ライフサイエンスコーパス: hotspot

1 ic properties and intrinsic electromagnetic "hotspots".

2 ubtle local perturbations at SBD allosteric 'hotspots'.

3 rom nonrandom nucleation sites at the Golgi (hotspots).

4 nced Raman sectroscopy (EC-SERS) at a single hotspot.

5 of the Peruvian Andes-to-Amazon biodiversity hotspot.

6 ted in the Brazilian Cerrado, a biodiversity hotspot.

7 decrease as much as in villages outside the hotspot.

8 PRDM9-bound loci do not become recombination hotspots.

9 one missed 27% of wildflower viewing utility hotspots.

10 ecies have different suites of recombination hotspots.

11 19 adenosine-to-inosine (A-to-I) RNA editing hotspots.

12 tepwise evolution, to discover novel peptide hotspots.

13 are two of the most fragmented biodiversity hotspots.

14 pulated nuclear genomes can be considered as hotspots.

15 rial to the shallow mantle beneath plume-fed hotspots.

16 ersion occurs in multiple, separated genomic hotspots.

17 eous human exposures and localized pollution hotspots.

18 es in molecules located within the plasmonic hotspots.

19 middle insula, bracketed by the two cortical hotspots.

20 matically different evolutionary dynamics of hotspots.

21 magnitude to emissions from other marine DMS hotspots.

22 , population size changes, and recombination hotspots.

23 d upwelling by eddy-transport at topographic hotspots.

24 only a small number of putative sex-specific hotspots.

25 imated hatchling yields associated with each hotspots.

26 In this work, we present oncodomain hotspots, a new 'domain-centric' method for identifying

27 , P22S, N98S and E396K) and three mutational hotspots accounting for 37 (55%) and 50 (75%) kindreds,

28 pioid/orexin stimulations in either cortical hotspot activated Fos throughout a distributed "hedonic

29 These sequences also strongly increased Chi hotspot activity in E. coli cells.

30 In addition, we identified 13 trans-eQTL hotspots, affecting from ten to hundreds of genes, sugge

31 (e.g., normal mode analysis, flexibility and hotspot analysis, cryo-EM flexible fitting, and transiti

32 hypotheses concerning the roles of different hotspot and coldspot motifs in the evolution of B-cell l

33 ency was strong (r(2) = 0.64 and 0.58 at the hotspot and darkspot, respectively), and can be utilized

34 is will be important in predicting extrusion hotspots and dynamics in vivo, with potential applicatio

35 By identifying spatial hotspots and impactful products, awareness of policy-mak

36 ions for VRC-PG04 maturation, as well as SHM hotspots and intrinsically frequent deletions associated

37 o characterize the average error rate, error hotspots and lesion bypass fidelity of several DNA polym

38 n this study, however, we propose mutational hotspots and relevant clinical-genetic associations that

39 also demonstrate that generation of new SHM hotspots and saturation of existing hotspot regions (e.g

40 h published experimental data on aggregation hotspots and solubility of mutational variants of one of

41 biannual distribution to combat transmission hotspots and suboptimal responses to treatment.

42 ruggedness and amino acid-specific epistatic hotspots and that inference is additionally confounded b

43 The speciation hotspots and their function significantly overlap with t

44 l results by year, identified seven foraging hotspots and tracked these summaries to describe the dyn

45 ironments around the globe are biodiversity 'hotspots' and important reservoirs of genetic diversity.

46 that the positively curved membranes are CME hotspots, and that key CME proteins, clathrin and dynami

47 and potential temporal variability of these hotspots, and the consequences for nitrogen processing,

48 y humans, the site of multiple domestication hotspots, and the location of the largest Pleistocene me

49 Hedonic hotspots are brain sites where particular neurochemical

50 These hotspots are not random and often co-localize with DNA s

51 imorphic recombination, the vast majority of hotspots are shared between the sexes, with only a small

52 rlying hotspot formation, we have found that hotspots are significantly smaller than a Golgi subdomai

53 th America, the world's richest biodiversity hotspot, are home to many rapid radiations.

54 old higher incidence of Beijing strains in a hotspot area (33%) compared to non-hotspot areas (17%).

55 ains in a hotspot area (33%) compared to non-hotspot areas (17%).

