ライフサイエンスコーパス: human

1 e profiles on neurodevelopmental outcomes in humans.

2 up of Denisovans after diverging from modern humans.

3 r-group viruses are also more immunogenic in humans.

4 ishing different forms of these disorders in humans.

5 he ontogenesis of hemispheric asymmetries in humans.

6 cancers and various congenital disorders in humans.

7 tion for RAG off-target cleavage observed in humans.

8 pproach for Hh-associated medulloblastoma in humans.

9 ng those mixtures that are most prevalent in humans.

10 hanol-induced liver disease both in mice and humans.

11 ht represent an adaptation of pH1N1 virus to humans.

12 hed results and global ancestry estimates in humans.

13 ligence and socio-cognitive abilities within humans.

14 orts murine ovarian follicles to produce the human 28-day menstrual cycle hormone profile, which cont

15 We established a mouse xenograft model of human acute myeloid leukemia (AML) that enabled chemothe

16 Severe human adenovirus (HAdV) infections are an increasing thr

17 Here we show that hydrolase levels between human ALF from healthy and CF patients differ.

18 This work shows that each human alpha satellite array produces a unique set of non

19 Mice transgenic for human alphaS (line M20) injected in the hippocampus with

20 from eutherian mammals, including bulls and humans, also contain multiple cysteine residues that for

21 sphorus) from fertilizers, fossil fuels, and human and livestock waste.

22 Human and mouse pluripotent stem cell-derived CMs (PSC-C

23 investigate the ligand specificities of the human and murine forms of the myeloid C-type lectin rece

24 ntified in June 2012 and has since spread in humans and camels.

25 ics, and radiation dosimetry of (64)CuCl2 in humans and to assess the ability of (64)CuCl2 PET/CT to

26 d to the original tumours in immunocompetent humans, and hypoxia was reduced by adoptive TH1 transfer

27 , and common features of major proteins with human anelloviruses, and PCV2 DNA may be present in huma

28 ssociated with reduced ADAMTS7 expression in human aortic endothelial cells and lymphoblastoid cell l

29 e brain and small postcanine teeth of modern humans are among our most distinctive features, and tren

30 derlying SAg-associated immunosuppression in humans are ill-defined.

31 Variants in GDF5 are associated with human arthritis and decreased height, but the causal mut

32 ating that this chemical cue is preserved in humans as well; E2D induces postural avoidance, increase

33 Human astroviruses are recognized as a leading cause of

34 transporter 1 (eENT1) levels are reduced in humans at high altitude and in mice under hypoxia.

35 HCN remodeling likely occurs in human athletes, as well as in rodent models.

36 social behaviors, and highlight the role of human attachment in providing a template for two-brain c

37 ance imaging (fMRI) response patterns in the human auditory cortex.

38 e dimeric form of the toxin, suggesting that human B cells recognize epitopes on the dimerized form o

39 In both mouse and human B cells, BCR ligands that deliver a TLR9 agonist i

40 Mouse BALF and human BALF had a strong positive correlation with 2040 m

41 The latter assume that modern humans benefited from some selective advantage over Nean

42 c Bcl-2 proteins DP5 and PUMA and consequent human beta-cell apoptosis.

43 d THBS1 is cytoprotective to rat, mouse, and human beta-cells exposed to cytokines or thapsigargin-in

44 f drug transporters, SLC and ABC, in resting human blood neutrophils.

45 Antimony, which has damaging effects on the human body and the ecosystem, can be released into soils

46 ately interface with the soft tissues of the human body are of growing interest, due to their emergin

47 ed into presumably all the cell types of the human body in vitro.

48 to play important physiological roles in the human body.

49 as9 genome-editing system to target cells in human body.

50 active isoform in mice (corresponding to the human BRAF(D594A) mutation) triggers lung adenocarcinoma

51 n spontaneous BOLD signal variability in the human brain across the lifespan.

52 ws direct access to pathological and control human brain tissue based on an individual's genetic arch

53 llenge through the analysis and modelling of human brain voltage activity recorded simultaneously acr

54 multimodal information is represented in the human brain.

