ライフサイエンスコーパス: how

1 a and the immune system, and we will discuss how a dietary-induced disruption of the intestinal envir

2 t how the body reacts to motor commands, but how a network of spiking neurons can learn non-linear bo

3 accessible information for use in predicting how a patient will respond to a given proposed drug or t

4 filament has long been studied to understand how a polymer composed of a single protein can switch be

5 goal of structural biology is to understand how a protein's 3-dimensional conformation determines it

6 We illustrate how a systems pharmacology approach combining experiment

7 vidence to address 3 research questions: (1) How accurate is teledermatology for skin cancer diagnosi

8 ssion of AE3 in neurons, which could explain how AE3 reduces seizure susceptibility.

9 , providing a potential mechanism to explain how ageing influences their amplitude and function.

10 worldwide highlights the need to understand how aging promotes CVD in order to develop new strategie

11 n's disease (PD), it is important to examine how AgNPs affect microglial inflammation to fully assess

12 Here, we characterize how an anti-idiotypic antibody (E1) binds antibody HM14c

13 Thus, this work provides key details into how an EV71 IRES structure adapts to hijack a cellular p

14 growth rate (lambda) is key to understanding how animal populations will respond to changing climatic

15 How animals achieve this task, and its underlying sensor

16 al perspective, our work helps shed light on how ants and other social insects can obtain relatively

17 Very little is known about how archaeal cells orchestrate transcription on a system

18 How are fear memories organized?

19 de insights into fundamental questions about how aromatic compounds behave.

20 We discuss how associated genetic variants can lead to understandin

21 e Borrelia burgdorferi Here, we investigated how B. burgdorferi exploits Fn to interact with endothel

22 describe the challenges involved and discuss how basic developmental studies have contributed to and

23 g high-dimensional and heterogeneous data is how best to interrogate increasingly specific subphenoty

24 is work exposes a strategy for understanding how biophysical characteristics contribute to function.

25 We show how brain regions tend to coordinate by forming a highly

26 tures, allowing us to systematically dissect how brains learn.

27 In this issue Ohsaki et al. explain how breastfeeding can prevent the onset of food allergie

28 Understanding how broadly neutralizing antibodies (bnAbs) to HIV envel

29 How BTX autoresistance arises in such frogs remains a my

30 city for plants, it remained unknown if, and how, calcineurin B-like calcium sensors (CBLs) and CBL-i

31 role of the inhibitory microenvironment and how CAR T cells can be further engineered to maintain ef

32 This work shows how catechol, pyrogallol, 3-methylcatechol, 4-methylcate

33 is is orchestrated at the cellular level and how cell fate is affected by severe tissue damage.

34 in vegetative tissues, providing evidence of how cell proliferation is controlled in an identity-spec

35 ough many open questions remain, elucidating how cells repair themselves is important for our mechani

36 How cells respond to pathogen-mediated disruption of gen

37 However, little is known about how cells sense and respond to mechanical compression.

38 complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transc

39 These findings provide new insights into how chromatin regulation modulates stochastic gene expre

40 our data provide a molecular explanation for how circadian phases, such as wake-sleep onset times, ca

41 ing rates and it is imperative to understand how communities assemble if we have to prevent their col

42 How complex ecosystems (termed anchialine) thrive in thi

43 Herein, we describe how content on www.personalizedcancertherapy.org is gene

44 How cortical circuits are altered and contribute to the

45 However, it remained unclear how cryptochromes regulate the BIC gene activity.

46 roduction, and advances our understanding of how defective FA signaling contributes to aging and canc

47 d to quantify SM degradation and to identify how degradation controls SM export at the catchment scal

48 ore phenotypic plasticity and, specifically, how demographic and ecological variation influence socia

49 Our results show how design changes in vehicle parameters (e.g., mass, en

50 Thus, how detection of U:G mismatches is translated into the s

51 hymal partners provides new understanding of how different cell types are maintained in the adult lun

52 However, knowing how different species' metabolisms will integrate to rea

53 f these diseases, it is not fully understood how distinct GJB2 mutations result in hearing loss alone

54 We illustrate how distinct signalling mechanisms direct stress-depende

55 ating from 11 eastern U.S. states to address how divergent demographic histories influence geographic

56 t-studied systems lack a complete picture of how diverse physical and chemical cues act upon individu

57 How does the brain reorganize when one of these channels

58 Little is known about how donor factors, timing of procurement, and geographic

59 Here, we test for the first time how early-life stress drives developmental programming a

60 cal features of network structures influence how easily distress can spread within the system.

