntermolecularly disulfide-linked ecto-ATPase homotrimer.

32 endent of the presence of its N-terminal DBD homotrimer.

33 the SUN2 protein SUN domain, which reveals a homotrimer.

34 eractions, by axial rotation of the collagen homotrimer.

35 binds to the outside surface of the PabPCNA homotrimer.

36 protein that assembles as a pseudohexameric homotrimer.

37 sphatases, namely, that they may function as homotrimers.

38 e uncharacteristic formation of proalpha1(I) homotrimers.

39 t nucleoplasmic NF7 exists primarily as free homotrimers.

40 ermined from the analysis of charge pairs in homotrimers.

41 ately 700 kDa, all of which were composed of homotrimers.

42 hat mediate membrane fusion usually exist as homotrimers.

43 tendency of the transmembrane helix to form homotrimers.

44 -tail-tendon homotrimers were similar to oim homotrimers.

45 , resulting in rings composed of five to six homotrimers.

46 p70 promoter when compared with HSF1 or HSF2 homotrimers.

47 rol, and sphingolipid and form highly stable homotrimers.

48 extensive post-translational modification of homotrimers.

49 d the kinetically trapped misfolded form are homotrimers.

50 lpha-helical and sufficient for formation of homotrimers.

51 copy dUTPases have been shown to assemble as homotrimers.

52 not cleave the C-propeptide of pro-alpha1(V) homotrimers.

53 contrast to the native molecule which forms homotrimers.

54 ike seed storage proteins that organize into homotrimers.

55 d for the ability of these molecules to form homotrimers.

56 ly linked F2 and F1 polypeptides that formed homotrimers.

57 and mechanical behavior between hetero- and homotrimers.

58 imer formation and simultaneously discourage homotrimers.

59 without preactivation that unravels the CHP homotrimers.

60 mposition due to varying amounts of residual homotrimers.

61 ntiparallel beta sheets and that they formed homotrimers.

62 all studies of collagen helices have been on homotrimers.

63 stinct structural similarity to the resistin homotrimer, a small cytokine associated with obesity and

64 d embryonic survival suggest that alpha1(V)3 homotrimers, a rare collagen V isoform that occurs in th

65 cinomas are reported to contain alpha1(I)(3) homotrimers, a type I collagen isoform normally not pres

66 Ligation by PSTPIP1, which is also a homotrimer, activates pyrin by unmasking its PYD, thereb

67 turbidity most likely caused by formation of homotrimer aggregates.

68 smaller amounts of stable [pro alpha 1(I)]3 homotrimer also being formed.

69 s are believed to have evolved from the same homotrimer ancestor and they have substantial sequence h

70 ious studies have shown that the enzyme is a homotrimer and adopts a pinwheel shape.

71 y contacts of DIII-stem in the alphavirus E1 homotrimer and describe a sensitive and quantitative in

72 UT-B is a homotrimer and each protomer contains a urea conduction

73 actor 1 (HSF1) is converted to a DNA-binding homotrimer and is hyperphosphorylated.

74 CNA), a potential anticancer target, forms a homotrimer and is required for DNA replication and numer

75 LTalpha is secreted as a homotrimer and signals through two TNF receptors of 55-6

76 teraction of the protein subunits within the homotrimer and their interaction with the viral and targ

77 tumor necrosis factor receptors (TNFRs) as a homotrimer and via lymphotoxin beta receptor (LTbetaR) a

78 strated that EMILIN-3 forms disulfide-bonded homotrimers and higher order oligomers.

79 with a Mr indicative of the existence of SBP homotrimers and homodimers.

80 n Xenopus oocytes, we found that MEC-4 forms homotrimers and MEC-4 and MEC-10 form 4:4:10 heterotrime

81 nce, we studied interactions of alpha1(I)(3) homotrimers and normal alpha1(I)(2)alpha2(I) heterotrime

82 ExbB and ExbD complexes were homodimers and homotrimers and suggested that ExbB also interacted with

83 eratures revealed that microunfolding of oim homotrimers and wild-type heterotrimers occurs at simila

84 The transporter is a homotrimer, and each subunit contains a continuous membr

85 ce that NF7 is recruited to the nucleus as a homotrimer, and expression of several mutated forms of N

86 2 mutant was fully infectious, formed the E1 homotrimer, and had the wild-type pH dependence of infec

87 the characteristic stability of the starting homotrimer, and is free of lipid and other contaminants.