55 ells and correlate with metastatic status in human breast cancer patients.

56 IL-13-induced goblet cell differentiation of human bronchial epithelial cells.

57 or partially permissive for the majority of human cancer cells that harbor defects in antiviral sign

58 Herein we show in a diverse array of human cancer cells that IMP2 overexpression stimulates a

59 mone calcitonin is intimately connected with human cancer development and proliferation.

60 compendium of 2218 primary tumours across 12 human cancer types and systematically screen for homozyg

61 ule that drives progression of many types of human cancer, but the basis for its actions remains obsc

62 or suppressor or as an oncogene in different human cancers, but direct evidence for its role in tumor

63 nts has improved patient outcomes in several human cancers, no such advance has been achieved in musc

64 s) encode long non-coding RNAs implicated in human carcinogenesis.

65 and pharmacological/genetic modification of human cardiac progenitor cells (hCPCs) are necessary int

66 mere-length measurements in relatively small human cardiac samples and offers an attractive technique

67 of the strain types among the sources and in human cases allows inference on the likely source of eac

68 Cholera is a severe dehydrating illness of humans caused by toxigenic strains of Vibrio cholerae O1

69 , we developed a transgenic mouse expressing human CD39 (hCD39).

70 , NPM-ALK is capable of transforming primary human CD4(+) T cells into immortalized cell lines indist

71 mals models of autoimmunity and Th17-skewing human cell culture in vitro.

72 orming genome-wide landscapes in a series of human cell lines.

73 Fragment-based screening in human cells thus provides an extensive proteome-wide map

74 ibacterial mechanisms, and are non-toxic for human cells, a prerequisite for using them as novel anti

75 of protein kinases regulate key processes in human cells, and protein kinases play a pivotal role in

76 llowing gene inactivation and replacement in human cells, we demonstrate that CENP-A mutants that can

77 cilitate the study of cellular mechanisms in human cells, we established several human stem cell line

78 li and co-localizes with R-loops in cultured human cells.

79 es the ability of poxviruses to replicate in human cells.

80 Apolipoprotein E isolated from human cerebrospinal fluid carries sulfatide that can be

81 -containing 5 (ABHD5), the defective gene in human Chanarin-Dorfman syndrome, is a highly conserved r

82 atory activity, and CRISPR/Cas9 targeting of human chondrocytes demonstrates that the region regulate

83 oid mouse embryonic stem cells with an extra human chromosome and human induced pluripotent stem cell

84 frequency to IGH and AID off-target sites in human chronic lymphocytic leukaemia and mantle cell lymp

85 By using human clinical specimens, we also showed that miR-152 ex

86 tween the neurobiological systems supporting human cognition and emerging computational systems capab

87 ion (i.e., inhibitory control) are essential human cognitive abilities.

88 pharyngeal phenotypes in zebrafish models of human congenital disorders.

89 to infect EpiCorneal cells, a 3-dimensional human corneal tissue model.

90 ike cells to their terminally differentiated human counterparts using defined phenotyping, to make su

91 palate and/or lip are among the most common human craniofacial malformations and involve multiple ge

92 nimal model that replicates the phenotype of human CTEPH.

93 eductase (CPR) is the redox partner for most human cytochrome P450 enzymes.

94 in modulating Rab7B and P2RX7 expression in human DCs.

95 ity.SIGNIFICANCE STATEMENT Activation of the human default mode network (DMN) can be measured with fM

96 dengue virus have highlighted the need for a human DENV challenge model to better evaluate the candid

97 These results suggest an archaic human diaspora early in the Middle Pleistocene.

98 persistent organic pollutants (POPs) in the human diet.

99 etion of p19/Arf is detected, recapitulating human disease.

100 sembly, function, evolution, and its role in human disease.

101 impact on research related to MPYS-mediated human diseases and medicine.

102 apeutic target for treating hypoxic-ischemic human diseases and organ transplantation.

103 tanding of the role of global methylation in human diseases, especially cancer.