61 Large-scale studies have revealed how editing is regulated both in cis and in trans.

62 conceptual model, we propose a framework of how eDNA is transported, retained, and resuspended in st

63 This not only sheds new light on how efficient nature is in preventing biologically momen

64 Assessing how endocrine disrupting compounds (EDCs) affect populat

65 including climatic and temporal variations, how ENMs may be released into the environment, and the e

66 ual rotifer Brachionus calyciflorus, we test how environmental complexity affects the evolution of se

67 indings provide insights into the problem of how epigenetic states are inherited through cell divisio

68 In these situations, we show how errors in positions can be corrected essentially com

69 e of these sites after 18 months, indicating how evidence of disturbance can be obscured in this envi

70 Perceptual learning refers to how experience can change the way we perceive sights, so

71 Here, we describe how F-specific antibodies protect against RSV and why sp

72 Further study as to how fish tolerate what is an early lethal mutation in ma

73 their role in immunology and it is described how focused libraries of TAs have been used to discover

74 generalized additive model (GAM) to examine how future changes in temperature and salinity could aff

75 How GABAergic interneurons regulate the segregation and

76 However, little is known about how genes are specifically affected by early malnutritio

77 Then, we discuss how genome editing techniques enable a radically new set

78 In this review, we discuss how genome-wide association studies (GWASs) and recent d

79 , using in situ electron microscopy, we show how gold and silver nanocrystals nucleate from supersatu

80 We discuss how growing understanding of key anatomic sanctuaries fo

81 Our findings show how GSK3 kinase inhibition can greatly enhance the matur

82 ication is critical for our understanding of how heart formation is initiated during embryonic develo

83 Here, we investigate how heat waves affect emissions of volatile organic comp

84 ation of an integrated approach to elucidate how heterogeneity at the transcriptional level manifests

85 To illustrate, we show how hierarchical Bayesian models of ecological diffusion

86 icing assay can be used to explore in detail how HIV-1 splicing is regulated and, with moderate throu

87 This study addresses how IFN-gamma can suppress activation of diabetogenic CD

88 Using prion permissive cells, we determined how impairment of endocytosis affects productive infecti

89 However, it remains unclear how infection initially becomes latent.

90 Significant interest has emerged in how inflammation regulates HSC fate and how it affects t

91 discrete components of commitment, resolving how innate lymphoid, myeloid, and dendritic, and B-cell

92 Where and how interaction analyses are implemented in the brain is

93 lation are discussed as a model illustrating how interdependent targeting of different silencing path

94 d in how inflammation regulates HSC fate and how it affects the long-term functionality of HSCs and t

95 l for studying the plasticity of meiosis and how it can be modulated.

96 utions depend on both the level of noise and how it impacts a particular computation.

97 ng of the basic biology of this parasite and how it interacts with its ruminant host.

98 anagement support at end of life entails and how it is enacted in practice.

99 nce or rarity, thus offering a first view on how it varies across space and time and revealing the es

100 em, is shifting from "if it can be done" to "how it will be done." Moving from a theoretical stage to

101 account this environmental heterogeneity and how its effects on regeneration dynamics play out in lon

102 g motivated behavior, but it remains unclear how its inputs from different sources interact.

103 However, it remains unclear how LAP shapes both the activation and outcome of the im

104 n of sentences and word lists to investigate how left-hemispheric brain activity varies during the fo

105 who speak of the desire to control when and how life will end.

106 all and perceived by the fetus, dependent on how light interfaces with maternal tissue.

107 are a valuable resource to elucidate further how LinE proteins and the related SCs of other species r

108 However, how living cell functions can be modulated via opsins by

109 However, surprisingly little is known about how LMP1 expression is regulated in epithelial cells, an

110 To better understand how loss of D2-family dopamine receptors can ameliorate

111 gether, our results reveal new insights into how macrophages enhance cancer cell metastasis, and they

112 lying signaling pathways, it remains unclear how macroscopic features of branched organs, including t

113 How McSCs respond to injury, however, remains largely un

114 SoPIN1 and PIN1b in Arabidopsis illustrates how membrane and tissue-level accumulation, transport ac

115 eactions, they are good systems for studying how metabolic enzymes communicate via substrate channeli

116 -encoding transcripts, little is known about how miRNAs themselves are degraded.

117 interaction, enhancing our understanding of how mitochondria properly localize in axons.