88 The inner membrane component AcrB is a homotrimer, and it has been postulated that the monomers

89 The enzyme is a homotrimer, and previous studies suggested that the acti

90 cherichia coli, AcrB, is known to exist as a homotrimer, and this construction is essential for drug

91 Homotrimers are further discouraged by reducing hydroxyp

92 m of chain assembly and why [pro alpha2(1)]3 homotrimers are not formed.

93 s in fibers from type I (as well as type II) homotrimers are not sensitive to pH between pH 6 and 7.5

94 Because the homotrimers are universally secreted by cancer cells and

95 y within this region, matrilin-2 will form a homotrimer as matrilin-1 does.

96 he left-handed beta-helix family and forms a homotrimer as the functional unit.

97 died in the past using collagen-like peptide homotrimers as a model system.

98 proline motifs to create optimal packing in homotrimer assembly distinct from classical trimeric coi

99 early phases of folding, but no longer after homotrimer assembly.

100 n purine nucleoside phosphorylase (PNP) is a homotrimer binding tightly to the transition state analo

101 SAT (a dimer of homotrimers) binds a maximum of two molecules of OASS (a

102 known as BlyS) was initially described as a homotrimer, but Liu and colleagues claim that it is a 60

103 In contrast, angiopoietin-1 forms some homotrimers, but predominantly exists in higher order mu

104 ther TNF superfamily ligands are noncovalent homotrimers, but the form under which CD40 exists in the

105 pological arrangement of monomers within the homotrimer by comparing atomic force microscopy (AFM) im

106 The chimeric A-NC1 peptide forms a homotrimer by itself, and a series of heterotrimers with

107 ssive addition of monomers to homodimers and homotrimers, can cause substantial amounts of protein to

108 tional alpha2 chains and formation of type I homotrimers cause severe bone pathology (osteogenesis im

109 ain by an alpha-1 chain, resulting also in a homotrimer collagen molecule.

110 f a section of mouse type I heterotrimer and homotrimer collagen molecules are developed to explore t

111 We found that at the same heating rate oim homotrimers completely denature at approximately 2.5deg.

112 The homotrimers completely replace the heterotrimers only in

113 induced the rapid formation of a stable CERT homotrimer complex in keratinocytes as determined by Wes

114 ositol-3-phosphate synthase (IP synthase), a homotrimer composed of a 68-kDa polypeptide in most mamm

115 The human copper transporter hCTR1 is a homotrimer composed of a plasma membrane protein of 190

116 YfkE forms a homotrimer, confirmed by disulfide crosslinking.

117 ive structure and convert to a highly stable homotrimer conformation during the fusion of the viral a

118 both the prefusion dimer and the postfusion homotrimer conformations.

119 The fiber protein is a homotrimer consisting of an N-terminal tail, a long shaf

120 rget membranes and refolds to a hairpin-like homotrimer containing a central core trimer and an outer

121 Human PNP is a homotrimer containing three tryptophan residues at posit

122 n purine nucleoside phosphorylase (PNP) is a homotrimer, containing three nonconserved tryptophan res

123 determined for the class I proteins, the E1 homotrimer contains the fusion peptide region responsibl

124 The homotrimer contains three high affinity ATP-binding site

125 n of MIF or the functional activities of MIF homotrimers could have therapeutic benefits during ocula

126 y more stable than the corresponding alanine homotrimer (deltaT(m) = 25 degrees C, deltadeltaG(unf) =

127 At the same, constant temperature, homotrimers denature approximately 100 times slower than

128 The crystal structure of the E. coli LpxA homotrimer, determined previously at 2.6 A in the absenc

129 The crystal structure of the E. coli LpxA homotrimer, determined previously in the absence of lipi

130 s results in secretion of collagen alpha1(I) homotrimer, diminished intracellular colocalization of c

131 iquitin to reside on the surface of the PCNA homotrimer, distinct from the position identified in the

132 pathology; for example, synthesis of 10-15% homotrimers due to a polymorphism in the alpha1(I) gene

133 the viral fusion peptide and forms a stable homotrimer during fusion.

134 fusion peptide loop and converts to a stable homotrimer during the fusion reaction.

135 mer to a highly stable, membrane-inserted E1 homotrimer (E1HT).

136 Within the context of the homotrimer, each H-NS1-64 protomer consists of three alp

137 Within a homotrimer, each monomer-monomer interface exhibits an a

138 stacked rings in the pore formed by the CTR1 homotrimer, each of which is required for maximal copper

139 al that in contrast to the heterotrimer, the homotrimer easily forms kinks and freely rotates with an

140 ystal structure of the Escherichia coli LpxD homotrimer (EcLpxD).

