ライフサイエンスコーパス: homozygous mice

1 weeks of age, the time of seizure onset for homozygous mice.

2 ed by 19% in heterozygous mice and by 69% in homozygous mice.

3 thdrawal (FPW) in wild type mice, but not in homozygous mice.

4 tion of paw withdrawal in both wild type and homozygous mice.

5 ygous mice, but had no significant effect in homozygous mice.

6 no translocation occurred in deltaF508 Cftr homozygous mice.

7 loss of cerebellar Purkinje neurons in aged homozygous mice.

8 gous mice but the increase was attenuated in homozygous mice.

9 sporters were not significantly decreased in homozygous mice.

10 r of wild-type mice was completely absent in homozygous mice.

11 -BP1 and S6 in muscle and adipose tissues of homozygous mice.

12 otoacoustic emissions (SOAEs) in 70% of the homozygous mice.

13 increased in vivo thrombosis, in Pro32Pro33 homozygous mice.

14 d aberrant collagen fibers in tibiae of seal homozygous mice.

15 can be used to distinguish heterozygous from homozygous mice.

16 us with more severe deficits detected in the homozygous mice.

17 e of NDUFS4 protein in all tissues tested of homozygous mice.

18 d forkhead box A2 (Foxa2), were decreased in homozygous mice.

19 d by the early embryonic lethality of HMG-17 homozygous mice.

20 increased in Cx50D47A lenses, especially in homozygous mice.

21 s was not affected by the lack of Arc in GFP homozygous mice.

22 nked with phenotypes of Er-heterozygous and -homozygous mice.

23 activities were significantly reduced in the homozygous mice.

24 ance in most WT and CF heterozygous, but not homozygous mice.

25 o be essential as has been observed in ERCC1 homozygous -/- mice.

26 d (3H-U69,593) binding were abolished in the homozygous (-/-) mice.

27 ere evaluated in wild-type, heterozygous and homozygous mice 1 week following TBI.

28 Surprisingly, homozygous mice also displayed threefold enlargement by

29 Eyes of adult heterozygous and homozygous mice also were evaluated histologically.

30 cultures from adult ears and kidneys of Atm homozygous mice and found that these cultures immortaliz

31 recessive trait causing a dwarf phenotype in homozygous mice and has been mapped to the distal region

32 alters inner and outer retinal layers in cbs homozygous mice and older cbs heterozygous mice, and it

33 MYCN) extended tumor latency and survival in homozygous mice and prevented oncogenesis in hemizygous

34 l of PR mRNA in ovariectomized wild-type and homozygous mice, and a marked increase in expression aft

35 H67D homozygous mice, C294Y homozygous mice, and H67D/C294Y compound heterozygous mi

36 These changes were more severe in the homozygous mice, and were associated with decreased rod

37 In the cerebella of cdf/cdf homozygous mice, approximately 40% of Purkinje cells are

38 Nevertheless, the homozygous mice are fertile and are normal in gross appe

39 Homozygous mice are hypersusceptible to Staphylococcus a

40 e known expression of the VDR in fetal life, homozygous mice are phenotypically normal at birth and d

41 served in older homozygous animals, although homozygous mice are smaller than wild type littermates t

42 Homozygous mice are viable and fertile and have grossly

43 The FAT10 knockout homozygous mice are viable and fertile.

44 However, these homozygous mice are viable, but growth-retarded and infe

45 20(DeltaRRM)mice with a further reduction in homozygous (-/-) mice at only the intact myocyte level.

46 Homozygous mice bearing mutated MyBP-C alleles are viabl

47 -V2475F mutation appears embryonic-lethal in homozygous mice, but heterozygous mice have no alteratio

48 H67D homozygous mice, C294Y homozygous mice, and H67D/C294Y c

49 in wild-type (+/+), heterozygous (+/-), and homozygous (-/-) mice carrying a null mutation of c-fos.

