ライフサイエンスコーパス: hub

1 TP63 and NF-kappaB complexes through an AP-1 hub, further supporting our findings.

2 d from the RNA-Seq dataset that indicated 50 hub genes, most of which are involved in transport proce

3 A hub-and-spoke circuit of neurons connected by gap juncti

4 A hub-and-spoke model in South India improved STEMI care t

5 rm for the assembly of the A-Q complex and a hub for the localization of mother cell and forespore pr

6 We then applied a hub identification strategy to the significant FFLs and

7 the anterior temporal lobe (ATL) serves as a hub for a distributed neural circuit that represents per

8 inal domain (CTD) of FtsZ, which serves as a hub for FtsZ regulation.

9 enhancer (TSS) in its 3'UTR that serves as a hub for interactions throughout the region.

10 us organelle in mammalian cells, serves as a hub for lipid metabolism.

11 rhinal cortex (mEC) has been identified as a hub for spatial information processing by the discovery

12 ription factor, was recently positioned as a hub gene in a module of the genes with the highest expre

13 ed astrocytes implicated EGFR signaling as a hub in C3-dependent responses.

14 ork analysis reveal that CPH1 functions as a hub linking key motor and structural proteins that conta

15 results establish the pulvinar nucleus as a hub linking the visual cortex with subcortical regions i

16 results establish the pulvinar nucleus as a hub linking the visual cortex with subcortical regions i

17 We also propose that Hsp47 likely acts as a hub molecule during collagen folding and secretion by di

18 or enrichment analysis identified c-MYC as a hub of miR-203-induced transcriptomic changes in squamou

19 Premotor area F5 acted as a hub that shared the visual coding of AIP only temporaril

20 crucial for word comprehension, serving as a hub to integrate auditory and conceptual processing.

21 ly growth response protein 2 identified as a hub transcription factor within the top GO term, and a p

22 ith species accumulation curve richness as a hub.

23 K-Akt signalling pathway was identified as a hub.

24 ny interactions with other genes is called a hub gene, which usually plays an essential role in gene

25 ucleocytoplasmic transport and constitutes a hub for control of gene expression.

26 iphosphate hydrolysis state of KaiC create a hub around which nighttime signaling events revolve, inc

27 abled the resolution of contributions from a hub of key brainstem structures to endogenous analgesia.

28 tion at serine 319, FOXO1 binds to IQGAP1, a hub for activation of the MAPK pathway, and impedes IQGA

29 The Myddosome is a hub for inflammatory and oncogenic signaling and has a h

30 ed, and modulated by inflammation; DLG4 is a hub protein in the microglial inflammatory response; and

31 Recently, we found that Nop4 is a hub protein in the nucleolar large subunit (LSU) process

32 ectivity of the nucleus accumbens (NAcc) - a hub of the reward network - focusing on how connectivity

33 s a distinct role in gating and represents a hub for powerful allosteric modulation of AMPA receptor

34 We show that the differentiation into such a hub neuron involves the sex-specific scaling of several

35 nary intervention (PCI) during STEMI using a hub-and-spoke model.

36 slightly lower resolutions: portal (9.2 A), hub (8.5 A), tailspike (10.9 A), and needle (10.5 A).

37 ch that incorporates prior information about hub genes.

38 Activation hubs connect 3.4 enhancers per promoter and exhibit a st

39 the organization of innate immune activation hubs at SILT that mature and are continuously sustained

40 ed loops together form multi-loop activation hubs at key macrophage genes.

41 vents, suggesting that multi-loop activation hubs involving cell-type-specific transcription factors

42 , we observed close interactions among aging hubs, which renders the aging subnetworks vulnerable to

43 three test gene expression datasets, and all hub genes were consistently downregulated in obese subje

44 es against invading pathogens, they are also hubs of metabolic activity.

45 nterior temporal lobe, known to be an amodal hub for semantic processing and related to cross-situati

46 trary to the depletion of interactions among hub genes in biological networks, we observed close inte

47 ed associations and identified essential and hub genes.

48 n propagation units in neuronal networks and hub structure in transportation networks.

