ライフサイエンスコーパス: hot spot

1 locations between the gold nanoparticles or "hot spots".

2 ventricle (LV) areas were identified as CL "hot spots".

3 e nanocarriers and creating the enhancement "hot spots".

4 fficiently focus light into nanoscale field 'hot spots'.

5 icating these areas as future food security 'hot spots'.

6 alcified areas of (18)F-NaF were identified (hot spots).

7 ors occurred at a small number of positions (hot spots).

8 romatic region serves as a secondary binding hot spot.

9 e, inverted repeats comprise a recombination hot spot.

10 inverted repeats constitute a recombination hot spot.

11 gion E, previously identified as specificity hot spot.

12 re released, with littoral zones acting as a hot spot.

13 preader which is significant for eliminating hot spots.

14 as the morphology and strength of resonator hot spots.

15 regions probably coincide with 5-micrometer hot spots.

16 ions and activities of meiotic recombination hot spots.

17 rved the predicted radio counterpart of such hot spots.

18 ughout Scotland and to identify transmission hot spots.

19 des a basis for identifying HCV transmission hot spots.

20 e generation of hot plasmonic electrons from hot spots.

21 iched for CAD risk and resided at regulatory hot spots.

22 y signal in hybrid nanostructures containing hot spots.

23 s, trans-factors, and chromosomal regulatory hot spots.

24 rall hydrophobic character with some charged hot spots.

25 and controls the activation of recombination hot spots.

26 ticularly if river deltas are consistent CH4 hot spots.

27 led receptors occurs preferentially at these hot spots.

28 mbination in the genomes with cold spots and hot spots.

29 bridges, resulting in the formation of SERS hot spots.

30 ion marks at mammalian meiotic recombination hot spots.

31 ively bind C3b near ligand-guided functional hot spots.

32 s SAR exploration to map GPCR-ligand binding hot spots.

33 he composition of antibody-binding energetic hot spots.

34 l areas forms several European air pollution hot-spots.

35 scribed resistance mechanism, including FKS1 hot spot 1 and hot spot 2 mutations.

36 nce mechanism, including FKS1 hot spot 1 and hot spot 2 mutations.

37 hoods were 0.88 times as likely to live in a hot spot [95% CI (confidence interval): 0.80-0.97; P = 0

38 residues in the energetically most important hot spot, a ligand moiety that sufficiently overlaps wit

39 one acetylation marks are necessary for both hot spot activity and crossover resolution.

40 etter resolution of small-scale CH4 emission hot spots afforded by hydroacoustics will bring us close

41 replication and that these changes occur in hot spots along the HRSV genome.

42 pplications as they support abundant E field hot spots along their surface and within their open inte

43 Those hot spots also can be embedded in broader anatomical pat

44 pattern helps the bacterium to localize near hot spots, an exploitative behavior, its exploratory pot

45 States), which also serves as a biodiversity hot spot and critical nursery grounds for offshore fishe

46 s of an anchor site, which is the top-ranked hot spot and dominates the free energy of binding, surro

47 utations occurred in 8% of samples--at three hot spots and 13 minor sites--and correlated significant

48 a major determinant of meiotic recombination hot spots and acts through sequence-specific DNA binding

49 n, which could contribute to the UV mutation hot spots and cold spots.

50 ly silence Arabidopsis euchromatic crossover hot spots and is associated with increased nucleosome de

51 d the evolutionary turnover of recombination hot spots and its consequences, we mapped DSB hot spots

52 thylation is sufficient to silence crossover hot spots and plays a key role in establishing domains o

53 ents in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AI

54 g a negligible temperature increase in their hot spots and surrounding environments.

55 SERS and TERS, including the concept of SERS hot spots and the plasmonic nanostructures necessary for

56 dized metabolites, the blocking of metabolic hot spots and the preparation of biological probes.

57 engthening subsidence produced a mesospheric hot-spot and caused extreme enrichment of photochemicall

58 en structural mimicry and a crucial peptide "hot spot" and demonstrate its role, along with the MHC,

59 erranean Basin is a climate and biodiversity hot spot, and climate change threatens agro-ecosystems s

60 to identify ERV progenitors, recombinational hot spots, and segments that are always replaced, never

61 tering substrates with spatially homogeneous hot spots are developed.

