ライフサイエンスコーパス: homotrimeric

1 The homotrimeric (41,184-Da subunit) phosphonopyruvate decar

2 are 28 known types of collagen that can form homotrimeric (AAA) or heterotrimeric (AAB and ABC) compo

3 ort the hypothesis that all Scl proteins are homotrimeric and cell wall-anchored.

4 Both proteins are homotrimeric and center about a long alpha-helix, featur

5 Acid-sensing ion channels (ASICs) form both homotrimeric and heterotrimeric ion channels that are ac

6 ASIC proteins can form both homotrimeric and heterotrimeric ion channels.

7 Both homotrimeric and heterotrimeric type I collagen molecule

8 CaiT is a homotrimeric antiporter that exchanges l-carnitine (CRN)

9 However, homotrimeric assemblies have always remained the most th

10 In this motif, a coiled coil (formed by homotrimeric association of the N-terminal regions of th

11 Homotrimeric bacterial collagen proteins with a Gly-to-A

12 Type XVIII collagen is a homotrimeric basement membrane molecule of unknown funct

13 The discovery of a discretely folded homotrimeric betabetaalpha motif (BBAT1) was recently re

14 ns, and comparison of the heterotrimeric and homotrimeric C-pro structures and stability.

15 o-hArgI-C(PEG-20K)); (ii) engineering of the homotrimeric Co-hArgI into a linked, monomeric 110kDa po

16 A metal-assembled homotrimeric coiled coil based on the GCN4-p1 sequence h

17 omprises two, noncovalent, heterodimeric and homotrimeric coiled-coil bundles.

18 te that N36(Mut(e,g)) acts by disrupting the homotrimeric coiled-coil of N-terminal helices in the pr

19 ss force sensitive than the proteolysis of a homotrimeric collagen model peptide, consistent with stu

20 inding sequences have been identified in the homotrimeric collagen types II and III, however, it is u

21 xyl-terminal non-collagenous domain (NC2) of homotrimeric collagen XIX forms a stable trimer and subs

22 kDa, indicating that the protein exists as a homotrimeric complex in solution.

23 An application is illustrated with a 95 kDa homotrimeric complex of the acyltransferase protein, Lpx

24 o the mitochondrial matrix, where it forms a homotrimeric complex organized in a doughnut-shaped stru

25 Moloney murine leukemia virus (MoMuLV) is a homotrimeric complex whose monomers consist of linked su

26 hereas most TNF receptors normally form only homotrimeric complexes, the preligand assembly domains i

27 and size exclusion chromatography suggest a homotrimeric configuration.

28 Here, we report the homotrimeric crystal structure of 2OST from chicken, in

29 lex has a four-layered structure composed of homotrimeric discs of PaaF and PaaG.

30 The homotrimeric DNA replication protein proliferating cell

31 r (HSF) is the only known sequence-specific, homotrimeric DNA-binding protein.

32 The homotrimeric enzyme Mt-Cam from Methanosarcina thermophi

33 Complete inhibition of the homotrimeric enzyme occurs at one mole of inhibitor per

34 nithine transcarbamoylase (OTC), a cytosolic homotrimeric enzyme of yeast, do not require CCT action.

35 ull-length (763-aa) M. smegmatis PNPase is a homotrimeric enzyme with Mg(2+)*PO(4)-dependent RNA 3'-p

36 collagenous substrates, we have constructed homotrimeric, fluorogenic triple-helical peptide (THP) m

37 provides a rationale for the prominence of a homotrimeric form of type I procollagen (alpha1 trimer)

38 e have determined the crystal structure of a homotrimeric fragment from ACRP30 at 2.1 A resolution.

39 cally and therapeutically active recombinant homotrimeric fragment of human lung surfactant protein D

40 tic administration of rfhSP-D, a recombinant homotrimeric fragment of human SP-D comprising the alpha

41 Thrombospondin 1 (TSP1) is a homotrimeric glycoprotein composed of 150-kDa subunits c

42 Influenza hemagglutinin (HA), a homotrimeric glycoprotein crucial for membrane fusion, u

43 high affinity to thrombospondin-1 (TSP-1), a homotrimeric glycoprotein that is a potent inhibitor of

44 bular "head" domain of hemagglutinin (HA), a homotrimeric glycoprotein.