49 often utilize overlapping host networks, and hub proteins within these networks represent attractive

50 2AC, CCNA1 in blood are leading pathways and hub genes that were associated with both RSV load and se

51 e topological properties (i.e., sparsity and hub gene structure) of complex networks in the regulariz

52 highly interconnected regions (rich club and hubs within it) form a topologically continuous band ext

53 Here, we examine how modules and hubs shape the collective dynamics on networks and we fi

54 tween the posterior default mode network and hubs of high connectivity (many located in the frontal l

55 etabolic profiles we identified pathways and hubs transcription factors regulated during drought cond

56 interaction is affected by both 'latch' and 'hub' mutations, suggesting a key role for these unique f

57 14-3-3 adaptors are hub proteins that are attractive targets to manipulate c

58 ntial for maintaining proteostasis; many are hub genes - involved in RNA processing, cytoskeletal met

59 OmpA and YiaD, and carbapenemase Oxa-23 are hubs of the identified interaction network.

60 Thus, meiotic chromosome axes are hubs for regulated proteolysis via SUMO-dependent contro

61 wo regulatory GTPases, Nog2 and Nog1, act as hub proteins to interact with multiple, distant assembly

62 sian ancestry we identified host caspases as hub proteins that mediate the lethality of multiple path

63 uring drought conditions and that may act as hubs in the transcriptional network.

64 Our results indicate that residues acting as hubs for multiple interactions frequently led to the mos

65 s, pulmonary diseases and Crohn's disease as hubs and thus pointing to common inflammatory processes

66 of multi-protein complexes that function as hubs of signal transduction in eukaryotic cells.

67 e propose that the Aux/IAA genes function as hubs that integrate genetic and environmental informatio

68 plM and trmD, which have functional roles as hubs in a hierarchical scale-free fractal protein-protei

69 actions, such as with proteins that serve as hubs for essential cellular functions.

70 have high closeness scores and thus serve as hubs with strong connections to all other residues.

71 e selected based on their identification as "hub" areas of the default mode and cortical salience net

72 ion sets; improvements to track and assembly hub support; and a new interactive tool, the "Data Integ

73 EBI metagenomics is a freely available hub for the analysis and archiving of metagenomic and me

74 that nuage granules can be considered to be hubs for active, mobile, and transient complexes.

75 iosciences eastern and central Africa (BecA) hub, and the International Glossina Genome Initiative.

76 also established direct associations between hubs and validated drivers of heart regeneration with mu

77 esting-state functional connectivity between hubs of the reading/language networks.

78 the proposed algorithm, is that the biggest hub structures (e.g., top ten) in the GRN all center at

79 ES7 as a bait indicate that ES7 is a binding hub for a variety of non-ribosomal proteins essential to

80 ition of mitochondria as a major biochemical hub, contributions of mitochondrial dysfunction to vario

81 Both hubs were biased by inputs from the insula identified fr

82 of neuronal connectivity, showing that brain hubs display a tight coordination of gene expression, of

83 ar, ceramide serves as an essential building hub for complex sphingolipids, but also as an organizer

84 he expression of these networks is driven by hub genes with human-specific patterns of expression.

85 ronmental cues integrated by dendritic cell "hubs" are discussed.

86 e, where the two Cas2 domains form a central hub (twofold axis of symmetry) flanked by two Cas1 lobes

87 f wedges that are organized around a central hub complex.

88 tment trans-Golgi Network (TGN) is a central hub divided into multiple subdomains hosting distinct tr

89 nucleosome surface may function as a central hub during DSB repair, directing specific patterns of hi

90 ur results suggest that the ATL is a central hub for representing and retrieving person knowledge.

91 ng platform protein (MAVS) acts as a central hub for RIG-I receptor proximal signal propagation.

92 termini of nine Sas-6 dimers form a central hub of approximately 12 nm radius from which nine dimer

93 Greater Middle East (GME) has been a central hub of human migration and population admixture.

94 Therefore, Rb proteins act as a central hub of quiescence and homeostasis by coordinating the re

95 e holoenzyme is organized by a rigid central hub complex, while positioning of the kinase domains is

96 on an acentric disk is formed on the central hub of the apoptosome.

97 As the central hub of the metabolism machinery, the mammalian target of

98 nscriptional regulators often act as central hubs to integrate multiple nutrient and stress signals.