118 Understanding how MkMPs target, deliver cargo and alter the fate of HS

119 Finally, we discuss how modern detection and diagnostic technologies as well

120 Here, we investigated how motor cortical activity changed in the presence of a

121 We present models for how MRX-Sae2 creates entry sites for the long-range rese

122 autoreactive T cells and helps to understand how MSCs ameliorate symptoms in lupus-prone MRL.Fas(lpr)

123 roperties of the resulting network depend on how much of the inferred connectivity is eventually reta

124 oftentimes unknown, at a genome-wide scale, how much transdifferentiated cells differ quantitatively

125 lity, provides a unique opportunity to study how multimodal information is represented in the human b

126 , in part because of a poor understanding of how mutations in genes such as GRN contribute to disease

127 We show how myocardial region-specific heterogeneity in cell fun

128 These results highlight how nanoscale changes can induce reactivity in 2D materi

129 ory systems have led to detailed accounts of how negative images are formed at the level of synaptic

130 s the commonly overlooked difference between how net and gross carbon fluxes affect the long-term car

131 Addressing how neural circuits underlie behavior is routinely done

132 However, how neuronal morphology is maintained in the adult brain

133 of venom genes in parasitoid wasps to study how new gene functions evolve.

134 amination of their properties can illuminate how new species evolve.

135 ion in evolutionary developmental biology is how new traits evolve.

136 Our work sheds light on how nuclear organization and Polycomb group (PcG) protei

137 We investigated how OA affects the impact of a cubozoan predator on thei

138 This illustrates how optical absorption methods have become a competitive

139 Next, we studied how optogenetic stimulation of these projections affects

140 Results extend the understanding of how organic carbon and nitrite loads modulate N2O accumu

141 respond to, and perhaps sense stresses; and how organisms with a similar sensitive cytoskeleton may

142 y detrimental to health, deeper knowledge of how our biological clocks change with age may create val

143 tient cases from our institution and discuss how our management reflects what we have learned about t

144 erythematosus (SLE); however, it is unclear how Ox40L contributes to SLE pathogenesis.

145 s, our data reveal an important mechanism of how p97 maintains lysosomal homeostasis, and implicate t

146 These results inspired a model that shows how pairings between long repeated sequences could be ef

147 t cells provide novel explanations regarding how pH may drive cellular processes; how plants may resp

148 attempt to disentangle the discrepancies in how physicists and biologists use the term 'precision' t

149 ed by excretion of Phe derivatives; however, how plants endure Phe accumulating conditions in the abs

150 garding how pH may drive cellular processes; how plants may respond to, and perhaps sense stresses; a

151 es carrying rock2 and rock3 alleles revealed how plants respond to locally enhanced cytokinin signali

152 Mechanistic insight into how polycations disrupt and cross cell membranes is need

153 Therefore, this study investigated how preexisting antibodies to historical influenza virus

154 approach provides a better understanding of how prostate cancer cells respond heterogeneously to and

155 Importantly, we demonstrated how proteomics data could be readily integrated with tra

156 finished water; however, it remains unclear how quality and quantity of overall allochthonous and au

157 uracy of this record allow us to investigate how rainfall in the region responds to D-O events.

158 However, how relative levels of hepatocyte and cholangiocyte gene

159 l epithelium is key to renal physiology, but how renal tubules regulate capillary development remains

160 To investigate how reward history modulates OFC activity, we recorded O

161 It remains unclear how RICD sensitivity is calibrated in T cells derived fr

162 ical AD.SIGNIFICANCE STATEMENT Understanding how risk factors for Alzheimer's disease (AD) affect bra

163 Friction plays a key role in how ruptures unzip faults in the Earth's crust and relea

164 NO2(-) during normoxia places constraints on how S-nitrosation occurs in vivo and on its mechanisms o

165 d holo-forms of the HCN4 isoform, reflecting how S672R remodels the free energy landscape for the mod

166 The results demonstrate how sensory information regulates state-dependent reflex

167 However, it is not yet known whether or how sensory stimulation might trigger abnormal sensory p

168 hology, but we lack a basic understanding of how sex differences in the human cerebellum are distribu

169 Thus, understanding how sex impacts immunity requires the elucidation of com

170 e single-cell studies has begun to elucidate how signaling dynamics determine cell physiology and rep

171 a neuronal circuit in a marine worm reveals how simple networks of neurons can control behavior.

