ライフサイエンスコーパス: host defense

1 stratum corneum and provide innate cutaneous host defense.

2 f rapidly evolving pathogens is critical for host defense.

3 mportant mediators of tissue homeostasis and host defense.

4 under stress and has also been implicated in host defense.

5 s have adopted multiple means to dampen this host defense.

6 f peroral arsenic on pulmonary antibacterial host defense.

7 ling molecule affecting barrier function and host defense.

8 y is an important immunoglobulin function in host defense.

9 -binding proteins is a cornerstone of innate host defense.

10 e previously uncharacterized protein Eros in host defense.

11 al surfaces and a role in phagocyte-mediated host defense.

12 f host cells to recognize PVs as targets for host defense.

13 immune system during tissue inflammation and host defense.

14 rapy has the additional benefit of enhancing host defense.

15 crobial peptides, are key elements of innate host defense.

16 family, and its main function is related to host defense.

17 IL-1 family members are central mediators of host defense.

18 f TBK1 by HDAC9, are essential events during host defense.

19 rs is a particular requirement for effective host defense.

20 d pathogens is an essential aspect of innate host defense.

21 ization of host proteins and protection from host defense.

22 erived effector molecules and trigger robust host defense.

23 onserved functions in tissue maintenance and host defense.

24 ion between these two subsets contributes to host defense.

25 nd injury and are critical for antimicrobial host defense.

26 ng their ability to respond and facilitating host defense.

27 egulator of neutrophil effector responses in host defense.

28 igger transcriptional programs important for host defense.

29 the variability in human serum FH levels on host defense.

30 s a critical role in regulating myeloid cell host defense.

31 perly unfold their functional properties for host defense.

32 ne models restored leukocyte recruitment and host defense.

33 Neutrophils play a crucial role in host defense.

34 sis TCP14 transcription factor to manipulate host defense.

35 eserve vascular integrity while coordinating host defense.

36 its effects on ocular immune homeostasis and host defense.

37 ted catalysis against microbial antigens for host defense.

38 ath have been described that are also key to host defense.

39 oteins that provide for a rapid and powerful host defense.

40 sis antagonists to neutralize this antiviral host defense.

41 s of diarrhea and intestinal barrier loss to host defense.

42 evelopment, proliferation, regeneration, and host-defense.

43 esilience of these structured communities to host defenses.

44 action between pathogenic microorganisms and host defenses.

45 otect pathogens from immune surveillance and host defenses.

46 nal regulators of gene expression related to host defenses.

47 for strain-specific responses that suppress host defenses.

48 n potently facilitate poxvirus adaptation to host defenses.

49 oorganisms that are always evolving to evade host defenses.

50 e that limits viral replication and promotes host defenses.

51 s that it encodes which function to modulate host defenses.

52 airway surface liquid, which impaired airway host defenses.

53 host autophagy cargo receptor to counteract host defenses.

54 al cells into microenvironments conducive to host defenses.

55 ria, with likely roles in protection against host defenses.

56 iral gRNA is likely important for countering host defenses.

57 and the ability of a virus to counteract the host defenses.

58 ncluding human cytomegalovirus (HCMV), evade host defenses.

59 Inhibiting ATP12A reversed host defense abnormalities in human and pig airways.

60 ing ROR-gammat could also result in impaired host defense after infection or enhanced tissue damage.

61 the quality of the inflammatory response and host defense against a gram-positive bacterial infection

62 response to virus infection and thus mediate host defense against a range of DNA and RNA viruses.

63 caspase-11 differentially contributed to the host defense against A. fumigatus infection and to endot

64 hils are known to play a pivotal role in the host defense against Aspergillus infections.

65 17A has been shown to play critical roles in host defense against bacterial and fungal infections at

66 ) activity, but the participation of PTEN in host defense against bacterial infection is less well un

67 However, the role of type I IFNs in host defense against bacterial infections is enigmatic.

68 O synthase-2 (NOS2) plays major functions in host defense against bacterial infections.

69 tosolic multiprotein complexes that initiate host defense against bacterial pathogens by activating c

70 However, the molecular basis of host defense against disseminated candidiasis remains el

71 rk uncovered a new mechanism responsible for host defense against HCV infection, and could potentiall

72 deltaT cells provide immune-surveillance and host defense against infection and cancer.

73 vidence suggests they have multiple roles in host defense against infection.

74 Collectively, PTI contributes to host defense against infections by a broad range of path

75 ne cell subsets in human lymphocyte biology, host defense against infections, and immune regulation.

