ライフサイエンスコーパス: homozygous deletion

1 ve oncogenes or fragile sites ("unexplained" homozygous deletions).

2 s 96 genomic regions recurrently targeted by homozygous deletions.

3 lines are superior for the identification of homozygous deletions.

4 n a specific area of common heterozygous and homozygous deletions.

5 occurrence of cancer gene amplifications and homozygous deletions.

6 al events, including 24 amplifications and 7 homozygous deletions.

7 nd include high-amplitude amplifications and homozygous deletions.

8 ated the genome landscape within unexplained homozygous deletions.

9 not translated, 4 were intronic, and 2 were homozygous deletions.

10 elocytic leukemia zinc finger (PLZF) protein homozygous deletions.

11 ions, some with high-level amplifications or homozygous deletions.

12 as project, 93 (21%) have KLLN hemizygous or homozygous deletions.

13 mic alterations including amplifications and homozygous deletions.

14 All of the putative homozygous deletions (10) and high-level amplifications

15 The homozygous deletion abolished U50 function in a colony f

16 Based on homozygous deletions affecting metabolic enzymes in 16 T

17 n cancer types and systematically screen for homozygous deletions, aiming to identify rare tumour sup

18 creased rates of LOH using the collection of homozygous deletion alleles of nonessential genes.

19 The odds ratio (OR) for p16INK4A homozygous deletion among alcohol consumers in the upper

20 ted over 50 sites (amplifications, potential homozygous deletion and gains or losses which extended o

21 ozygosity and copy number changes, including homozygous deletion and gene amplification, were similar

22 PTEN tumor suppressor was discovered by its homozygous deletion and other mutations in cancer.

23 evealed only minor expression differences in homozygous deletion and wild-type mice.

24 Then, we searched for homozygous deletions and amplifications in the tumor DNA

25 rs using approaches that can reliably detect homozygous deletions and amplifications.

26 (TSG) at 3p12, a region defined by hemi and homozygous deletions and functional analysis.

27 showing signatures of positive selection for homozygous deletions and identify candidate tumour suppr

28 Chromosomal abnormalities, including homozygous deletions and loss of heterozygosity, are amo

29 tative tumor suppressor genes by determining homozygous deletions and loss of heterozygosity.

30 We found homozygous deletions and mutations of MITOSTATIN gene in

31 sed to screen 117 lung cancer cell lines for homozygous deletions and none were identified.

32 polymorphisms in NQO1 (Pro187Ser) and GSTM1 (homozygous deletion) and asthma risk in children with hi

33 reduced in LKB1-null cell lines (mutation or homozygous deletion) and this partial degradation occurs

34 dies have shown that loss of heterozygosity, homozygous deletions, and abnormal expression of the FHI

35 ed and mapped regions of single-copy losses, homozygous deletions, and amplicons of various sizes in

36 ncers, including 8.1% heterozygous and 12.1% homozygous deletions, and were linked to advanced tumor

37 hat the genomic positions of the unexplained homozygous deletions are not randomly determined (P < 0.

38 Homozygous deletions are rare in cancers and often targe

39 , supports the hypothesis that hemizygous or homozygous deletions are responsible for the abnormal ex

40 ithelial tumours and when further defined by homozygous deletions, are often the location of tumour s

41 DEAR1 undergoes loss-of-function mutations, homozygous deletion, as well as copy-number losses in mu

42 Mouse embryonic stem (ES) cells with a homozygous deletion at Acvr1 were used to generate chime

43 Genetic studies revealed a 175-kb homozygous deletion at chromosome 2q13, which encompasse

44 Genetic analysis revealed a homozygous deletion at the DNA level of 1758bp, predicte

45 In nine glioblastomas homozygous deletions at 1p36 were identified.

46 The finding of hemizygous or homozygous deletions at band 14 on chromosome 13 in a va

47 Homozygous deletions at DMBT1 repeat 2-4 to 2-7 were fou

48 ood by TaqMan and BioTrove assays identified homozygous deletions at the M1 and T1 loci of GST (GSTM1

49 a tendency to reduce the adverse effects of homozygous deletions by minimizing the number of genes r

50 DUTT1 maps within a region of overlapping homozygous deletions characterized in both small cell lu

51 The 178 unexplained homozygous deletions clustered into 131 genomic regions,

52 s on the yeast whole-genome heterozygous and homozygous deletion collections and quantified the growt