45 neutralizing antibody responses than did the homotrimeric gp140s.

46 ichia coli diacylglycerol kinase (DAGK) is a homotrimeric helical integral membrane protein in which

47 to bias the self-assembly into collagen-like homotrimeric helices that are capable of fibrillogenesis

48 and (4S-Flp-4R-Flp-Gly)7 do not form stable homotrimeric helices, mixtures of these two peptides for

49 ix stability have been performed on collagen homotrimeric helices.

50 Homotrimeric hemagglutinin (HA) is one of the major spik

51 The homotrimeric HIV-1 envelope glycoprotein (Env) undergoes

52 n E synthase 1 (mPGES-1) is an alpha-helical homotrimeric integral membrane inducible enzyme that cat

53 ics of membrane insertion and folding of the homotrimeric integral membrane protein diacylglycerol ki

54 The homotrimeric iron protein contains a covalently bound fe

55 ge is crucial for tissue remodeling, but its homotrimeric isoform is resistant to all collagenases.

56 The homotrimeric isoform of type I collagen, which consists

57 The homotrimeric ligand tumor necrosis factor alpha (TNFalph

58 ng crevices between pairs of monomers of the homotrimeric ligand.

59 upon binding to their cognate receptors in a homotrimeric manner.

60 udies to map the oligomeric interface of the homotrimeric membrane protein diacylglycerol kinase (DAG

61 Homotrimeric MIF levels correlated with the severity of

62 aturing experiments result in heterotrimeric/homotrimeric mixtures.As the proportion of hydroxyprolin

63 em was developed for bacterial production of homotrimeric model polypeptides.

64 lambda Exonuclease is a toroidal homotrimeric molecule and this quaternary structure is a

65 Both BLyS and APRIL have been described as homotrimeric molecules, a feature common to members of t

66 Human peroxidasin 1 is a homotrimeric multidomain peroxidase that is secreted to

67 GltPh from Pyrococcus horikoshii is a homotrimeric Na(+)-coupled aspartate transporter.

68 rfhSP-D, containing homotrimeric neck and lectin domains, was expressed in E

69 ith respect to ORF1p, a coiled coil-mediated homotrimeric nucleic acid chaperone that can form tightl

70 acterized KsHDH as a covalently cross-linked homotrimeric octaheme protein as found for HAO and HAO-r

71 Collagen triple helices can be homotrimeric or heterotrimeric, and while some types of

72 ng, right-handed, parallel beta-helix of the homotrimeric P22 tailspike adhesin exhibits predominantl

73 structure with a similar architecture to the homotrimeric PCNA DNA-binding clamp.

74 assemble into a protein ring resembling the homotrimeric PCNA of humans but with three unique protei

75 We found that a triple-helical, homotrimeric peptide mimetic of a putative alpha2beta1 b

76 main A3 bound to a collagen type III-derived homotrimeric peptide.

77 stitutions for Gly in these Gly-Pro-Hyp-rich homotrimeric peptides shows a significant correlation wi

78 The homotrimeric PII signal transduction protein of Escheric

79 Tumor necrosis factor (TNF)-alpha, a homotrimeric, pleiotropic cytokine, is secreted in respo

80 The homotrimeric PNPase engages RNase E on the periphery of

81 tual fusion process involves a switch from a homotrimeric prehairpin intermediate conformation, consi

82 replication proteins such as the ring-shaped homotrimeric proliferating cellular nuclear antigen (PCN

83 F-alpha) exists in its functional state as a homotrimeric protein and is involved in inflammation pro

84 mers, respectively, cis-CaaD appears to be a homotrimeric protein as assessed by gel filtration chrom

85 of diacylglycerol kinase (s-DAGK), a 40 kDa homotrimeric protein having nine transmembrane segments.