56 tudy countries continue to live in mortality hotspots-areas where, if current trends continue, the Su

57 Dominant variants at the hotspots arose via convergent microevolution, appear to

58 We defined transmission risk hotspots as geopolitical subunits within communities wit

59 sistent with a germline recurrent mutational hotspot associated with an allele-specific neurodevelopm

60 between populations and a strong trans-eQTL hotspot at TLR1 that decreases expression of pro-inflamm

61 Kv3-type potassium channels, with clustered hotspots at boutons and restricted expression at adjoini

62 ad spectrum of molecular function, including hotspots at paralogous residues of Ras-related small GTP

63 a change in nPCR parasite prevalence outside hotspot boundaries (p >/= 0.187).

64 Hotspot boundaries are driven by the malaria diagnostic

65 target malaria interventions in areas where hotspot boundaries are uncertain.

66 nt metrics lead to consistent delineation of hotspot boundaries.

67 uation zone in relation to distance from the hotspot boundary 8 wk (p = 0.27) or 16 wk post-intervent

68 he relationships between (3)He/(4)He values, hotspot buoyancy flux, and upper-mantle shear wave veloc

69 highest maximum (3)He/(4)He ratios have high hotspot buoyancy fluxes and overlie regions with seismic

70 ching bacterial groups also produce traction hotspots, but with forces around 100 pN that fluctuate r

71 demonstrate the ability to control extrusion hotspots by geometrically inducing defects through micro

72 analysis of hotspots by PCR overlapped with hotspots by microscopy at a moderate setting but not at

73 We observed long-term stability of hotspots by PCR and microscopy but not RDT.

74 Pooled data analysis of hotspots by PCR overlapped with hotspots by microscopy a

75 Hotspots by RDT were predictive of PCR/microscopy at the

76 There were statistically significant malaria hotspots by RDT, microscopy, and PCR for all sites excep

77 lts show that capturing low VAF mutations at hotspots by sufficient sequencing coverage and carefully

78 These hotspots can be systematically evolved to create high-af

79 nsity generated by a molecule adsorbed on a "hotspot" can be digitalized.

80 METHODS AND We validated a 46-gene hotspot cancer panel assay allowing multiple gene testin

81 However, designation of hotspots (CES values above the median) based on species

82 persistence of high-risk transmission areas (hotspots) challenges the current malaria control strateg

83 ng genomic imprinting, meiotic recombination hotspot choice, and placental growth.

84 al tool, HotSpot3D, to identify such spatial hotspots (clusters) and to interpret the potential funct

85 ded library of non-synonymous mutations into hotspot codons 12 and 13 of Kras in adult somatic cells

86 Four trans-eQTL hotspots coincided with GLS disease QTLs mapped in the s

87 ) was enriched for genes with trans-eQTLs in hotspots coinciding with GLS resistance QTLs on chromoso

88 ter analysis reveals that de novo beta-actin hotspots colocalize with docked RNA granules at the base

89 at reducing prevalence and intensity in the hotspot compared with other villages.

90 We found that CO intervals are enriched in hotspots compared to the genomic background.

91 only occur on about 1% of the area, geologic hotspots contribute 17% to the annual CH4 emission estim

92 sequence identity encompassing 700 bp at the hotspot core, the presence of PRDM9 binding sites perfec

93 Local hotspots could influence control and conservation of par

94 reement (Kappa = 0.424) was observed between hotspots defined based on parasite prevalence by polymer

95 Detection of hotspots depends on the sensitivity of the diagnostic to

96 er PCR testing to guide asymptomatic malaria hotspot detection once the prevalence of infection falls

97 Using the Lagrangian hotspot detection, we demonstrate that NOX hotspots occu

98 identified in laboratory strains reflect the hotspot diversity of natural populations or whether broa

99 results suggest a model in which PRDM9-bound hotspot DNA is brought to the chromosomal axis by the ac

100 Misincorporation at hotspots does not appear to be stimulated by pausing.

101 For metals, a predominantly hotspot-driven spatial pattern was found, i.e., we ident

102 nd, i.e., we identified historical pollution hotspots (e.g., Sorfjord in western Norway) for mercury,

103 lateral inhibition is amplified; 2) Where no hotspots emerge, NE levels are only high enough to activ

104 cations to prevent rapid allele fixation and hotspot erosion in populations.