53 ll prostate epithelium is inhibited by Grp78 homozygous deletion, corresponding with suppression of A

54 The prevalence of the homozygous deletion (del/del) genotype was 23%.

55 Next-generation sequencing identified homozygous deletions, deleterious mutations, or both in

56 Embryos produced by homozygous deletion females exhibit disorganized nuclei

57 eam reporter gene expression in strains with homozygous deletions for either gene, showing that each

58 However, DNA within homozygous deletions has higher flexibility.

59 There is evidence that homozygous deletion (HD) of chromosome 19p at the LKB lo

60 Biallelic or homozygous deletion (HD) of FOXO3 was detected in 8 of 3

61 d with 55 markers to identify new regions of homozygous deletion (HD) on chromosome 9p.

62 Detected aberrations include homozygous deletions, hemizygous deletions, copy-neutral

63 ic deletions in the tumor genome, especially homozygous deletions (HODs), have provided important pos

64 e recurrent region of loss contained a focal homozygous deletion in 11q24.2-q24.3 including the ETS1

65 defect led to the identification of a large homozygous deletion in FANCC, the first cancer cell line

66 f either, significantly predicted p16(INK4A) homozygous deletion in HNSCC.

67 The patient also harbored a homozygous deletion in IFNAR1 (IFNAR1*557Gluext*46), whi

68 th LOH in sporadic clear cell RCC as well as homozygous deletion in lung cancer.

69 s/ins)) as the primary disease locus while a homozygous deletion in MAP9 (MAP9 (del/del)) was later i

70 solated tRNALysCUU gene that was absent as a homozygous deletion in one of the parents.

71 ous studies have determined that mice with a homozygous deletion in the adapter protein p66(shc) have

72 The homozygous deletion in the cell lines was mapped to a 5.

73 ts do not exhibit any phenotype, whereas the homozygous deletion in the entire epiblast leads to panc

74 ith KS and their sister with nIHH harbored a homozygous deletion in the PROK2 gene (p.[I55fsX1]+[I55f

75 ng the c-myc and c-erbB-2 genes and apparent homozygous deletions in 3p21, 5q33, 8p23, 8p21, 9q34, 16

76 We identified 281 homozygous deletions in 636 cancer cell lines.

77 Here we identified 2,428 somatic homozygous deletions in 746 cancer cell lines.

78 4*1B and CYP3A5*3 variants and did not carry homozygous deletions in both GSTM1 and GSTT1 (denoted lo

79 However, most homozygous deletions in cancer genomes are unexplained.

80 Homozygous deletions in cancer genomes occur over recess

81 re, to elucidate further the pathogenesis of homozygous deletions in cancer, we investigated the geno

82 Hemizygous and homozygous deletions in cell lines/xenografts of prostat

83 (VEGFA) and 11q13 (FGF19/CNND1), as well as homozygous deletions in chromosome 9 (CDKN2A).

84 d adr-2, and characterize strains containing homozygous deletions in each, or both, of these genes.

85 Luca) region has been defined by overlapping homozygous deletions in lung and breast cancer cell line

86 elic losses and the discovery of overlapping homozygous deletions in lung and breast tumour-cell line

87 In particular, overlapping homozygous deletions in lung cancers have been identifie

88 gene, is a site of frequent heterozygous and homozygous deletions in many cancer cells and precancero

89 nto 131 genomic regions, 27 of which exhibit homozygous deletions in more than one cancer cell line.

90 We propose that homozygous deletions in such passenger genes can expose

91 Mice carrying homozygous deletions in the Ets-1 gene exhibited blunted

92 Truncating mutations and homozygous deletions in the hSNF5/INI1/BAF47 subunit of

93 h known and novel genomic amplifications and homozygous deletions in these cancer samples.

94 Many homozygous deletions, including those that are in multip

95 competitive repopulation advantage, whereas homozygous deletion induces hematopoietic stem cell fail

96 es were analyzed for loss of heterozygosity, homozygous deletion, intragenic mutations, and promoter

97 Homozygous deletions, intragenic breaks, or microdeletio

98 Inactivation of tumour-suppressor genes by homozygous deletion is a prototypic event in the cancer

99 This EST mapping within the homozygous deletion is also expressed in HeLa cells, the

100 Hypothesizing that p16INK4A homozygous deletion is associated with tobacco and alcoh

101 inactivation of the PTEN gene by mutation or homozygous deletion is significantly lower than the rate

102 The gene count within homozygous deletions is low compared with the rest of th

103 Among homozygous deletions, loci containing Rb1, CDKN2A/B, CSM

104 didate genes for the phenotypes presented by homozygous deletion mice.