62 Three major hot spots are discovered in remote binding areas: Asp81,

63 of gamma radiation levels are provided, and hot spots are discussed.

64 gnizing that most of the world's worst toxic hot spots are now located in low- and middle-income coun

65 At these sites, "hot spots" are generated where analyte molecules are tra

66 formed between adjacent Ag-nanorods, where "hot spots" are generated.

67 reakdown, which may align with recombination hot spots, are enriched near CpG islands and transcripti

68 ates <0.05 Mg C ha(-1) yr(-1), although some hot-spot areas showed eroded SOC >0.45 Mg C ha(-1) yr(-1

69 nique to provide extremely dense and regular hot spot arrays for highly sensitive surface-enhanced Ra

70 s and the identification of novel structural hot spots as targets for pharmacological intervention.

71 rustule surface, which provides high density hot spots as well as strongly coupled optical resonances

72 lity loci for prostate cancer, including the hot spot at 8q24.

73 d upwelling that ascends beneath the Reunion hot spot at the time of the Deccan eruptions.

74 1) the side chains of hydrophobic projecting hot spots at positions i, i + 3, and i + 7 of an alpha-h

75 of the side chains of hydrophobic projecting hot spots at positions i, i + 3, and i + 7 of an alpha-h

76 bbing and pulling motions to reach endocytic hot spots at the filopodial base.

77 late organic matter (POM) induces diagenetic hot spots at the sediment-water interface (SWI).

78 In conventional 'hot-spot'-based nonlinear processes such as surface-enha

79 We identify the formation of strong hot spots between all particles as the main mechanism fo

80 TCR binding necessitates hot-spot burial, yielding high energetic penalties that

81 d on a Au structure not only can locate SERS hot spots but also modify the surface chemistry to reali

82 on are directed to a subset of genomic loci (hot spots) by sequence-specific binding of the PRDM9 pro

83 how conserved and selective PDE interaction hot spots can accommodate the large diversity of chemica

84 ulation of population inversion at plasmonic hot spots can be spatially modulated by the diffractive

85 h charge carriers transferred from plasmonic hot spots can drive chemistry.

86 decreased protection of this major amyloid "hot spot" can trigger protein misfolding.

87 Thus, mtCU "hot spots" can be formed at the cardiac muscle mitochond

88 hat reduced protection of the major amyloid "hot spot", combined with the structural integrity of the

89 arkably similar core functional epitope, or "hot spot," consisting mainly of positions that are conse

90 s from health facilities in intervention and hot spot control areas were monitored as proxy for malar

91 ify the antibodies' epitope as an 'antigenic hot spot' critical for virus entry.

92 In contrast, at a distal hot spot, crossovers were recovered only in males even t

93 We identified error hot spots (d = 200) for U:G misreading in second and U:U

94 fies an important functional capsid surface "hot spot" dictating receptor attachment, transduction ef

95 occurred on all chromosomes, and integration hot spot distribution was correlated with human genomic

96 This process has also created high-density "hot spots" due to multi-type plasmonic couplings in thre

97 to influence the locations of recombination hot spots during meiosis by sequence-specific DNA bindin

98 (SERS) substrate with a thermally inducible hot spot effect for sensitive measurement of Raman-activ

99 optimized particle gaps to produce inducible hot spot effects on thermal shrink.

100 were explored for the creation of inducible hot spot effects.

101 ated that AgNP spacing is crucial for strong hot spot effects.

102 receptors/transcription factors in trans to hot spot enhancers serves as an effective biological str

103 ly yield aptamers that recognize a dominant "hot spot" epitope.

104 We found that hot spot erosion governs the preferential usage of some

105 Sequencing of hot spot exons in CNTNAP2 led to discovery of a 5 bp ins

106 adjacent hydrophobic surface as a functional hot spot for eEF1A modulation.

107 We find Australia to be a global hot spot for variability, with semi-arid ecosystems in t

108 e rich in cholesterol and sphingolipids, are hot spots for a number of important cellular processes.

109 in specific genomic islands, which represent hot spots for BGC acquisition.