99 ike cysteine proteases (PLCPs) being central hubs in plant immunity.

100 e presence of densely interconnected central hubs of connectivity discriminated behavioural conscious

101 olutionary signatures, and occupying central hubs in the human interactome.

102 s a dramatic disruption of the hCS chromatin hub.

103 results show that the thalamus is a circuit hub in motor preparation and suggest that persistent act

104 w insights into the observed patterns of cis-hubs and trans-eQTL regulation across tissue types.

105 iators" of trans-eQTLs, including those "cis-hubs" involved in regulation of many trans-genes.

106 t domains on late Golgi, and these clathrin "hubs" dispersed in synchrony after the late Golgi marker

107 Sulawesi repeatedly acted as colonization hub for different segments of the Sunda Arc.

108 y informative, with the global and community hubs differing in regulatory potential and likelihood of

109 PHC differentiates into a densely connected hub sensory neuron/interneuron, integrating a large numb

110 A-insensitive 5 (ABI5) as a highly connected hub.

111 ontaining a small number of highly-connected hub nodes that controlled large numbers of downstream ge

112 he insula, one of the most densely connected hubs in the developing cortex, is a major source of the

113 A cycle defect could be the major connecting hub between SDH-mutated tumors and the (18)F-FDG uptake

114 e show that projections between connectivity hubs of the mouse brain are both central (i.e., they pla

115 er systems containing prominent connectivity hubs.

116 tion (global efficiency, number of connector hub nodes).

117 We highlight conserved hubs in hormone cross talk and discuss evolutionary adva

118 formation, while also serving as consumption hubs of "hard" water and energy infrastructures.

119 ated Ca(2+) signaling represent a convergent hub function shared across the spectrum of autistic diso

120 in the anterior insular cortex (AIC), a core hub of the "salience network" that is critical for perce

121 These emergent synergies, and the core hubs of interaction that they define, identify subsets o

122 brain stimulation to a heteromodal cortical hub implicated in semantic processing.

123 ferior frontal gyrus (IFG) is a key cortical hub in the circuits of emotion and cognitive control, an

124 tic memory propose that heteromodal cortical hubs integrate distributed semantic features into cohere

125 The liver is a critical hub for numerous physiological processes.

126 force the notion that the cMRF is a critical hub for oculomotility by proving that it contains premot

127 ggests that the human thalamus is a critical hub region that could integrate diverse information bein

128 phosphorylation could identify (1) critical hubs in platelet signaling toward aggregation and (2) no

129 The prefrontal cortex (PFC) is a crucial hub for the flexible modulation of recent memories (exec

130 rt, strongly suggesting this was the crucial hub of early US HIV/AIDS diversification.

131 on factors and co-factors with five defining hubs linking 47 genes in a network.

132 anization comprising modules and high-degree hubs.

133 T corepressor is an intrinsically disordered hub protein responsible for binding and coordinating the

134 c counterparts, use intrinsically disordered hub proteins for network assembly and subcellular organi

135 nd neuropeptides act dynamically at distinct hubs of the circuit to produce multiple suppressive even

136 ematical simulations to demonstrate distinct hubs at the cardiac intercalated disc, populated by clus

137 Dynamic hub load score (DHub) assessed its variability over time

138 The phagosome becomes a dynamic hub receiving traffic from multiple sources, the ER-Golg

139 In summary, dynamic hub load relates to cognitive functioning in patients un

140 be tracked and even predicted using dynamic hub load, suggesting it may be used as a prognostic mark

141 terogeneity of response profiles within each hub mirrors the distinct patterns of functional coupling

142 We identified eight hub genes which likely play important roles in obesity m

143 L2L11, we identify a haematopoietic enhancer hub that is inactivated by the EBV repressors EBNA3A and

144 on, whereas pre-assembly of a multi-enhancer hub increased the frequency of OR choice in cis.

145 gically efficient and biologically expensive hubs of the brain anatomical network had greater rates o

146 at contains several differentially expressed hub genes.

147 over, crosstalk between transcription factor hub expression modulated by structural variants and meth

148 ts, as they affect more transcription factor hubs in the tissue-specific network.