105 r presenting with hyperlipidemia caused by a homozygous deletion mutation in CYP7A1.

106 We report a novel, homozygous, deletion mutation in a child of Nicaraguan d

107 These recurrent homozygous deletions occur either over tumour suppressor

108 For example, while CDKN2A homozygous deletions occur in a context of FGFR3-activat

109 PCR analysis further identified homozygous deletion of 11q13 sequences in a primary tumo

110 ysis revealed that all affected dogs share a homozygous deletion of 7.8 kb in the NHEJ1 gene.

111 ed a pool of 4,627 diploid strains each with homozygous deletion of a nonessential gene to identify t

112 owth factor (VEGF) stimulation with regional homozygous deletion of Alk1 induces severe dysplasia in

113 Although homozygous deletion of all three critical CDKN2A exons (

114 Homozygous deletion of ASF1A is seen in 10%-15% of certa

115 Homozygous deletion of beta1 integrins in the endotheliu

116 In the mouse, homozygous deletion of Bin1 causes developmental lethali

117 ssociated with pancreatic agenesis; however, homozygous deletion of both Gata4 and Gata6 is necessary

118 Homozygous deletion of both RST1 and RST2 (rst-) causes

119 Mice with homozygous deletion of both TP53 and PIP4K2B were not vi

120 Delta11/Delta11)p53(+/-) mice that carried a homozygous deletion of Brca1 exon 11 and a p53 heterozyg

121 dren, in which there is frequent concomitant homozygous deletion of CDKN2A (five of seven cases).

122 During a study of SV40 in relation to homozygous deletion of CDKN2A in mesotheliomas, we becam

123 In contrast, expression of CD8 or CD62L, homozygous deletion of CDKN2A/CDKN2B, NOTCH1 and/or FBXW

124 We found that homozygous deletion of Chk1 immediately before carcinoge

125 Mice harboring a homozygous deletion of Cyp24a1 (BVE(Cyp24a1-null)) exhib

126 ion was derived from study of knockout mice: homozygous deletion of dab2 results in early embryonic l

127 Mice with a homozygous deletion of DBH (Dbh-/-) have a selective and

128 gressive PDAC was observed in the setting of homozygous deletion of either p53 or p16(Ink4a), the lat

129 Homozygous deletion of Ets2 in p53 mutant mice resulted

130 in 3 of 20 ovarian tumor samples, as well as homozygous deletion of exon 2 in the lung adenocarcinoma

131 Genetic evaluation revealed a homozygous deletion of exon 21 in CARD11 as the underlyi

132 SRP to 2p24, where we identified an in-frame homozygous deletion of exon 5 in WDR35.

133 Meanwhile, FLPe-mediated homozygous deletion of exon 7 completely eliminated GBE

134 FoxO1(3A/LXXAA), those with cardiac-specific homozygous deletion of FoxO1 (c-FoxO1(-/-)), and beclin1

135 tumors induced by the Neu (ErbB-2) oncogene, homozygous deletion of Gab2 in mice had only a modest ef

136 Homozygous deletion of Gad1 significantly reduced miniat

137 Homozygous deletion of GDE1 results in a buildup of inte

138 (HSC) and progenitor function in mice with a homozygous deletion of Gli1 (Gli1(null)).

139 We show that homozygous deletion of glycogen synthase kinase (GSK) 3b

140 Here, we report that homozygous deletion of Grp78 specifically in mouse prost

141 and breast cancer were more consistent with homozygous deletion of GSTM1 or GSTT1, the AAgenotype of

142 However, among subjects with homozygous deletion of GSTM1, carriers of a serine allel

143 Homozygous deletion of Hic1 in mice results in major dev

144 Mice with a homozygous deletion of Id4 (Id4(-/-)) have reduced body

145 naling and ADPKD cell proliferation in vitro Homozygous deletion of ILK in renal collecting ducts (CD

146 We demonstrate here that homozygous deletion of Ink4a-Arf bypasses the requiremen

147 Here we showed that homozygous deletion of Jmjd3 resulted in severe delay of

148 Homozygous deletion of Letm1 in mice resulted in embryon

149 Whereas homozygous deletion of LKB1 led to embryonic lethality,

150 Homozygous deletion of murine abi2 produced abnormal phe

151 cterized a mouse model with heterozygous and homozygous deletion of Mybphl.