105 (4)He values ranging from low to high, other hotspots exhibit only low (3)He/(4)He ratios.

106 reproductive success differed among foraging hotspots; females using southern foraging areas laid nes

107 g the waste disposal system of the cell as a hotspot for ascaroside biosynthesis.

108 ing that it may act as a tunable interaction hotspot for ATP-dependent chromatin remodellers and, by

109 infectious diseases in Hong Kong which is a hotspot for emerging infectious diseases due to its high

110 Southeastern Asia is a recognised hotspot for emerging infectious diseases, many of which

111 erted formin 2 gene (INF2) in the mutational hotspot for FSGS.

112 In a Californian grassland, a hotspot for global biodiversity, we used a seed vacuum t

113 and identifies the eastern Weddell Sea as a hotspot for habitat-forming species.

114 The Coral Triangle is a hotspot for marine biodiversity held in its coral reefs,

115 e between different types of epithelium is a hotspot for pre-neoplastic metaplasia and malignancy, bu

116 multi-functional poliovirus protein 2B as a hotspot for the accumulation of minor alleles that facil

117 ice-container interfaces were identified as hotspots for generating freezing stress on susceptible n

118 trehalose-binding-protein reveals allosteric hotspots for GFP insertion and results in high-dynamic r

119 Hotspots for intrahost variation were detected in 59%-78

120 ive map of integration sites and chromosomal hotspots for micro-organism genomic insertions.

121 em, which can cause fork collapse and act as hotspots for replication termination.

122 These studies reveal hotspots for sequence evolution with implications for ta

123 in the PAR-binding pocket that can serve as hotspots for the development of novel therapeutics.

124 We show that active clusters are hotspots for transcription factor binding sites.

125 outh-west Iberian Peninsula) are global PCB "hotspots" for marine mammals.

126 omain sequence, suggesting the existence of "hotspots" for this protein-protein interaction.

127 stigating the molecular mechanism underlying hotspot formation, we have found that hotspots are signi

128 d that only gamma-TuNA inhibition suppressed hotspot formation.

129 Finally, we identified seven MS indel driver hotspots: four in known cancer genes (ACVR2A, RNF43, JAK

130 Plasmonic hotspots generate a blinking Surface Enhanced Raman Spec

131 e of the target protein-protein interaction, hotspots grafting with CDR loop swapping is an attractiv

132 Confinement of matter in these 'hotspots' has previously been accomplished through ineff

133 lem with this hypothesis is that, while some hotspots have (3)He/(4)He values ranging from low to hig

134 We find that the existing AID / APOBEC hotspots have a large impact on retrotransposons and non

135 Persistent hotspots have been described after mass drug administrat

136 Here we review the 'tumor hotspot' hypothesis that explains how the tissue-intrins

137 The supraclavicular hotspot identified on IRT closely corresponded to the ar

138 Microinjected at the MPTA hotspot identified, exposure of 1900 or fewer neurons to

139 It is unknown, however, whether hotspots identified in laboratory strains reflect the ho

140 They have become an immunology hotspot, implicated in infections, but also in a diverse

141 ositive breast cancer, harbours a mutational hotspot in its promoter leading to overexpression throug

142 importance of this region as a recombination hotspot in lagoviruses.

143 Focusing on the RNA editing hotspot in miR-200b, a key tumor metastasis suppressor,

144 igonucleotides from a chromosomal breakpoint hotspot in the human c-MYC oncogene containing both pote

145 Plant roots, a metabolically active hotspot in the soil, take an essential part in below-gro

146 riched for specific driver events, including hotspot in-frame insertions that target KBTBD4 and 'enha

147 scan statistics were used to find infection hotspots in 3 populations: 5- to 8-year-olds, 9- to 12-y

148 SPECT/CT identified hotspots in 4 patients at sites where SNs were resected.

149 Here, we report the mapping of two hedonic hotspots in cortex, where mu opioid or orexin stimulatio

150 percentages of mutations under 5% VAF across hotspots in EGFR, KRAS, PIK3CA, and BRAF are 16%, 11%, 1

151 RAS hotspots in NS5A were found at amino acids 28, 30, 31, a

152 toring network, identifying recent mortality hotspots in southern and northern Europe.

