ライフサイエンスコーパス: homotropic

1 hat the effects of MgADP are diminished by a homotropic activation equal to -1.3 kcal/mol.

2 by the wild-type tetramer due to the lack of homotropic activation.

3 ultiple metal binding sites and thus exhibit homotropic allosteric (cooperative) responses.

4 -CoA with this noncatalytic site facilitates homotropic allosteric activation.

5 Positive homotropic allosteric anion binding was observed and is

6 NMR spectroscopy) suggest that the negative homotropic allosterism arises from the guest forming C-H

7 of research, the mechanistic basis for GCK's homotropic allostery remains unresolved.

8 s assemble into nanoclusters might allow for homotropic allostery, in which individual TCRs could pos

9 , displays substrate- and reaction-dependent homotropic and heterotropic cooperative behavior.

10 of such binding intermediates gives rise to homotropic and heterotropic cooperative kinetics of this

11 The mechanism of the observed homotropic and heterotropic cooperativity in P450 3A4-ca

12 ave proven that some P450's demonstrate both homotropic and heterotropic cooperativity toward a numbe

13 tic regioselectivity and unusual patterns of homotropic and heterotropic cooperativity, for which sev

14 n hexamer stability to measure the effect of homotropic and heterotropic effectors on the dissociatio

15 -site reactivity that is modulated by strong homotropic and heterotropic ligand binding interactions

16 regulatory subunits had essentially the same homotropic and heterotropic properties as the native cat

17 of the enzyme is in part responsible for the homotropic and heterotropic properties of aspartate tran

18 rmine the influence of domain closure on the homotropic and heterotropic properties of the enzyme.

19 The complete abolition of homotropic and heterotropic regulation from stabilizing

20 It is the enzyme-bound Mn(2+) that induces homotropic binding of PEP with Mn(2+)-activated YPK.

21 Consistent with functional data, homotropic control appears to depend on nucleotide state

22 ropose a structural symmetry-based model for homotropic control in the AAA(+) characteristic ring arc

23 o acid globally enhances functional positive homotropic cooperative activation of CaSR in response to

24 three-state SMB model involving two positive homotropic cooperative transitions linked by a negative

25 own to bind to mAChRs with a strong positive homotropic cooperativity (a Hill slope of approximately

26 Negative homotropic cooperativity also characterizes Zn(2+) bindi

27 which T state stabilization is required for homotropic cooperativity and for heterotropic effects.

28 The enzyme exhibits homotropic cooperativity and is allosterically regulated

29 indicates that the enzyme exhibited limited homotropic cooperativity and little if any regulatory pr

30 ant enzymes exhibited dramatic reductions in homotropic cooperativity and the ability of the heterotr

31 e Glu-239 interactions necessary to maintain homotropic cooperativity and the T allosteric state.

32 within the ECD in tuning functional positive homotropic cooperativity caused by changes in [Ca(2+)]o.

33 omotropic cooperativity for TST and positive homotropic cooperativity for 9-AP with Hill-equation-der

34 nity for both substrates, decreased positive homotropic cooperativity for both substrates and activat

35 tes based on an expanded two-state model for homotropic cooperativity for threonine deaminase.

36 d that binding occurs with apparent negative homotropic cooperativity for TST and positive homotropic

37 play a critical role in the manifestation of homotropic cooperativity in aspartate transcarbamoylase

38 aspartate-binding site and for inducing the homotropic cooperativity in aspartate transcarbamoylase.

39 Homotropic cooperativity in Escherichia coli aspartate t

40 To explore the mechanism of homotropic cooperativity in human cytochrome P450 3A4 (C

41 addition, gallamine also displayed positive homotropic cooperativity in its interactions with M3 rec

42 These results establish that homotropic cooperativity in ligand binding can result fr

43 Enzyme-bound Mg(2+) does not influence the homotropic cooperativity in PEP binding to YPK.

44 It is the MgADP complex that induces homotropic cooperativity in PEP binding.

45 g the linker in 10L-fCzrA abolishes negative homotropic cooperativity of Zn(II) binding and reduces D

46 n upper and lower catalytic trimers restores homotropic cooperativity so that a binding event at one

47 l and one mutant catalytic subunit exhibited homotropic cooperativity with a Hill coefficient of 1.4

48 cytochrome P450 (P450) isoforms demonstrate homotropic cooperativity with a number of substrates, in

49 was accompanied by an important increase in homotropic cooperativity with both substrates.