50 Homozygous mice carrying a null mutation for the DARPP-3

51 Remarkably, homozygous mice carrying the alphaA-R49C mutant exhibit

52 t dendrite complexity is severely reduced in homozygous mice deficient in Reelin signaling both in vi

53 Homozygous mice demonstrate variable expression of abnor

54 Although normal at birth, homozygous mice develop hindlimb paralysis from Day 13,

55 Homozygous mice (-/-) develop normally and suffer mild c

56 d onto the PL/J inbred strain, virtually all homozygous mice developed a chronic inflammatory skin di

57 JAK2V617F-homozygous mice developed a severe hematopoietic stem ce

58 Homozygous mice die at embryonic day 14.5 in cardiac fai

59 Most homozygous mice die by 3 months.

60 Homozygous mice die in utero at embryonic days 11.5-12.5

61 As homozygous mice die in utero, we generated FADD-/- embry

62 no death in utero occurred, the majority of homozygous mice die within two weeks after birth.

63 re phenotypically normal, but 50- 85% of the homozygous (-/-) mice died in utero at embryonic day 11.

64 Most homozygous mice died during gastrulation and organogenes

65 The majority ( approximately 90%) of double-homozygous mice died during the neonatal period.

66 All the homozygous mice died perinatally.

67 Homozygous mice died within 12 h of birth.

68 Homozygous mice display defects consistent with HGPS, in

69 Lens fiber cells of alphaA-R49C homozygous mice displayed an increase in cell death by a

70 The homozygous mice displayed elevated islet hA that correla

71 n CD18 was generated by gene targeting, with homozygous mice displaying increased circulating neutrop

72 n an embryonic failure of NMJ formation, and homozygous mice do not survive postpartum.

73 Ed deleted homozygous mice (Ed-/-) have moderately reduced numbers

74 In the normal homozygous mice, electrical field stimulation caused a b

75 Unexpectedly, homozygous mice (Elovl4(del/del)) display scaly, wrinkle

76 nsive defects were found in the brain of the homozygous mice, especially in the ventral region of the

77 Pde6b(H620Q) homozygous mice exhibit a hypomorphic phenotype with par

78 Pudgy (pu) homozygous mice exhibit clear patterning defects at the

79 al and do not develop brachydactyly, whereas homozygous mice exhibit features resembling RRS.

80 RAG1-S723C homozygous mice exhibit impaired lymphocyte development

81 However, homozygous mice exhibited complete deafness, as well as

82 Ets1(DeltaVII) homozygous mice express no p51-Ets1 and elevated levels

83 transmission were bred to homozygosity, the homozygous mice expressed no GUS enzyme activity but exp

84 e of congenital hypothyroid goiter; further, homozygous mice expressing two cog/cog alleles (linked t

85 formation and bone mass in both F508del-Cftr homozygous mice (F508del Cftr(tm1Eur)) and Cftr(+/+) lit

86 Clock homozygous mice failed to show the dramatic increase in

87 Homozygous mice for all three mutations were fetal letha

88 The supermodel mutation protected homozygous mice from high fat diet-induced obesity, like

89 Microphthalmic eyes of adult homozygous mice had a poorly developed cornea, and the a

90 Furthermore, the homozygous mice had no thyroid gland but had a normal pa

91 and cell size is also found in hypomorphic, homozygous mice harboring a single amino acid mutation (

92 f these viable Fli1(DeltaCTA)/Fli1(DeltaCTA) homozygous mice has reduced platelet numbers.

93 Double homozygous mice have characteristic defects of the crani

94 Affected homozygous mice have no detectable GALNS enzyme activity

95 Homozygous mice have PCD characterized by hydrocephalus,

96 zygous Fli1(DeltaCTA) mice are viable, while homozygous mice have reduced viability.

97 Homozygous mice have significantly smaller spleens and t

98 No homozygous mice however were identified at birth, consis

99 ect along the anterior-posterior axis in all homozygous mice identified.

100 stablished with wild-type, heterozygous, and homozygous mice in a Mendelian ratio.

101 R activity in the nasal airways of DeltaF508 homozygous mice in vivo.

102 The defect in tlt homozygous mice is limited to the utricle and saccule of

103 t the defect in development in CD8 transgene homozygous mice is the result of a reduction in secondar

104 However, 100% of homozygous mice lack most or all of their corpus callosu

105 c-Fos homozygous mice lack osteoclasts with a failure of the t

106 a3 gene by deletion of exon 5 and found that homozygous (-/-) mice lacked detectable mRNA on Northern

107 se oligonucleotides and in the skin of Acra7 homozygous mice lacking alpha7 nAChR channels.