104 R signalling is associated with a variety of human diseases, including metabolic disorders and cancer

105 stantially to the understanding of important human diseases.

106 ate the therapeutic relevance of V-ATPase in human diseases.

107 cilia, which has important implications for human disorders related to primary cilia dysfunctions, s

108 sociated with a range of increasingly common human disorders, including Alzheimer and Parkinson disea

109 s have the same size distribution as infused human donor platelets and are preferentially incorporate

110 etermined using a variety of TLR-transfected human embryonic 293 cell lines, while the PF-deficient m

111 e established several human stem cell lines: human embryonic stem cell (hESC) line carrying the commo

112 arch stipulates that experiments with intact human embryos must not allow them to develop beyond 14 d

113 abnormalities are remarkably common in early human embryos, our understanding of early embryonic soma

114 II transactivator can reduce the capacity of human endothelial cells to recruit and activate alloreac

115 duced cell adhesion onto TNF-alpha-activated human endothelial monolayers.

116 Here, we develop skin grafts from mouse and human epidermal progenitors that were engineered by CRIS

117 similar properties to the recently described human epigenetic clock.

118 irical findings suggest that the contents of human episodic memory are often constructed in the servi

119 Murine and human ETV6-RUNX1 pB-ALL revealed recurrent genomic alter

120 Humans exhibit considerable motor variability even acros

121 strual cycle hormone profile, which controls human female reproductive tract and peripheral tissue dy

122 nctional MRI to measure brain function in 32 human fetuses in utero and found that systems-level neur

123 nelloviruses, and PCV2 DNA may be present in human food and vaccines.

124 biodistribution, and radiation dosimetry in humans for the highly selective sigma-1 receptor PET age

125 nto tubulin and native sulfur phasing of the human G protein-coupled adenosine receptor.

126 morphology of aggregates formed by the P23T human gammaD-crystallin mutant associated with congenita

127 For many years, only a small fraction of the human genome was believed to regulate cell function and

128 elements are predicted to be present in the human genome, but direct evidence for their biological f

129 In the human genome, translation initiation from non-AUG codons

130 his study, we present the first quantitative human genome-wide map of DNA lesions induced by ultravio

131 ts (STRs) are hyper-mutable sequences in the human genome.

132 ure providing PIC binding specificity in the human genome.

133 ables fast and affordable sequencing of full human genomes.

134 C) demonstrated functional complexation with human growth hormone binding protein (hGHBp) to the diff

135 It is a matter of fact that the human gut microbiome also includes a non-bacterial fract

136 e polymers drives microbial diversity in the human gut microbiota.

137 d profile, but are important contributors to human health and disease.

138 oncentration of 857 mug/kg, and exceeded the human health cancer screening value of 12 mug/kg in 48%

139 rculating RNAs for monitoring and diagnosing human health has grown significantly.

140 tomic arrangements in matter to the study of human health in medicine.

141 ence particle properties and impact climate, human health, and ecosystems.

142 dy of complex diseases in quest of improving human health.

143 In human heart failure, Ser199 (equivalent to Ser200 in mou

144 carcinoma (HepG2) cell line or immortalized human hepatocytes (IHH) and activation of its downstream

145 selective adaptation of B. pertussis to the human host.

146 stimulates vigorous immune responses in the human host; forcing selection of viral variants that esc

147 , from soil and plants to diverse tissues in human hosts.

148 t skin biopsies obtained during asymptomatic human HSV-2 reactivation exhibit a higher density of ner

149 and lysins can be fused to the Fc region of human IgG, creating a fully functional homodimer (or "ly

150 human induced Treg cells suppress syngeneic human ILC2s through ICOSL to control airway inflammation

151 tation assays, hRETNTg(+)Tlr4(-/-) mice, and human immune cell culture, we demonstrate that hRetn bin

152 During human immunodeficiency virus (HIV) disease, chronic immu

153 As the epidemiological epicenter of the human immunodeficiency virus (HIV) pandemic, the Democra

154 itude), moderate malnutrition, or an unknown human immunodeficiency virus (HIV) status in an HIV-ende

155 e HCV infection in participants with chronic human immunodeficiency virus type 1 (HIV-1) infection.