141 The approximately 84-kDa Pgp3 homotrimer, encoded on a cryptic plasmid, consists of gl

142 a stability comparable to that of a (POG)10 homotrimer even though D and K occur 20 times in the het

143 We observed the homotrimer fibers to be resistant to pericellular degrad

144 The aggregates promoted nucleation of homotrimer fibrils that served as seeds for mixed and he

145 s suggest that invasive cancer cells may use homotrimers for building MMP-resistant invasion paths, s

146 odel of collagen VIII assembly in which four homotrimers form a tetrahedron stabilized by central int

147 Thus, UVB-induced CERT homotrimer formation accounts, at least in part, for apo

148 However, both G91A membrane association and homotrimer formation had an acid-shifted pH threshold an

149 rity of CBF1 point mutants were deficient in homotrimer formation, proteolytic processing, and transp

150 ain of the CERT protein was required for the homotrimer formation, whereas neither the pleckstrin hom

151 association, but was essentially inactive in homotrimer formation.

152 order self-assembly but was dispensable for homotrimer formation.

153 a purification method for the E1 ectodomain homotrimer from the alphavirus Semliki Forest virus.

154 The crystal structure of the TgMIF homotrimer has been determined to 1.82 A, and although i

155 However, the [pro alpha 2(1)]3 homotrimer has not been detected, raising questions as t

156 and reconstituted fibers composed of type I homotrimers, heterotrimers and their mix.

157 positions was required to generate a stable homotrimer; however, the driving force for Smad2 self-as

158 eat and hydrogen peroxide to assemble into a homotrimer in a reversible and redox-regulated manner.

159 Pyrin exists as a homotrimer in an autoinhibited state due to intramolecul

160 imer or about the mechanism of action of the homotrimer in fusion.

161 ng ligand (TRAIL) protein is known to form a homotrimer in solution.

162 so demonstrated the dissociation of the PCNA homotrimer in the presence of NEIL1 and DNA, while small

163 The presence of the GDPDLd17 homotrimer in the viral baseplate structure involved in

164 The protein assembles into a propeller-like homotrimer in which each blade contains a GT-B-type glyc

165 We showed that LAMP-2A exists as a homotrimer in which the membrane-spanning helices wrap a

166 sent in healthy tissues, but the role of the homotrimers in cancer pathophysiology is unclear.

167 uration recombinant Scl proteins migrated as homotrimers in gel electrophoresis with and without SDS.

168 comparison, we report forces between type II homotrimers in reconstituted fibers.

169 wild type and mutant PCNAs were able to form homotrimers in solution and to sustain growth of a null

170 alpha1(VIII) and alpha2(VIII), that can form homotrimers in vitro and in vivo.

171 This coiled-coil domain forms a homotrimer, in both solution and crystal structure, and

172 rsion from a dimer on the virus surface to a homotrimer inserted into the host cell membrane.

173 tions resulting in formation of alpha1(I)(3) homotrimers instead of normal type I collagen cause mild

174 Each subunit of the chalice-shaped homotrimer is composed of short amino and carboxy termin

175 Formation of the E1 homotrimer is critical to membrane fusion, but the mecha

176 ha2 chain, the hydroxyproline content of the homotrimer is higher than the heterotrimer, which may ac

177 he R-Smad/Smad4 heterotrimer over the R-Smad homotrimer is largely enthalpy driven, contributed by th

178 h concentration, formation of a proton-bound homotrimer is observed in the case of N-methylaziridine.

179 However, the cyclohexylalanine homotrimer is of comparable stability to the 2:1 complex

180 The structure of the homotrimer is that of a trimeric hairpin in which E1 dom

181 hypothesize that the lack of pro alpha 2(I) homotrimers is not due to the inability of the C-pro alp

182 In a homotrimer, it is impossible to determine whether the co

183 vation process involves the formation of HSF homotrimers, leading to high-affinity DNA binding.

184 ytokines, heterotrimer LT alpha 1 beta 2 and homotrimer LIGHT, and activates multiple signaling pathw

185 SEC indicated that all variants purified as homotrimers like the wild type.

186 iological unit is a 24-mer composed of eight homotrimers located at the corners of a cubic cage-like

187 ether LT alpha functions through an LT alpha homotrimer (LT alpha3) or LT alpha/beta heterotrimers.