110 Our analysis unveils hot spots for contaminant discharge to marine waters and

111 RNA-binding sites represent hot spots for defined posttranslational modifications su

112 s show that gamma-secretase presents several hot spots for either orthosteric or allosteric inhibitio

113 The complex structure reveals binding hot spots for future inhibitor design and suggests a new

114 solved measurements in identifying potential hot spots for future study.

115 Hot spots for inhibition with PFA or CPHM occur at templ

116 different types of mutations and identified hot spots for mutations in a lacZalpha (the alpha comple

117 d microenvironments that make them potential hot spots for prebiotic biochemistry.

118 Sinking particles were hot spots for PUA production that contained concentratio

119 hat the mitochondrial telomeres appear to be hot spots for recombination driven replication, and that

120 nces at polymerization interfaces, which are hot spots for sequence divergence between tubulin isofor

121 precipitated iron(III) (oxy)hydroxides, are hot spots for the removal and redissolution of iron, ass

122 The aquatic environment is considered a hot-spot for horizontal gene transfer, and lake sediment

123 ics (overall decrease of 43% since 2005) and hot-spots for suicide by jumping (reduction of 86% since

124 Our results demonstrate a surprising "hot spot" for gp135 protein delivery at the base of the

125 The intercalated disc (ID) is a "hot spot" for heart disease, as several ID proteins have

126 thout adequate waste treatment are possible "hot spots" for AR transmission, and waste treatment must

127 ofluidic channel, enabling an enrichment of "hot spots" for surface enhanced Raman scattering detecti

128 the skin, highlight touch dome epithelia as "hot spots" for tumor formation, and implicate cutaneous

129 graphic screening identified three distinct "hot-spots" for fragment binding within the NRF2 binding

130 For example, the "hot spot" formed at the interstitial site (gap) between

131 se patterns of riparian zone in the cold and hot spots found that land-use patterns had an important

132 ich has long been speculated to result from 'hot spot' generation at localized microstructures in the

133 Hot spots had the highest absolute TBR (3.89 +/- 1.87, P

134 Winter polar hot-spots have been observed on other planets, but detec

135 Direct experimental evidence of such hot spots, however, is exceptionally limited; mechanisms

136 ocardial wall, with discrete excitations, or hot spots (HS), occurring at cathodal tissue surfaces or

137 dentify and classify interfacial residues as Hot-Spots (HS) and Null-Spots (NS).

138 used to identify the active areas and these "hot spots" (HS) that were subsequently treated with foca

139 uggests that inadvertently omitting emission hot spots (i.e., areas of high flux) could lead to signi

140 nt system: in silico active site mapping for hot spot identification to guide rational structure-base

141 ps to chromosomal locus 6q14.1, a mutational hot spot in lymphoproliferative disorders.

142 s within fairly charged patches may form the hot spots in AIM2(PYD) self-association and may represen

143 Spatial analysis revealed high-risk hot spots in Borneo, the central Amazon and the Congo Ba

144 d human genetic disorders and/or defined CNV hot spots in epilepsy.

145 ot spots and its consequences, we mapped DSB hot spots in four major subspecies of Mus musculus with

146 of multiple probe types identify the binding hot spots in good agreement with experimental data.

147 ing mechanism has evolved to attenuate error hot spots in initial selection such as those found here.

148 arge nonequilibrium deformations at discrete hot spots in lipid vesicles and thus inducing an overall

149 rs of relative crossover frequencies between hot spots in males.

150 algorithm (RA) was proposed to determine the hot spots in metabolic networks, around which transcript

151 show that the recombinogenic cores of active hot spots in mice harbor several histone H3 and H4 acety

152 the most comprehensive maps of recombination hot spots in oocytes to date.

153 Sunlight-induced C to T mutation hot spots in skin cancers occur primarily at methylated

154 generation of intense, localized microscale hot spots in solid composites during mild ultrasonic irr

155 Scintigraphy revealed abnormal hot spots in subcutaneous tissue and diaphragmatic pleur

156 We identified and structurally verified hot spots in the interface between RHOGAPs and RHO prote

157 cated the existence of age-related glycation hot spots in the plant proteome.

