ライフサイエンスコーパス: hookworm

1 nts in targeting parasitic roundworms (e.g., hookworms).

2 dren coinfected with Schistosoma mansoni and hookworm.

3 Albendazole is the drug of choice against hookworm.

4 dren coinfected with Schistosoma mansoni and hookworm.

5 t doses comparable with its known effects on hookworm.

6 that has previously been isolated from adult hookworms.

7 lp in devising new drugs or vaccines against hookworms.

8 rotein extracts of adult Ancylostoma caninum hookworms.

9 represent new potential drug targets against hookworms.

10 prevalence of elephantiasis (16.7% to 5.3%), hookworm (10.3% to 1.9%), roundworm (34.5% to 2.3%), and

11 ndividuals infected with M. perstans but not hookworm, 2.33 (95% CI, 1.47-3.69); for individuals infe

12 h Schistosoma japonicum (15.6%, P = .03) and hookworm (22.0%, P = .05) were significantly lower among

13 (30.8%, P = .02) and for those infected with hookworm (31.8%, P = .0002).

14 Common maternal infections were hookworm (45%), Mansonella perstans (21%), Schistosoma m

15 prevalence of elephantiasis (12.6% to 4.6%), hookworm (7.8% to 0%), roundworm (33.5% to 6.1%), and wh

16 le alone significantly reduced prevalence of hookworm (8.1% to 1.3%), roundworm (28.4% to 0.9%), and

17 Pyrantel-oxantel significantly reduced hookworm (93.4% to 85.2%), roundworm (22.8% to 1.4%), an

18 endazole significantly reduced prevalence of hookworm (94.0% to 71.8%), roundworm (62.0% to 1.4%), an

19 in vitro and in vivo data indicate that the hookworm A. ceylanicum is a particularly sensitive and u

20 We estimate that the prevalence of hookworm, A lumbricoides, and T trichiura among school-a

21 the data in space and estimate risk of with hookworm, A lumbricoides, and T trichiura over a grid of

22 We hypothesize that hookworms actively manipulate the host immune response t

23 Hookworms, aggressive, blood-feeding, intestinal nematod

24 ble egg antigen and SmTAL2) or somatic adult hookworm (AHW) antigens either decreased after treatment

25 terior secretory glands of the dog-infecting hookworm Ancylostoma caninum and the human-infecting hoo

26 , from the blood-feeding stage of the canine hookworm Ancylostoma caninum and vaccinated dogs with th

27 The hematophagous hookworm Ancylostoma caninum produces a family of small,

28 evelopment in vitro, activated larvae of the hookworm Ancylostoma caninum released a 42-kDa protein,

29 The dog hookworm Ancylostoma caninum secretes an astacin-like me

30 (75-84 amino acids) anticoagulants from the hookworm Ancylostoma caninum termed AcAP (A. caninum ant

31 vel glutathione S-transferase from the adult hookworm Ancylostoma caninum, and its possible role in p

32 e similarity to Ac-GST-1, a GST from the dog hookworm Ancylostoma caninum.

33 m AcAP5, its homologue isolated from the dog hookworm Ancylostoma caninum.

34 factor (NIF), a glycoprotein produced by the hookworm Ancylostoma caninum.

35 Hamsters were infected with the hookworm Ancylostoma ceylanicum and vaccinated with the

36 e report two x-ray crystal structures of the hookworm Ancylostoma ceylanicum DAF-12 ligand binding do

37 Ancylostoma caninum and the human-infecting hookworm Ancylostoma ceylanicum, and BmK1, the C-termina

38 bitory Factor (MIF) has been cloned from the hookworm Ancylostoma ceylanicum.

39 ) has been used to model infections with the hookworm Ancylostoma ceylanicum.

40 41-kDa glycoprotein isolated from the canine hookworm (Ancylostoma caninum), binds to the I domain of

41 41-kD glycoprotein isolated from the canine hookworm (Ancylostoma caninum), is a beta2 integrin anta

42 rin-binding protein isolated from the canine hookworm (Ancylostoma caninum).

43 -transmitted helminths Ascaris lumbricoides, hookworm (Ancylostoma duodenale and Necator americanus),

44 eases of the major blood-feeding nematodes - hookworms (Ancylostoma spp. and Necator americanus) and

45 (Ascaris lumbricoides, Trichuris trichiura, hookworm [Ancylostoma duodenale and Necator americanus],

46 testinal brush border membrane of the canine hookworm, Ancylostoma caninum, contains aspartic proteas

47 Unlike other hookworms, Ancylostoma ceylanicum infects both humans an

48 Oxantel pamoate had low efficacy against hookworm and A. lumbricoides.

49 ng the development of new methods to control hookworm and human immunological diseases.