172 on multielectrode recordings to investigate how single GC neurons respond to intraorally delivered t

173 We investigated how Sirtuin 1 (SIRT1), a conserved mammalian NAD(+)-depe

174 These findings provide insights into how skeletal stem and progenitor cells interact with oth

175 Animal models have begun to elucidate how skin barrier defects can lead to systemic allergen s

176 al activity during bond formation, revealing how social interactions can recruit brain reward systems

177 formal model of optimal policing to explore how society might reasonably resolve the tension between

178 tical model and a set of experiments showing how soft electrodes can be successfully employed in capa

179 Here, we examined how solutes and macromolecules are separated when they e

180 Highlighted topics include how solution-processing techniques can control the distr

181 odels provide a biophysical understanding of how stem cell scaling is maintained during organ growth

182 Our results demonstrate how stress alters CA1 circuit function through the impai

183 However, few studies have investigated how stress impact humans raised in an overprotective man

184 unction emerges during early development and how structural patterning goes hand-in-hand with functio

185 However, it is unknown whether or how subtle differences in spike timing drive differences

186 ations in the transcriptome of NAc MSNs, but how such alterations influence cocaine's effects on dend

187 Here we illustrate how such conditions promote chemotherapy resistance in p

188 which control drug response and illustrates how such data can add substantial confidence to target i

189 drug response and immunity, and we highlight how such improvements enable a greater understanding of

190 ineage-based design strategies to illustrate how such in-depth analysis can offer conceptual improvem

191 We explore how such individual changes in a variety of species migh

192 How synaptic growth is terminated after reaching proper

193 utilization, and, with examples, demonstrate how synthetic biology may maximize CO2 uptake within and

194 This is a tale of how technology drove the discovery of the molecular basi

195 The latter structure indicates how tension between the two motor domains keeps their cy

196 Here we examined how the abundance of motor and nonmotor cross-linkers af

197 However, little is known about how the activity of these proteins is regulated.

198 Here we examined how the anatomical composition of a genetically defined

199 The brain needs to predict how the body reacts to motor commands, but how a network

200 However, how the brain implements this important decision heurist

201 How the calibrated CPI affected performance of the updat

202 We determined how the chemical composition of primary ambient PM2.5 so

203 To enquire how the circadian system protects aging organisms, here

204 orientations is demonstrated, which explains how the conversion reaction occurs in alpha-MnO2 materia

205 of its constituent XPB and XPD ATPases, and how the core and kinase subcomplexes of TFIIH are connec

206 Here we probe how the crystal packing alters microsecond dynamics, usi

207 any low photon-number image irrespective of how the data is collected.

208 tributions of these synthetic approaches and how the development of novel Ub-based reagents is greatl

209 amnosus (P) to zebrafish in order to explore how the dietary lipid content may influence the gut micr

210 However, we have largely ignored how the differentiation into the NKT cell subsets is reg

211 rms, necessitating a deeper understanding of how the distinct transcriptional programs controlled by

212 We ask how the distribution of mutational effects of a transcri

213 How the diverse TCRs interact with a multitude of MHC mo

214 The present work aimed to examine how the doxycycline-inducible lentiviral-mediated ChR2 e

215 ed with a strong Allee effect to investigate how the frequency of periodic spatial disturbances affec

216 l genome into the host during infection, but how the genome is organized and delivered is not known.

217 nsion theory is developed to help understand how the gradient metasurface tailors the incident beams,

218 We furthermore show how the level of added noise can be continuously adapted

219 They reveal how the metamorphic properties of KaiB, a protein that a

220 We also evaluate how the method chosen for extrapolation into nonanalog c

221 over time along these dimensions will reveal how the nature of language reflects human minds, rather

222 sol mass spectrometry is used to investigate how the ozone (O3) concentration, relative humidity (RH)

223 Understanding how the paradox biases local observations can inform bet

224 of T2 requires an understanding of precisely how the position of nuclear spins relative to the electr

225 However, how the protein profile changes to facilitate the cells

226 We describe here important differences in how the Rb and p107 C-terminal domains (CTDs) associate

227 In describing how the renaissance has unfolded, we attempt to describe

228 and animals and (ii) can be used to predict how the resulting geometry of biological networks then g

229 ature, Brown et al. (2017) shed new light on how the skin handles the activation of oncogenic pathway

230 However, it is unknown how the tangerine and red tomato juices differ in biolog

231 Additionally, we investigated how the timing of exercise relative to AOM exposure, and

232 Consequently, it is less clear how the unbound, sensing riboswitch refolds into the lig

233 We explore how the understanding and control of the characteristic

234 little is known at the molecular level as to how the viruses are recognized and transmitted.

235 lineage of cells is central to understanding how the wide diversity of cell types develops.

236 uch as how they are distributed in space and how their relative velocities change in various chemical

237 rs Allee effects in our model and we explore how these Allee effects respond to such evolution.

238 We have begun to ask questions about how these cells can be regulated to mitigate the collate

239 How these different activities are mediated is not known

240 How these different aspects of cell behavior are coordin

241 x homeostasis in immune cell metabolism, and how these factors are reflected in different metabolic p

242 ues, such as bile salts and alkaline pH, but how these factors influence ToxR is not yet understood.