158 a-camera images and a nephron model revealed hot spots in the proximal renal tubules.

159 ivocally in the murine inferior vena cava as hot spots in vivo by simultaneous acquisition of anatomi

160 Seasonal increases in malaria continue in hot spots in Zanzibar.

161 CpG dinucleotides are the main mutational hot-spot in most cancers.

162 a potential strategy to identify structural hot-spots in proteins as targets for pharmacological res

163 t this region may represent a recombination "hot spot" in CoV genomes.

164 egion that has become the new deforestation "hot spot" in South America.

165 We identify the dominant Fermi surface "hot-spots" in the inter-band scattering channel, which a

166 I, at discrete regions in the genome coined "hot spots." In mammals, meiotic DSB site selection is di

167 he occurrence of non-Cbl cobalt in pig liver hot spots indicating particular Co.

168 Residue 51 represents a "kinetic hot spot" instead of a "thermodynamic hot spot." Kinetic

169 One of these hot-spot is the residential district of Ostrava Radvanic

170 nterfaces, only a small subset of residues ("hot spots") is crucial for the binding free energy of th

171 inetic hot spot" instead of a "thermodynamic hot spot." Kinetic regulation allows PCD to adopt two di

172 he helicase/nuclease RecBCD at recombination hot-spots, known as Chi.

173 maps in both males and females at two mouse hot spots located in different regions of the same chrom

174 One hot spot, located centrally on chromosome 1, behaved sim

175 nts provides precise and reliable control of hot spot locations and permits microcontrol of the initi

176 nce described in finches, but concordance in hot spot locations between commercial breeds is only mar

177 Summary A "hot spot" magnetic resonance (MR) imaging cell tracking

178 provide a multitude of applications, such as hot-spot management, nonequilibrium hot-carrier generati

179 ternally applied electric field using single-hot spot microscopic surface-enhanced Raman spectroscopy

180 Thus, the sites of glycation hot spots might be defined by protein structure that ind

181 ts, together with a focus on a small peptide hot spot, might place limits on peptide antigen cross-re

182 rR) as specific bridging molecules in a SERS hot-spot model.

183 show in this study that the lamin A p.R482W hot spot mutation prevents adipogenic gene expression by

184 ormal DNA samples and identified a recurrent hot-spot mutation (c.1712A>G; p.Gln571Arg) in the enhanc

185 due to PPAR gamma gene amplification or RXRA hot-spot mutation (S427F/Y) drives 20-25% of human bladd

186 In summary, this study revealed that a hot-spot mutation in EZH1 is the second most frequent ge

187 f the BICD2 protein, and include a possible 'hot spot' mutation, p.Ser107Leu present in four families

188 Some of the most prevalent individual hot-spot mutations we identified included: KRAS (KRAS G1

189 eate interparticle junctions where sensitive hot spots needed for SERS enhancement are present, and (

190 rhood made it almost twice as likely to be a hot spot, odds ratio = 1.75 (95% CI: 1.10-2.79; P = 0.01

191 To identify drivers of this effect at a hot spot of antiandrogenicity in the German river Holtem

192 In the context of the biodiversity hot spot of southwestern Indian Ocean islands and their

193 and capacity (in MW) within the global solar hot spot of the state of California (United States).

194 racting with the same hydrophobic projecting hot spots of alpha-helix.

195 probe molecules, the FTMap server finds the hot spots of an average-size protein in <1 h.

196 Tropical mountains are hot spots of biodiversity and endemism, but the evolutio

197 bution across the biofilm, with concentrated hot spots of c-di-GMP.

198 of mechanobiologists because these sites are hot spots of epithelial tension.

199 beaches along urban coastlines are frequent hot spots of fecal indicator bacteria (FIB) pollution.

200 These analyses reveal hot spots of fluctuations that set the stage for large-s

201 cal anion species localized in the plasmonic hot spots of individual gold nanosphere oligomers, corro

202 There are two hot spots of intrusion, one in the Luzon Strait and the

203 ypomethylation and detecting hypomethylation hot spots of LTRs and LINEs.

204 ional mapping server that identifies binding hot spots of macromolecules-i.e., regions of the surface

205 man melanocytes bearing mutations in the two hot spots of NRAS, NRAS(G12) and NRAS(Q61).