152 In this study, we have shown that homozygous deletion of Nf1, the Ras GTPase gene underlyi

153 We further show that mice with homozygous deletion of Notch3 do not develop pulmonary h

154 ns in the known NPHP genes, particularly the homozygous deletion of NPHP1 at 2q13, have been identifi

155 , these alterations are most commonly due to homozygous deletion of p16(INK4a) and less commonly due

156 EWS-FLI1 fusion type, p53 mutation, and homozygous deletion of p16/p14ARF have each been shown t

157 Homozygous deletion of p16/p14ARF, and p53 mutations wer

158 To examine the effects of homozygous deletion of p190A, embryonic mammary buds wer

159 femoral artery mechanical injury, mice with homozygous deletion of p21Cip1 displayed accelerated pro

160 l injury was markedly increased in mice with homozygous deletion of p27(Kip1), characterized by promi

161 g Kras(G12D) activation with heterozygous or homozygous deletion of p53 (mean survival of 56 weeks vs

162 for distant metastases relative to mice with homozygous deletion of p53 or p16(Ink4a)/p19(Arf).

163 d mammary tumor formation in mice carrying a homozygous deletion of p53, uncovering a complex relatio

164 Homozygous deletion of PAPPA in mice leads to lifespan e

165 llele and mouse embryonic fibroblasts with a homozygous deletion of PERK exhibited attenuated phospho

166 Homozygous deletion of Pkd1 or Pkd2, the genes encoding

167 Homozygous deletion of PSPHL was detected in 61% of CW c

168 Mice carrying homozygous deletion of Pten alleles developed widespread

169 Homozygous deletion of Pten causes embryonic lethality,

170 We report that homozygous deletion of PTEN in mammary epithelial cells

171 tion conditions, which was associated with a homozygous deletion of PTEN, the first reported in MM.

172 Previously, we showed that homozygous deletion of Rb in a prostate tissue recombina

173 Intriguingly, the homozygous deletion of ribosomal protein S6 kinase 1 (S6

174 iological roles of RINT-1, we found that the homozygous deletion of Rint-1 caused early embryonic let

175 generated mutant mice harboring alleles with homozygous deletion of ROCK1 (ROCK1(-/-)).

176 Consistently, homozygous deletion of Shp2 inhibited adipocyte differen

177 otes UVB-induced skin tumorigenesis, whereas homozygous deletion of SIRT1 suppresses skin tumor devel

178 In contrast, homozygous deletion of Sirt1 triggers cellular apoptotic

179 We found that specific homozygous deletion of Sox4 in the adult prostate epithe

180 Consequently, homozygous deletion of src homology 3 and cysteine rich

181 Homozygous deletion of SRC-3 in mice completely prevents

182 Homozygous deletion of survival of motor neuron 1 (SMN1)

183 Here we show that homozygous deletion of the aryl hydrocarbon receptor-int

184 sis in mice skin in vivo using mice with the homozygous deletion of the C-terminal transcriptional ac

185 Mice with homozygous deletion of the Cav-1 gene develop PH and rig

186 Mice with homozygous deletion of the coding sequence of KCNE1 have

187 Homozygous deletion of the cyclin D1 gene, enhanced expr

188 Homozygous deletion of the Efnb2 C-terminus caused abnor

189 Homozygous deletion of the EP1, EP2, or EP3 receptors di

190 We show that mice with homozygous deletion of the Ets transcription factor Erg

191 mouse embryo fibroblasts (MEF) or MEF with a homozygous deletion of the Gab1 gene (-/- MEF) with H(2)

192 Homozygous deletion of the gene encoding either receptor

193 T-ALL samples harbored either a mutation or homozygous deletion of the gene FBW7, a ubiquitin ligase

194 regulated by promoter hypermethylation or by homozygous deletion of the gene locus in certain cancers

195 Here we show that conditional homozygous deletion of the Hoxa cluster (Hoxa(-/-)) resu

196 We recently found that homozygous deletion of the insulin-degrading enzyme (IDE

197 Both heterozygous and homozygous deletion of the Lzts2-targeted allele in mice

198 Homozygous deletion of the MCM9 found in various cancers

199 Our results demonstrate that homozygous deletion of the Mdm4 RING domain results in p

200 Herein, we show that homozygous deletion of the miR-29a/b-1 bicistron results

201 further demonstrate that this loss is due to homozygous deletion of the miR-31-encoding gene that res

202 Homozygous deletion of the MRP1 gene in primary murine n

203 blood transplantation from donors carrying a homozygous deletion of the NKG2C gene.

