ライフサイエンスコーパス: homozygously

1 set form of neurodegeneration when inherited homozygously.

2 Exon 7 of the telSMN gene is homozygously absent in approximately 95% of SMA patients

3 and p53, mouse embryonic fibroblasts (MEFs) homozygously deficient for both atm and p53 were used to

4 Thus, despite its location in a homozygously deleted 17p13.3 locus, it is unlikely that

5 The homozygously deleted are contained a new candidate tumor

6 gene were codeleted with INK4A in all of the homozygously deleted cases analyzed.

7 on; (ii) approximately 1% of the parents are homozygously deleted for both exons 7 and 8; (iii) one a

8 nslocation breakpoint, and exon 5 within the homozygously deleted fragile region.

9 Five of six products of the RDA were homozygously deleted from the tumor DNA.

10 tin remodeler, as one of the most frequently homozygously deleted genes in PCa, second only to PTEN i

11 In addition, we identified common homozygously deleted genes that have functions relevant

12 hosphodiesterase subtype 4D (PDE4D) gene was homozygously deleted in 198 cases of 5,569 primary solid

13 p15 was found to be homozygously deleted in 22% of the tumor derived cell li

14 We found that the locus D17S829 was homozygously deleted in 23 out of 70 patients, and ident

15 within the epicenter of the deletions and is homozygously deleted in 3.5% (7/200) of breast tumors.

16 Rhobtb2 is homozygously deleted in 3.5% of primary breast cancers,

17 ame set of samples, p16INK4a was found to be homozygously deleted in 32% of the tumor derived cell li

18 The p16/MTS1 gene was found to be homozygously deleted in 41.7% of tumors and methylated i

19 led that both p16(INK4a) and p15(INK4b) were homozygously deleted in a cheek pouch carcinoma cell lin

20 One of these, BE758-6, which was homozygously deleted in a number of colon carcinoma cell

21 DBC1), initially cloned from a region (8p21) homozygously deleted in breast cancers, forms a stable c

22 However, cIAP1 and cIAP2 are recurrently homozygously deleted in multiple myeloma (MM), resulting

23 , including the fragile site locus FRA3B, is homozygously deleted in multiple tumor-derived cell line

24 ssor gene loci, most notably SMAD4, which is homozygously deleted in nearly one-third of cases.

25 Homozygously Deleted in Pancreatic Cancer 4 (DPC4), a re

26 portion of 22q11, which is heterozygously or homozygously deleted in pediatric rhabdoid tumors of the

27 s reported to span FRA3B and was shown to be homozygously deleted in several gastric and colonic tumo

28 ed to the human chromosome 3p21.3 region and homozygously deleted in small cell lung cancer cell line

29 ave constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, inc

30 into one of the human lung cancer cell lines homozygously deleted in this region resulted in a very l

31 ort that the COOH-terminal region of BRG1 is homozygously deleted in two carcinoma cell lines, prosta

32 esentational difference analysis, which were homozygously deleted in various cancer cell lines were p

33 with MTAP in a glioma xenograft, and that is homozygously deleted in various malignant cell lines.

34 s of embryonic fibroblasts derived from mice homozygously deleted of the cyclin D1 gene (cyclin D1(-/

35 The telomeric SMN (SMN1) copy is homozygously deleted or converted in >95% of SMA patient

36 neurons (SMN) gene, the SMA disease gene, is homozygously deleted or mutated in more than 98% of SMA

37 3.3, was recently identified and found to be homozygously deleted or mutated in several different typ

38 deleted in breast cancer), was cloned from a homozygously deleted region at human chromosome 8p21.

39 cancer-1 (DBC-1) was initially cloned from a homozygously deleted region in breast and other cancers

40 ion pattern of a human gene located within a homozygously deleted region of a metastatic prostate can

41 re found among the five genes located in the homozygously deleted region.

42 Three novel noncontiguous homozygously deleted regions were detected and ranged in

43 S126 marker at chromosome band 9p21 by using homozygously deleted tumor cell lines and fluorescence i

44 P) gene is located on 9p21 and is frequently homozygously deleted, along with p16(cdkN2a/ARF), in a w

45 t occur within 1p36, most known TSGs are not homozygously deleted, and biallelic inactivation of CDKN

46 uct, suggesting that regions of the gene are homozygously deleted.

47 ker, suggesting that regions of the gene are homozygously deleted.

48 signaling, which is rarely downregulated or homozygously deleted.

49 ional AI4 T cells only developed in controls homozygously expressing NOD-derived H2(g7) molecules.

50 c.191dupA in exon 5 of ANO5 in 20 patients, homozygously in 15 and in compound heterozygosity with o

51 man IRAK2, L392V (rs3844283), which is found homozygously in approximately 15% of Caucasians, to be a

52 In mouse lung tissue where BRG1 was homozygously inactivated, immunostaining for apoptotic m

53 E2-centered nine-SNP haplotype, when present homozygously, increases the risk for IGE (odds ratio 6.1

54 However, a non-truncating homozygously inherited missense mutation in a Bedouin fa

55 c analyses show that all examined humans are homozygously inverted relative to the reference genome f

56 ed on the p.Met700Lys patient mutation, used homozygously (KI/KI) or combined with a knockout allele

57 er lenses, where native Cx46 was deleted and homozygously knocked into the Cx50 locus, displayed sign

58 On the other hand, mice that are homozygously lacking a normal E2F-1 gene develop cancers

59 omal region 3p21.3, which is hemizygously or homozygously lost in some breast cancer patients.

60 nsduction, only the negative TOV-112 and the homozygously mutated (MUT) MCF7 cells, but not the OV-90

61 Mice homozygously mutated in MITF showed a dramatic decrease

62 h after the gamma-irradiation (8 Gy) of p53 homozygously null animals.

63 lls, and we have also shown that female mice homozygously null for ALADIN are sterile.

64 rly slower than the cone-driven ERGs of mice homozygously null for arrestin (Arrestin -/-), whose con

65 F-1/CIP1 expression was not detected in mice homozygously null for p53.

66 antitated after irradiation of mice rendered homozygously null for the p53 gene.

67 ouse intestinal epithelia was assessed using homozygously null mice.

68 rom mice carrying S1 or S2 heterozygously or homozygously or in combination.

69 ansgenes and carrying either the rd mutation homozygously or the rhodopsin mutation heterozygously wa

70 s of lymphocytes expressing DQB1*0601 chains homozygously were as high as those observed for cells ex