76 tory molecules that play a major role in the host defense against infections, autoimmunity, and autoi

77 amma (IFN-gamma) is an essential mediator of host defense against intracellular pathogens, including

78 ial associated molecular patterns to promote host defense against invading pathogens.

79 family of cytokines have important roles in host defense against invading viruses and bacteria.

80 gnaling are essential for regulating mucosal host defense against many invading pathogens.

81 ould serve as novel GPCR targets to modulate host defense against microbial infection.

82 ice with the PGE analog misoprostol improved host defense against MRSA skin infection by restoring DC

83 ophage lysosomal engorgement in compromising host defense against mycobacteria.

84 IFN-gamma is a critical mediator of host defense against Mycobacterium tuberculosis (Mtb) in

85 ings elucidate a novel role for PPARgamma in host defense against P. aeruginosa Strategies that activ

86 intestinal mucous layer provides a critical host defense against pathogen exposure and epithelial in

87 ll (DC) migration is essential for efficient host defense against pathogens and cancer, as well as fo

88 Although inflammasomes are essential for host defense against pathogens and contribute to autoimm

89 ray of functional capabilities important for host defense against pathogens and tumors.

90 Natural killer (NK) cells are important in host defense against pathogens, and they can subsequentl

91 ools have elucidated the functions of DCs in host defense against pathogens, autoimmunity, and cancer

92 e oxygen species, which are required for the host defense against pathogens.

93 icidins are a key, nonredundant component of host defense against pulmonary infection with RSV, funct

94 immune memory contributes to the protective host defense against recurring MRSA infection.

95 copper transport into the phagosome mediates host defense against S Typhimurium, which is counteracte

96 our hypothesis that platelets participate in host defense against S. aureus both through direct killi

97 apacity of mouse platelets to participate in host defense against S. aureus infection was determined

98 y cytokine gamma interferon (IFN-gamma), and host defense against the intracellular pathogens Toxopla

99 nflammatory monocytes (iMO) are critical for host defense against toxoplasmosis and malaria but their

100 required for selective autophagy of Mtb and host defense against tuberculosis infection.

101 criptional signature and the role of CD14 in host defense against UTI in the bladder.

102 to modulation, augmentation of the Cu-based host defense against UTI represents a novel approach to

103 gE-dependent effector mechanisms in acquired host defense against venoms.

104 ng cytotoxic T lymphocytes are essential for host defense against viral infection and cancer.

105 beta-defensin family plays a role in host defense against viral infection, however its role i

106 potent antiviral gene program essential for host defense against viruses.

107 We conclude that M-CSF is critical to host defenses against bacterial pneumonia by mediating s

108 signaling plays a crucial role in regulating host defenses against extracellular pathogens, particula

109 e receptor 2 (TLR2) plays a critical role in host defenses against mycobacterial infections.

110 Mast cells (MCs) are involved in host defenses against pathogens and inflammation.

111 ccine development and provides insights into host defenses against pathogens and the immunological me

112 iratory disease is able to promote antiviral host defenses against the influenza virus.

113 Cystic fibrosis (CF) disrupts respiratory host defenses, allowing bacterial infection, inflammatio

114 ed for leukocyte recruitment and appropriate host defense and act through G protein-coupled receptors

115 has the novel dual properties of increasing host defense and decreasing pathogen virulence by inhibi

116 tional role of the ELR(+) chemokine CXCL1 in host defense and disease following infection of the CNS

117 her investigated for their functions in both host defense and disease.

118 munoglobulin E (IgE) and have been linked to host defense and diverse immune-system-mediated diseases

119 immune stimulation are critical processes in host defense and homeostasis, with the complement activa

120 in which microbiota dysbiosis can influence host defense and immunity, and in turn may contribute to

121 gonists of innate immune receptors to induce host defense and immunity, or that serve as regulators o

122 Both host defense and immunopathology are shaped by the order

123 ymphoid cells (ILCs) play important roles in host defense and inflammation.

124 CE3 proteins and suggest a role in epidermal host defense and LCE3B/C-del-mediated psoriasis risk.

125 and immunity, or that serve as regulators of host defense and mediators of immune evasion.

126 hogen growth or tissue damage is critical to host defense and organ homeostasis.

127 nflammatory cytokine known to play a role in host defense and pathologic inflammation in murine model

128 Platelets are necessary for host defense and prevention of hemorrhage during sepsis,

129 to control macrophage phenotypic change for host defense and resolution from lung injury.

130 nisms by which hepcidin contributes to renal host defense and suggest that targeting hepcidin offers

131 torically known mainly for their function in host defense and the clearance of apoptotic cells, macro

132 biofilm communities that resist clearance by host defenses and available chemotherapies.