188 alpha and beta subunits and is secreted as a homotrimer, LTalpha3.

189 I) chain capable of forming a triple-helical homotrimer not normally found in nature.

190 mes: ATCase, previously considered a Class C homotrimer, now falls into Class A, whereas the DHOase i

191 (3)) mice as well as artificial alpha1(I)(3) homotrimers obtained by refolding of rat-tail-tendon col

192 The homotrimers occur in fetal tissues, fibrosis, and cancer

193 diacylglycerol kinase (DAGK) functions as a homotrimer of 13 kDa subunits, each of which has three t

194 chromatography showed that the protein was a homotrimer of 34-kDa catalytic chains.

195 Procollagen VII is a homotrimer of 350-kDa pro-alpha1(VII) chains, each consi

196 Procollagen VII is a homotrimer of 350-kDa proalpha1(VII) chains.

197 Human copper transporter 1 (hCTR1) is a homotrimer of a 190-amino acid monomer having three tran

198 strated that only 2 equiv of AdoCbl bind per homotrimer of ATR and that binding of ATP to the vacant

199 ergy transfer to the PSII reaction center, a homotrimer of CP26 and a heterotrimer of CP26 and Lhcb3.

200 Each fiber is a homotrimer of gene product 8.5 (gp8.5) and consists of t

201 eficiency virus type 1 (HIV-1) function as a homotrimer of gp120/gp41 heterodimers to support virus e

202 bunits, UreA, UreB, and UreC, assembled as a homotrimer of individual UreABC heterotrimers (UreABC)(3

203 ngly suggest that this inactive complex is a homotrimer of mTERF.

204 The homotrimer of parallel, coiled coil alpha-helices contai

205 ace adjacent to the subunit interface of the homotrimer of PCNA in addition to the PIP-box binding ca

206 that Ski-(16-192) interacted directly with a homotrimer of receptor-regulated Smad protein (R-Smad),

207 cone photoreceptors and may correspond to a homotrimer of RHBDD2(L).

208 of the transmembrane 1 domain of the intact homotrimer of the integral membrane protein, diacylglyce

209 tween the viral and cellular membranes, is a homotrimer of three subunits, each containing two disulf

210 Both srf-4 and srf-5 formed E1 homotrimers of decreased stability compared to the homot

211 e formation of six-helix bundles (6HBs) from homotrimers of gp41, from which a number of synthetic pe

212 ment to host cells is mediated by 20-nm-long homotrimers of spike envelope protein S.

213 lear single quantum coherence experiments on homotrimers of the B peptide show trimer peaks which dis

214 imers of decreased stability compared to the homotrimers of the wild type and the srf-3 mutant.

215 Generation of the E1 homotrimer on fusion-incompetent membranes identified an

216 ate effects of a small fraction of alpha1(I) homotrimers on formation, properties, and remodeling of

217 rent for the three different subunits in the homotrimer, on the ligand-binding site.

218 mphocytes and functions as either a secreted homotrimer or a membrane-associated heterotrimer that in

219 e E1 conformational changes or the resulting homotrimer or about the mechanism of action of the homot

220 It exists as homotrimers or complexes containing multiple homotrimer

221 ASICs are formed as homotrimers or heterotrimers of several isoforms (ASIC1a

222 mbled from triple helices that can be either homotrimers or heterotrimers.

223 NMR and MMP kinetic studies of a series of homotrimer peptides that model type III collagen have be

224 The results show that homotrimer persistence length is half of that of the het

225 urs efficiently in recombinant pro-alpha1(V) homotrimers produced in 293-EBNA human embryonic kidney

226 peptide capable of spontaneous assembly as a homotrimer, producing a thermostable beta-trefoil archit

227 The Mt-CamH homotrimer purified from E. coli cultured with supplemen

228 milar to the wild-type, it does not form the homotrimer quaternary structure of the wild-type.

229 However, the formation of the H3A homotrimer required a much lower pH and showed reduced e

230 s because it is neutral (zwitterionic) while homotrimers should be destabilized because of charge rep

231 X-ray crystallographic analysis of the homotrimer showed that the design process had near-atomi

232 rs in solution, and 15 (four homodimers, six homotrimers, six homotetramers and one homopentamer) had

233 LIGHT is a homotrimer that activates proapoptotic and integrin-indu

234 pon exposure to mildly acidic pH and forms a homotrimer that appears necessary for fusion.