206 We show that PLRV virions have hot spots of protein interaction and multifunctional sur

207 Spatial scan statistics detected three hot spots of SFTS that accounted for 69.1% of SFTS cases

208 ve important implications for predicting the hot spots of UVB-induced lesions in nucleic acids.

209 n from coarse-to-fine grain sizes promoted a hot-spot of organic matter degradation and biomass growt

210 Both occur within the mutational "hot spot" of the keratin 10 (K10) 2B rod domain, adjacen

211 ng behaviour interact to create predictable "hot spots" of fear on the reef where herbivores withhold

212 RAS, and do not affect the three mutational "hot spots" of RAS.

213 In this way, we defined a theta hot spot on a group level and investigated whether proxi

214 an NMR complex structure revealed a binding hot spot on CXCL12 that normally interacts with the I4/I

215 ng antibodies target four spatially distinct hot spots on RTA, which we refer to as epitope clusters

216 on of previous efforts in mapping functional hot spots on the bile acid scaffold, we here demonstrate

217 We find hot spots on the plasma membrane, at least partially def

218 te" and provides a means to block all three "hot spots" on (Ca)S100B, which will impact next generati

219 f plasmonic applications based on individual hot spots or ensembles of hot spots with high uniformity

220 idues within the amyloid core IAPP region as hot spots or key residues of its cross-interaction with

221 The first one (possibly associated to hot spots or whole Fermi sheets) has a strong mass enhan

222 fted in a manner designed to produce either "hot spot" or "widespread" striatal innervation.

223 of neighborhoods with significantly higher (hot spots) or lower (cold spots) rates of surgery.

224 in disease-causing mutations compared to non-hot spots (p=0.05), regardless of their occurrence in co

225 model of Li-Fraumeni syndrome harbouring the hot-spot p53R172H mutation described an elevated level o

226 gher affinity than allele A bound A-specific hot spots, perhaps explaining why the former is dominant

227 eracting with the second protein and (2) the hot spot pockets of PPI complexes had different sizes, s

228 falciparum-specific RDT were conducted in 5 hot spots (population, 12 000) in Zanzibar in 2012.

229 in highly similar recognition of an apical 'hot-spot' position in the peptide with tolerance of sequ

230 Both well-established hot spot prediction methods and new approaches to analyz

231 imental mutagenesis data with computational "hot spot" predictions.

232 binding region serves as the primary binding hot spot, preferably binding small tertiary amines.

233 was detected for many markers, sometimes as hot spots present in different populations.

234 to engage a polymorphic, positively charged "hot-spot" region that is almost exclusive to the alpha1-

235 advocated in recent Paris agreement, several hot spot regions experiencing highest droughts are ident

236 elevant protein-protein interactions contain hot-spot regions on secondary structural elements, which

237 FK506-binding protein FKBP12, as well as in "hot spot" regions containing sites of mutations implicat

238 n resistance involves amino acid changes in "hot spot" regions of FKS-encoded subunits of glucan synt

239 f how fragments coincide with binding energy hot spots--regions of the protein where interactions wit

240 Several genetic hot spots regulating a large number of transcript level

241 random, and conformational features of their hot spots remain poorly understood.

242 ibody, a HCDR3 tryptophan binds similarly to hot spot residue Phe(279) Mutation of this HCDR3 Trp res

243 ed at these conserved contact and activation hot-spot residue positions.

244 We identify three hot spot residues (Galphas/Galphaq-Gln-384/Leu-349, Gln-

245 Specific amino acids in hot spot residues provide a link to ocular cell tropism

246 structural differences in proximity to these hot spot residues that explain divergent cross-species b

247 lable for a few GPCRs, identifies activation hot-spot residues in the TM domains that get rewired upo

248 This hot spot seems to be highly characteristic for PTFL.

249 with an oligonucleotide representing a known hot spot sequence and report the structure here.

250 leotide representing a known PRDM9c-specific hot spot sequence, and compared the structure with that

251 ng of various alleles of hPRDM9 to different hot spot sequences.