50 effective elimination strategy for targeting hookworm and liver and intestinal fluke infections throu

51 Maternal hookworm and M. perstans infections were associated with

52 47-3.69); for individuals infected with both hookworm and M. perstans, 1.85 (CI, 1.24-2.76).

53 4+ cell counts were highest in subjects with hookworm and Mansonella perstans infection.

54 Hookworm and Mansonella perstans infections were associa

55 tion to modulate the host immune response to hookworm and other parasites.

56 e site of infection by a parasitic helminth (hookworm) and gluten-dependent inflammation in humans wi

57 50 were infected with T. trichiura, 443 with hookworm, and 293 with A. lumbricoides.

58 treatment in children with afebrile malaria, hookworm, and Schistosoma haematobium infection.

59 ed helminthiases - ascariasis, trichuriasis, hookworm, and strongyloidiasis - in addition to the inte

60 transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) are widespread and of

61 prior to and following infection with human hookworms, and following challenge with escalating doses

62 en administered as a mucosal vaccine against hookworm anemia.

63 represent a useful strategy for controlling hookworm anemia.

64 in parasite survival and the pathogenesis of hookworm anemia.

65 ed risk of wheeze, and IgG4 to somatic adult hookworm antigen with a reduced risk of HDM-SPT sensitiv

66 e vaccination of hamsters with soluble adult hookworm antigens emulsified in alum led to partial prot

67 infected animals following stimulation with hookworm antigens was partially restored in the presence

68 IgG1, and IgG4 responses to schistosome and hookworm antigens, including the allergen-like proteins

69 educed host lymphoproliferative responses to hookworm antigens.

70 Hookworms are a leading cause of anemia in developing co

71 of anemia control in schoolchildren in whom hookworms are endemic, and should be complemented with s

72 Hookworms are hematophagous nematodes capable of growth,

73 Hookworms are hematophagous nematodes that infect a wide

74 Hookworms are human parasites that have devastating effe

75 th infections, ascariasis, trichuriasis, and hookworm, are common clinical disorders in man.

76 Soil-transmitted helminths (hookworm, Ascaris lumbricoides, and Trichuris trichiura)

77 or soil-transmitted helminth infections (ie, hookworm, Ascaris lumbricoides, Trichuris trichiura) wit

78 s shown to confer partial protection against hookworm-associated growth delay without a measurable ef

79 The hookworm-associated immunodepression may have important

80 at AceKI plays a role in the pathogenesis of hookworm-associated malnutrition and growth delay, perha

81 ified in alum led to partial protection from hookworm-associated pathology in the absence of reductio

82 ctor Xa inhibitory activity is predictive of hookworm bloodfeeding capabilities in vivo.

83 s with Ac-ASP-1 also exhibited reductions in hookworm burden in the muscles.

84 Hookworm burden reductions from Ac-ASP-1 immunization we

85 -ASP-1-vaccinated mice also resulted in lung hookworm burden reductions.

86 ma responses were negatively associated with hookworm burden, decreasing by 18 pg/mL for each increas

87 eductions in fecal egg counts and intestinal hookworm burden.

88 ogel elicited 32 and 39% reductions in adult hookworm burdens (P < 0.05) following N. americanus larv

89 otection is manifested by reductions in lung hookworm burdens at 48 h postchallenge.

90 sitive association between P. falciparum and hookworm but no association between P. falciparum and Sc

91 as as follows: for individuals infected with hookworm but not M. perstans, 1.53 (95% confidence inter

92 ts and excretory/secretory products of adult hookworms but not the infective third stage larvae.

93 uld represent a potential mechanism by which hookworms can regulate gluten-induced inflammation and m

94 one in six, people worldwide are infected by hookworms causing gastrointestinal blood loss and iron d

95 num (Ac-ASP-1) results in protection against hookworm challenge infections.

96 Plasmodium-hookworm coinfection exhibits marked age dependency and

97 , and consequences of Plasmodium species and hookworm coinfection in rural communities in Uganda.