156 Three-dimensional (3D) ordered arrays of human immunoglobulin G (IgG) were fabricated using well-

157 Here, using human in vivo deuterium labeling, we demonstrate that cl

158 dogs produced different facial movements to humans in comparable states of emotional arousal.

159 CTC and CPC characterization in humans in vivo is still challenging.

160 Human induced pluripotent stem cells (iPSCs) are ideal c

161 tem cells with an extra human chromosome and human induced pluripotent stem cells with trisomy 21, as

162 slational approach, we then demonstrate that human induced Treg cells suppress syngeneic human ILC2s

163 pCRP* constitutes the major CRP species in human-inflamed tissue and allows binding of complement f

164 ote gene expression patterns associated with human inflammatory bowel diseases.

165 Early humans inherited activating KIR2DS4 and an inhibitory li

166 Here, we used human intracranial recordings and visual word-by-word pr

167 Deficiency of factor X (F10) in humans is a rare bleeding disorder with a heterogeneous

168 SdrF bound human keratins 1 and 10 and adhered to keratinocytes and

169 kinase, leading to synergistic inhibition of human leukemia cell viability.

170 e response to bacterial stimulation and less human leukocyte antigen - antigen D related.

171 ping analysis to dissect associations in the human leukocyte antigen region, which suggests important

172 sed strategy relies on initial prediction of human leukocyte antigen-binding peptides by in silico al

173 However, the differential response of human leukocytes to MPLA and LPS has not been well chara

174 on across mammals, since dogs do not display human-like facial expressions.

175 monotherapy before or after establishment of human-like pathology.

176 onstruction map on a radiological image of a human lung and forms an interactive resource for the sci

177 that mouse models can be used to interrogate human lung metabolome changes.

178 enocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensity for

179 Based on the observations in humans, mechanistic experiments were designed in a mouse

180 apitulates key histopathological features of human melanomagenesis was created by inducing a BRafV600

181 dy characterizes a heterogenic population of human melanopsin-ir RGCs, which most likely are involved

182 RATIONALE: Myocardial delivery of human mesenchymal stem cells (hMSCs) is an emerging ther

183 ogenic potential of adipose tissue - derived human mesenchymal stem cells (hMSCs) was evaluated in vi

184 ed, including the parent forms and the major human metabolites of mephedrone, methadone, cocaine, her

185 The phosphoprotein of human metapneumovirus (HMPV) forms homotetramers compose

186 Whereas the use of Infinium Human Methylation BeadChips has shown great utility in c

187 The new algorithm was tested on the human microbiome project (HMP) dataset, currently one of

188 the transcriptional mechanisms that specify human microglia phenotypes are largely unknown.

189 l reveal how the nature of language reflects human minds, rather than the world to which language ref

190 Human mitochondria contain a genome (mtDNA) that encodes

191 lity to atherosclerosis, provides a clinical human model that can be utilized to investigate the link

192 Competitive binding of the human monoclonal antibody (mAb) LE2E9 revealed overlappi

193 Using the Transwell system, both murine and human monocytes sorted with magnetic beads in the inner

194 5 times higher in a chimpanzee muscle than a human muscle of similar size.

195 In humans, mutations in the NMD factor gene, UPF3B, cause i

196 Overexpression of human MYCN in the context of Rb inactivation increased t

197 The normal function of the human myocardium requires the proper generation and util

198 in the size and the number of neurons in the human nervous system, as well as the cellular and molecu

199 accommodating the protracted development of human neural cells.

200 gulation of this mechanism leads to numerous human neurodegenerative or neurodevelopmental disorders.

201 However, human neurodevelopmental disorders related to EBF3 have

202 However, the protracted timing of human neuron specification and functional maturation rem

203 rons with validation in additional mouse and human neurons and multiple learning tests from 1486 rats

204 These data were translated by assessing human neutrophil-endothelial interactions under flow: PD

205 this article, we report that rhAPC binds to human neutrophils via integrin VLA-3 (CD49c/CD29) with a

206 f cereals and pseudocereals most utilized in human nutrition.