204 with a mild form of JS were found to have a homozygous deletion of the NPHP1 gene identical, by mapp

205 In contrast, homozygous deletion of the NRC gene is embryonic lethal.

206 Moreover, homozygous deletion of the OLFM4 gene significantly corr

207 Homozygous deletion of the orthologous enhancer region i

208 Homozygous deletion of the p16(INK4a)/p14(ARF)/p15(INK4b

209 One somatic event in this pathway, homozygous deletion of the p16INK4A gene, is commonly ob

210 Mice with homozygous deletion of the plasminogen activator inhibit

211 nctional connectivity.SIGNIFICANCE STATEMENT Homozygous deletion of the Pten gene in neuronal subpopu

212 cancer-prone, heterozygous APC mutant mice, homozygous deletion of the Rad52 gene suppressed tumor g

213 blated by siRNA or chicken DT40 cells with a homozygous deletion of the RNF4 gene displayed increased

214 Herein, homozygous deletion of the Sirt1 gene in mice resulted i

215 of motor neuron (SMN) protein resulting from homozygous deletion of the SMN1 gene.

216 of acute myeloid leukemia (AML) in mice with homozygous deletion of the upstream regulatory element (

217 Mice with a homozygous deletion of this gene die at various time poi

218 matic hydrocarbons found in tobacco smoke; a homozygous deletion of this gene in approximately 50% of

219 ter region, while four (36%) had evidence of homozygous deletion of this region.

220 Both patients had a homozygous deletion of TNFRSF11B, with identical break p

221 lt from osteoprotegerin deficiency caused by homozygous deletion of TNFRSF11B.

222 PR/Cas9, we created a transgenic line with a homozygous deletion of TpnC41C and compared its phenotyp

223 n and reduced apoptosis, in situ Conversely, homozygous deletion of TRAP1 delays prostatic tumorigene

224 endent homozygous frameshift mutations and a homozygous deletion of two exons in PIEZO2 that segregat

225 when donor and recipient were mismatched for homozygous deletion of UGT2B17, a gene expressed in GVHD

226 gene (UNC5B(-/flox)) and mice with targeted homozygous deletion of UNC5B in kidney epithelial cells

227 in human colorectal cancer (CRC) cells with homozygous deletion of VEGF alleles to determine the pot

228 We demonstrate the homozygous deletion of WWOX exons from ovarian cancer ce

229 Indeed, homozygous deletion of Xrcc1 does not impair A-EJ of I-S

230 While homozygous deletions of 86 kb were achieved with up to 8

231 Large homozygous deletions of 9p21 that inactivate CDKN2A, ARF

232 All 22 cell lines examined showed homozygous deletions of 9p21.3, centering at the CDKN2A/

233 alyses showed that all affected patients had homozygous deletions of a single SNP (rs721575) and thei

234 rves of transgenic mice with heterozygous or homozygous deletions of APP.

235 fetal liver (FL) cells from mice containing homozygous deletions of both STAT5a and STAT5b genes (ST

236 expressing Cre-recombinase to generate focal homozygous deletions of Cbp in the nucleus accumbens (NA

237 Homozygous deletions of CDKN2A (9p21), PTEN (10q26), and

238 Somatic homozygous deletions of chromosomal regions in cancer, w

239 hromosome (PAC) contig encompassing a set of homozygous deletions of chromosome 16q23-24.1 found in p

240 Homozygous deletions of chromosome 9p21 are known to tar

241 t the increased viability of embryos bearing homozygous deletions of exon 11 may be due to expression

242 ess, the finding that murine embryos bearing homozygous deletions of exon 11 survive longer than embr

243 Homozygous deletions of exons 1 to 7 are predominantly s

244 ific alterations included amplifications and homozygous deletions of genes not yet implicated in epen

245 expressing Cre recombinase to generate focal homozygous deletions of Hdac3 in area CA1 of the dorsal

246 Of these deletions, 86 were homozygous deletions of known recessive cancer genes, 17

247 g nonsynonymous or splice site mutations and homozygous deletions of NER genes.