243 eristics of CRISPR-Cas systems and highlight how these features can be used in industrial settings.

244 This article summarizes how these multifaceted functions of exosomes may promote

245 To gain insight into the molecular basis for how these mutations contribute to epileptic encephalopat

246 Thus, precisely how these mutations inactivate BAP1 is unknown.

247 Further research is needed to understand how these noncardiac complications may affect the long-t

248 n lineage allocation, but it remains unclear how these processes are coordinated.

249 velopment within the CNS is well recognized, how these progenitors regulate the vasculature outside t

250 Here we propose a new model for how these proteins can initiate autoimmunity.

251 To understand how these receptors distinguish ACh and Cho, we used sin

252 Furthermore, by monitoring how these stochastic properties are affected by spore de

253 less odorants dissolved in water and whether/how these two modalities converge in the same neurons.

254 To understand the genetic architecture of how these two organs covary during developmental ontogen

255 However, the molecular details of how these two proteins interact have yet to be establish

256 udy in three different models of this system how these two seemingly conflicting criteria are met.

257 Here we characterize how these viruses evolved during replication in cell cul

258 ns result in MEK1 constitutive activity, but how they affect MEK1 regulation and function remains lar

259 ution of the well-known Lewis pairs, such as how they are distributed in space and how their relative

260 itters, but relatively little is known about how they are formed.

261 The values of texture indices and how they changed as a function of the activity distribut

262 review six principles of living systems and how they compare and contrast with engineered systems.

263 where they come from, where they reside, and how they function in normal homeostasis and wound repair

264 lic Ca(2+) flux into enzymatic activity, but how they function is poorly understood.

265 verse rhythmic activities in the cortex, but how they interact to orchestrate specific band activity

266 ically distributed in lymph nodes (LNs), but how this affects adaptive responses has not been extensi

267 However, how this altered metabolism contributes to tumour metast

268 ing whether SRs compete for Cul1 and, if so, how this competition is managed.

269 It is currently unclear how this is orchestrated at the cellular level and how c

270 As an example, we describe how this method can be used to covalently immobilize Wnt

271 on dynamics is critical for understanding of how this modification influences protein stability, loca

272 But how this occurs, and the functional importance of S-nitr

273 e local neuronal activity, but it is unclear how this relationship affects information encoding in hi

274 ors and showed in a proof-of-principle study how this virus-host interaction can be employed to enhan

275 the TRIM21 effector mechanism, and highlight how this work is exposing the previously restricted intr

276 ot the internal structures or anything about how those compound eyes may have functioned.

277 logy paper [1], Zambon et al. reinvestigated how three myosin isoforms participate in the formation a

278 How tightly bound charge transfer (CT) excitons dissocia

279 ive, step-by-step tutorials that demonstrate how to fit such models in a variety of software programs

280 describe a detailed protocol that describes how to initiate the in vitro differentiation of mouse an

281 uld be helpful for a better understanding of how to manage antibiotic-resistant bacteria in the futur

282 is needed to inform firm recommendations on how to protect this vulnerable population.

283 Thanks to the method, we also show how to reliably and easily estimate the detergent corona

284 In particular, we demonstrate how trapping energy in well-defined train of polarizatio

285 tensively studied, little is known regarding how tumor cell rolling on selectins facilitates adhesion

286 The X-ray data show how Tyr34 maintains solvent exclusion and the core H-bon

287 tion have emerged as an excellent example of how ubiquitin signals control inflammatory responses.

288 Our findings reveal how UTX regulates the development of iNKT cells through

289 r calcium dynamics of VSMC and to understand how variation in protein levels that arise due to diabet

290 We also show how vascular endothelial growth factor (VEGF) regulates

291 Our study may allow clinicians to estimate how VF results are affected by varying degrees of unreli

292 Nor is it known precisely how villus cell migration is affected when proliferation

293 Thus, understanding how viruses evade or exploit macrophage function will pr

294 ublished a Registered Report, that described how we intended to replicate selected experiments from t

295 he limitations to mental effort exertion and how we manage those limited cognitive resources.

296 In this work, we provide an overview of how well-established concepts in the fields of quantum c

297 ic pathways in the stem cell compartment and how wild-type cells limit the proliferation of mutant ce

298 normal cells, but it is not fully understood how WRN deficiency leads directly to telomere dysfunctio

299 y acids; however, very little is known about how zDHHC enzymes contribute to acyl chain heterogeneity

300 These observations allow us to understand how ZIF-8 crystals self-assemble and the subsequent infl