207 ious ectoparasites, bed bugs rely heavily on human or animal blood sources for survival, mating and r

208 ucture of 277 RT017 isolates from animal and human origins from six continents, isolated between 1990

209 In this article, we demonstrate that a human ornithine transcarbamylase gene containing various

210 The chromosomal regions across the human orthologous were interrogated for putative periodo

211 with findings from recent genomic studies in humans, our findings provide additional support for the

212 assays on purified immune subsets including human pan-T cells, CD4(+) T cells, CD8(+) T cells, B cel

213 scribed as highly beta-cell selective in the human pancreas and constitutes a tentative surrogate ima

214 cal utility, we analyzed the proteomes of 10 human pancreatic cancer cell lines to a depth of >8,700

215 enhancers is a novel regulatory mechanism in human pancreatic cancer.

216 Human participants altered the learning rates used for t

217 We show that human participants report seeing a third flash when only

218 , relative to those with high salivary FGF2, human participants with low salivary FGF2 exhibited sign

219 a, the model organism Neurospora crassa, the human pathogen Sporothrix schenckii, and the ergot fungu

220 single-stranded RNA (+RNA) viruses including human pathogens hepatitis C virus (HCV), Severe acute re

221 he lack of disease models recapitulating the human pathology.

222 from normal to cirrhotic to HCC tissues from human patients.

223 al sequences corresponding to anelloviruses, human pegivirus 1, herpesviruses, and papillomaviruses w

224 ime course of error-related processing while humans performed a difficult visual discrimination task.

225 Knockdown of LY6E in human peripheral blood mononuclear, SupT1, and THP-1 cel

226 h clinical characteristics that resemble the human phenotype.

227 ts, odor stimulation enhanced theta power in human piriform cortex, with robust effects at the level

228 Mutations in human PKP2 associate with a life-threatening arrhythmoge

229 technique for three-dimensional analyses of human placental vessels; (ii) demonstrate the utility of

230 We confirmed that human plasma contains immunoglobulins that can neutraliz

231 Because the model recapitulates human poliovirus infection and poliomyelitis, it can be

232 potential spread and emerging threat to the human population.

233 drought, rising temperatures, and expanding human populations are increasing water demands.

234 etic mark in particular, DNA methylation, in human populations, and the examination of DNA methylatio

235 were associated with geographically distinct human populations, whereas few strains occurred in multi

236 nteractions (GxEs) in large-scale studies of human populations.

237 esults suggest an age-specific difference in human postvaccination responses.

238 In healthy human pregnancies, maternal hepcidin concentrations are

239 ently, restoring high levels of SOX5/6/21 in human primary glioblastoma cells enabled expression of C

240 on other protective mechanisms, although non-human primate (NHP) studies as well as the RV144 vaccine

241 on, and epithelial-mesenchymal transition in human prostate cancer cell lines, and stable overexpress

242 that ERG is an effector of SPOP mutation in human prostate cancer or mouse models.

243 ion and quality control, we provide a scored human protein-protein interaction network (InWeb_InBioMa

244 d to identify sulfated proteins in yeast and human proteome microarrays, and we expect such approache

245 ructure and comprise a large fraction of the human proteome play important roles in numerous cellular

246 nt pharmacokinetic profile and efficacy in a human PTEN-deficient LNCaP prostate carcinoma xenograft

247 presence of adenosine triphosphate (ATP) the human RAD51 (HsRAD51) recombinase can form a nucleoprote

248 studies have investigated how stress impact humans raised in an overprotective manner.

249 ting high-throughput screening (HTS) data to human relevance have been limited.

250 heless, European sites containing well-dated human remains associated with an Acheulean toolkit remai

251 l care across Latin America, particularly in human resources.

252 ion, engaging an evolutionary perspective on human rhythmic perception and cognition.