98 Prevalence of Plasmodium-hookworm coinfection was 15.5% overall and highest among

99 Since the 1990s, the major approach to hookworm control has been morbidity reduction in school-

100 lel efforts to develop new and complementary hookworm control tools, such as new anthelmintic drugs (

101 the potential for selectively inhibiting the hookworm cytokine as a means of reducing parasite surviv

102 a-responsive myeloid cells promote repair of hookworm-damaged lung tissue, because LysM(Cre)TGF-betaR

103 nt study was designed to determine whether a hookworm-derived recombinant neutrophil inhibitory facto

104 that severe dietary iron restriction impairs hookworm development in vivo but that moderate iron rest

105 involved and understand the epidemiology of hookworm disease.

106 h A. ceylanicum and followed for evidence of hookworm disease.

107 are promising candidates as vaccines against hookworm disease.

108 of worker productivity are diminished during hookworm disease.

109 iron deficiency anemia are the hallmarks of hookworm disease.

110 er mammals, providing a laboratory model for hookworm disease.

111 Heritability for hookworm egg count was 17% before treatment and 25% afte

112 ignificantly greater in children with > 2000 hookworm eggs/g feces at baseline.

113 d the antibody responses of individuals from hookworm endemic areas of Brazil and China against the m

114 significant proportion of the population in hookworm-endemic areas had increased levels of IgE to Na

115 c studies in adults and children residing in hookworm-endemic areas were conducted to assess the prev

116 improving birthweight and infant survival in hookworm-endemic regions.

117 ers that were orally vaccinated with soluble hookworm extract (the latter animals were also resistant

118 moral immune responses against soluble adult hookworm extracts and excretory-secretory products that

119 cinated dogs were significantly smaller than hookworms from control dogs.

120 -Ac-CP-2 antibodies were bound to the gut of hookworms from vaccinated dogs, which suggests that thes

121 Characterization of this first hookworm genome sequence identified genes orchestrating

122 demonstrate a postgenomic application of the hookworm genome sequence.

123 Sequencing hookworm genomes and finding which genes they express du

124 Hookworm glutathione S-transferases (GSTs) are critical

125 iron absorptions in the afebrile malaria and hookworm groups were 12.9% and 32.2% (P < 0.001) before

126 79.1% and 88.0% in the afebrile malaria and hookworm groups with no significant differences pre- and

127 in fecal egg counts and the number of female hookworms in vaccinated dogs.

128 acilitate the specific study of bloodfeeding hookworms in vivo without prior exposure of the host to

129 d at least one stool nematode, most commonly hookworm (in 9.2%).

130 Hookworms infect over 400 million people, stunting and i

131 Although blood-feeding hookworms infect over a billion people worldwide, little

132 As controls, hookworm-infected hamsters were treated with the anthelm

133 inimidyl ester-positive lymphocytes from the hookworm-infected vaccinated group were reduced by 50% r

134 s expressing IFNgamma were reduced following hookworm infection (23.9%-11.5%; P = .04), with correspo

135 ng shoes was associated with reduced odds of hookworm infection (OR 0.29, 95% CI 0.18-0.47) and infec

136 es (OR 0.62, 95% CI 0.44-0.88), but not with hookworm infection (OR 0.80, 95% CI 0.61-1.06).

137 5% confidence interval [CI], 1.03-2.14), and hookworm infection (OR, 1.77; 95% CI, 1.22-2.55) were th

138 e association between Plasmodium-species and hookworm infection among preschool-aged children (odds r

139 Hookworm infection and gluten exposure were associated w

140 Hookworm infection appeared to modify the relationship b

141 Mortality was lower in subjects with hookworm infection at enrollment.

142 risk of wheeze was independently reduced by hookworm infection by an odds ratio of 0.48 (95% CI 0.24

143 Other molecular mechanisms of hookworm infection cause a systematic suppression of the

144 In school-age children, hookworm infection does not produce inflammation or incr

145 Thus, coincident hookworm infection exerts a profound inhibitory effect o

146 g human immunity to both schistosomiasis and hookworm infection has been associated with IgE response

147 of an effective recombinant vaccine against hookworm infection in humans.

148 t loss and anemia) of Ancylostoma ceylanicum hookworm infection in Syrian golden hamsters of the outb

149 Predisposition to human hookworm infection in this area results from a combinati

150 ficant role for host genetics in determining hookworm infection intensity has also been shown, but th

151 In multivariate analyses, hookworm infection intensity was the strongest explanato

152 Hookworm infection is a major cause of anemia and malnut

153 Human hookworm infection is a major cause of anemia and malnut

154 Hookworm infection is a major cause of iron deficiency a

155 Hookworm infection is associated with growth delay and i

156 Together, these data demonstrate that hookworm infection is associated with impaired function

157 escence-activated cell sorting revealed that hookworm infection is associated with reduced percentage