108 Homozygous mice lacking D3 receptors display increased l

109 e observed alterations of eye development in homozygous mice leading to severe anatomical and morphol

110 genesis in AFB1-treated p53 heterozygous and homozygous mice not expressing HBsAg.

111 The number of homozygous mice observed was lower than expected under m

112 Homozygous mice of both sexes also lack preputial glands

113 IL-4Ralpha-/-, beta2-microglobulin-/- double homozygous mice produced less IL-4 than did either IL-4R

114 NMJs in homozygous mice progressively degrade postnataly.

115 When L9'A homozygous mice received a 10 mg/kg nicotine injection,

116 on of cartilage link protein gene (Crtl1) in homozygous mice resulted in a severe chondrodysplasia an

117 In contrast, homozygous mice (RLC-/-) had no RLC-f mRNA or protein an

118 Homozygous mice show large reductions in brain tissue mo

119 Themis(I23N) homozygous mice show reduced CD4(+) and CD8(+) T lymphoc

120 Islets from RIPCre;KD-mTOR (Homozygous) mice showed reduced mTORC1 and mTORC2 signal

121 in a gene dosage-dependent fashion, with the homozygous mice showing the greatest protection.

122 ss IA Pi3k catalytic subunits; nevertheless, homozygous mice still displayed hypoglycaemia, lower ins

123 ular damage beginning at 3 weeks of age, and homozygous mice supported up to 97% parenchymal repopula

124 No homozygous mice survive postnatally.

125 Tbx5 deficiency in homozygous mice (Tbx5(del/del)) decreased expression of

126 sis of ALS and FTLD-TDP, we generated TDP-25 homozygous mice (TgTDP-25(+/+)), thereby further increas

127 roexcitatory changes were more pronounced in homozygous mice than in heterozygotes, consistent with t

128 spontaneous null allele of Ednrb results in homozygous mice that are predominantly white and die as

129 Homozygous mice that do not express K4 develop a spectru

130 uman osteocalcin promoter, were crossed with homozygous mice that express loxP-flanked Cnb1 (Cnb1(f/f

131 Med30 causing progressive cardiomyopathy in homozygous mice that, although viable during lactation,

132 In homozygous mice, the extent of anemia generally correlat

133 the most severe phenotype is observed in the homozygous mice, this model will still provide a test-be

134 therefore used the skin of heterozygous and homozygous mice to create a cDNA library, and we report

135 In contrast, EGFPf-positive DRGs from homozygous mice (TRPM8(EGFPf/EGFPf)) had drastically red

136 In these homozygous mice, we observed increased intrinsic efficac

137 for wild-type (+/+), heterozygous (+/-), and homozygous (-/-) mice were 92%, 53%, and <5%, respective

138 n or obese (gold-thioglucose [GTG]-injected) homozygous (-/-) mice were compared with lean or obese a

139 Tes wild-type (+/+), heterozygous (+/-), and homozygous (-/-) mice were divided into four groups: mic

140 The corneas of heterozygous and homozygous mice were characterized by clinical observati

141 mEC layer II neurons of heterozygous and homozygous mice were hyperexcitable and generated long-l

142 Mertk(nmf12) homozygous mice were mated to mice lacking the entire Tn

143 Accordingly, homozygous mice were more severely affected than heteroz

144 The embryonic and neonatal homozygous mice were reduced in size by approximately 25

145 Compared to wild-type mice, the GNPTAB homozygous mice were smaller, had elevated levels of ser

146 The lenses of homozygous mice were the first to opacify at any given d

147 c microvesicular steatosis in pubescent male homozygous mice, which is absent in transgenic females.

148 Homozygous mice with a null mutation in the MMP-9/gelati

149 Most importantly, chronic treatment of the homozygous mice with naltrexone did not produce the expe

150 Homozygous mice with the equivalent P465L mutation die i

151 2 months of age in the Alb-Cre+/-/Cprlox+/+ (homozygous) mice, with corresponding decreases in liver

152 Interestingly, while such a mutation in homozygous mice would lead to limited survival of approx