235 DarA is a homotrimer that binds three molecules of c-di-AMP, each

236 physiological stress, HSF1 is converted to a homotrimer that binds to its cognate DNA binding site wi

237 overmodified heterotrimers, and proalpha1(I) homotrimers that are compatible with normal skeletal gro

238 Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors tha

239 environmental factors result in synthesis of homotrimers that consist of three alpha1(I) chains.

240 g mutations at D50N or Y108F are secreted as homotrimers that fail to bind either TNF receptor and ar

241 VIII) or alpha2(VIII) assembled and secreted homotrimers that were stable in denaturing conditions an

242 xtensive contacts between E1 subunits in the homotrimer, the D188K mutant identifies an important "ho

243 ody (mAb) binding and forms an SDS-resistant homotrimer, the virus associates hydrophobically with th

244 rd the neighboring subunit of the functional homotrimer, thereby forming hydrogen bonds with Arg(104)

245 n-mouse hybrid trimers and truncated chicken homotrimers; this indicated that the mutant could assemb

246 , and each also formed high-molecular-weight homotrimers, thus supporting this model.

247 so found to interact directly with an R-Smad homotrimer to form a hexamer and with an R-Smad.Smad4 he

248 HSFs bind as homotrimers to conserved promoter DNA recognition sites

249 e in which E2 and E1 dissociate and E1 forms homotrimers, triggering fusion of the viral membrane wit

250 Homotrimer triple helices have different stability and l

251 tability and less efficient unwinding of the homotrimer triple helix at the collagenase cleavage site

252 centrifugation revealed that CMP-C36 forms a homotrimer under physiological conditions.

253 homotrimers or complexes containing multiple homotrimer units in plasma.

254 esponds to low pH to form the more stable E1 homotrimer via conformational changes different from tho

255 is, and suggest that Poldelta binds the PCNA homotrimer via its three subunits.

256 e here demonstrated that formation of the E1 homotrimer was efficiently triggered under low-pH condit

257 The preformed homotrimer was extremely stable to moderately harsh cond

258 Here, the E1 homotrimer was formed in vitro from either virus or solu

259 Once formed, the low-pH-induced E1 homotrimer was very stable and was only dissociated unde

260 The MMP-resistant homotrimers were produced by all invasive cancer cell li

261 es of changes in thermal stability of type I homotrimers were reported previously, but the results we

262 In this study, we found that these homotrimers were resistant to all collagenolytic matrix

263 microunfolding of artificial rat-tail-tendon homotrimers were similar to oim homotrimers.

264 as of infected mice, suggesting that the MIF homotrimers were the functionally active form of MIF.

265 ld be of general relevance.EIAV dUTPase is a homotrimer where each subunit folds into a twisted antip

266 human TRAIL leads to a disulfide bond-linked homotrimer which can be expressed at high levels as a se

267 This domain exists as a homotrimer, which is predicted to be self-associated thr

268 LT alpha exists in its soluble form as a homotrimer, which like TNF only binds the TNF receptors,

269 hCtr1 multimeric complex, consistent with a homotrimer, which was not observed following copper trea

270 bryonic kidney cells are able to form stable homotrimers, which are rapidly converted into smaller po

271 However, homotrimers, which by definition will contain glycine mu

272 ed to be in stable proximity within the DAGK homotrimer, while position 52 appears to be more distal

273 re of lambda exonuclease revealed a toroidal homotrimer with a central funnel-shaped channel for trac

274 HI0719 is a homotrimer with a distinct cavity located at the subunit

275 arlier studies have shown that ORF1p forms a homotrimer with an asymmetric dumbbell shape, in which a

276 RANKL self-associates as a homotrimer with four unique surface loops that distingui

277 Deglycosylation of the full-length homotrimer with peptide N-glycosidase-F under native con

278 ain self-assembles into an atypical expanded homotrimer with sparse monomer-monomer interfaces.

279 the three-dimensional structure of the DAGK homotrimer with the use of solution nuclear magnetic res

280 ary and sufficient to direct the assembly of homotrimers with correctly aligned triple-helices.

281 sfection with prolyl 4-hydroxylase generated homotrimers with stable pepsin-resistant triple-helical

282 (BtPNP) purine nucleoside phosphorylases are homotrimers with the catalytic sites located near the su

283 P2X7Rs are obligate homotrimers, with each subunit having two transmembrane

284 Elastase also cleaved the homotrimer within an E1 loop located near the fusion pep