158 Predisposition to heavy or light human hookworm infection is consistently reported in treatment

159 Our data show that, although hookworm infection leads to a minor increase in microbia

160 Treatment of hookworm infection neither affected inflammation biomark

161 Experimental hookworm infection of the trial subjects resulted in mai

162 sed to determine the impact of A. ceylanicum hookworm infection on host cytokine responses and lympho

163 To determine the role of coincident hookworm infection on responses at steady-state and on M

164 so we examined the influence of experimental hookworm infection on the predicted outcomes of escalati

165 demonstrate that the presence of coincident hookworm infection significantly diminished both spontan

166 iron restriction mediates susceptibility to hookworm infection using the hamster model of Ancylostom

167 In addition, hookworm infection was associated with a significantly r

168 1.34; 95% CI, 1.05-1.71; 20 studies), while hookworm infection was associated with a significantly s

169 Additionally, coincident hookworm infection was associated with increased adaptiv

170 Predisposition to heavy or light hookworm infection was observed, with a phenotypic corre

171 h P. falciparum infection, but the effect of hookworm infection was seen only in the absence of M. pe

172 Hookworm infection was undetectable after 1 year.

173 CRs against hookworm infection were 57% (moxidectin) and 56% (iverme

174 However, in infants of mothers with hookworm infection, albendazole treatment reduced interl

175 s observed among children without detectable hookworm infection, but no association was observed amon

176 Hookworm infection, in contrast, was associated with exp

177 lopment of NTD vaccines, including those for hookworm infection, schistosomiasis, leishmaniasis, and

178 As part of on-going efforts to control hookworm infection, The Human Hookworm Vaccine Initiativ

179 ring chronic helminth infection; at least in hookworm infection, this suppression may protect against

180 on the risk of an individual harboring heavy hookworm infection.

181 anti-ASP-2 IgE levels and the risk of heavy hookworm infection.

182 important new tool for the control of human hookworm infection.

183 -1 is a possible drug and vaccine target for hookworm infection.

184 are efficacious vaccines in animal models of hookworm infection.

185 of Australia who were suffering from endemic hookworm infection.

186 weight loss and anemia caused by a secondary hookworm infection.

187 immunity and restricts lung injury following hookworm infection.

188 viduals with LTB with or without concomitant hookworm infection.

189 but not IL-4-driven Type 2 responses during hookworm infection.

190 SP-2-specific IgE likely induced by previous hookworm infection.

191 ency anemia that is the clinical hallmark of hookworm infection.

192 nd 73% of severe anemia were attributable to hookworm infection; < 10% of anemia was attributable to

193 Hookworm infections and tuberculosis (TB) are coendemic

194 These results suggest that hookworm infections have an immunomodulatory effect by i

195 pathogenesis by allowing the study of adult hookworm infections in a species with well-characterized

196 hamsters (i.e., those with neither previous hookworm infections nor treatment) were also vaccinated.

197 he effect of concurrent (active) and treated hookworm infections on the immunogenicity of vaccination

198 species for examining host immunity to human hookworm infections.

199 interbirth intervals, whereas infection with hookworm is associated with delayed first pregnancy and

200 Where hookworm is heavily endemic, deworming programs can impr

201 ustainability of benzimidazole deworming for hookworm is of concern because of the variable efficacy

202 ) is the major protein secreted by infective hookworm larvae (Ancylostoma caninum).

203 er third-stage Ancylostoma caninum infective hookworm larvae (L3) or alum-precipitated recombinant An

204 animals with living irradiated, third-stage hookworm larvae (L3), we examined the antibody responses

205 rotein 2 (Na-ASP-2) is secreted by infective hookworm larvae on entry into human hosts.

206 TP-1 is critical for the invasion process of hookworm larvae, and moreover, that antibodies against t

207 was found to be highly toxic to early stage hookworm larvae.

208 tion with third-stage Ancylostoma ceylanicum hookworm larvae.

209 be to measure the kinetics of ASP release by hookworm larvae.

210 was the major protein released by activated hookworm larvae.

211 l protect against asthma, but infection with hookworm may reduce the risk of this disease.

212 The relative bioactivities of human and hookworm MIF proteins were compared using in vitro assay

213 s aimed at defining mechanisms through which hookworms modulate the host cellular immune response.