248 f nephronophthisis cases are caused by large homozygous deletions of NPHP1, but six genes responsible

249 Homozygous deletions of p14ARF were detected in 12 of 53

250 K4c) often occurred in tumors also harboring homozygous deletions of p16(INK4a).

251 Homozygous deletions of recessive cancer genes and fragi

252 It is caused by homozygous deletions of STE20-related kinase adaptor alp

253 ulation of murine embryonic fibroblasts with homozygous deletions of the c-src, fyn, and yes genes fa

254 No homozygous deletions of the CFHR1 and CFHR3 genes, which

255 Recently, homozygous deletions of the chromosomal band 6q23, invol

256 ses their levels, we characterized mice with homozygous deletions of the IDE gene (IDE --).

257 e found 28% to 45% hemizygous and 15% to 57% homozygous deletions of the OLFM4 gene via fluorescence

258 Five homozygous deletions of tumour suppressor genes were con

259 that biallelic PTEN inactivation, by either homozygous deletion or deletion of one allele and mutati

260 Homozygous deletion or missense mutation in DJ-1 results

261 Homozygous deletion or mutation of the survival of motor

262 rvival motor neuron protein (SMN) due to the homozygous deletion or rare point mutations in the survi

263 d adenoid cystic carcinomas reported to have homozygous deletion or significant underexpression of AS

264 Together with point mutations, homozygous deletions or duplications in PARK2 are respon

265 ments were observed in this study indicating homozygous deletions or insertions in the breast tumor D

266 ructural signatures that distinguish between homozygous deletions over recessive cancer genes and fra

267 Individuals were genotyped for a homozygous deletion polymorphism in the M1 gene loci of

268 A common homozygous deletion polymorphism of the GSTM1 gene elimi

269 Our study provides a genome-wide homozygous deletion profile in HG serous carcinomas, whi

270 its role is controversial, e.g., some DMBT1 homozygous deletions reflect unmasking of constitutional

271 s been identified in a 120-kb critical tumor homozygous deletion region (found in lung and breast can

272 a(2+)-channel complex, was identified in the homozygous deletion region of chromosome 3p21.3 in human

273 18 different ESTs localized adjacent to the homozygous deletion showed the presence of a transcript

274 o 18 kb) located on chromosome 22 and even a homozygous deletion smaller than 1 kb with high-resoluti

275 osteosarcoma model, we identified a somatic homozygous deletion specifically targeting Smpd3.

276 e that, whereas nuclear pore proteins of the homozygous deletion strain are devoid of O-GlcNAc, nucle

277 tive markers, we created approximately 3,000 homozygous deletion strains affecting 674 genes, or roug

278 all mice with Kras(G12D) activation and Pten homozygous deletion succumbed to cancer by 3 weeks of ag

279 Likewise, newly discovered PCR-validated homozygous deletions suggested candidate tumor-suppresso

280 r, the gene has not been reported to undergo homozygous deletion, suggesting that DICER1 is haploinsu

281 Application to clusters of unexplained homozygous deletions suggests that many are in regions o

282 eral loci, some containing large, inherited, homozygous deletions that are likely mutations.

283 -stage, sarcomatous histology and P16/CDKN2A homozygous deletion to be significant independent advers

284 ration of tobacco use, the OR for p16(INK4A) homozygous deletion was 1.3 (95% CI, 0.5-3.0) and 1.9 (9

285 rian aging phenotype of the Wv mice, whereas homozygous deletion was accompanied by a compensatory in

286 No homozygous deletion was detected at locus 74k in the 5'

287 n KLF5, and neither promoter methylation nor homozygous deletion was detected in any of the cell line

288 However, surprisingly, when a homozygous deletion was generated in C. albicans, the ce

289 However, the homozygous deletion was significantly associated with un

290 reviously characterized loci, two regions of homozygous deletion were found, one near the PTPRD locus

291 Focal homozygous deletions were detected at 8p22, 10q23.31, 13

292 Homozygous deletions were detected in 51 genomic clones,

293 ach other, as irreversible mutations such as homozygous deletions were frequently not inherited from

294 Homozygous deletions were identified within the RPS6KA2

295 ere confirmed, and several potentially novel homozygous deletions were identified.

296 Except for the CDKN2A/B region, these homozygous deletions were not present in either SBT or L

297 s of amplifications and deletions, including homozygous deletions, were identified.

298 Some cancer cell lines have multiple homozygous deletions whereas others have none, suggestin

299 We have also observed a 5.7-kb homozygous deletion within this interval in HeLa cells (

300 Frequent allelic loss and homozygous deletions within chromosome 3p in human lung