153 utational hotspots near VMP1/MIR21 and indel hotspots in surfactant protein genes (SFTPA1, SFTPB, and

154 minantly from M. m. domesticus Recombination hotspots in wild castaneus show little overlap, however,

155 ficantly, codons 244 and 248 are mutational "hotspots" in nonsmall cell and small cell lung cancers,

156 s during surgery, but with respect to pelvic hotspots, in most cases they are more probably related t

157 y protocols and risk analysis at biosecurity hotspots including national ports.

158 helicase, which recruits it to recombination hotspots, independently of mismatch recognition.

159 cific compounds, because engineering of this hotspot induces opposing functional outcomes by Stg and

160 locally inhibitory effects of an artificial hotspot insertion can be both Tel1-independent and chrom

161 and large animals moving nutrients away from hotspots into the continental interior.

162 While MT clustering in hotspots is equally well described by both models, simul

163 tspots, suggesting that our understanding of hotspots is incomplete.

164 The sparsity of such hotspots is made up for by enhanced tracer residence tim

165 a-plate settings, mantle plumes may generate hotspots, large igneous provinces and hence considerable

166 tions via two mechanisms: 1) Where there are hotspots, lateral inhibition is amplified; 2) Where no h

167 Volcanic hotspot lavas, like those erupted at Hawaii and Iceland,

168 resistance, we retrogressively surveyed the hotspot loci and quantified the number of SNPs and/or ge

169 es can mostly be explained by differences in hotspot magnitude, rather than location.

170 We present a new global hotspot map of spatial variation in our zoonotic EID ris

171 In each case, the fragment hotspot maps are able to rationalize a Free-Wilson analy

172 These hotspots may be sites of selective susceptibility to dou

173 to sites where SNs were resected, remaining hotspots may have been caused by residual lymphatic flow

174 Targeting hotspots may represent an efficacious strategy for reduc

175 reast cancer cells and at the translocation 'hotspot', MLL.

176 exception of a number of sequence-dependent hotspots, most misincorporations are distributed relativ

177 ineages, somatic hypermutation, is biased by hotspot motifs which violates important assumptions in m

178 consequences of the idea that the number of hotspot motifs, and perhaps the mutation rate in general

179 ously reported assay, the restriction enzyme hotspot mutation assay (IgkappaREHMA), to evaluate in vi

180 f JEM, Chheda et al. report that a conserved hotspot mutation associated with an aggressive form of b

181 e position of the mutation), which is also a hotspot mutation in human liver tumors whose incidence c

182 mouse model to activate the Pik3ca (H1047R) hotspot mutation in the heterozygous state from its endo

183 nvestigate the differences between the three hotspot mutation sites in IDH1 and IDH2 using conditiona

184 by the manifestation of several known cancer hotspot mutations among the identified alterations.

185 Hotspot mutations in the isocitrate dehydrogenase 1 (IDH

186 n factor binding, we observed that recurrent hotspot mutations resulted in decreased luciferase activ

187 progressive enrichment of pre-existing FBW7 hotspot mutations, and are cross-resistant to other targ

188 and underpinned by specific fusion genes or hotspot mutations, which may be of diagnostic and possib

189 s of meiotic double-strand DNA breaks at the hotspot near the His4 locus, is found in diploids that u

190 inomas revealed noncoding somatic mutational hotspots near VMP1/MIR21 and indel hotspots in surfactan

191 evidence that norepinephrine induces local "hotspots": Norepinephrine mainly decreases evoked respon

192 We identified a persistent hotspot, not associated with study arm, where S. mansoni

193 n hotspot detection, we demonstrate that NOX hotspots occurred at bus stops, during cold starts, on i

194 Transmission risk hotspots occurred in three of 21 parishes in west Uganda

195 stablishment of Bsal in the U.S., which is a hotspot of salamander biodiversity.

196 aling ligand gene previously identified as a hotspot of shape-tuning alleles involved in wing mimicry

197 The structural and functional hotspot of this interaction partially restructured the h

198 l effects to be largely neutral, and reveals hotspots of activating mutations in residues that restra

199 by glacial weathering results in pronounced hotspots of biological production in an otherwise iron-l

200 a suitable intercontinental bioindicator of hotspots of bird richness, even under climate change sce

201 Many geographic hotspots of cooperative breeding have experienced a hist

202 Intertidal sediments are important hotspots of dissimilatory nitrate reduction and interact

203 down, with a "morphorate map" revealing that hotspots of entrance hole evolution are clustered in hig

204 Thus, LC activation promotes a few hotspots of excitation in the context of widespread supp

205 from wildlife reservoirs) occurred mostly in hotspots of forest fragmentation.