253 Here we show that human RNase H2 is unable to process an abasic rNMP (rAP

254 individual N291G and P294K substitutions in human RR additively affect substrate specificity.

255 In human sarcoidosis patients, mTORC1 activation, macrophag

256 he selectivity of detecting cTnT and cTnI in human serum with wide dynamic range.

257 Mutations in human SF3b1 have been linked to many diseases such as my

258 DRGK1 decreases SOX9 expression and causes a human skeletal dysplasia, identifying a mechanism that r

259 the first time the presence of ACSL6 mRNA in human skeletal muscle and the role that ACSL6 plays in l

260 mechanism for increasing metabolic power in human skeletal muscle.

261 plays in lipid synthesis in both rodent and human skeletal muscle.

262 (n = 15), from the Hamann-Todd collection of human skeletons compiled from 1912 to 1938, and 15 indiv

263 in hydrophobic gating, Leu267 and Leu270 in human Slo2.1 were each replaced by 15 different residues

264 nisms in human cells, we established several human stem cell lines: human embryonic stem cell (hESC)

265 ncient mobility is crucial for understanding human strategy at exploiting temporally and spatially pa

266 A recent human study demonstrated that demanding cognitive shifts

267 Next, the current that passed through a human subject during the attack was measured.

268 the expressive power of such models for real human subjects remains unknown.

269 al tolerance to haptens and alleviate ACD in human subjects.

270 e and neurodegenerative conditions affecting humans, such as multiple sclerosis, neuromyelitis optica

271 a GP bound to a neutralizing antibody from a human survivor at 3.2-angstrom resolution.

272 esponses induced by naive and in vivo-primed human T helper 2 cells.

273 Human T-cell leukemia virus type 1 (HTLV-1) is the etiol

274 dence of avian influenza virus infections in humans, the immune correlates of protection for avian in

275 monocytes are commonly described in mice and humans: the classical inflammatory monocytes, which are

276 rnal circulating vitamin D concentrations in humans.This study sought to advance the current understa

277 essing Notch receptors further validates the human thymus as a DC-poietic organ, which provides selec

278 Human tissues are an important link between organ-specif

279 In humans, tolerance of the loss of one or both functional

280 We observed the same patterns in human transcriptomes and we further show that AS rates c

281 Mechanisms supporting human ultra-cooperativeness are very much subject to deb

282 are correlated with serious complications in humans, understanding these processes may improve clinic

283 e first antibody-drug conjugate approved for human use by the FDA.

284 anization into striped-based subdivisions in human V2 and V3.

285 trol subjects was hybridized onto Nanostring human v2 miRNA microarray array and expression data were

286 Following lab validation, we performed a human validation by collecting fingerprick whole blood s

287 nthine barrier (BLB) was investigated in the human vestibular endorgan, the utricular macula, using p

288 mice, the dominance of Vlambda pairing with human VH for HIV-1 Env V2 recognition resulted in human

289 V2 Abs were isolated that used the same human VH gene segment as an RV144 V2 Ab but paired with

290 VH for HIV-1 Env V2 recognition resulted in human VH pairing with mouse lambda L chains instead of a

291 aracterizing spatial encoding throughout the human visual pathways.

292 Thus, despite the absence of the human Vlambda locus in these humanized mice, the dominan

293 rred to as ventromedial prefrontal cortex in humans; vmPFC/mOFC) is involved in constraining the deci

294 m 176 subjects to show that signals from the human white-matter contain meaningful information.

295 In vitro exposure of human whole blood to PhNHOH and NOB demonstrated that on

296 ocessing enzyme Dicer (ADicerKO), as well as humans with lipodystrophy, exhibit a substantial decreas

297 roduction, particularly in a species such as humans with low population differentiation.

298 D2 receptor (D2R) antagonist amisulpride] in humans with resting-state functional magnetic resonance

299 idespread disease of wildlife, livestock and humans world-wide, but long-term empirical datasets desc

300 increasing appreciation for the role of the human Y chromosome in phenotypic differences between the