149 e network-based analyses identified 13 focus hub genes (IL-6, IL-1beta, CXCL2, STAT3, NUPR1, Jun, CSF

150 rstanding of the interactions between folded hubs and their intrinsically disordered partners.

151 modular organisation with rich-club forming hubs.

152 We investigated functional hub load and postsurgical cognitive deterioration in pat

153 y, MeCP2 has been cast as a multi-functional hub that integrates diverse processes that are essential

154 unusual 'molecular latch' and a functional 'hub'.

155 conditions and highlight influential genes (hubs).

156 ormation transfers are coordinated by global hub regions within cognitive control networks.

157 le host pathways as they target several host hub proteins.

158 roposed method in lung cancer has identified hub genes whose mRNA expression predicts cancer progress

159 as well as an activity-based map to identify hubs mediating the behavioral effects of cocaine.

160 kinase, as the most topologically important hub in protein-protein interaction networks within the 1

161 We have demonstrated that incorporating hub gene information in estimating network structures ca

162 stidial metabolite, MEcPP, as the initiation hub, transducing signals to adjust the activity of hard-

163 ical input, it could serve as an integration hub for sensory and cognitive signals.

164 suggests that zDHHC17 may be an interaction hub regulating many cellular processes.

165 dual cells represent a cell-cell interaction hub with a large number of potential incoming and outgoi

166 veal how Ctf4 forms a replisomal interaction hub that coordinates replication fork progression and si

167 Several novel interaction hubs and functional interactions were discovered.

168 silencing and converge into interchromosomal hubs that assemble over the transcriptionally active OR.

169 rate the importance of highly interconnected hub regions in the consolidation of a fear memory.

170 that were primarily governed by intramodular hub regions.

171 ls, Pdx1 and Nkx6.1, were observed in islet "hub" cells.

172 eptor of the kinase 'WalK' (erWalK) as a key hub for bridging extracellular signal input and intracel

173 is increasingly becoming recognized as a key hub for integrating quality control processes associated

174 Here, we have shown that a key hub in the insulin signaling pathway, activation of p70

175 In particular, MSI was a key hub, highly connected with other biomarkers in proximal

176 ch identified AGAMOUS-LIKE22 (AGL22), as key hub gene in a TF GRN.

177 Many of the key hubs identified in conjunction with clinical response ar

178 enetic and pharmacological targeting of key 'hub' proteins in such pathways was sufficient to modulat

179 previously neglected virus in Haiti, a known hub for pathogen spread to the Americas, warrants close

180 aratus is increasingly recognized as a major hub for cellular signaling and is involved in numerous p

181 ectivity identified MKK3 as one of the major hub proteins in the network.

182 bodies (SPBs) in yeast, are vital mechanical hubs that maintain load-bearing attachments to microtubu

183 carbon (1C) cycle is a fundamental metabolic hub in cells that enables the synthesis of nucleotides a

184 ng increasingly central energy and metabolic hubs.

185 echanism for the role of CFTR as a molecular hub.

186 esis via interactions with central molecular hubs linked to autism spectrum disorders.

187 sphere, thereby reducing the wind speed near hub height.

188 or temporal lobe served as the major network hub for face processing in controls, this was not the ca

189 cancer therapy, and they function as network hubs to coordinate actin and microtubule dynamics.

190 nd NAC regulators were identified as network hubs.

191 that aging genes not only tend to be network hubs, playing important roles in communication among dif

192 However, identifying network hubs is often impractical, and they can be misleading if

193 mmunities that play the roles of the network hubs of smaller peripheral communities.

194 frontal cortex is a critical neuroanatomical hub for controlling motivated behaviours across mammalia

195 habenula acts as a critical neuroanatomical hub that connects and regulates brain regions important

196 R and represents a potential neuroanatomical hub connecting the nucleus tractus solitarius (NTS), the

197 amily is therefore identified as a major new hub of immune regulation.

198 The LDCs are mainly non-hubs, but form a densely connected group overlapping on

199 The expression of hub genes confirmed by qRT-PCR, ELISA (IL-6, IL-1beta, a

200 Disruption of this pathway by mutation of hub residue R788, which forms the center of a cluster of

201 nd is driven by age-related strengthening of hub edges present both within and between modules.