133 p facilitate the sequestration of dsRNA from host defenses and concentrate replication factors to enh

134 effectors into host cells in order to evade host defenses and establish infection.

135 cellular proteins allows viruses to suppress host defenses and generate infectious progeny.

136 Neutrophils play a key role in host defenses and have recently been implicated in the p

137 to inhibit bacterial virulence would enhance host defenses and improve the treatment of resistant inf

138 chanisms in infected macrophages to overcome host defenses and proliferate.

139 Chemokines are essential for antimicrobial host defenses and tissue repair.

140 ssential for understanding how CoVs overcome host defenses and to maximize potential therapeutic inte

141 damage is a core mechanism of innate immune host defense, and inflammasomes represent a central cyto

142 rons and the immune system to regulate pain, host defense, and inflammatory diseases.

143 lls in which they are expressed that mediate host defense, and the consequences of circadian variatio

144 by which hepcidin and hypoferremia modulate host defense, and the spectrum of microbes affected, are

145 ocesses, including cellular differentiation, host defense, and tissue fibrosis.

146 stem to study mechanisms of pathogenesis and host defenses, and

147 likely to play important roles in subverting host defenses, and constitute a valuable pool of anti-in

148 ion; angiogenesis; apoptosis; vascular tone; host defenses; and genomic stability.

149 with those of mast cells) can contribute to host defense as components of adaptive T helper cell typ

150 These findings established host defense as the paradigm for eosinophil function.

151 ntly recognized to play an important role in host defense at mucosal sites, where it prevents invasio

152 protozoan interaction that increases mucosal host defenses at the cost of an increased risk of inflam

153 nses by cytokines is essential for effective host defense, avoidance of toxicity and homeostasis, but

154 nate lymphoid cells (ILCs) play key roles in host defense, barrier integrity, and homeostasis and mir

155 he Salmonella bacteria less resistant to the host defenses both in vitro and in vivo.

156 alled pyroptosis that promotes antimicrobial host defense but may contribute to sepsis.

157 suppressing activity with a potency enabling host defense but with limited toxicity, appropriate for

158 ature during sepsis where they contribute to host defense, but also cause tissue damage and organ dys

159 Complement plays a key role in host defense, but its dysregulation can cause autologous

160 ce that symbiotic microbes play key roles in host defense, but less is known about how symbiotic micr

161 enalis evades and disrupts the first line of host defense by degrading human mucin-2 (MUC2), depletin

162 ion plays an important role in orchestrating host defense by different cell types in nonmucosal tissu

163 that FGF23 acts directly on PMNs and dampens host defense by direct interference with chemokine signa

164 monocyte precursor cells and contributes to host defense by mediating microbial killing.

165 s B virus X protein (HBx) as a suppressor of host defenses consisting of RNAi-based silencing of vira

166 tion of electrolyte transport, and rescue of host defense defects.

167 ile inflammasome activation is essential for host defense, deregulated inflammasome responses and exc

168 oid cells and acts as a critical mediator of host defense during infection and injury.

169 le immune effector mechanisms to promote the host defense during influenza virus infection.

170 et GPVI, but not CLEC2, contributes to local host defense during pneumonia-derived sepsis by enhancin

171 epithelial cell proliferation and antiviral host defense during the normal wound healing response.

172 required for mononuclear phagocyte-mediated host defenses during bacterial pneumonia in a murine mod

173 Thus, the temporal transition of host defense from innate to adaptive immunity is unexpec

174 Blood neutrophils perform an essential host-defense function by directly migrating to bacterial

175 a3, alias TCIRG1, a known antimycobacterial host defense gene, as a top hub gene.

176 as implicated in expression of autophagy and host defense genes in nematodes and mammalian cells.

177 the expression of a broad range of antiviral host defense genes.

178 truggle for existence drove the evolution of host defenses, giving rise to a perpetual arms race.

179 DNA modifications in gene expression during host defense have long been appreciated.

180 munity, death-independent roles for RIPK3 in host defense have not been demonstrated.

181 Because of its critical role in countering host defenses, HBx represents an attractive target for a

182 peptide receptor 2 (FPR2) play key roles in host defense, immune regulation, and resolution of infla

183 lence and mechanisms of resistance to innate host defense in an important emerging CA-S. aureus linea

184 tify a novel mechanism involved in poor skin host defense in diabetes and propose a targeted strategy

185 propose a targeted strategy to restore skin host defense in diabetes.