206 ed as threatened, and provide maps of global hotspots of fragmentation for the world's terrestrial ma

207 pulations using GWAS and identified probable hotspots of genetic variation which correlate with pheno

208 In addition, hotspots of invasive species and the most susceptible na

209 We identified 33 hotspots of large (>100 kb) tandem duplications, a mutat

210 Geographical hotspots of potential HIV transmission risk and detectab

211 Protein repeats are considered hotspots of protein evolution, associated with acquisiti

212 Dam reservoirs are hotspots of sediment accumulation, primary productivity

213 Similar results were observed for hotspots of seroprevalence.

214 Other hotspots of smoke occurrence are found over state and na

215 ant spatial patterns of SOC loss were found: Hotspots of SOC loss coincided with some major cropping

216 cies geographic range), we identified global hotspots of species at risk from climate change that inc

217 ies demonstrated that the cuckoo can predict hotspots of taxonomic diversity and functional diversity

218 arily an indicator that these areas are also hotspots of the other climatic stressors examined.

219 l strategies need to respond to geographical hotspots of transmission.

220 d to identify and determine the etiology of "hotspots" of concentrated multidrug-resistant tuberculos

221 t on the molecular interactions mediated by 'hotspots' of the SF3B1 and U2AF1 pre-mRNA splicing facto

222 e report an interaction between a functional hotspot on ubiquitin and the N-terminus of histone H2A.

223 ity, antibody recognition sites or antigenic hotspots on AAVs and other related parvoviruses might be

224 e was enriched for genes with trans-eQTLs in hotspots on chromosomes 9 and 10, which also coincided w

225 onal fragment mapping methods aim to predict hotspots on protein surfaces where small fragments will

226 We investigate the strength of various hotspots on their known biological targets by evaluating

227 distinct preferred nucleotide contexts (or "hotspots") on foreign genomes such as viruses and retrot

228 osition, interacting with both CC-885 and a 'hotspot' on the cereblon surface.

229 n the DO, we overlaid putative recombination hotspots onto our CO intervals.

230 occurs when it comes in contact with mixing hotspots over rough topography.

231 slow-growing cells formed colicin-expressing hotspots, placing a significant burden on expressers.

232 equences, with binding disrupted by the SDHD hotspot promoter mutations in both quantitative mass spe

233 one third of the total population living in hotspots regardless of metric tested.

234 new SHM hotspots and saturation of existing hotspot regions (e.g., CDR3) does not majorly influence

235 Mutation 'hotspot' regions in the genome are susceptible to geneti

236 e CAPN14 gene is positioned in an epigenetic hotspot regulated by IL-13, a TH2 cytokine with increase

237 We conclude that hotspots require gamma-TuNA activity, which facilitates

238 lexibility profiles, and identify functional hotspot residues at key domain-domain interfaces.

239 Further analysis of antibody binding hotspot residues defined groups of residues essential fo

240 itional residues in the network of the known hotspot residues of different anti-Ebola antibodies that

241 specific mutated genes, frequency, mutation hotspot residues, in silico predictions, and functional

242 ch reveals spatial variations and potential "hotspots" risk due to EPFR exposure across Memphis and p

243 ature VRC-PG04 has low SHM capability due to hotspot saturation but also demonstrate that generation

244 d Pro-Glu-Ser-Thr-rich domains, the same two hotspots seen in T-cell acute lymphoblastic leukemias, a

245 zymatic and genetic results redefine the Chi hotspot sequence, implicate the nuclease domain in Chi r

246 A subset of the genes adjacent to SNP hotspots showed statistically significant enrichment in

247 Our time series from this biodiversity hotspot shows that forest and savanna area both declined

248 e overall (average = 1.6%), we identified 96 hotspot sites with 5%-25% abnormal individuals.

249 ersity of snakes in the Atlantic Forest (AF) hotspot, South America.