50 of the double mutant revealed the absence of homotropic cooperativity with either steroid substrate.

51 le interactions involving Asp-236, exhibited homotropic cooperativity, and heterotropic interactions

52 vity than the wild-type enzyme, exhibited no homotropic cooperativity, and the binding of both carbam

53 enzyme, but the disulfide bonds also impart homotropic cooperativity, never observed in the wild-typ

54 allosteric effectors to the holoenzyme shows homotropic cooperativity, suggestive of a conformational

55 For the positive homotropic cooperativity, the allosteric kinetics minimi

56 ne binding by the wild-type enzyme displayed homotropic cooperativity, whereas substrate binding by L

57 duced spin shift in CYP3A4 reveals prominent homotropic cooperativity, which is characterized by a Hi

58 tic unit that displays enhanced activity and homotropic cooperativity.

59 global conformational change that manifests homotropic cooperativity.

60 l CYP isoforms exhibit positive and negative homotropic cooperativity.

61 e transcarbamoylase and functionally induced homotropic cooperativity.

62 of 2.5 and an S(50) of 4.5 muM indicative of homotropic cooperativity.

63 se, to ATP allosteric inhibition, and to F6P homotropic cooperativity.

64 Homotropic coordination is functionally important to rem

65 pares to -2.87 kcal/mol for a hybrid with no homotropic coupling but all four unique heterotropic int

66 In addition, the homotropic couplings for the allosteric ligands have bee

67 ) experiments to provide novel insights into homotropic Cu-binding cooperativity, gas-phase stabiliti

68 rlying energetics are vastly different, with homotropic Delta(DeltaH) and Delta(-TDeltaS) values both

69 al concentrations of protein and ligand) for homotropic dimeric and trimeric protein-ligand systems.

70 applied to four ligand-receptor binding and homotropic dissociation models.

71 r the dCMP deaminase activity and a positive homotropic effector for the dCTP deaminase activity, and

72 in hexameric PspF(1-275) indicates negative homotropic effects between subunits.

73 the R-state subunits, which provide positive homotropic effects, and by the coordination of anions to

74 cooperative transitions linked by a negative homotropic interaction.

75 ibition of a control hybrid that removed the homotropic interactions in PEP binding.

76 esses positive and negative heterotropic and homotropic interactions involving two classes of sites.

77 most interesting that the strong, positive, homotropic interactions of THA at both M2 and M3 recepto

78 itude of different types of heterotropic and homotropic interactions that are possible between the fo

79 possible interactions, including active site homotropic interactions, allosteric site homotropic inte

80 ite homotropic interactions, allosteric site homotropic interactions, and heterotropic interactions b

81 2+)-activated T298S and T298A do not exhibit homotropic kinetic cooperativity with phosphoenolpyruvat

82 tertiary structural changes rather than the homotropic ligation-linked T/R quaternary structural tra

83 These results on the homotropic mechanism are consistent with a concerted tra

84 e second zinc site, which collectively drive homotropic negative cooperativity of Zn(2+) binding (Del

85 phosphorylase b' shows no allostery, neither homotropic nor heterotropic.

86 the behaviors of which are regulated by the homotropic, O(2)-linked T/R quaternary structural transi

87 he bacterial heptose isomerase GmhA displays homotropic positive and negative cooperativity among its

88 The homotropic regulation of the Escherichia coli pyruvate d

89 ens counterpart, lost both heterotrophic and homotropic responses.

90 Lysine is a homotropic substrate for the latter enzyme.