202 load, because of consistently high usage of hub regions.

203 The concept of 'hub (over)load', caused by (over)use of the most importa

204 ("signalosomes") assembled by oligomerizing hub proteins following their recruitment to signal-activ

205 SHub indicates larger processing pressure on hub regions.

206 domisation was stratified by major centre or hub and was done in blocks (six, eight, or ten).

207 urrogate networks in which either modules or hubs are destroyed, we find that functional complexity a

208 y endosome can act as an upstream pathogenic hub in AD.

209 tein (FBP) family represent cellular pathway hubs, and their overexpression in liver cancer (hepatoce

210 spoke health care centers to the 4 large PCI hub hospitals and leveraged recent developments in publi

211 tures, with the amygdala acting as a pivotal hub of the interaction between harm and mental state.

212 ore suggest that CYFIP2 could be a potential hub for targeting treatment of the disease.

213 ntifies protein farnesylation as a potential hub of the signaling network affecting multiple aspects

214 PPI hubs reveal new regulatory mechanisms for cancer genes l

215 We hypothesized that Asia is a primary hub for the recent international spread of ciprofloxacin

216 element binding protein (CREB) is a primary hub of activity-driven genetic programs in neurons contr

217 us (LDTg), an understudied neural processing hub for reward and homeostatic feeding signals.

218 The Ctf4/AND-1 protein hub, which links DNA replication, repair, and chromosome

219 The 14-3-3 protein hub, which plays wide-ranging roles in cellular processe

220 an essential component named conoid protein hub 1 (CPH1), which is conserved in apicomplexan parasit

221 ighlight the importance of essential protein hubs in controlling biological networks of MTOCs in earl

222 d reflect the assembly of functional protein hubs and DNA processing during the rate-limiting steps o

223 tion, local efficiency, number of provincial hub nodes) and measures of network integration (global e

224 carbon metabolism genes, including pyruvate hub enzymes and fermentation pathways and virulence gene

225 type was associated with numerous long-range hub nodes and an abnormal integration of left thalamus a

226 rain and muscle ARNT-like 1) is a regulatory hub for transcriptional coactivators and repressors that

227 chondria is emerging as a central regulatory hub that determines mitochondrial morphology under stres

228 c, ancestral, and multifunctional regulatory hub integrating the in-phase oscillation of two global t

229 DipM and LdpF, which may serve as regulatory hubs coordinating the activities of multiple autolytic e

230 al lobe (ATL) is a semantic representational hub.

231 clinical response are also cellular response hubs.

232 nucleus accumbens (the pleasure and reward 'hub' in the brain) influences wheel running behaviour in

233 position of the gap junctions connecting RMG hub neurons with sensory spoke neurons is unknown.

234 at the innexin gene unc-9 is required in RMG hub neurons to drive aggregation and related behaviors,

235 Expression of unc-1(dn) in RMG hub neurons, ADL or ASK pheromone-sensing neurons, or UR

236 ties of their postsynaptic partners, the RMG hub interneurons.

237 ing pathway and show that it acts in the RMG hub interneurons.

238 at the ANE syndrome mutation disrupts Nop4's hub function by abrogating several of Nop4's protein-pro

239 Several hub genes of the epithelial growth and repair module wer

240 The expression levels of several hub genes, including AKT1, BRCA1, CCDC134, UBD, and ZIC2

241 In eukaryotes, several "hub" proteins integrate signals from different interacti

242 ereby promoting the formation of a signaling hub enabling integration of distinct signaling pathways

243 o function as a shock absorber and signaling hub.

244 ion of T cells (LAT) is a critical signaling hub connecting T cell antigen receptor triggering to dow

245 ated kinase 1 (TAK1) is a critical signaling hub responsible for translating antigen binding signals

246 better understanding of the immune signaling hub controlled by AtZAR1.

247 olgi itself serves as an important signaling hub capable of initiating stress responses.

248 nels might constitute an important signaling hub for stress response and for pathophysiology and trea

249 apamycin complex 1 (mTORC1), a key signaling hub for the regulation of cellular growth and proliferat

250 Importantly, we identify a novel signaling hub centering on the NLRX1 (nucleotide-binding, lots of

251 he role of SnRK1, which is a sugar-signaling hub that regulates metabolism and transcription in respo

252 termination is facilitated by the signaling hub RPM-1.