86 oliferating cell nuclear antigen (PCNA) is a homotrimeric protein that functions as a sliding clamp d

87 Apo2L/TRAIL is a homotrimeric protein that interacts with five receptors:

88 P22 tailspike is a homotrimeric protein that is prone to aggregation via mi

89 The structure reveals a homotrimeric protein that resembles TNF with receptor-bi

90 onal methodology to design a self-assembling homotrimeric protein with [Fe(Bpy-ala)3](2+) complexes a

91 In eukaryotes the ring-shaped homotrimeric protein, proliferating cell nuclear antigen

92 nB and GlnK represent a widespread family of homotrimeric proteins (GlnB-K) that bind and respond to

93 entially expressed on the heterotrimeric and homotrimeric proteins.

94 The protein adopts a homotrimeric quaternary structure built around a central

95 Viral hemagglutinin is a homotrimeric receptor, and thus, tri- or oligovalent lig

96 PCNA is a homotrimeric ring-shaped sliding DNA clamp that can faci

97 oliferating cell nuclear antigen (PCNA) is a homotrimeric, ring-shaped protein complex that functions

98 al methods to delineate the mechanism of the homotrimeric RND-type proton/drug antiporter AcrB, the a

99 he homodimeric Escherichia coli beta and the homotrimeric Saccharomyces cerevisiae proliferating cell

100 PII proteins are small homotrimeric signal transduction proteins that regulate

101 duplication of an ancestral gene encoding a homotrimeric single-repeat protein.

102 The homotrimeric sliding clamp proliferating cell nuclear an

103 l nuclear antigen (PCNA), the subunit of the homotrimeric sliding clamp, in which the rev6-1 mutation

104 ors, including herpes simplex virus UL42 and homotrimeric sliding clamps such as proliferating cell n

105 h contain substitutions that destabilize the homotrimeric sliding DNA clamp.

106 ed with P. aeruginosa, MIF is primarily in a homotrimeric state.

107 A stable homotrimeric structure for the transmembrane domain (TM)

108 a(beta)(alpha) peptide that forms a discrete homotrimeric structure in solution, was evaluated with 1

109 Additional evidence for the homotrimeric structure of MIF under native solution cond

110 p21-based PCNA antagonist, we exploited the homotrimeric structure of PCNA and developed multivalent

111 blished that the sec180e complex is a stable homotrimeric structure which assembles prior to secretio

112 Glutamate transporters have a homotrimeric subunit structure with a large central wate

113 n of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.

114 MTAP is a ubiquitously expressed homotrimeric-subunit enzyme critical to polyamine metabo

115 edominantly as dodecamers consisting of four homotrimeric subunits each.

116 Hemagglutinin (HA) is a homotrimeric surface glycoprotein of the influenza virus

117 f Hsp47 in its free form and in complex with homotrimeric synthetic collagen model peptides, each com

118 he interactions between the 180 kDa wildtype homotrimeric tailspike protein of the bacteriophage P22

119 herichia coli bacteriophage HK620 is a large homotrimeric tailspike that cleaves the O18A1 type O ant

120 P22 tailspike is a homotrimeric, thermostable adhesin that recognizes the O

121 In contrast to all previously characterized homotrimeric TNF family members, the mouse GITRL crystal

122 Homotrimeric TNF superfamily ligands signal by inducing

123 and is activated by RANK ligand (RANK-L), a homotrimeric, TNF-like cytokine.

124 In contrast to homotrimeric transporters of the RND (resistance-nodulat

125 In wild-type homotrimeric transporters, the glutamate concentration d

126 wever, most synthetic systems have addressed homotrimeric triple helices.

127 collagenous substrates, we have constructed homotrimeric triple-helical peptide (THP) models of the

128 Of interest, fCECs predominantly secreted homotrimeric type I collagen, [alpha1(I)](3), with heter

129 to the alpha-helical transmembrane domain of homotrimeric type I integral membrane protein, influenza

130 alpha1(I)(2)alpha2(I) heterotrimers, unlike homotrimeric types II and III.

131 n of invasive cancer cells on the surface of homotrimeric versus normal (heterotrimeric) type I colla

132 heterotrimeric structures based on published homotrimeric X-ray data.