186 ukocyte recruitment into inflamed tissue and host defense in mice and humans.

187 rograms, likely contributes to the localized host defense in recurrent MRSA SSSI.

188 Lipoxin A4 augments host defense in sepsis and reduces Pseudomonas aeruginos

189 mensal bacteria provide key signals ensuring host defense in the skin and gut.

190 We review the mechanisms underlying host defense in the very young, and discuss how specific

191 on of FGF receptor 2 (FGFR2) on PMNs rescued host defense in these mice.

192 ramework for histone release and function in host defense in vivo was revealed with the discovery of

193 f the contribution of phagocytosis and other host defenses in the research for, and the design of, an

194 IFNs can activate cell-intrinsic host defenses in virtually any cell type ranging from pr

195 on could have broader effect on compromising host defense including the induction of immune suppressi

196 g infection, bacteria must overcome multiple host defenses, including nutrient iron limitation, to pe

197 S. aureus challenge promoted MyD88-dependent host defense initiated by IL-1beta rather than IL-36, su

198 These results suggest that initial host defense is enhanced in Nrf2 null mice, resulting in

199 However, the ability of SCVs to resist host defenses is largely uncharacterized.

200 efferocytosis, is considered beneficial for host defense, little is known about Mtb-infected necroti

201 Host defense may have been the original selection pressu

202 y mononuclear phagocyte system is a critical host defense mechanism composed of macrophages, monocyte

203 as HC3-HA complexes that could be part of a host defense mechanism filling some important gaps in ou

204 ne and bacteria backbone interfered with the host defense mechanism of DNA methylation-mediated trans

205 enables B. pertussis to evade the key innate host defense mechanism of reactive oxygen species-mediat

206 ng infected bladder epithelium is a powerful host defense mechanism that reduces bacterial burden.

207 Apoptosis is an important antiviral host defense mechanism.

208 nd less harmful interventions, while keeping host defense mechanisms against infections and tumors in

209 Although inflammasomes are a crucial part of host defense mechanisms against pathogens, the exuberant

210 ar sieves that isolate the virus genome from host defense mechanisms and allow the passage of nucleot

211 ely, but both pathogens can counteract these host defense mechanisms and promote their infectivity.

212 sis is a key component of both inhibition of host defense mechanisms and replication of the bacterium

213 Multiple host defense mechanisms protect the female genital tract

214 plant physiology through the potentiation of host defense mechanisms still needs further investigatio

215 ive molecules that target a wide spectrum of host defense mechanisms to allow ticks to feed on the ve

216 e of understanding how the virus counteracts host defense mechanisms.

217 herefore must be efficiently counteracted by host defense mechanisms.

218 ate host cell signaling pathways and subvert host defense mechanisms.

219 licate viral genomes to avoid or disable the host defense mechanisms.

220 ection while the mutant strain is cleared by host defense mechanisms.

221 pressure by acquiring genes that counteract host defense mechanisms.

222 effector cells that have important roles in host defense, metabolic homeostasis and tissue repair bu

223 ks secrete many salivary factors that target host defense molecules.

224 Antimicrobial peptides (AMPs) are a class of host-defense molecules that neutralize a broad range of

225 As one of the first lines of host defense, monocytes play important roles in clearing

226 ints to a key role of monocytes in amphibian host defenses, monocytes are also thought to be importan

227 By contrast, their role in immune host defense of the CNS remains speculative, given the i

228 n of inflammation and contributes to mucosal host defense of the nasopharyngeal niche, a reservoir fo

229 Rather than compromising host defenses, pathogen-mediated inhibition of anorexia

230 ethesdensis evades phagolysosomal killing, a host defense pathway intact in both normal and CGD MDM,

231 This crucial host defense pathway is orchestrated by the sensing of i

232 rate that a cell-autonomous, Rab32-dependent host defense pathway plays a central role in the defense

233 phage and the virus mechanism to inhibit key host defense pathways.

234 talk between the complement system and other host defense pathways.