253 rturbations, but the nature of the signaling hub(s) involved have remained an enigma.

254 action is unclear, with JAKs being signaling hubs for several cytokines.

255 d led to the identification of key signaling hubs around the G proteins RAP1B and GNB1, the kinases P

256 s has revealed the presence of key signaling hubs that contribute to tumor progression and acquisitio

257 porter of transport flux, or as a signalling hub for the integration of multiple inputs.

258 ts of a transcriptionally centred signalling hub that pleiotropically regulates plant growth and deve

259 Ras proteins are important signalling hubs frequently dysregulated in cancer and in a group of

260 the protein MORC2 and by the human silencing hub (HUSH) complex subunits MPP8 and TASOR.

261 Endosomes are the major protein-sorting hubs of the endocytic pathway.

262 ample, downregulation of the female-specific hub gene Dusp6 in mouse prefrontal cortex mimicked stres

263 ntergroup comparison revealed Oprm1-specific hubs and captured a unique Oprm1 gene-to-network signatu

264 We calculated stationary hub load score (SHub) indicating to what extent brain re

265 enting the striatum and identifying striatal hubs of overlapping inputs, these results help to transl

266 Our study defines YabA as a novel structural hub and explains how the protein tetramer uses independe

267 and avoid being biased toward highly-studied hub proteins, except when they are strongly implicated b

268 dical-induced cell death1 (RCD1) is one such hub, interacting with many transcription factors via the

269 dentification and characterization of "super-hub" signaling nodes located on atrial axial tubules tha

270 AT couplon "super-hubs" thus underlie faster excitation-contraction coupli

271 l synaptic transmission require the synaptic hub protein Munc13.

272 e confirm through phylogenetic analysis that hub interfaces are strongly conserved and rewiring of in

273 We show that hubs of this small-world network are preferentially loca

274 The hub genes and differential interaction patterns identifi

275 -NB) are sub-nuclear organelles that are the hub of numerous proteins.

276 itiating immune signaling, placing it at the hub of new interconnections between DNA replication, DNA

277 Ras is at the hub of signal transduction pathways controlling cell pro

278 red primarily hypothalamic neurons forms the hub of a complex neuroglial network that controls reprod

279 nd one catalytic domain may be parked on the hub, when an odd number of zymogens are bound.

280 This perspective focuses on the hub-protein 14-3-3, which has several hundred identified

281 hosphoenolpyruvate carboxykinase (PCK2), the hub molecule linking tricarboxylic acid (TCA) cycle, gly

282 fation specifically in the niche, termed the hub, led to increased GSC numbers and mispositioning of

283 We found that the hubs in biological networks allow for selective binding

284 Several of these hub genes are GWAS hits for traits that might involve dy

285 ferent species and measurement scales, these hubs show dense interconnectivity, forming a core or "ri

286 ture analysis will investigate whether these hubs are useful as drug targets for treating Acinetobact

287 increased SHub and decreased DHub relate to hub overload and thus poorer/deteriorating cognition.

288 ntimycobacterial host defense gene, as a top hub gene.

289 anced data discovery and access with a track hub registry and a selection of new REST end points.

290 subsequent movement of cattle between trade hubs caused its long-distance spread within the country.

291 Late endosomes are a major trafficking hub in the cell at the crossroads between endocytosis, a

292 ctor E2F2 as the center of a transcriptional hub in the NAD(+)-dependent network.

293 1 as the regulator of a post-transcriptional hub that determined the identity of marginal-zone B cell

294 e further observed Bicoid forming transient "hubs" of locally high density that facilitate binding as

295 The Turkey hub of the health cluster, a UN-activated humanitarian h

296 ture vectors from the tetrahedral sulfur(VI) hub.

297 hesis of covalently linked modules via S(VI) hubs.

298 les), we identified an abnormally widespread hub formation in LD, which particularly affected the pri

299 igh transcriptional coupling associated with hub connectivity is driven by genes regulating the oxida

300 hat significantly negatively correlated with hub genes.