214 ing a full-length GST protein from the human hookworm Necator americanus (and designated Na-GST-1, Na

215 The hookworm Necator americanus establishes infections of im

216 that the excretory/secretory products of the hookworm Necator americanus inhibited eosinophil recruit

217 The hookworm Necator americanus is the predominant soil-tran

218 in secreted by infective larvae of the human hookworm Necator americanus, has been solved to resoluti

219 Trials using helminths like hookworm (Necator americanus) or porcine whipworm (Trich

220 One exception is infection with the human hookworm, Necator americanus, where virtually no protect

221 infection with the blood-feeding intestinal hookworm, Necator americanus.

222 l established that infection with the rodent hookworm Nippostrongylus brasiliensis induces a strongly

223 y and anamnestic immunity against the rodent hookworm Nippostrongylus brasiliensis.

224 Employing a rodent model of infection with hookworm (Nippostrongylus brasiliensis), we characterize

225 nfection intensity, types of worms (ascaris, hookworm, or trichuris), risk of bias, cluster versus in

226 Hookworm-P. falciparum coinfection and M. perstans-P. fa

227 ation factor Xa has been identified from the hookworm parasite Ancylostoma ceylanicum using reverse t

228 es of purified recombinant Cry5B against the hookworm parasite Ancylostoma ceylanicum, a bloodfeeding

229 for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for t

230 nd iii) enhances type 2 immunity against the hookworm parasite Nippostrongylus brasiliensis.

231 Hookworms, parasitic nematodes that infect nearly one bi

232 ons of these molecular mechanisms to chronic hookworm parasitism and host clinical outcomes.

233 development of larvae into egg-laying adult hookworms (patency) coincided with a switch to Th2 predo

234 AWT to mice may further our understanding of hookworm pathogenesis by allowing the study of adult hoo

235 nd vaccine targets and should help elucidate hookworm pathogenesis.

236 Hookworm, Plasmodium, and Schistosoma infections contrib

237 lt worms, suggesting a biologic role for the hookworm platelet inhibitor in vivo.

238 This protein, named the hookworm platelet inhibitor, has an estimated molecular

239 io, 0.19), ascaris (prevalence ratio, 0.06), hookworm (prevalence ratio, 0.07), or trichuris (prevale

240 Hookworms produce a vast repertoire of structurally and

241 es in the tautomerase sites of the human and hookworm proteins.

242 tigen-specific antibody responses, and adult hookworms recovered from the intestines of vaccinated do

243 responses to AHW antigen and protection from hookworm reinfection were observed in this sample of sch

244 ect of ivermectin on the morbidity caused by hookworm-related cutaneous larva migrans in patients in

245 Hookworms remain major agents of global morbidity, and v

246 ally arrested third stage infective larva of hookworms resumes development upon entry into the defini

247 een cloned from adult Ancylostoma ceylanicum hookworm RNA.

248 most important of these interactions is the hookworm's interruption of nutrient acquisition by the h

249 sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in

250 , but the protein was detected only in adult hookworm somatic extracts and excretory/secretory produc

251 his is the first anticoagulant cloned from a hookworm species for which humans are recognized permiss

252 t virulence factors from related Ancylostoma hookworm species may have significant implications for h

253 ortant therapeutic target in human parasitic hookworm species that infect more than 600 million peopl

254 These parasites, which include two hookworm species, Ancylostomaduodenale and Necator ameri

255 el and albendazole affected schistosome- and hookworm-specific humoral responses differently from tho

256 ly one organism is endemic; schistosome- and hookworm-specific responses were not associated, and the

257 Results: Schistosoma mansoni, hookworm, Strongyloides stercoralis, and Mansonella pers

258 ng capabilities between these two species of hookworm, suggesting that factor Xa inhibitory activity

259 tor localized to the subcuticle of the adult hookworm, suggesting that it has a potential in vivo rol

260 es between hamsters and humans infected with hookworms, suggesting that hamsters will be a useful ani

261 fection with Nippostrongylus brasiliensis, a hookworm that infects the lung and intestine.

262 Dogs and cats are hosts to hookworms that may cause zoonotic disease, most notably,

263 nowledge of the molecular mechanisms used by hookworms to survive for extended periods in the human h

264 rASP-1 offers promise as a hookworm vaccine antigen.

265 rts to control hookworm infection, The Human Hookworm Vaccine Initiative has identified candidate vac

266 rugs (e.g. tribendimidine) and a recombinant hookworm vaccine.

267 with worse iron status; the association with hookworms was strongest by far.

268 ichuris trichiura, Ascaris lumbricoides, and hookworms were all associated with worse iron status; th

269 Bloodfeeding hookworms, which currently infect over a billion people

270 The soil-transmitted helminths or nematodes (hookworms, whipworms, and Ascaris) are roundworms that i