235 tribute to HIV-1 pathogenesis by stimulating host-defense pathways that target foreign nucleic acids

236 regulator (IDR) peptide-1002 is a synthetic host defense peptide derivative with strong anti-inflamm

237 keratinocyte expression of the antimicrobial/host defense peptide human beta-defensin 2 (hBD2) was fo

238 first evidence that nanoparticles can alter host defense peptide structure and function, indicating

239 LL-37 is a host defense peptide with antimicrobial and immunomodula

240 One host defense peptide with well-characterized antimicrobi

241 small molecule mimics of naturally occurring host defense peptides (HDP), we have identified several

242 ession of epithelium- and neutrophil-derived host defense peptides (HDPs) (LL-37 and human beta-defen

243 We studied host defense peptides from the skin of the South Indian

244 We propose that host defense peptides that kill microbes directly and ac

245 organisms, AMPs can also be referred to as 'host defense peptides', emphasizing their additional imm

246 Host defense peptides, also known as antimicrobial pepti

247 role of RfaH in LPS synthesis, resistance to host defense peptides, and virulence of Yersinia, we con

248 Antimicrobial host defense peptides, neuropeptides, major basic protei

249 Despite enhanced sensitivity to host defense peptides, the Y. pseudotuberculosis Deltarf

250 be associated with resistance to endogenous host-defense peptides.

251 Inflammation is a host defense process against infection.

252 Mycobacterium tuberculosis can evade host defense processes, thereby ensuring its survival an

253 crobial GBPs to PVs as part of a coordinated host defense program.

254 Because macrophage host defense properties can be regulated by surfactant a

255 0A8/S100A9 oligomer) is a metal-sequestering host-defense protein that prevents bacterial acquisition

256 The delivery of several host defense proteins to PVs is controlled by IFN-induci

257 cal and pathophysiological processes such as host defense, regulation of gene expression, cellular ho

258 1 family, and its immunological relevance in host defense remain largely unknown.

259 Whether the lung microbiome influences IPF host defense remains unknown.

260 Host defense requires the specification of CD4(+) helper

261 sis We hypothesized that HopAF1 inhibits the host defense response by manipulating MTN activity and c

262 t differences as CF pigs showed a diminished host defense response compared with their non-CF counter

263 ithin these modules that are involved in the host defense response include NLRC4, PGLYRP1, MMP9, and

264 dy, we show that K6a network remodeling is a host defense response that directly up-regulates product

265 gulating development, adult homeostasis, and host defense response.

266 programming critical to mount an appropriate host defense response.

267 ytosolic sensor, which detects and initiates host defense responses against microbial DNA.

268 he regulation of salicylic and jasmonic acid host defense responses as well as virus-specific movemen

269 keratinocyte differentiation, and heightened host defense responses typify psoriasis.

270 These enzymes contribute to host-defense responses including coagulation, inflammati

271 rculating blood is an effective mechanism of host defense, responsible for the killing of pathogens a

272 gether, our data point to Ccr7 as a critical host defense restriction factor limiting neuroinflammati

273 counting for direct participation of TBK1 in host defense signaling have been well described.

274 tions during disease is proposed to optimize host defense strategies against infection.

275 es during development, and whether this is a host defense strategy or active recruitment by the paras

276 When larvae were reared on different hosts, defense suppression differed among host plants.

277 nating multiple cell types into an effective host defense system against pathogens and malignant cell

278 eveloped distinct strategies to overcome the host defense system.

279 cept whereby mobile genetic elements capture host defense systems and repurpose them for different st

280 RNA (dsRNA) during replication must overcome host defense systems designed to detect this infection i

281 V-induced ISG15 accumulation is triggered by host defenses that detect cytoplasmic double-stranded DN

282 Human cytomegalovirus (HCMV) counteracts host defenses that otherwise act to limit viral protein

283 provides an overview of mammalian antifungal host defenses that show promise for informing therapeuti

284 Thanks to phagocytic leucocytes and other host defenses, the vast majority of these infections are

285 RAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interfero

286 erting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism a

287 rtant insights into our understanding of the host defense to HuNoVs that differs from that to MNV.

288 owing to their pleiotropic effects in early host defense to infection and organ pathologies.

289 presses autoimmune diseases while preventing host defense to infection and promoting tumor growth and

290 nd developing novel strategies for enhancing host defense to infections in newborns.

291 vacuole provides a shelter against cytosolic host defense to the cost of limited access to nutrients.

292 imal model, little is known about the innate host defense to these viruses.

293 tal adenocarcinoma, has evolved from that of host defense to tumor offense.

294 hages, respectively, in native mucocutaneous host defenses to S. aureus.

295 ation of innate immune responses critical to host defense upon microbial infection.

296 bc017643, and show that it is essential for host defense via the phagocyte NAPDH oxidase.

297 ich beneficial organisms adapt to circumvent host defenses, we experimentally evolved ecologically di

298 Many genes involved in host defense were induced by IL-17 in a TRAF3IP2-depende

299 AD patients, possibly leading to a disturbed host defense, which facilitates bacterial persistence.

300 Innate and adaptive host defenses will then influence whether new infection