250 At fine scale, we reveal a stereotyped hotspot structure-DSBs occur within narrow zones between

251 In the most severe exposure hotspots, suboptimal conditions for calcifying organisms

252 Here we show that, among hotspots suggested to overlie mantle plumes, those with

253 of CO intervals do not overlap any putative hotspots, suggesting that our understanding of hotspots

254 Hotspot-targeted interventions did not result in a chang

255 ghly recurrent and tumor-type-specific indel hotspots targeting the noncoding regions of highly expre

256 ), which is a highly threatened biodiversity hotspot that occurs in Brazil, Paraguay and Argentina.

257 system is explored in an attempt to identify hotspots that can serve as targets for restoring functio

258 s, and compare these results to hypothetical hotspots that did not evolve.

259 terior of rhodoliths are marine biodiversity hotspots that function as seedbanks and temporary reserv

260 , and Mug20) are protein determinants of DSB hotspots - they bind DSB hotspots with high specificity

261 uld be used by policy-makers and managers in hotspots to formulate increased surveillance and early-w

262 complexes with additional proteins to allow hotspots to proceed into the next phase of recombination

263 uping of lymphocyte interactions by paratope hotspots) to cluster TCRs with a high probability of sha

264 Due to oncodomain hotspots' unique ability to assess rare variants, we exp

265 network, and an empirical Montreal wireless hotspot usage network.

266 were tested for evidence of being regulatory hotspots using adipose expression.

267 genome-wide using cytological assays and at hotspots using molecular assays, we show that juvenile m

268 ased geostatistical (MBG) approach to detect hotspots using Plasmodium falciparum parasite prevalence

269 mors that are wild-type at the BRAF mutation hotspot, V600.

270 CO2 fluxes from mid-ocean ridges and oceanic hotspot volcanoes.

271 One hedonic hotspot was found in anterior orbitofrontal cortex (OFC)

272 A novel, recurrent hotspot was identified at a posttranslationally modified

273 00 sequence fragments, where a recombination hotspot was identified at the ORF1-ORF2 junction.

274 used to detect asymptomatic parasitemia, and hotspots were detected using the spatial scan statistic.

275 Notably, these tandem-duplication hotspots were enriched in breast cancer germline suscept

276 Genes adjacent to indel hotspots were functionally related to G-protein coupled

277 While numerous biologically plausible hotspots were identified, their detection strongly relie

278 In total, 243 hotspots were novel and appeared to affect a broad spect

279 f the population was sampled, no PCR derived hotspots were reliably detected and at least 21% of the

280 h utilize metallic nanoparticles to create a hotspot where fluorescence signals are enhanced by plasm

281 Our analysis identifies hotspots where both conventional and unconventional oil

282 ted moving poleward, away from ocean warming hotspots where temperatures 2-3 degrees C above long-ter

283 otionally salient information through local "hotspots" where norepinephrine release interacts with gl

284 In contrast to hotspots, which are a few kilobases in size, and widely

285 anisms that make PPR wetlands biogeochemical hotspots, which ultimately leads to their critical, but

286 ade routes decided the major plague outbreak hotspots, while navigable rivers determined the geograph

287 occurs at 1- to 2-kb genomic regions termed hotspots, whose positions and activities are determined

288 iversity survey on the Indo-Malayan coast, a hotspot with a large global mangrove distribution.

289 By equipping the hotspot with a molecular beacon-like structure, we combi

290 wide SNP density analysis identified 18 SNP hotspots with comparison to the 1000 Genome Projects (1K

291 dividual cells exert local traction in small hotspots with forces on the order of 50 pN.

292 determinants of DSB hotspots - they bind DSB hotspots with high specificity and are required for DSB

293 malies in the upper mantle, unlike plume-fed hotspots with only low maximum (3)He/(4)He ratios.

294 lakes have been identified as biogeochemical hotspots with steep redox gradients.

295 ant eQTL formed 125 significant distant eQTL hotspots with their targets significantly enriched in sp

296 few molecules within each coupled plasmonic hotspot, with near thousand-fold enhancement of the inci

297 ted vasculitis, and suggest that a molecular hotspot within the MPO molecule contains important CD8(+

298 Seven additional hotspots without substrate on baseline anatomic imaging

299 erica are the most species-rich biodiversity hotspot worldwide with c. 15% of the world's plant speci

300 racks" oceanic sharks within their space-use hotspots year-round.