252 Use of a dual hot-spot signal-amplification strategy based on AuNP-AgN

253 other chromatin features needed for meiotic hot spot specification are largely unknown.

254 es insertion of Ty1 elements upstream of the hot spot SUF16 tRNA locus and abolishes the interaction

255 Energetic hot spots tend to be enriched in disease-causing mutatio

256 d ability and are more efficient in removing hot spots than Cu and Al foils.

257 these nNOS-inhibitor complexes reveal a new hot spot that explains the selectivity of 14 and why con

258 These observations reveal a hot spot that is located 41 +/- 12 degrees east of the s

259 a second active upwelling below the Comores hot spot that likely contributed to the region of partia

260 n, which is typically concentrated in narrow hot spots that are controlled by genetic and epigenetic

261 increases sequence diversity specifically at hot spots that become active in the hybrids.

262 getic epitope by determining the interfacial hot-spot that dominates the binding affinity for an anti

263 entified 13 skin associated transcriptional "hot spots" that represent activated chromosomal regions.

264 eptor mRNA expression was lower in striatal 'hot-spots' that generate eating or hedonic impact only i

265 n the stem region of TGGAA repeat DNA act as hot spots to facilitate the transition between the two c

266 re of the warmest hemisphere (centred on the hot spot) to be about 1,300 kelvin hotter (2,700 +/- 270

267 ropose that sequence divergence generated by hot spot turnover may create an impediment for recombina

268 Local groundwater hot spots under city centers and under industrial areas

269 evolutionary rescue' in montane biodiversity hot spots under climate change scenarios.

270 ide) bound to PDK1 and mapped binding energy hot spots using mutational analysis.

271 inciples of super-resolution imaging of SERS hot spots using single molecules to probe local electrom

272 A hot spot was localized in the farm, which corresponded t

273 11.0%), and mean distance between the local hot spots was 25.4 +/- 16.1 mm.

274 The TBR of the hot spots was computed after isocontour thresholding.

275 ound throughout the gustatory cortex, but a "hot spot" was observed in its anterior-posterior center

276 As crossovers are disfavored at such hot spots, we propose that sequence divergence generated

277 s been theorized to produce the 5-micrometer hot spots; we observed the predicted radio counterpart o

278 Recombination hot spots were concentrated at the boundary of the genes

279 Transmission hot spots were detected with 45% of samples from patient

280 The histidine oxidation hot spots were identified, which include conserved histi

281 Hot spots were localized to inner-city, impoverished nei

282 of magnitude higher rates at a few selected hot spots where Fe(III), U(VI), and FeRB were at their m

283 e prevalent, particularly within Gag and Nef hot spots where ligand sequences overlap, (iii) noncanon

284 h Hawaii, Samoa, and Iceland but not beneath hot spots whose OIB yield normal (182)W and homogeneousl

285 ant changes on HslU binding, have identified hot spots whose perturbation leads to an allosteric path

286 Allele C was found to bind a C-specific hot spot with higher affinity than allele A bound A-spec

287 ased on individual hot spots or ensembles of hot spots with high uniformity and improved controllabil

288 Three genomic loci were identified as hot spots with multiple root architectural plasticity tr

289 These ultrasonic hot spots, with heating rates reaching ~22,000 K s(-1),

290 bipyridine molecules, localized in plasmonic hot spots within individual gold nanosphere oligomers.

291 lf, is generated by a smaller set of hedonic hot spots within limbic circuitry.

292 substrate in vivo Two reproducible small-RNA hot spots within the 3' UTR/sfRNA of the wild-type virus

293 ng revealed that TPP interacted with binding hot spots within the PPARgamma ligand binding domain.

294 We identified at least five interaction hot spots within the predicted functional regulatory ele

295 due to extensive ligand sampling from select hot spots within these viral proteins.

296 mechanism and a possible role of plasmonic "hot spots" within the metal nanostructures, remain poorl

297 ambiguous identification of phosphorylation "hot spots" within virion proteins.

298 ities of all possible variants and find the "hot-spot" within the limit of experimental time.

299 ard cues through the recruitment of hedonic 'hot spots' within the brain's reward circuitry.

300 r possible impact to human health in similar hot-spots worldwide.